Aim To investigate in vivo optical coherence tomography (OCT) for imaging of periocular basal cell carcinoma (BCC). Methods Consecutive patients with periocular BCC were prospectively investigated with VivoSight OCT imaging prior to surgical excision. Histology sections were compared with OCT images with regard to lesion measurements (x, y and z dimensions) and histological features. Results A total of 15 patients with biopsy proven BCC were recruited. The OCT horizontal margins correlated positively with histology (r=0.8 and 0.66, x and y axes) and could be identified in 3/15 (x axis) and 6/15 (y axis) cases. The ...

Hypertrophy of the plantar stratum corneum (SC) of the epidermis (also known as hyperkeratosis) is one of the skin's primary protective responses, triggered by either physiological stresses, a result of underlying disease (eg, psoriasis, palmoplantar keratoderma), or external mechanical stresses. In the case of the foot the most common presentations of hyperkeratosis are: anhidrosis, calluses, corns and heel fissures. This article reviews the current evidence in the field of hyperkeratosis of the foot and will present the treatment options available to practitioners and patients. The gaps in the knowledge surrounding the efficacy of treatments are discussed and novel methods ...

Optical coherence tomography (OCT) is a non-invasive, tomographic imaging technique which generates high-resolution in-vivo images up to mid-dermal layers. Due to continuous technological improvements, OCT is moving from research projects into daily dermatological practice. It can complement other imaging methods like high-frequency ultrasound or confocal microscopy. There is a wide variety of indications for OCT. In addition to aiding in the diagnosis and clinical monitoring of inflammatory dermatoses, OCT is a very useful and feasible technique in dermato-oncology.

A detector circuit for a multi-channel interferometer, typically as may be used in an optical coherence tomography device, comprising: a plurality of measurement channels (43) each comprising a measurement detector (31); and a balance channel (44) comprising a balance detector (30), each of the measurement detectors (31) and the balance detector (30) having a light sensitive area and an electrical output configured to output a signal indicative of the intensity of light incident on the light sensitive area, in which each measurement channel (43) is provided with a feedback circuit (40) comprising: a variable gain circuit (35) having an input ...

According to the Skin Cancer Foundation, one person dies from skin cancer every hour in the United States — a good reason why everyone should schedule regular skin examinations. But you may ask, how do dermatologists know when a skin growth or mole needs to be removed? In the past, every worrisome skin lesion required a biopsy, meaning a small piece of tissue was surgically removed and sent to a pathology laboratory. If the biopsy showed cancer, additional surgery was needed. Even today, surgical biopsy and removal continues to be the standard of care for skin cancer. Fortunately, we have newer ...

Optical coherence tomography (OCT) is a noninvasive diagnostic method that offers a view into the superficial layers of the skin in vivo in real-time. An infrared broadband light source allows the investigation of skin architecture and changes up to a depth of 1 to 2 mm with a resolution between 15 and 3 μ m, depending on the system used. Thus OCT enables evaluation of skin lesions, especially nonmelanoma skin cancers and inflammatory diseases, quantification of skin changes, visualization of parasitic infestations, and examination of other indications such as the investigation of nails. OCT provides a quick and useful diagnostic imaging ...

Background Optical coherence tomography (OCT) is an evolving optical technology that is capable of delivering real-time, high-resolution signatures of tissue. Objectives The purpose of this immediate ex vivo prospective clinical study was: (1) to assess the sensitivity and specificity of OCT on biopsy material in identifying potentially malignant and malignant oral lesions, (2) to determine the inter-observer agreement in the analysis of specific image parameters, and (3) to find out the oral epithelial thickness for different pathology groups. Materials and methods This prospective study involved 125 suspicious oral lesions from 125 patients. The lesions were surgically biopsied and subjected to ...

Optical coherence tomography (OCT) is an imaging technology with the potential to provide high-resolution images of the skin non-invasively. With this device, it is possible to identify a host of skin structures including tumors. In this case report, we demonstrate the use of an OCT device in delineating a lateral tumor margin of an ill-defined basal cell carcinoma prior to Mohs micrographic surgery. Following surgery, the OCT images are compared to histologic sections to confirm their accuracy. OCT technology has the potential to be a vital tool for dermatologists and particularly Mohs surgeons in identifying tumor margins and potentially reducing ...