1. Michael Pircher

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    1. Mentioned In 87 Articles

    2. Total retinal blood flow measurement by three beam Doppler optical coherence tomography

      Total retinal blood flow measurement by three beam Doppler optical coherence tomography
      We present measurements of total retinal blood flow in healthy volunteers using a three beam Doppler optical coherence tomography (D-OCT) technique. This technology has the advantage of a precise determination of the flow vector without the use of any a-priori information on the vessel geometry. Circular D-OCT scans around the optic disc were recorded and venous as well as arterial total blood flow was determined and compared for each subject ...
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    3. Spectral degree of polarization uniformity for polarization-sensitive OCT

      Spectral degree of polarization uniformity for polarization-sensitive OCT
      Depolarization of light can be measured by polarization-sensitive optical coherence tomography (PS-OCT) and has been used to improve tissue discrimination as well as segmentation of pigmented structures. Most approaches to depolarization assessment for PS-OCT such as the degree of polarization uniformity (DOPU) rely on measuring the uniformity of polarization states using spatial evaluation kernels. In this article, we present a different approach which exploits the spectral dimension. We introduce the ...
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    4. Melanin Pigmentation in Rat Eyes: In Vivo Imaging by Polarization-Sensitive Optical Coherence Tomography and Comparison to Histology

      Melanin Pigmentation in Rat Eyes: In Vivo Imaging by Polarization-Sensitive Optical Coherence Tomography and Comparison to Histology
      Purpose : The purpose of this study was to demonstrate polarization-sensitive optical coherence tomography (PS-OCT) for imaging pigmented structures in the posterior eye segments of albino and pigmented rats and to correlate depolarization contrast of the retinal pigment epithelium (RPE) and choroid in in vivo PS-OCT to melanin pigmentation detected in postmortem histologic serial sections. Methods : In vivo three-dimensional PS-OCT imaging was performed in adult albino and pigmented rat eyes at ...
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    5. Polarization-Sensitive Optical Coherence Tomography and Conventional Retinal Imaging Strategies in Assessing Foveal Integrity in Geographic Atrophy

      Polarization-Sensitive Optical Coherence Tomography and Conventional Retinal Imaging Strategies in Assessing Foveal Integrity in Geographic Atrophy
      Purpose : To compare current imaging methods with respect to their ability to detect the condition of the fovea in patients with geographic atrophy (GA). Methods : The retinas of 176 eyes with GA were imaged using two spectral-domain optical coherence tomography (SD-OCT) systems, Cirrus HD-OCT and Spectralis HRA+OCT, and fundus autofluorescence (FAF) and infrared imaging (IR) was used in the scanning laser ophthalmoscope (SLO) mode. Polarization-sensitive OCT (PS-OCT), which selectively ...
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    6. Comparison of the polarization properties in the retinas of different rodents using high resolution polarization sensitive OCT

      Comparison of the polarization properties in the retinas of different rodents using high resolution polarization sensitive OCT
      Animal models play an important role for understanding the pathophysiology of glaucoma and age-related macular degeneration. With these models, longitudinal studies can be performed and therefore there is need for non-invasive evaluation of disease progress. For that purpose optical coherence tomography (OCT) can be used. Since tissues with different polarization properties are important in these diseases, polarization sensitive OCT (PS-OCT) could be a valuable tool in preclinical research. In this ...
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    7. In vivo imaging of retinal and choroidal vasculature in the rodent eye using optical coherence tomography

      In vivo imaging of retinal and choroidal vasculature in the rodent eye using optical coherence tomography
      In vivo imaging technologies such as optical coherence tomography (OCT) and rodent models enable longitudinal studies of different ophthalmic pathologies and their underlying physiological changes. In this work a custom-made high resolution polarization sensitive OCT system is used to image the posterior eye of small rodents like mice and rats. Enface projections at certain depths/levels in the three-dimensional (3D) reflectivity images enable to visualize different vascular structures in the ...
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    8. Polarisation-sensitive OCT is useful for evaluating retinal pigment epithelial lesions in patients with neovascular AMD

      Polarisation-sensitive OCT is useful for evaluating retinal pigment epithelial lesions in patients with neovascular AMD
      Background/aims To examine the reproducibility of lesion dimensions of the retinal pigment epithelium (RPE) in neovascular age-related macular degeneration (AMD) with polarisation-sensitive optical coherence tomography (PS-OCT), specifically imaging the RPE. Methods Twenty-six patients (28 eyes) with neovascular AMD were included in this study, and examined by a PS-OCT prototype. Each patient was scanned five times at a 1-day visit. The PS-OCT B-scan located closest to the macular centre presenting ...
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    9. POLARIZATION-SENSITIVE Optical Coherence Tomography System

      POLARIZATION-SENSITIVE Optical Coherence Tomography System
      In a polarization-sensitive optical coherence tomography system, an interferometer includes single mode fibers and a plurality of polarization controllers. At least one of the plurality of polarization controllers is disposed on each of the fibers of the interferometer. The fibers include a fiber for sample light beam, a fiber for reference light beam, and a fiber for detection light beam. An image forming unit determines a pixel value from a ...
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    10. Identification of Drusen Characteristics in Age-related Macular Degeneration by Polarization-Sensitive Optical Coherence Tomography

      Identification of Drusen Characteristics in Age-related Macular Degeneration by Polarization-Sensitive Optical Coherence Tomography
      ...h for articles by this author , Maria Platzer x Maria Platzer Search for articles by this author , Michael Pircher x Michael Pircher Search for articles by this author , Christoph K. Hitzenberger x Christoph K....
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    11. Analysis of optimum conditions of depolarization imaging by polarization-sensitive optical coherence tomography in the human retina

      Analysis of optimum conditions of depolarization imaging by polarization-sensitive optical coherence tomography in the human retina
      Measurement and imaging of depolarization by polarization-sensitive optical coherence tomography (PS-OCT) requires averaging of Stokes vector elements within two- or three-dimensional (3-D) evaluation windows to obtain the degree of polarization uniformity (DOPU). By use of a PS-OCT system with an integrated retinal tracker, we analyze optimum conditions for depolarization imaging, data processing, and segmentation of depolarizing tissue in the human retina. The trade-offs between figures of merit like DOPU imaging ...
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    12. Three-beam Doppler optical coherence tomography using a facet prism telescope and MEMS mirror for improved transversal resolution

      Three-beam Doppler optical coherence tomography using a facet prism telescope and MEMS mirror for improved transversal resolution
      An improved three-beam Doppler optical coherence tomography system was developed. It utilizes a custom-made three-facet prism telescope to improve the transversal resolution at the sample. Furthermore, a two-axis gimbal-less MEMS mirror is used to minimize off-pivot beam movement at the pupil of the eye, enabling circular scanning for in vivo retinal measurements. We demonstrate the systems abilities for in vitro circular scanning to measure absolute flow and to reconstruct the ...
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    13. Peripapillary rat sclera investigated in vivo with polarization sensitive optical coherence tomography

      Peripapillary rat sclera investigated in vivo with polarization sensitive optical coherence tomography
      Purpose: To demonstrate polarization sensitive (PS) optical coherence tomography (OCT) for non-invasive, volumetric, and quantitative imaging of the birefringent properties of the peripapillary rat sclera. To compare the findings in PS-OCT images to state-of-the-art histomorphometric analysis of the same tissues. Methods: A high-speed PS-OCT prototype operating at 840 nm was modified for imaging the rat eye. Densely sampled PS-OCT raster scans covering an area of ~1.5 mm 1.5 ...
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    14. Single input state polarization sensitive swept source optical coherence tomography based on an all single mode fiber interferometer

      Single input state polarization sensitive swept source optical coherence tomography based on an all single mode fiber interferometer
      ...Author Affiliations Wolfgang Trasischker,^* Stefan Zotter, Teresa Torzicky, Bernhard Baumann, Richard Haindl, Michael Pircher, and Christoph K. Hitzenberger ^Center for Medical Physics and Biomedical Engineering, Medic...
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    15. RETINAL PIGMENT EPITHELIUM FINDINGS IN PATIENTS WITH ALBINISM USING WIDE-FIELD POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY

      RETINAL PIGMENT EPITHELIUM FINDINGS IN PATIENTS WITH ALBINISM USING WIDE-FIELD POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY
      Purpose: To investigate pigmentation characteristics of the retinal pigment epithelium (RPE) in patients with albinism using wide-field polarization-sensitive optical coherence tomography compared with intensity-based spectral domain optical coherence tomography and fundus autofluorescence imaging. Methods: Five patients (10 eyes) with previously genetically diagnosed albinism and 5 healthy control subjects (10 eyes) were imaged by a wide-field polarization-sensitive optical coherence tomography system (scan angle: 40 x 40[degrees] on the retina), sensitive ...
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  2. About Michael Pircher

    Michael Pircher

    Michael Pircher graduated from the Experimental Physics Department of the University of Technology of Graz, Austria in 2000. In 2003 he finished his PhD at the University of Technology of Vienna. From 2003 to 2006 he worked as a Postdoc at the Center for Biomedical Engineering and Physics of the Medical University of Vienna. From 2006 to 2012 he was working as an Assistant Professor at the Center for Medical Physics and Biomedical Engineering of the Medical University of Vienna where he gained his Habilitation in 2008. Currently he is Associate Professor and faculty member of the same department. His scientific interest lies in retinal imaging, adaptive optics, new contrast techniques in optical coherence tomography, coherence microscopy