1. Mette Mogensen

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    1. Mentioned In 39 Articles

    2. Two Optical Coherence Tomography Systems detect Topical Gold Nanoparticles in Hair follicles, Sweat Ducts and Measure Epidermis

      Two Optical Coherence Tomography Systems detect Topical Gold Nanoparticles in Hair follicles, Sweat Ducts and Measure Epidermis
      Optical coherence tomography (OCT) is an optical imaging technology that enables real time, highresolution, cross-sectional and en face investigation of skin by detecting reflected broad-spectrum near-infrared light from tissue. OCT provides micron-scale spatial resolution and millimeter-scale depth of penetration [1]. Several commercial OCT systems with handheld probes targeted for Dermatology are now available [2]. The ability of OCT to achieve high diagnostic accuracy in skin diseases is hampered by the ...
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    3. Suction blister lesions and epithelialization monitored by optical coherence tomography

      Suction blister lesions and epithelialization monitored by optical coherence tomography
      Background/purpose Our objective was to assess epithelialization of suction blister lesions by optical coherence tomography (OCT) and benchmark it to histology using epidermal thickness (ET) as the primary outcome. Methods Thirty-two healthy volunteers were recruited to Study 1 and 2. One 10-mm suction blister was raised on each buttock, and the blister roof was excised. Lesions were covered with moisture-retaining dressing. In Study 1, the lesions were OCT-scanned on ...
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      Mentions: Mette Mogensen
    4. Vehicle type affects filling of fractional laser-ablated channels imaged by optical coherence tomography

      Vehicle type affects filling of fractional laser-ablated channels imaged by optical coherence tomography
      Ablative fractional laser (AFXL) is an emerging method that enhances topical drug delivery. Penetrating the skin in microscopic, vertical channels, termed microscopic treatment zones (MTZs), the fractional technique circumvents the skin barrier and allows increased uptake of topically applied drugs. This study aims to elucidate the impact of vehicle type on the filling of MTZs from application of liquid, gel, and cream vehicles. Ex vivo pig skin was exposed to ...
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    5. Optical coherence tomography imaging of bullous diseases

      Optical coherence tomography imaging of bullous diseases
      Background Optical coherence tomography (OCT) is a non-invasive optical imaging technique with a micrometer resolution that may potentially offer real-time bedside imaging of sufficient detail to allow for morphological discrimination between different types of bullae. Objective To explore the potential of OCT in bullous skin disorders by looking at a set of patients with skin blisters of known origin and study the OCT images for possible hallmarks of the blistering ...
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    6. Fractional laser-assisted drug uptake: Impact of time-related topical application to achieve enhanced delivery

      Fractional laser-assisted drug uptake: Impact of time-related topical application to achieve enhanced delivery
      Background and Objective Ablative fractional laser (AFXL) is acknowledged to increase uptake of topically applied agents in skin. AFXL channels gradually close over time, which may impair this capability. The time frame for applying a drug after AFXL exposure remains to be established. The aim of this study, was to investigate the importance of time-related topical application after AFXL exposure and to relate resultant uptake in skin with AFXL channel ...
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      Mentions: Mette Mogensen
    7. Diagnostic accuracy of optical coherence tomography in actinic keratosis and basal cell carcinoma

      Diagnostic accuracy of optical coherence tomography in actinic keratosis and basal cell carcinoma
      Background Early diagnosis of non-melanoma skin cancer (NMSC) is potentially possible using optical coherence tomography (OCT) which provides non-invasive, real-time images of skin with micrometre resolution and an imaging depth of up to 2 mm. OCT technology for skin imaging has undergone significant developments, improving image quality substantially. The diagnostic accuracy of any method is influenced by continuous technological development making it necessary to regularly re-evaluate methods. Objective The objective ...
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    8. Dynamic Optical Coherence Tomography Capillaroscopy A New Imaging Tool in Autoimmune Connective Tissue Disease

      Dynamic Optical Coherence Tomography Capillaroscopy A New Imaging Tool in Autoimmune Connective Tissue Disease
      Importance Vasculopathy characterized by functional and structural abnormalities of the microcirculation plays an important role in systemic sclerosis and dermatomyositis. Although there are several advantages in using capillaroscopy, the method does not offer insight on the skin architecture, flow status, or morphology of the deeper dermal vessels. Dynamic optical coherence tomography (D-OCT) is a recently developed OCT technique that enables detection of high-speed changes in back-scattered light caused by moving ...
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    9. Spatiotemporal closure of fractional laser-ablated channels imaged by optical coherence tomography and reflectance confocal microscopy

      Spatiotemporal closure of fractional laser-ablated channels imaged by optical coherence tomography and reflectance confocal microscopy
      Background and Objective Optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) offer high-resolution optical imaging of the skin, which may provide benefit in the context of laser-assisted drug delivery. We aimed to characterize postoperative healing of ablative fractional laser (AFXL)-induced channels and dynamics in their spatiotemporal closure using in vivo OCT and RCM techniques. Study design/Materials and Methods The inner forearm of healthy subjects ( n =6) was ...
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    10. Optical Coherence Tomography and Cryosurgery (Book Chapter)

      Optical Coherence Tomography and Cryosurgery (Book Chapter)
      Optical coherence tomography (OCT) provides real-time, cross-sectional skin images to a depth of up to 2 mm. OCT is a convenient and fast imaging technology that can be used bedside. In dermatology, the pretherapeutic delineation of both actinic keratoses (AK) and keratinocyte carcinomas has been a natural focus for applied OCT research, and more recently OCT research has turned on non-invasive monitoring of treatments. Previous studies have found good agreement ...
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    11. Imaging of collagen deposition disorders using optical coherence tomography

      Imaging of collagen deposition disorders using optical coherence tomography
      Background Collagen deposition disorders such as hypertrophic scars, keloids and scleroderma can be associated with significant stigma and embarrassment. These disorders often constitute considerable impairment to quality of life, with treatment posing to be a substantial challenge. Optical coherence tomography (OCT) provides a non-invasive, easily applicable bedside optical imaging method for assessment of the skin. It is hypothesized that OCT imaging may be useful in assessing fibrosis to avoid additional ...
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    12. Optical Coherence Tomography Imaging of Non-melanoma Skin Cancer Undergoing Photodynamic Therapy Reveals Subclinical Residual Lesions

      Optical Coherence Tomography Imaging of Non-melanoma Skin Cancer Undergoing Photodynamic Therapy Reveals Subclinical Residual Lesions
      Background Photodynamic therapy with methyl aminolaevulinate (MAL-PDT) is a widely used non-invasive treatment modality for non-melanoma skin cancer (NMSC). The outcome of MAL-PDT is usually primarily evaluated clinically. Optical coherence tomography (OCT) is a non-invasive imaging technology based on interferiometry. OCT has been proven to provide high accuracy in identifying NMSC lesions and performing thickness measurements of thin tumours. Objectives To describe the OCT morphology in in-vivo NMSC lesions during ...
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    13. Optical coherence tomography imaging of non-melanoma skin cancer undergoing imiquimod therapy

      Optical coherence tomography imaging of non-melanoma skin cancer undergoing imiquimod therapy
      Purpose To explore the application of optical coherence tomography (OCT) imaging of basal cell carcinomas (BCC) and actinic keratosis (AK) before, during and after imiquimod treatment and the ability of OCT to predict treatment outcome. Methods The study subjects were 20 patients with biopsy-verified BCC (9) or AK (11). Patients were OCT-scanned before, after 1 and 4 weeks of imiquimod treatment and after 3 months. Lesions were identified clinically and ...
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    14. Optical coherence tomography imaging of non‐melanoma skin cancer undergoing imiquimod therapy

      Optical coherence tomography imaging of non‐melanoma skin cancer undergoing imiquimod therapy
      Purpose To explore the application of optical coherence tomography (OCT) imaging of basal cell carcinomas (BCC) and actinic keratosis (AK) before, during and after imiquimod treatment and the ability of OCT to predict treatment outcome. Methods The study subjects were 20 patients with biopsy-verified BCC (9) or AK (11). Patients were OCT-scanned before, after 1 and 4 weeks of imiquimod treatment and after 3 months. Lesions were identified clinically and ...
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    15. Skin Cancer A Practical Approach (Textbook)

      Skin Cancer A Practical Approach (Textbook)
      Optical coherence tomography (OCT) has developed rapidly since its first realisation in medicine and is currently an emerging technology in the diagnosis of skin disease. OCT is an interferometric technique that detects reflected and backscattered light from tissue and is often described as the optical analogue to ultrasound. The inherent safety of the technology allows for in vivo use of OCT in patients. The main strength of OCT is the ...
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  2. About Mette Mogensen

    Mette Mogensen

    Mette Mogensen, MD, is with the Department of Dermatology at Roskilde Hospital in Denmark and witht he University of Copenhagen.