1. Michael Pircher

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    1. Mentioned In 115 Articles

    2. Mapping of Corneal Layer Thicknesses With Polarization-Sensitive Optical Coherence Tomography Using a Conical Scan Pattern

      Mapping of Corneal Layer Thicknesses With Polarization-Sensitive Optical Coherence Tomography Using a Conical Scan Pattern
      Purpose : We demonstrate segmentation and mapping of corneal layers (epithelium, Bowman's layer, and stroma) across the entire cornea (limbus to limbus), using additional contrast provided by polarization-sensitive optical coherence tomography (PS-OCT) and analyze the reproducibility of the procedure. Methods : A custom built PS-OCT system operating at 1045 nm central wavelength with conical scanning was used for image acquisition. Conical scanning allows for almost perpendicular beam incidence on the corneal ...
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    3. Adaptable switching schemes for time-encoded multichannel optical coherence tomography

      Adaptable switching schemes for time-encoded multichannel optical coherence tomography
      We introduce the approach of variable time encoding for multichannel optical coherence tomography (OCT). High-speed fiber optical switches are applied for sequential sample arm switching to enable quasisimultaneous image acquisition from three different orientation angles. In comparison with previous multichannel OCT (using simultaneous sample illumination), time-encoded multichannel OCT has no need for division of illumination power among the respective channels to satisfy laser safety requirements. Especially for ophthalmic applicationsin particular ...
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    4. Compact akinetic swept source optical coherence tomography angiography at 1060 nm supporting a wide field of view and adaptive optics imaging modes of the posterior eye

      Compact akinetic swept source optical coherence tomography angiography at 1060 nm supporting a wide field of view and adaptive optics imaging modes of the posterior eye
      Imaging of the human retina with high resolution is an essential step towards improved diagnosis and treatment control. In this paper, we introduce a compact, clinically user-friendly instrument based on swept source optical coherence tomography (SS-OCT). A key feature of the system is the realization of two different operation modes. The first operation mode is similar to conventional OCT imaging and provides large field of view (FoV) images (up to ...
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    5. Large field of view adaptive optics scanning laser ophthalmoscopy and optical coherence tomography

      Large field of view adaptive optics scanning laser ophthalmoscopy and optical coherence tomography
      Adaptive Optics (AO) retinal imaging is revealing microscopic structures of the eye in a non-invasive way. Due to anisoplanatism, conventional AO systems are efficient on small 1x1 field of view (FoV). We present a lens-based AO scanning laser ophthalmoscope (SLO) set-up with 2 deformable mirrors (DM), providing high-resolution retinal imaging on a 4x4 FoV, for an eye pupil diameter of 7 mm. The first DM is in a pupil plane ...
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    6. Visualization of neuritic plaques in Alzheimer’s disease by polarization-sensitive optical coherence microscopy

      Visualization of neuritic plaques in Alzheimer’s disease by polarization-sensitive optical coherence microscopy
      One major hallmark of Alzheimers disease (AD) and cerebral amyloid angiopathy (CAA) is the deposition of extracellular senile plaques and vessel wall deposits composed of amyloid-beta (A ). In AD, degeneration of neurons is preceded by the formation of A plaques, which show different morphological forms. Most of them are birefringent owing to the parallel arrangement of amyloid fibrils. Here, we present polarization sensitive optical coherence microscopy (PS-OCM) for imaging mature ...
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    7. Polarization-sensitive optical coherence tomography in the anterior mouse eye

      Polarization-sensitive optical coherence tomography in the anterior mouse eye
      Polarization-sensitive optical coherence tomography (PS-OCT) provides intrinsic contrast related to tissue microstructure. In the past, PS-OCT has been successfully used for imaging the anterior eye of humans in a variety of pathologic conditions. Here, we present PS-OCT imaging of the anterior eye in mice. Spectral domain PS-OCT centered at a wavelength of 840 nm was performed in anaesthetized laboratory mice. Three dimensional data sets were acquired at a 70 kHz ...
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    8. Development and Application of Optical Coherence Tomography (OCT)

      Development and Application of Optical Coherence Tomography (OCT)
      To celebrate the 25th anniversary of the introduction of OCT, the special feature issue entitled Development and Application of Optical Coherence Tomography (OCT) had been initiated. OCT originated from low coherence interferometry [ 1 ] and was adapted for tomographic imaging in 1991 [ 2 ]. In OCT, broad bandwidth light is used in order to produce cross-sectional images of turbid and translucent samples with high axial resolution (in the order of a few ...
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    9. THREE-DIMENSIONAL ANALYSIS OF RETINAL MICROANEURYSMS WITH ADAPTIVE OPTICS OPTICAL COHERENCE TOMOGRAPHY

      THREE-DIMENSIONAL ANALYSIS OF RETINAL MICROANEURYSMS WITH ADAPTIVE OPTICS OPTICAL COHERENCE TOMOGRAPHY
      Purpose: To characterize retinal microaneurysms (MAs) in patients with diabetes using adaptive optics optical coherence tomography (AOOCT) and compare details found in AOOCT with those found in commercially available retinal imaging techniques. Methods: Patients with diabetes and MA in the macular area were included in this pilot study. The area of interest, identified in standard fluorescein angiography, was imaged using an AO fundus camera and AOOCT. Microaneurysms were characterized in ...
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    10. IMAGING OF VITELLIFORM MACULAR LESIONS USING POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY

      IMAGING OF VITELLIFORM MACULAR LESIONS USING POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY
      Purpose: To examine the involvement of the retinal pigment epithelium (RPE) in the presence of vitelliform macular lesions (VML) in Best vitelliform macular dystrophy (BVMD), autosomal recessive bestrophinopathy, and adult-onset vitelliform macular degeneration using polarization-sensitive optical coherence tomography (PS-OCT). Methods: A total of 35 eyes of 18 patients were imaged using a PS-OCT system and blue light fundus autofluorescence imaging. Pathogenic mutations in the BEST1 gene, 3 of which were ...
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    11. Multi-directional optical coherence tomography for retinal imaging

      Multi-directional optical coherence tomography for retinal imaging
      We introduce multi-directional optical coherence tomography (OCT), a technique for investigation of the scattering properties of directionally reflective tissue samples. By combining the concepts of multi-channel and directional OCT, this approach enables simultaneous acquisition of multiple reflectivity depth-scans probing a mutual sample location from differing angular orientations. The application of multi-directional OCT in retinal imaging allows for in-depth investigations on the directional reflectivity of the retinal nerve fiber layer, Henles ...
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    12. Polarisation-sensitive optical coherence tomography for material

      Polarisation-sensitive optical coherence tomography for material
      Optical Coherence Tomography (OCT) is an emerging technology for high-resolution non-contact imaging of semi-transparent structures. Originally developed for medical diagnostics, we extend the OCT-technique to problems posed in material testing and characterisation. Layer thickness and refractive indices as well as internal structures of polymer parts have been determined within this study. An extension of OCT, namely polarisation-sensitive OCT (PS-OCT) has been used to identify regions of increased anisotropy within injection-moulded ...
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    13. Special Feature Development and Application of Optical Coherence Tomography (OCT)

      Special Feature Development and Application of Optical Coherence Tomography (OCT)
      To celebrate the 25th anniversary of the introduction of OCT, the special feature issue entitled Development and Application of Optical Coherence Tomography (OCT) had been initiated. OCT originated from low coherence interferometry [1] and was adapted for tomographic imaging in 1991 [2]. In OCT, broad bandwidth light is used in order to produce cross-sectional images of turbid and translucent samples with high axial resolution (in the order of a few ...
      Read Full Article
    14. 1-15 of 115 1 2 3 4 5 6 7 8 »
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  2. About Michael Pircher

    Michael Pircher

    Michael Pircher graduated from the Experimental Physics Department of the University of Technology of Graz, Austria in 2000. In 2003 he finished his PhD at the University of Technology of Vienna. From 2003 to 2006 he worked as a Postdoc at the Center for Biomedical Engineering and Physics of the Medical University of Vienna. From 2006 to 2012 he was working as an Assistant Professor at the Center for Medical Physics and Biomedical Engineering of the Medical University of Vienna where he gained his Habilitation in 2008. Currently he is Associate Professor and faculty member of the same department. His scientific interest lies in retinal imaging, adaptive optics, new contrast techniques in optical coherence tomography, coherence microscopy