1. Michael B. Wallace

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    1. Mentioned In 12 Articles

    2. A Micro Pill Camera Captures Images in Cancer Screening

      A Micro Pill Camera Captures Images in Cancer Screening
      Getting histologic images of the esophagus and other parts of the digestive tract may soon be as easy as getting patients to swallow pill-sized cameras. Called tethered capsule endomicroscopy (TCE), the technology can take multiple microscope images and it shows promise for diagnosing and monitoring Barrett's esophagus. The cameras allow for getting real-time histological images of tissue without requiring anesthesia or endoscopy in what some researchers are referring to ...
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    3. Volumetric laser endomicroscopy and its application to Barrett's esophagus: results from a 1,000 patient registry

      Volumetric laser endomicroscopy and its application to Barrett's esophagus: results from a 1,000 patient registry
      Volumetric laser endomicroscopy (VLE) uses optical coherence tomography (OCT) for real-time, microscopic cross-sectional imaging. A US-based multi-center registry was constructed to prospectively collect data on patients undergoing upper endoscopy during which a VLE scan was performed. The objective of this registry was to determine usage patterns of VLE in clinical practice and to estimate quantitative and qualitative performance metrics as they are applied to Barrett's esophagus (BE) management. All ...
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    4. Measuring Barrett’s Epithelial Thickness with Volumetric Laser Endomicroscopy as a Biomarker to Guide Treatment

      Measuring Barrett’s Epithelial Thickness with Volumetric Laser Endomicroscopy as a Biomarker to Guide Treatment
      Background Radiofrequency ablation (RFA) treatment outcomes vary for unknown reasons. One hypothesis is that variations in Barretts epithelial thickness (BET) are associated with reduced RFA efficacy for thicker BET and strictures for thinner BET. Volumetric laser endomicroscopy (VLE) is an imaging modality that acquires high-resolution, depth-resolved images of BE. However, the attenuation of light by tissue and the lack of layering in Barretts tissue challenge BET measurements and the study ...
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    5. Volumetric laser endomicroscopy in Barrett’s esophagus: interobserver agreement for interpretation of Barrett’s esophagus and associated neoplasia among high-frequency users

      Volumetric laser endomicroscopy in Barrett’s esophagus: interobserver agreement for interpretation of Barrett’s esophagus and associated neoplasia among high-frequency users
      Abstract Background and Aims Targeting neoplasia in Barretts esophagus (BE) is challenging. Volumetric laser endomicroscopy (VLE) is a new imaging technique that allows for real time cross-sectional microstructure imaging that can detect BE neoplasia. The interobserver agreement among users in practice is unknown. Methods Eight high-volume users of VLE from different academic centers in the United States evaluated 120-stored VLE images blinded to the endoscopic and clinical findings. There were ...
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    6. Barrett's Esophagus: Advanced Imaging Options For Early Cancer Detection

      Barrett's Esophagus: Advanced Imaging Options For Early Cancer Detection
      This Video describes the basic approach to endoscopic inspection of Barrett's esophagus. It Focuses on new imaging technologies that increase our ability to detect precancerous or cancerous changes and thus allow us to better target treatment to these areas. For more information on Barrett's Esophagus, visit: http://www.mayoclinic.org/diseases-co...
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    7. Safety and feasibility of volumetric laser endomicroscopy in patients with Barrett’s esophagus (with videos)

      Safety and feasibility of volumetric laser endomicroscopy in patients with Barrett’s esophagus (with videos)
      Background Volumetric laser endomicroscopy (VLE) produces high-resolution, cross-sectional surface, and subsurface images for detecting neoplasia, targeting biopsies, and guiding real-time treatment. Objective To evaluate the safety and feasibility of the Nvision VLE system. Design Prospective, multicenter study. Setting Tertiary-care medical centers. Patients One hundred patients with suspected Barretts esophagus, including 52 patients with prior endotherapy. Interventions The first-generation Nvision VLE Imaging System, a balloon-centered, rotating optical probe provided images of ...
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    8. Advanced Imaging in Barrett's Esophagus

      Advanced Imaging in Barrett's Esophagus
      BE is estimated to be present in up to 5.6% of the US population and is the precursor lesion for esophageal adenocarcinoma, which has a poor 5-year survival rate of 17%.1,2 Surveillance endoscopy is now the primary management approach for BE, with 4-quadrant biopsies being obtained every 1 to 2 cm at designated intervals in an attempt to identify dysplasia and early neoplasia. The goal of this ...
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    9. Advanced Endoscopic Imaging in the Upper Gastrointestinal Tract (Textbook)

      Advanced Endoscopic Imaging in the Upper Gastrointestinal Tract (Textbook)
      Advanced endoscopic imaging incorporates several methods to enhance visualization of the upper gastrointestinal tract. It is an evolving field within advanced endoscopy and particularly important for the endoscopist performing ESD, as these modalities can aid all stages of ESD. Advanced imaging involves several different techniques, from chromoendoscopy (e.g. Lugols solution, methylene blue, indigo carmine), to optical enhancement methods (e.g. magnified endoscopy, narrow band imaging, confocal endomicroscopy) and electronic ...
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    10. Optical frequency domain imaging in patients with Barrett's neoplasia: an ex vivo case study with correlated endoscopic and histology views

      Optical frequency domain imaging in patients with Barrett's neoplasia: an ex vivo case study with correlated endoscopic and histology views
      This video (, available online at www.giejournal.org) describes the optical frequency domain interferometry (OFDI) imaging technique, which is a U.S. Food and Drug Administrationapproved and commercially available second-generation of optical coherence tomography, and its close correlation with endoscopic views and histopathology results in patients with Barrett's esophagus.
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    11. Somewhere over the rainbow

      Somewhere over the rainbow
      The endoscopic management of Barrett’s esophagus associated neoplasia has traditionally been done by using endoscopic imaging with random biopsies, followed later by treatment. Endoscopic, as opposed to surgical, treatment is increasingly becoming the standard of care as evidenced by recent landmark studies on the effectiveness of radiofrequency ablation1 and photodynamic therapy.2 Proper treatment is predicated on accurate detection and precise localization of neoplasia. It has been well-known that ...
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    12. New Technologies for Imaging of Barrett’s Esophagus

      New Technologies for Imaging of Barrett’s Esophagus
      Several important endoscopic imaging modalities have recently been approved for use and are commercially available. This chapter briefly reviews these developments and the implication for patients with Barretts esophagus, especially advanced dysplasia and mucosal carcinoma. Important developments in biophotonics have been moving from the experiment laboratory to the gastrointestinal endoscopy unit. Narrow band imaging, auto-fluorescence, confocal fluorescent microscopy, spectroscopy and optical coherence tomography are reviewed. Unresolved issues for most of ...
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  2. About Michael B. Wallace

    Michael B. Wallace

    Michael B. Wallace, M.D., is at the Mayo Clinic in Jacksonville Florida and he focuses on advanced imaging systems for the detection and treatment of early cancers and pre-cancerous lesions of the gastrointestinal tract. These include methods to detect early cancer in Barrett's esophagus and subsequent imaging-guided endoscopic removal of the lesions. Similarly, his team has used advanced imaging systems to detect, characterize and remove advanced pre-cancerous lesions and early cancers from the colon through endoscopic resection. Together with basic optical physics researchers, Dr. Wallace is exploring methods to detect large field effects in the vicinity of pre-cancerous growths, which will improve screening and localization methods, such as for colonoscopy and pancreatic cancer detection.