1. Michael D. Abràmoff

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    1. Mentioned In 64 Articles

    2. Optical Coherence Tomography Analysis Based Prediction of Humphrey 24-2 Visual Field Thresholds in Patients With Glaucoma

      Optical Coherence Tomography Analysis Based Prediction of Humphrey 24-2 Visual Field Thresholds in Patients With Glaucoma
      Purpose : A pilot study showed that prediction of individual Humphrey 24-2 visual field (HVF 24-2) sensitivity thresholds from optical coherence tomography (OCT) image analysis is possible. We evaluate performance of an improved approach as well as 3 other predictive algorithms on a new, fully independent set of glaucoma subjects. Methods : Subjects underwent HVF 24-2 and 9-field OCT (Heidelberg Spectralis) testing. Nerve fiber (NFL), and ganglion cell and inner plexiform (GCL ...
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    3. A Machine-Learning Graph-Based Approach for 3D Segmentation of Bruch’s Membrane Opening from Glaucomatous SD-OCT Volumes

      A Machine-Learning Graph-Based Approach for 3D Segmentation of Bruch’s Membrane Opening from Glaucomatous SD-OCT Volumes
      Bruchs membrane opening-minimum rim width (BMO-MRW) is a recently proposed structural parameter which estimates the remaining nerve fiber bundles in the retina and is superior to other conventional structural parameters for diagnosing glaucoma. Measuring this structural parameter requires identification of BMO locations within spectral domain-optical coherence tomography (SD-OCT) volumes. While most automated approaches for segmentation of the BMO either segment the 2D projection of BMO points or identify BMO points ...
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    4. Automated assessment of glaucoma loss from optical coherence tomography

      Automated assessment of glaucoma loss from optical coherence tomography
      Systems and methods for assessing glaucoma loss using optical coherence topography. One method according to an aspect comprises receiving optical coherence image data and assessing functional glaucoma damage from retinal optical coherence image data. In an aspect, the systems and methods can map regions and layers of the eye to determine structural characteristics to compare to functional characteristics.
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    5. Reproducibility of Retinal Thickness Measurements across Spectral-Domain Optical Coherence Tomography Devices using Iowa Reference Algorithm

      Reproducibility of Retinal Thickness Measurements across Spectral-Domain Optical Coherence Tomography Devices using Iowa Reference Algorithm
      PURPOSE: Establishing and obtaining consistent quantitative indices of retinal thickness from a variety of clinically used Spectral-Domain Optical Coherence Tomography scanners. DESIGN: Retinal images from five Spectral-Domain Optical Coherence Tomography scanners were used to determine total retinal thickness with scanner-specific correction factors establishing consistency of thickness measurement across devices. PARTICIPANTS: 55 Fovea-centered Spectral-Domain Optical Coherence Tomography volumes from eleven subjects were analyzed, obtained from Cirrus HD-OCT, RS-3000, Heidelberg Spectralis, RTVue ...
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    6. Quantitative Analysis of Retinal OCT

      Quantitative Analysis of Retinal OCT
      Clinical acceptance of 3-D OCT retinal imaging brought rapid development of quantitative 3-D analysis of retinal layers, vascu-lature, retinal lesions as well as facilitated new research in retinal diseases. One of the cornerstones of many such analyses is segmentation and thickness quantification of retinal layers and the choroid, with an inherently 3-D simultaneous multi-layer LO-GISMOS (Layered Optimal Graph Image Segmentation for Multiple Objects and Surfaces) segmentation approach being extremely well ...
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    7. Automated Segmentability Index for Layer Segmentation of Macular SD-OCT Image

      Automated Segmentability Index for Layer Segmentation of Macular SD-OCT Image
      Purpose : To automatically identify which spectral-domain optical coherence tomography (SD-OCT) scans will provide reliable automated layer segmentations for more accurate layer thickness analyses in population studies. Methods : Six hundred ninety macular SD-OCT image volumes (6.0 6.0 2.3 mm 3 ) were obtained from one eyes of 690 subjects (74.6 9.7 [mean SD] years, 37.8% of males) randomly selected from the population-based Rotterdam Study. The dataset ...
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    8. Evaluating Efficacy of Aflibercept in Refractory Exudative Age-Related Macular Degeneration With OCT Segmentation Volumetric Analysis

      Evaluating Efficacy of Aflibercept in Refractory Exudative Age-Related Macular Degeneration With OCT Segmentation Volumetric Analysis
      BACKGROUND AND OBJECTIVE: To use automated segmentation software to analyze spectral-domain optical coherence tomography (SD-OCT) scans and evaluate the effectiveness of aflibercept (Eylea; Regeneron, Tarrytown, NY) in the treatment of patients with exudative age-related macular degeneration (AMD) refractory to other treatments. PATIENTS AND METHODS: Retrospective chart review of 16 patients refractory to bevacizumab (Avastin; Genentech, South San Francisco, CA)/ranibizumab (Lucentis; Genentech, San Francisco, CA) treatment was conducted. Visual acuity ...
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    9. Choroidal thickness maps from spectral domain and swept source optical coherence tomography: algorithmic versus ground truth annotation

      Choroidal thickness maps from spectral domain and swept source optical coherence tomography: algorithmic versus ground truth annotation
      Background/aims The purpose of the study was to create a standardised protocol for choroidal thickness measurements and to determine whether choroidal thickness measurements made on images obtained by spectral domain optical coherence tomography (SD-OCT) and swept source (SS-) OCT from patients with healthy retina are interchangeable when performed manually or with an automatic algorithm. Methods 36 grid cell measurements for choroidal thickness for each volumetric scan were obtained, which ...
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    10. Snapshot spectral domain optical coherence tomographer

      Snapshot spectral domain optical coherence tomographer
      Provided is a snapshot spectral domain optical coherence tomographer comprising: a light source providing a plurality of beamlets; a beam splitter, splitting the plurality of beamlets into a reference arm and a sample arm; a first optical system that projects the sample arm onto multiple locations of a sample; a second optical system for collection of a plurality of reflected sample beamlets; a third optical system projecting the reference arm ...
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    11. Characterizing the Impact of Off-Axis Scan Acquisition on the Reproducibility of Total Retinal Thickness Measurements in SDOCT Volumes

      Characterizing the Impact of Off-Axis Scan Acquisition on the Reproducibility of Total Retinal Thickness Measurements in SDOCT Volumes
      Purpose : Off-axis acquisition of spectral domain optical coherence tomography (SDOCT) images has been shown to increase total retinal thickness (TRT) measurements. We analyzed the reproducibility of TRT measurements obtained using either the retinal pigment epithelium (RPE) or Bruch's membrane as reference surfaces in off-axis scans intentionally acquired through multiple pupil positions. Methods : Five volumetric SDOCT scans of the macula were obtained from one eye of 25 normal subjects. One ...
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    12. Validity of Automated Choroidal Segmentation in SS-OCT and SD-OCT

      Validity of Automated Choroidal Segmentation in SS-OCT and SD-OCT
      Purpose. To evaluate the validity of a novel fully automated three-dimensional (3D) method capable of segmenting the choroid from two different optical coherence tomography scanners: swept-source OCT (SS-OCT) and spectral-domain OCT (SD-OCT). Methods. One hundred eight subjects were imaged using SS-OCT and SD-OCT. A 3D method was used to segment the choroid and quantify the choroidal thickness along each A-scan. The segmented choroidal posterior boundary was evaluated by comparing to ...
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    13. Fast and memory-efficient LOGISMOS graph search for intraretinal layer segmentation of 3D macular OCT scans

      Fast and memory-efficient LOGISMOS graph search for intraretinal layer segmentation of 3D macular OCT scans
      Image segmentation is important for quantitative analysis of medical image data. Recently, our research group has introduced a 3-D graph search method which can simultaneously segment optimal interacting surfaces with respect to the cost function in volumetric images. Although it provides excellent segmentation accuracy, it is computationally demanding (both CPU and memory) to simultaneously segment multiple surfaces from large volumetric images. Therefore, we propose a new, fast, and memory-efficient graph ...
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    14. Multimodal Segmentation of Optic Disc and Cup from SD-OCT and Color Fundus Photographs Using a Machine-Learning Graph-Based Approach

      Multimodal Segmentation of Optic Disc and Cup from SD-OCT and Color Fundus Photographs Using a Machine-Learning Graph-Based Approach
      In this work, a multimodal approach is proposed to use the complementary information from fundus photographs and spectral domain optical coherence tomography ( SD - OCT ) volumes in order to segment the optic disc and cup boundaries. The problem is formulated as an optimization problem where the optimal solution is obtained using a machine-learning theoretical graph-based method. In particular, first the fundus photograph is registered to the 2D projection of the SD ...
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    15. Optical density filters modeling media opacities cause decreased SD-OCT retinal layer thickness measurements with inter- and intra-individual variation

      Optical density filters modeling media opacities cause decreased SD-OCT retinal layer thickness measurements with inter- and intra-individual variation
      ...ntra-individual variation 1. Stanley Darma^1, 2. Pauline H. B. Kok^1, 3. Thomas J. T. P. van den Berg^2, 4. Michael D. Abràmoff^3, 5. Dirk J. Faber^4, 6. Caroline A. Hulsman^1, 7. Frank Zantvoord^1, 8. Maarten P. Mouri...
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  2. About Michael D. Abràmoff

    Michael D. Abràmoff

    Michael Abràmoff, MD, PhD, is an Assistant Professor of Ophthalmology in the Department of Ophthalmology and Visual Science at the University of Iowa.

  3. Quotes

    1. Effective treatments involving injections into the eye have recently become available to restore vision for people with the wet form of AMD...These treatments have benefits, but they are costly and the risk of serious side effects to the eye increases with repeated injections. Our study goal is to learn how to tailor dosing for each patient so that the minimal necessary number of injections is used.
      In University of Iowa to Study Macular Degeneration - Lands $2.8M NEI Grant