1. Meixiao Shen

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    1. Mentioned In 55 Articles

    2. BG-CNN: A Boundary Guided Convolutional Neural Network for Corneal Layer Segmentation from Optical Coherence Tomography

      BG-CNN: A Boundary Guided Convolutional Neural Network for Corneal Layer Segmentation from Optical Coherence Tomography
      Precise segmentation of corneal layers depicted on optical coherence tomography (OCT) images plays an important role in detecting corneal diseases, such as keratoconus and dry eye. In this study, we present a boundary guided convolutional neural network (BG-CNN) to extract different corneal layers. The developed network uses three convolutional blocks to construct two network modules derived from the classical U-Net network. This network was trained based on a dataset consisting ...
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    3. Machine learning helps improve diagnostic ability of subclinical keratoconus using Scheimpflug and OCT imaging modalities

      Machine learning helps improve diagnostic ability of subclinical keratoconus using Scheimpflug and OCT imaging modalities
      Purpose To develop an automated classification system using a machine learning classifier to distinguish clinically unaffected eyes in patients with keratoconus from a normal control population based on a combination of Scheimpflug camera images and ultra-high-resolution optical coherence tomography (UHR-OCT) imaging data. Methods A total of 121 eyes from 121 participants were classified by 2 cornea experts into 3 groups: normal (50 eyes), with keratoconus (38 eyes) or with subclinical ...
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    4. Modeling of gonioscopic anterior chamber angle grades based on anterior segment optical coherence tomography

      Modeling of gonioscopic anterior chamber angle grades based on anterior segment optical coherence tomography
      Background To quantitatively assess anterior chamber angle (ACA) structure by anterior segment optical coherence tomography (AS-OCT) and develop a model to evaluate angle width as defined by gonioscopy. Methods The ACAs of each quadrant were evaluated by gonioscopy, classified by the Scheie grading system, and assigned into one of the three grades: small angle (SA), moderate angle (MA), and large angle (LA). The eyes were imaged by AS-OCT, and ACA ...
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    5. Assessment of corneal viscoelasticity using elastic wave optical coherence elastography

      Assessment of corneal viscoelasticity using elastic wave optical coherence elastography
      The corneal viscoelasticity have great clinical significance, such as the early diagnosis of keratoconus. In this work, an analysis method which utilized the elastic wave velocity, frequency and energy attenuation to assess the corneal viscoelasticity is presented. Using phase‐resolved optical coherence tomography, the spatial‐temporal displacement map is derived. The phase velocity dispersion curve and center frequency are obtained by transforming the displacement map into the wavenumber‐frequency domain ...
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    6. In vivo evaluation of corneal biomechanical properties by optical coherence elastography at different cross-linking irradiances

      In vivo evaluation of corneal biomechanical properties by optical coherence elastography at different cross-linking irradiances
      Corneal collagen cross-linking (CXL) strengthens the biomechanical properties of damaged corneas. Quantifying the changes of stiffness due to different CXL protocols is difficult, especially in vivo . A noninvasive elastic wave-based optical coherence elastography system was developed to construct in vivo corneal elasticity maps by excitation of air puff. Biomechanical differences were compared for rabbit corneas given three different CXL protocols while keeping the total energy delivered constant. The Youngs modulus ...
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    7. Deep learning based early stage diabetic retinopathy detection using optical coherence tomography

      Deep learning based early stage diabetic retinopathy detection using optical coherence tomography
      Diabetic retinopathy (DR) is one of the leading causes of preventable blindness globally. Performing retinal examinations on all diabetic patients is an unmet need, and detection at an early stage can provide better control of the disease. The objective of this study is to provide an optical coherence tomography (OCT) image based diagnostic technology for automated early DR diagnosis, including at both grades 0 and 1. This work can help ...
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    8. Precise delineation and tumor localization based on novel image registration strategy between optical coherence tomography and computed tomography in the radiotherapy of intraocular cancer

      Precise delineation and tumor localization based on novel image registration strategy between optical coherence tomography and computed tomography in the radiotherapy of intraocular cancer
      Radiation-associated toxicities due to sophisticated ocular anatomy and shape variability of organs at risk (OARs) are major concerns during external beam radiation therapy (EBRT) of patients with intraocular cancer. A novel two-step image registration strategy between optical coherence tomography (OCT) and computed tomography (CT) images was proposed and validated to precisely localize the target in the EBRT of patients with intraocular cancer. Specifically, multiple features from OCT and CT images ...
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    9. Integrating Handcrafted and Deep Features for Optical Coherence Tomography Based Retinal Disease Classification

      Integrating Handcrafted and Deep Features for Optical Coherence Tomography Based Retinal Disease Classification
      Deep Neural Networks (DNNs) have been widely applied to automatic analysis of medical images for disease diagnosis, and to help human experts by efficiently processing immense amounts of images. While handcrafted feature has been used for eye disease detection or classification since the 1990s, DNN was recently adopted in this area and showed very promising performance. Since handcrafted and deep feature can extract complementary information, we propose in this paper ...
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    10. Long scan depth optical coherence tomography on imaging accommodation: impact of enhanced axial resolution, signal-to-noise ratio and speed

      Long scan depth optical coherence tomography on imaging accommodation: impact of enhanced axial resolution, signal-to-noise ratio and speed
      Background Spectral domain optical coherence tomography (SD-OCT) was a useful tool to study accommodation in human eye, but the maximum image depth is limited due to the decreased signal-to-noise ratio (SNR). In this study, improving optical resolutions, speeds and the SNR were achieved by custom built SD-OCT, and the evaluation of the impact of the improvement during accommodation was investigated. Methods Three systems with different spectrometer designs, including two Charge ...
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    11. Short term effect of choroid thickness in the horizontal meridian detected by spectral domain optical coherence tomography in myopic children after orthokeratology

      Short term effect of choroid thickness in the horizontal meridian detected by spectral domain optical coherence tomography in myopic children after orthokeratology
      AIM : To investigate choroidal thickness changes in the horizontal meridian after orthokeratology. METHODS : This is a prospective cross-sectional observed study. Subjects (n=30; 11.31.7y) with low-to-moderate myopia (-1.0 to -6.0 diopters), wore orthokeratology (Ortho-K) lenses for 3mo. Before and after Ortho-K, OCT scans were made through the fovea in the horizontal meridian. Choroid thickness around the fovea was acquired by custom software. The analyzed regions along ...
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    12. Characterization of Soft Contact Lens Edge Fitting during Daily Wear Using Ultrahigh-Resolution Optical Coherence Tomography

      Characterization of Soft Contact Lens Edge Fitting during Daily Wear Using Ultrahigh-Resolution Optical Coherence Tomography
      Purpose . To determine conjunctival overlap over the edge of soft contact lens and to visualize the peripheral postlens tear film (PoLTF) underneath soft contact lenses using ultrahigh-resolution optical coherence tomography (UHR-OCT). Methods . Twenty participants (4 males and 16 females, 23.03.7 years) were fitted with two different types of soft contact lenses randomly. The limbus with lens was imaged with the UHR-OCT at the horizontal meridian every two hours ...
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    13. Inner Retinal Microvasculature Damage Correlates With Outer Retinal Disruption During Remission in Behçet's Posterior Uveitis by Optical Coherence Tomography Angiography

      Inner Retinal Microvasculature Damage Correlates With Outer Retinal Disruption During Remission in Behçet's Posterior Uveitis by Optical Coherence Tomography Angiography
      Purpose : To quantify the inner retinal vascular changes that occur in the superficial and deep layers in patients with Behet's disease (BD) in remission using optical coherence tomography angiography (OCTA) and to evaluate the associations with outer retinal structure. Methods : Nineteen eyes from 19 patients with BD in remission were enrolled, including 10 eyes with less than five ocular attacks ( n 5) and nine eyes with five or more ...
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    14. Axial elongation measured by long scan depth optical coherence tomography during pilocarpine-induced accommodation in intraocular lens-implanted eyes

      Axial elongation measured by long scan depth optical coherence tomography during pilocarpine-induced accommodation in intraocular lens-implanted eyes
      We used an ultra-long scan depth optical coherence tomography (UL-OCT) system to investigate changes in axial biometry of pseudophakic eyes during pilocarpine- induced accommodation. The right eyes from 25 healthy subjects (age range 49 to 84 years) with an intraocular lens (IOL) were imaged twice in the non-accommodative and the accommodative states. A custom-built UL-OCT instrument imaged the whole eye. Then accommodation was induced by two drops of 0.5 ...
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    15. Characterization of Soft Contact Lens Fitting Using Ultra-Long Scan Depth Optical Coherence Tomography

      Characterization of Soft Contact Lens Fitting Using Ultra-Long Scan Depth Optical Coherence Tomography
      Objectives . To evaluate the centration and movement of soft contact lenses and to verify the repeatability of two repeated measurements of the lens centration and movement using ultra-long scan depth optical coherence tomography (UL-OCT). Methods . A 1-day Acuvue Define lens was tested on both eyes of 10 subjects (5 males and 5 females; mean age, 31.6 years). The centration and blink-induced movement of the contact lens were measured using ...
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    16. MACULAR MICROSTRUCTURAL FEATURES IN CHILDREN WITH TILTED DISK SYNDROME EVALUATED BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY

      MACULAR MICROSTRUCTURAL FEATURES IN CHILDREN WITH TILTED DISK SYNDROME EVALUATED BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY
      Purpose: To assess macular microstructure in eyes with tilted disk syndrome (TDS) and determine the relationship between TDS foveal morphology and visual function. Methods: Twenty-six TDS eyes from 19 children (aged 5~15 years) with a spherical equivalent refraction (SER) of -3.1 +/- 1.3 diopter (D) and 28 control eyes from 14 children (aged 7~12 years) with a SER of -3.0 +/- 0.7 D were recruited. Horizontal ...
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  2. About Meixiao Shen

    Meixiao Shen is with the School of Ophthalmology and Optometry at Wenzhou Medical College in China.