1. Michael Larsen

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    1. Mentioned In 20 Articles

    2. Developmental approach towards high resolution optical coherence tomography for glaucoma diagnostics

      Developmental approach towards high resolution optical coherence tomography for glaucoma diagnostics
      Glaucoma is caused by a pathological rise in the intraocular pressure, which results in a progressive loss of vision by a damage to retinal cells and the optical nerve head. Early detection of pressure-induced damage is thus essential for the reduction of eye pressure and to prevent severe incapacity or blindness. Within the new European Project GALAHAD (Glaucoma Advanced, Label free High Resolution Automated OCT Diagnostics), we will develop a ...
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      Mentions: Michael Larsen
    3. Thickness mapping of individual retinal layers and sectors by Spectralis SD-OCT in Autosomal Dominant Optic Atrophy

      Thickness mapping of individual retinal layers and sectors by Spectralis SD-OCT in Autosomal Dominant Optic Atrophy
      Purpose To assess layer- and location-specific retinal thickness deficits in autosomal dominant optic atrophy (ADOA) using Spectralis SD-OCT. Methods This cross-sectional study included 41 ADOA patients with OPA1 exon 28 (2826delT) mutation [age, 8.683.5 years; best-corrected visual acuity (BCVA), 889 Early Treatment Diabetic Retinopathy Study (ETDRS) letters] and 55 mutation-free first-degree relatives as healthy controls (age, 8.968.7; BCVA, 8099). Participants underwent routine examination and optical coherence ...
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    4. RELATION BETWEEN FLUORESCEIN ANGIOGRAPHIC AND SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY FINDINGS OF BLOOD FLOW TURBULENCE AT ARTERIOVENOUS CROSSINGS IN THE RETINA

      RELATION BETWEEN FLUORESCEIN ANGIOGRAPHIC AND SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY FINDINGS OF BLOOD FLOW TURBULENCE AT ARTERIOVENOUS CROSSINGS IN THE RETINA
      Purpose: To examine retinal blood flow at arteriovenous crossings using spectral-domain optical coherence tomography (SD-OCT). Methods: Retrospective observational case series of 11 arteriovenous crossings in 10 eyes examined by SD-OCT and fluorescein angiography on suspicion of manifest or imminent branch retinal vein occlusion. Results: Fluorescein angiographic evidence of turbulence was seen at 5 of 11 arteriovenous crossings, whereas laminar angiographic flow was intact at the crossing and downstream thereof at ...
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    5. Enhanced-Depth Imaging Optical Coherence Tomography of the Human Choroid In Vivo Compared With Histology After Enucleation

      Enhanced-Depth Imaging Optical Coherence Tomography of the Human Choroid In Vivo Compared With Histology After Enucleation
      Purpose : This study compared in vivo enhanced-depth imaging optical coherence tomography (EDI-OCT) with ex vivo histology of the choroid in human eyes. Methods : Three eyes in three patients with advanced iris melanoma without posterior segment involvement underwent EDI-OCT less than 24 hours prior to enucleation and, in one eye, immediately after enucleation. Following fixation in 4% buffered formaldehyde and paraffin embedding, serial sections of the whole eye were cut horizontally ...
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    6. Dark adaptation in relation to choroidal thickness in healthy young subjects: a cross-sectional, observational study

      Dark adaptation in relation to choroidal thickness in healthy young subjects: a cross-sectional, observational study
      Background Dark adaptation is an energy-requiring process in the outer retina nourished by the profusely perfused choroid. We hypothesized that variations in choroidal thickness might affect the rate of dark adaptation. Method Cross-sectional, observational study of 42 healthy university students (mean age 252.0 years, 29 % men) who were examined using an abbreviated automated dark adaptometry protocol with a 2 diameter stimulus centered 5 above the point of fixation. The ...
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    7. OPTICAL COHERENCE TOMOGRAPHY IN JUVENILE NEURONAL CEROID LIPOFUSCINOSIS

      OPTICAL COHERENCE TOMOGRAPHY IN JUVENILE NEURONAL CEROID LIPOFUSCINOSIS
      Purpose: To report optical coherence tomography findings obtained in two patients with juvenile neuronal ceroid lipofuscinosis. Methods: Two case reports. Results: Two 7-year-old girls presented with decreased visual acuity, clumsiness, night blindness, and behavioral problems. Optical coherence tomography showed an overall reduction in thickness of the central retina, as well as the outer and the inner retinal layers. The degenerative retinal changes were the same, despite different mutations in the ...
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    8. OPTICAL COHERENCE TOMOGRAPHY IN JUVENILE NEURONAL CEROID LIPOFUSCINOSIS

      OPTICAL COHERENCE TOMOGRAPHY IN JUVENILE NEURONAL CEROID LIPOFUSCINOSIS
      Purpose: To report optical coherence tomography findings obtained in two patients with juvenile neuronal ceroid lipofuscinosis. Methods: Two case reports. Results: Two 7-year-old girls presented with decreased visual acuity, clumsiness, night blindness, and behavioral problems. Optical coherence tomography showed an overall reduction in thickness of the central retina, as well as the outer and the inner retinal layers. The degenerative retinal changes were the same, despite different mutations in the ...
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    9. Mechanism of Retinal Pigment Epithelium Tear Formation Following Intravitreal Anti–Vascular Endothelial Growth Factor Therapy Revealed by Spectral-Domain Optical Coherence Tomography

      Mechanism of Retinal Pigment Epithelium Tear Formation Following Intravitreal Anti–Vascular Endothelial Growth Factor Therapy Revealed by Spectral-Domain Optical Coherence Tomography
      ...nt of Ophthalmology, Roskilde Hospital, Roskilde, Denmark + University of Copenhagen, Copenhagen, Denmark , * Michael Larsen Affiliations + University of Copenhagen, Copenhagen, Denmark + Department of Ophthalmology, Glo...
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    10. Flow patterns on spectral-domain optical coherence tomography reveal flow directions at retinal vessel bifurcations

      Flow patterns on spectral-domain optical coherence tomography reveal flow directions at retinal vessel bifurcations
      Purpose: To study intravascular characteristics of flowing blood in retinal vessels using spectral-domain optical coherence tomography (SD-OCT). Methods: Examination of selected arterial bifurcations and venous sites of confluence in 25 healthy 11-year-old children recruited as an ad hoc subsample from the population-based, observational Copenhagen Child Cohort 2000 study. Results: The blood stream in retinal arteries maintains a figure-of-8 SD-OCT profile consistent with a laminar flow in concentric sheets and a ...
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    11. Retinal and choroidal intravascular spectral-domain optical coherence tomography

      Retinal and choroidal intravascular spectral-domain optical coherence tomography
      Purpose: To examine retinal and choroidal blood vessels using spectral-domain optical coherence tomography (SD-OCT). Methods: Retrospective case series. Results: Scans through retinal blood vessels in healthy subjects demonstrated vessel wall reflexes and a tri-layer profile of the blood column on longitudinal scans and a figure-of-eight configuration on cross-sectional scans. Intravascular reflectivity decreased with increasingly oblique angles of observation and was absent when blood flow was parallel to the line of ...
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    12. Local retinal sensitivity in relation to specific retinopathy lesions in diabetic macular oedema

      Local retinal sensitivity in relation to specific retinopathy lesions in diabetic macular oedema
      Purpose:  To study microperimetric macular sensitivity in diabetic macular oedema (DMO) in relation to lesion characteristics obtained by optical coherence tomography (OCT), colour fundus photography, and fluorescein angiography (FA). Methods:  The study comprised 20 eyes in 15 patients with nonproliferative diabetic retinopathy and recently diagnosed untreated DMO. Investigations included microperimetry, fluorescein angiography, colour fundus photography, and OCT. All measures and gradings were made for each of the nine fields of ...
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    13. Evaluation of macular structure and function by OCT and electrophysiology in patients with vitelliform macular dystrophy due to mutations in BEST1

      ...to mutations in BEST1. Patrik Schatz,^1 Hanna Bitner,^2 Birgit Sander,^3 Stig K Holfort,^4 Sten Andreasson,^5 Michael Larsen,^6 and Dror Sharon^7 ^^1Ophthalmology, Glostrup Hospital, University of Copenhagen, Glostrup, D...
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    14. 1-15 of 20 1 2 »
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  2. About Michael Larsen

    Michael Larsen

    Michael Larsen is with the Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark and Department of Ophthalmology, Roskilde Hospital, Roskilde, Denmark.