1. Michael A. Choma

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    1. Mentioned In 33 Articles

    2. Yale University Receives NIH Grant for Massively Parallel Interferometric Confocal Microscopy using Degenerate Lasers

      Yale University Receives  NIH Grant  for Massively Parallel Interferometric Confocal Microscopy using Degenerate Lasers
      Yale University Receives 2014 NIH Grant for $209,850 for Massively Parallel Interferometric Confocal Microscopy using Degenerate Lasers. The principal nvestigator is Michael Choma. Below is a summary of the proposed work. Confocal microscopy uses geometric principles to generate cross-sectional images of scattering biological tissue. Traditional reflectance confocal microscopes use serial pixel acquisition, thereby limiting acquisition speeds. Parallelization of pixel acquisition would dramatically increase imaging speeds and enable the study ...
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    3. Yale University Receives NIH Grant for Development of a New Light Sources for Parallel Optical Coherence Tomography

      Yale University Receives NIH Grant for Development of a New Light Sources for Parallel Optical Coherence Tomography
      Yale University Receivesd a 2014 NIH Grant for $201,881 for Development of a New Light Sources for Parallel Optical Coherence Tomography. The principal investigator is Michel Choma. The program began in 2013 and ends in 2015. Below is a summary of the proposed work. The ability of optical coherence tomography (OCT) to perform high-speed, micron-scale, cross-sectional imaging has transformed ophthalmic medicine and has the potential to transform cardiovascular, gastrointestinal ...
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    4. Researchers at Yale Work to Improve Health of Premature Babies

      Researchers at Yale Work to Improve Health of Premature Babies
      Theres ongoing research to help babies born too soon. Yale researchers are looking into improving the health of premature babies by focusing on their under-developed lungs. What Yale researchers are doing is looking at the intricacies of how bacteria and viruses are moved in and out of the lungs in hopes of developing therapies and technology that could someday improve a premature babys chance of survival as well as quality ...
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    5. Yale University Receives NIH Grant for Development of a New Light Source for Parallel Optical Coherence Tomography

      Yale University Receives NIH Grant for Development of a New Light Source for Parallel Optical Coherence Tomography
      Yale University Received a 2013 NIH Grant for $233,135 for Development of a New Light Source for Parallel Optical Coherence Tomography. The principal investigator is Michael Choma. The program began in 2013 and ends in 2015. Below is a summary of the proposed work. The ability of optical coherence tomography (OCT) to perform high-speed, micron-scale, cross-sectional imaging has transformed ophthalmic medicine and has the potential to transform cardiovascular, gastrointestinal ...
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    6. Yale University Receives NIH Grant for Quantitative Optical Imaging of Cilia-Driven Fluid Flow

      Yale University Receives NIH Grant for Quantitative Optical Imaging of Cilia-Driven Fluid Flow
      Yale University received a 2013 NIH Grant for $396,270 for a quantitative Imaging of cilia-driven fluid flow. The principal investigator is Michael Choma. The program started in 2013 and lends in 2018. A summary of the program is given below. Respiratory diseases are major causes of pediatric morbidity and mortality. These diseases are incompletely understood, which is a barrier to improving clinical care. Therefore, new mechanisms of disease need ...
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    7. Systems And Methods For Imaging Using A Random Laser

      Systems And Methods For Imaging Using A Random Laser
      Systems and methods are provided for imaging using complex lasers. In general, a complex laser may be used as an electromagnetic source for an imaging application. The use of a lower spatial coherence configured complex laser in imaging applications may advantageously mitigate coherent artifacts in imaging such as cross-talk and speckle and improve overall image quality. Imaging applications where a complex laser may be useful include both incoherent imaging applications ...
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    8. Feature Of The Week 2/12/12: Researchers at Yale University use OCT to Characterize Microfluidic Ciliary Induced Fluid Flow

      Feature Of The Week 2/12/12: Researchers at Yale University use OCT to Characterize Microfluidic Ciliary Induced Fluid Flow
      Recently researchers at Yale University demonstrated a very novel application of optical coherence tomography using a Thorlabs OCT system.  The research involved characterizing microfluidic flow of fluid driven by cilia.  Below is a summary of this interesting novel application of OCT.Motile cilia are fingerlike projections from different epithelial surfaces that move in a periodic manner to generate directional fluid flow. For example, respiratory cilia generate a microfluidic-scale flow that ...
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    9. Microfluidic characterization of cilia-driven fluid flow using optical coherence tomography-based particle tracking velocimetry

      Microfluidic characterization of cilia-driven fluid flow using optical coherence tomography-based particle tracking velocimetry
      ...ms : Motion estimation and optical flow Citation Stephan Jonas, Dipankan Bhattacharya, Mustafa K. Khokha, and Michael A. Choma, "Microfluidic characterization of cilia-driven fluid flow using optical coherence tomography...
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    10. Physiological homology between Drosophila melanogaster and vertebrate cardiovascular systems

      Physiological homology between Drosophila melanogaster and vertebrate cardiovascular systems
      The physiology of the Drosophila melanogaster cardiovascular system remains poorly characterized compared with its vertebrate counterparts. Basic measures of physiological performance remain unknown. It also is unclear whether subtle physiological defects observed in the human cardiovascular system can be reproduced in D. melanogaster. Here we characterize the cardiovascular physiology of D. melanogaster in its pre-pupal stage by using high-speed dye angiography and optical coherence tomography. The heart has vigorous pulsatile ...
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    11. Heart wall velocimetry and exogenous contrast-based cardiac flow imaging in Drosophila melanogaster using Doppler optical coherence tomography

      Heart wall velocimetry and exogenous contrast-based cardiac flow imaging in Drosophila melanogaster using Doppler optical coherence tomography
      ...iomed. Opt., Vol. 15, 056020 (2010); doi:10.1117/1.3503418 Published 29 October 2010 ABSTRACT REFERENCES (33) Michael A. Choma Children's Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115 and Harvard Medi...
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    12. Methods, systems and computer program products for characterizing structures based on interferometric phase data

      Methods, systems and computer program products for characterizing structures based on interferometric phase data
      Structure profiles from optical interferometric data can be identified by obtaining a plurality of broadband interferometric optical profiles of a structure as a function of structure depth in an axial direction. Each of the plurality of interferometric optical profiles include a reference signal propagated through a reference path and a sample signal reflected from a sample reflector in the axial direction. An axial position corresponding to at least a portion ...
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    13. 16-30 of 33 « 1 2 3 »
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  2. About Michael A. Choma

    Michael A. Choma

    Michael A. Choma is an Assistant Professor of Diagnostic Radiology and of Biomedical Engineering at Yale School of Medicine.  Michael A. Choma, MD, PhD is a physician-scientist with expertise in pediatrics, biomedical optics, and biomedical engineering. His research uses innovative optical imaging methods to better understand and treat pediatric disease, including congenital heart disease and ciliary disease. Michael received his BS in Biomedical Engineering from Case Western Reserve University, his PhD in Biomedical Engineering from Duke University (thesis advisor: Joseph Izatt, PhD), and his MD from Duke University.  His PhD thesis research into optical coherence tomography (OCT), a non-contact optical imaging method that is the optical analogue of ultrasound imaging, contributed to next-generation OCT technologies that enabled a 100 to 1000-fold increase in clinical imaging speeds without compromising image quality or sensitivity. While Michael was a resident in pediatrics at Children's Hospital Boston, he pursued research in high-speed, high-resolution imaging of embryo hearts as a Visiting Clinical Fellow at the Wellman Center for Photomedicine at the Massachusetts General Hospital (research advisors: Guillermo Tearney, MD, PhD and Brett Bouma, PhD). After training in Boston, Michael came to the Yale School of Medicine to start a biomedical optics lab in the Department of Diagnostic Radiology.

  3. Quotes

    1. We know from other disease where the flow of mucus is impaired, we know that really reduces survival of patients.
      In Researchers at Yale Work to Improve Health of Premature Babies