1. Michael Pircher

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    1. Mentioned In 95 Articles

    2. Multi-Functional OCT Enables Longitudinal Study of Retinal Changes in a VLDLR Knockout Mouse Model

      Multi-Functional OCT Enables Longitudinal Study of Retinal Changes in a VLDLR Knockout Mouse Model
      We present a multi-functional optical coherence tomography (OCT) imaging approach to study retinal changes in the very-low-density-lipoprotein-receptor (VLDLR) knockout mouse model with a threefold contrast. In the retinas of VLDLR knockout mice spontaneous retinal-chorodoidal neovascularizations form, having an appearance similar to choroidal and retinal neovascularizations (CNV and RNV) in neovascular age-related macular degeneration (AMD) or retinal angiomatous proliferation (RAP). For this longitudinal study, the mice were imaged every 4 to ...
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    3. Automated Identification and Quantification of Subretinal Fibrosis in Neovascular Age-Related Macular Degeneration Using Polarization-Sensitive OCT

      Automated Identification and Quantification of Subretinal Fibrosis in Neovascular Age-Related Macular Degeneration Using Polarization-Sensitive OCT
      Purpose : To identify and quantify subretinal fibrosis in eyes with advanced neovascular age-related macular degeneration (nAMD) using polarization-sensitive optical coherence tomography (PS-OCT). Methods : Eyes of patients with subretinal fibrosis secondary to nAMD were included in this case series. All patients underwent a complete ophthalmic examination to clearly identify advanced nAMD lesions with fibrosis. Examinations of PS-OCT were performed using a novel system with an integrated eye tracker. Areas of fibrosis ...
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    4. Multi-modal adaptive optics system including fundus photography and optical coherence tomography for the clinical setting

      Multi-modal adaptive optics system including fundus photography and optical coherence tomography for the clinical setting
      We present a new compact multi-modal imaging prototype that combines an adaptive optics (AO) fundus camera with AO-optical coherence tomography (OCT) in a single instrument. The prototype allows acquiring AO fundus images with a field of view of 4x4 and with a frame rate of 10fps. The exposure time of a single image is 10 ms. The short exposure time results in nearly motion artifact-free high resolution images of the ...
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    5. Retinal Pigment Epithelial Features in Central Serous Chorioretinopathy Identified by Polarization-Sensitive Optical Coherence Tomography

      Retinal Pigment Epithelial Features in Central Serous Chorioretinopathy Identified by Polarization-Sensitive Optical Coherence Tomography
      Purpose : To determine the subclinical RPE lesions detected by tissue selective polarization-sensitive optical coherence tomography (PS-OCT) in eyes with central serous chorioretinopathy (CSC) and to compare PS-OCT findings to current imaging standards. Methods : In this prospective observational case series, individuals with unilateral or bilateral active CSC were imaged using PS-OCT at baseline and after resolution of serous retinal detachment. Features seen on PS-OCT were compared with corresponding lesions as seen ...
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    6. Polarization properties of single layers in the posterior eyes of mice and rats investigated using high resolution polarization sensitive optical coherence tomography

      Polarization properties of single layers in the posterior eyes of mice and rats investigated using high resolution polarization sensitive optical coherence tomography
      We present a high resolution polarization sensitive optical coherence tomography (PS-OCT) system for ocular imaging in rodents. The system operates at 840 nm and uses a broadband superluminescent diode providing an axial resolution of 5.1 m in air. PS-OCT data was acquired at 83 kHz A-scan rate by two identical custom-made spectrometers for orthogonal polarization states. Pigmented (Brown Norway, Long Evans) and non-pigmented (Sprague Dawley) rats as well as ...
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    7. Depth encoded three-beam swept source Doppler optical coherence tomography

      Depth encoded three-beam swept source Doppler optical coherence tomography
      A novel approach for investigation of human retinal and choroidal blood flow by the means of multi-channel swept source Doppler optical coherence tomography (SS-D-OCT) system is being developed. We present preliminary in vitro measurement results for quantification of the 3D velocity vector of scatterers in a flow phantom. The absolute flow velocity of moving scatterers can be obtained without prior knowledge of flow orientation. In contrast to previous spectral domain ...
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    8. Total retinal blood flow and reproducibility evaluation by three beam optical Doppler tomography

      Total retinal blood flow and reproducibility evaluation by three beam optical Doppler tomography
      We present a three beam optical Doppler tomography (ODT) technique suitable for 3-D velocity and flow measurements to evaluate total retinal blood circulation from and to the optic nerve head (ONH). The system consists of three independent ODT channels. Superluminescent diodes with a central wavelength of 840 nm and a spectral bandwidth of 50 nm were used. The sources are coupled to collimators resting in a specially designed mount to ...
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    9. Method and apparatus for processing polarization data of polarization sensitive optical coherence tomography

      Method and apparatus for processing polarization data of polarization sensitive optical coherence tomography
      A method for processing polarization data includes steps of acquiring a plurality of sets of polarization data items, converting the set of polarization data items into a representation including parameters of amplitude and phase, and averaging the converted set of polarization data items.
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    10. Total retinal blood flow measurement by three beam Doppler optical coherence tomography

      Total retinal blood flow measurement by three beam Doppler optical coherence tomography
      We present measurements of total retinal blood flow in healthy volunteers using a three beam Doppler optical coherence tomography (D-OCT) technique. This technology has the advantage of a precise determination of the flow vector without the use of any a-priori information on the vessel geometry. Circular D-OCT scans around the optic disc were recorded and venous as well as arterial total blood flow was determined and compared for each subject ...
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    11. Spectral degree of polarization uniformity for polarization-sensitive OCT

      Spectral degree of polarization uniformity for polarization-sensitive OCT
      Depolarization of light can be measured by polarization-sensitive optical coherence tomography (PS-OCT) and has been used to improve tissue discrimination as well as segmentation of pigmented structures. Most approaches to depolarization assessment for PS-OCT such as the degree of polarization uniformity (DOPU) rely on measuring the uniformity of polarization states using spatial evaluation kernels. In this article, we present a different approach which exploits the spectral dimension. We introduce the ...
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    12. Melanin Pigmentation in Rat Eyes: In Vivo Imaging by Polarization-Sensitive Optical Coherence Tomography and Comparison to Histology

      Melanin Pigmentation in Rat Eyes: In Vivo Imaging by Polarization-Sensitive Optical Coherence Tomography and Comparison to Histology
      Purpose : The purpose of this study was to demonstrate polarization-sensitive optical coherence tomography (PS-OCT) for imaging pigmented structures in the posterior eye segments of albino and pigmented rats and to correlate depolarization contrast of the retinal pigment epithelium (RPE) and choroid in in vivo PS-OCT to melanin pigmentation detected in postmortem histologic serial sections. Methods : In vivo three-dimensional PS-OCT imaging was performed in adult albino and pigmented rat eyes at ...
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    13. Polarization-Sensitive Optical Coherence Tomography and Conventional Retinal Imaging Strategies in Assessing Foveal Integrity in Geographic Atrophy

      Polarization-Sensitive Optical Coherence Tomography and Conventional Retinal Imaging Strategies in Assessing Foveal Integrity in Geographic Atrophy
      Purpose : To compare current imaging methods with respect to their ability to detect the condition of the fovea in patients with geographic atrophy (GA). Methods : The retinas of 176 eyes with GA were imaged using two spectral-domain optical coherence tomography (SD-OCT) systems, Cirrus HD-OCT and Spectralis HRA+OCT, and fundus autofluorescence (FAF) and infrared imaging (IR) was used in the scanning laser ophthalmoscope (SLO) mode. Polarization-sensitive OCT (PS-OCT), which selectively ...
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    14. Comparison of the polarization properties in the retinas of different rodents using high resolution polarization sensitive OCT

      Comparison of the polarization properties in the retinas of different rodents using high resolution polarization sensitive OCT
      Animal models play an important role for understanding the pathophysiology of glaucoma and age-related macular degeneration. With these models, longitudinal studies can be performed and therefore there is need for non-invasive evaluation of disease progress. For that purpose optical coherence tomography (OCT) can be used. Since tissues with different polarization properties are important in these diseases, polarization sensitive OCT (PS-OCT) could be a valuable tool in preclinical research. In this ...
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    15. In vivo imaging of retinal and choroidal vasculature in the rodent eye using optical coherence tomography

      In vivo imaging of retinal and choroidal vasculature in the rodent eye using optical coherence tomography
      In vivo imaging technologies such as optical coherence tomography (OCT) and rodent models enable longitudinal studies of different ophthalmic pathologies and their underlying physiological changes. In this work a custom-made high resolution polarization sensitive OCT system is used to image the posterior eye of small rodents like mice and rats. Enface projections at certain depths/levels in the three-dimensional (3D) reflectivity images enable to visualize different vascular structures in the ...
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    16. Polarisation-sensitive OCT is useful for evaluating retinal pigment epithelial lesions in patients with neovascular AMD

      Polarisation-sensitive OCT is useful for evaluating retinal pigment epithelial lesions in patients with neovascular AMD
      Background/aims To examine the reproducibility of lesion dimensions of the retinal pigment epithelium (RPE) in neovascular age-related macular degeneration (AMD) with polarisation-sensitive optical coherence tomography (PS-OCT), specifically imaging the RPE. Methods Twenty-six patients (28 eyes) with neovascular AMD were included in this study, and examined by a PS-OCT prototype. Each patient was scanned five times at a 1-day visit. The PS-OCT B-scan located closest to the macular centre presenting ...
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  2. About Michael Pircher

    Michael Pircher

    Michael Pircher graduated from the Experimental Physics Department of the University of Technology of Graz, Austria in 2000. In 2003 he finished his PhD at the University of Technology of Vienna. From 2003 to 2006 he worked as a Postdoc at the Center for Biomedical Engineering and Physics of the Medical University of Vienna. From 2006 to 2012 he was working as an Assistant Professor at the Center for Medical Physics and Biomedical Engineering of the Medical University of Vienna where he gained his Habilitation in 2008. Currently he is Associate Professor and faculty member of the same department. His scientific interest lies in retinal imaging, adaptive optics, new contrast techniques in optical coherence tomography, coherence microscopy