1. Michel Pâques

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    1. Mentioned In 22 Articles

    2. Curved-field optical coherence tomography: large-field imaging of human corneal cells and nerves

      Curved-field optical coherence tomography: large-field imaging of human corneal cells and nerves
      High-resolution optical imaging methods, such as confocal microscopy and full-field optical coherence tomography, capture flat optical sections of the sample. If the sample is curved, the optical field sections through several sample layers and the view of each layer is reduced. Here we present curved-field optical coherence tomography, capable of capturing optical sections of arbitrary curvature. We test the device on a challenging task of imaging the human cornea in ...
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    3. Optical Incoherence Tomography: a method to generate tomographic retinal cross-sections with non-interferometric imaging systems

      Optical Incoherence Tomography: a method to generate tomographic retinal cross-sections with non-interferometric imaging systems
      Optical tomographic cross-sectional images of biological samples were made possible by interferometric imaging techniques such as Optical Coherence Tomography (OCT) [1, 2, 3]. Owing to its unprecedented view of the sample, OCT has become a gold standard, namely for human retinal imaging in the clinical environment. In this Letter, we present Optical Incoherence Tomography (OIT): a completely digital method extending the possibility to generate tomographic retinal cross-sections to non-interferometric imaging ...
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    4. ATTENUATION OUTER RETINAL BANDS ON OPTICAL COHERENCE TOMOGRAPHY FOLLOWING MACULAR EDEMA: A Possible Manifestation of Photoreceptor Misalignmen

      ATTENUATION OUTER RETINAL BANDS ON OPTICAL COHERENCE TOMOGRAPHY FOLLOWING MACULAR EDEMA: A Possible Manifestation of Photoreceptor Misalignmen
      Purpose: Macular edema is a common retinal disease which may leave important anatomical and functional sequelaes. Directional fundus imaging consists of comparing on- and off-axis images to reveal angle-dependent reflectance properties of fundus structures, which may be related to misaligned photoreceptors . Here, we analyzed directional optical coherence tomography (OCT) and flood-illumination adaptive optics ophthalmoscopy images to detect evidence of misaligned photoreceptors following macular edema . Methods: Transversal, observational study. Nine patients ...
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    5. Highlighting Directional Reflectance Properties of Retinal Substructures From D-OCT Images

      Highlighting Directional Reflectance Properties of Retinal Substructures From D-OCT Images
      Optical coherence tomography (OCT), which is routinely used in ophthalmology, enables transverse optical imaging of the retina and, hence, the identification of the different neuronal layers. Directional OCT (D-OCT) extends this technology by acquiring sets of images at different incidence angles of the light beam. In this way, reflectance properties of photoreceptor substructures are highlighted, enabling physicians to study their orientation, which is potentially an interesting biomarker for retinal diseases ...
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    6. Multimodal Ophthalmic Imaging

      Multimodal Ophthalmic Imaging
      Knowledge of the pathogenesis of ocular conditions, a leading cause of blindness, has benefited greatly from recent advances in ophthalmic imaging. However, current clinical imaging systems are limited in resolution, speed, or access to certain structures of the eye. The use of a high-resolution imaging system improves the resolution of ophthalmoscopes by several orders of magnitude, allowing the visualization of many microstructures of the eye: photoreceptors, vessels, nerve bundles in ...
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      Mentions: Michel Pâques
    7. ADAPTIVE OPTICS OPHTHALMOSCOPY CONFERENCE SEPTEMBER 4TH, PARIS

      ADAPTIVE OPTICS OPHTHALMOSCOPY CONFERENCE SEPTEMBER 4TH, PARIS
      Late Summer Course - September 4 5, 2019 - Paris High resolution imaging technologies, exemplified by adaptive optics ophthalmoscopy (AOO) and optical coherence tomography (OCT) are progressively transferring from the lab to the clinic. This is an opportunity to better understand retinal diseases, to optimize their management but also to provide novel biomarkers for other medical specialities. However, there is still an unmet need in the field of clinical interpretation of AOO ...
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    8. Postdoctoral Research Fellow Position within the PARIS High Resolution Retinal Imaging Group

      Postdoctoral Research Fellow Position within the PARIS High Resolution Retinal Imaging Group
      A postdoctoral research fellow position is available within the PARIS high resolution retinal imaging group at the Quinze Vingts National Ophthalmology Hospital and Vision Institute in Paris, France. This is an excellent opportunity for a candidate to use adaptive optics ophthalmoscopy (AOO) and optical coherence tomography to conduct visual optics research in a clinical ophthalmology setting. The postdoc will work with a team of clinicians, engineers and scientists to develop ...
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    9. Cell Motility as Contrast Agent in Retinal Explant Imaging With Full-Field Optical Coherence Tomography

      Cell Motility as Contrast Agent in Retinal Explant Imaging With Full-Field Optical Coherence Tomography
      Purpose : To use cell motility as a contrast agent in retinal explants. Methods : Macaque and mouse retinal explants were imaged with high resolution full field optical coherence tomography (FFOCT) and dynamic FFOCT, coupled with fluorescence imaging. Results : Static and dynamic FFOCT create complementary contrast from different structures within a cell. When imaging in vitro samples, static FFOCT detects steep refractive index gradients to reveal stationary structures including fibers, vessels, collagen ...
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    10. Appearance of the Retina With Full-Field Optical Coherence Tomography

      Appearance of the Retina With Full-Field Optical Coherence Tomography
      Purpose : To interpret full-field optical coherence tomography (FFOCT) images of ex vivo retina. Methods : Flatmounted retinas of human, primate, pig, sheep, rat, and mouse were imaged using FFOCT. To identify retinal ganglion and amacrine cells, fixed samples immunolabeled against Tuj1 and Brn3a or live samples labeled in vitro with green fluorescent protein (GFP) were analyzed by combining FFOCT, fluorescence confocal microscopy (FCM), and fluorescence-FFOCT. To investigate postmortem tissue changes, time ...
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    11. NEW INSIGHT INTO THE MACULAR DEEP VASCULAR PLEXUS IMAGED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

      NEW INSIGHT INTO THE MACULAR DEEP VASCULAR PLEXUS IMAGED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.
      Purpose: To describe the macular deep capillary plexus (DCP) in normal eyes using optical coherence tomography angiography. Methods: Retrospective study including 41 consecutive normal eyes imaged using optical coherence tomography angiography (RTVue XR Avanti; Optovue Inc). Default autosegmentation of the superficial capillary plexus (SCP) and DCP, and manual adjustments of "deep settings" were used to analyze the organization of the normal macular microvascularization and to investigate in vivo the connection ...
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    12. Functional and high-resolution retinal imaging monitoring photoreceptor damage in acute macular neuroretinopathy

      Functional and high-resolution retinal imaging monitoring photoreceptor damage in acute macular neuroretinopathy
      Background To report functional and high-resolution retinal imaging abnormalities, including adaptive optics (AO) throughout the course of acute macular neuroretinopathy (AMNR). Methods Two female patients (four eyes) with a diagnosis of AMNR were observed at the Clinical Investigation Center, CHNO des Quinze-Vingts, Paris, France. The patients underwent detailed ophthalmic examination including best-corrected visual acuity, slit-lamp examination, kinetic and static perimetry, full-field and multifocal electroretinogram, infrared reflectance, autofluorescence imaging and spectral-domain ...
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      Mentions: Michel Pâques
    13. Full-Field Optical Coherence Tomography of Human Donor and Pathological Corneas

      Full-Field Optical Coherence Tomography of Human Donor and Pathological Corneas
      Purpose : To evaluate the performance of a full-field optical coherence tomography (FF-OCT) system in the study of human donor and pathological corneas and assess its suitability for use in eye banks. Methods : Our study was carried out using an FF-OCT system developed for non-invasive imaging of tissue structures in depth with ultrahigh resolution (1m in all directions). Images were acquired from eight stored human donor corneas (either edematous or after ...
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    14. Spectral-Domain Optical Coherence Tomography of the Rodent Eye: Highlighting Layers of the Outer Retina Using Signal Averaging and Comparison with Histology

      Spectral-Domain Optical Coherence Tomography of the Rodent Eye: Highlighting Layers of the Outer Retina Using Signal Averaging and Comparison with Histology
      Spectral-Domain Optical Coherence Tomography (SD-OCT) is a widely used method to observe retinal layers and follow pathological events in human. Recently, this technique has been adapted for animal imaging. This non-invasive technology brings a cross-sectional visualization of the retina, which permits to observe precisely each layer. There is a clear expansion of the use of this imaging modality in rodents, thus, a precise characterization of the different outer retinal layers ...
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      Mentions: Michel Pâques
    15. Recognition of Henle's Fiber Layer on OCT Images

      Recognition of Henle's Fiber Layer on OCT Images
      Mons et al made an important observation about how important is to recognize the normal anatomy of the Henle's fiber layer in the optical coherence tomography images (OCT). Spectral-domain (SD) OCT offers the possibility of evaluating retinal architecture at near-histologic levels of resolution. However, clinicians should be aware that optical variations induced by examination conditions might alter the reflectivity of the retinal layers. This consideration is particularly true when ...
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    16. Using Spectral-Domain Optical Coherence Tomography Imaging to Identify the Presence of Retinal Silicone Oil Emulsification After Silicone Oil Tamponade

      Using Spectral-Domain Optical Coherence Tomography Imaging to Identify the Presence of Retinal Silicone Oil Emulsification After Silicone Oil Tamponade
      Purpose: To describe small hyperreflective areas using spectral-domain optical coherence tomography (SD-OCT) imaging in eyes that have had silicone oil tamponade. Methods: Retrospective case series of 11 eyes of 11 patients. The authors retrospectively identified patients who underwent vitrectomy and silicone oil tamponade secondary to a rhegmatogenous retinal detachment (nine patients), panuveitis with retinal necrosis (one patient), or recurrent full-thickness macular hole surgery (one patient) who had manifestations of silicone ...
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  2. About Michel Pâques

    Michel Pâques is with the Centre d’Investigations Cliniques du CHNO des Quinze-Vingts, Université Paris VI.