1. Meixiao Shen

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    1. Mentioned In 47 Articles

    2. Long scan depth optical coherence tomography on imaging accommodation: impact of enhanced axial resolution, signal-to-noise ratio and speed

      Long scan depth optical coherence tomography on imaging accommodation: impact of enhanced axial resolution, signal-to-noise ratio and speed
      Background Spectral domain optical coherence tomography (SD-OCT) was a useful tool to study accommodation in human eye, but the maximum image depth is limited due to the decreased signal-to-noise ratio (SNR). In this study, improving optical resolutions, speeds and the SNR were achieved by custom built SD-OCT, and the evaluation of the impact of the improvement during accommodation was investigated. Methods Three systems with different spectrometer designs, including two Charge ...
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    3. Short term effect of choroid thickness in the horizontal meridian detected by spectral domain optical coherence tomography in myopic children after orthokeratology

      Short term effect of choroid thickness in the horizontal meridian detected by spectral domain optical coherence tomography in myopic children after orthokeratology
      AIM : To investigate choroidal thickness changes in the horizontal meridian after orthokeratology. METHODS : This is a prospective cross-sectional observed study. Subjects (n=30; 11.31.7y) with low-to-moderate myopia (-1.0 to -6.0 diopters), wore orthokeratology (Ortho-K) lenses for 3mo. Before and after Ortho-K, OCT scans were made through the fovea in the horizontal meridian. Choroid thickness around the fovea was acquired by custom software. The analyzed regions along ...
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    4. Characterization of Soft Contact Lens Edge Fitting during Daily Wear Using Ultrahigh-Resolution Optical Coherence Tomography

      Characterization of Soft Contact Lens Edge Fitting during Daily Wear Using Ultrahigh-Resolution Optical Coherence Tomography
      Purpose . To determine conjunctival overlap over the edge of soft contact lens and to visualize the peripheral postlens tear film (PoLTF) underneath soft contact lenses using ultrahigh-resolution optical coherence tomography (UHR-OCT). Methods . Twenty participants (4 males and 16 females, 23.03.7 years) were fitted with two different types of soft contact lenses randomly. The limbus with lens was imaged with the UHR-OCT at the horizontal meridian every two hours ...
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    5. Inner Retinal Microvasculature Damage Correlates With Outer Retinal Disruption During Remission in Behçet's Posterior Uveitis by Optical Coherence Tomography Angiography

      Inner Retinal Microvasculature Damage Correlates With Outer Retinal Disruption During Remission in Behçet's Posterior Uveitis by Optical Coherence Tomography Angiography
      Purpose : To quantify the inner retinal vascular changes that occur in the superficial and deep layers in patients with Behet's disease (BD) in remission using optical coherence tomography angiography (OCTA) and to evaluate the associations with outer retinal structure. Methods : Nineteen eyes from 19 patients with BD in remission were enrolled, including 10 eyes with less than five ocular attacks ( n 5) and nine eyes with five or more ...
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    6. Axial elongation measured by long scan depth optical coherence tomography during pilocarpine-induced accommodation in intraocular lens-implanted eyes

      Axial elongation measured by long scan depth optical coherence tomography during pilocarpine-induced accommodation in intraocular lens-implanted eyes
      We used an ultra-long scan depth optical coherence tomography (UL-OCT) system to investigate changes in axial biometry of pseudophakic eyes during pilocarpine- induced accommodation. The right eyes from 25 healthy subjects (age range 49 to 84 years) with an intraocular lens (IOL) were imaged twice in the non-accommodative and the accommodative states. A custom-built UL-OCT instrument imaged the whole eye. Then accommodation was induced by two drops of 0.5 ...
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    7. Characterization of Soft Contact Lens Fitting Using Ultra-Long Scan Depth Optical Coherence Tomography

      Characterization of Soft Contact Lens Fitting Using Ultra-Long Scan Depth Optical Coherence Tomography
      Objectives . To evaluate the centration and movement of soft contact lenses and to verify the repeatability of two repeated measurements of the lens centration and movement using ultra-long scan depth optical coherence tomography (UL-OCT). Methods . A 1-day Acuvue Define lens was tested on both eyes of 10 subjects (5 males and 5 females; mean age, 31.6 years). The centration and blink-induced movement of the contact lens were measured using ...
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    8. MACULAR MICROSTRUCTURAL FEATURES IN CHILDREN WITH TILTED DISK SYNDROME EVALUATED BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY

      MACULAR MICROSTRUCTURAL FEATURES IN CHILDREN WITH TILTED DISK SYNDROME EVALUATED BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY
      Purpose: To assess macular microstructure in eyes with tilted disk syndrome (TDS) and determine the relationship between TDS foveal morphology and visual function. Methods: Twenty-six TDS eyes from 19 children (aged 5~15 years) with a spherical equivalent refraction (SER) of -3.1 +/- 1.3 diopter (D) and 28 control eyes from 14 children (aged 7~12 years) with a SER of -3.0 +/- 0.7 D were recruited. Horizontal ...
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    9. Reconstruction of 3D surface maps from anterior segment optical coherence tomography images using graph theory and genetic algorithms

      Reconstruction of 3D surface maps from anterior segment optical coherence tomography images using graph theory and genetic algorithms
      Automatic segmentation of anterior segment optical coherence tomography images provides an important tool to aid management of ocular diseases. Previous studies have mainly focused on 2D segmentation of these images. A novel technique capable of producing 3D maps of the anterior segment is presented here. This method uses graph theory and dynamic programming with shape constraint to segment the anterior and posterior surfaces in individual 2D images. Genetic algorithms are ...
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    10. Real-Time Monitoring of Suprachoroidal Space (SCS) Following SCS Injection Using Ultra-High Resolution Optical Coherence Tomography in Guinea Pig Eyes

      Real-Time Monitoring of Suprachoroidal Space (SCS) Following SCS Injection Using Ultra-High Resolution Optical Coherence Tomography in Guinea Pig Eyes
      Purpose. To monitor the change of suprachoroidal space (SCS) using ultra high resolution-optical coherence tomography (UHR-OCT) following SCS injection with different drug formulations. Methods. An amount of 10 or 20 L of saline or indocyanine green (ICG) or triamcinolone acetonide (TA) suspension (40 or 80 mg/mL) was injected suprachoroidally into the guinea pig eye with a 30-gauge needle. Immediately after injection, the eyes were imaged by UHR-OCT from 60 ...
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    11. Macular Thickness Profiles of Intra-retinal Layers in Myopia Evaluated by Ultra-High Resolution Optical Coherence Tomography

      Macular Thickness Profiles of Intra-retinal Layers in Myopia Evaluated by Ultra-High Resolution Optical Coherence Tomography
      Purpose To investigate the thickness and variation profiles of eight intra-retinal layers in myopia. Design Prospective cross-sectional study. Methods Young subjects with spherical equivalents ranging from +0.50 to -10.25 diopters and good corrected vision were divided into emmetropic (n=20), low myopic (n=50), and high myopic (n=30) groups. Retinal images centered on the fovea along the horizontal and vertical meridians were obtained by ultra-high resolution optical ...
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    12. Biometry of Anterior Segment of Human Eye on Both Horizontal and Vertical Meridians during Accommodation Imaged with Extended Scan Depth Optical Coherence Tomography

      Biometry of Anterior Segment of Human Eye on Both Horizontal and Vertical Meridians during Accommodation Imaged with Extended Scan Depth Optical Coherence Tomography
      Purpose To determine the biometry of anterior segment dimensions of the human eye on both horizontal and vertical meridians with extended scan depth optical coherence tomography (OCT) during accommodation. Methods Twenty pre-presbyopic volunteers, aged between 24 and 30, were recruited. The ocular anterior segment of each subject was imaged using an extended scan depth OCT under non- and 3.0 diopters (D) of accommodative demands on both horizontal and vertical ...
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    13. Automatic Biometry of the Anterior Segment During Accommodation Imaged by Optical Coherence Tomography

      Automatic Biometry of the Anterior Segment During Accommodation Imaged by Optical Coherence Tomography
      Objective: To test accuracy and repeatability of a software algorithm that performs automatic biometry of the anterior segment of the human eye imaged with long scan depth optical coherence tomography (OCT). Methods: The ocular anterior segment imaging was performed with custom-built long scan depth OCT. An automatic software algorithm including boundary segmentation, image registration, and optical correction was developed for fast and reliable biometric measurements based on the OCT images ...
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    14. Monitor Corneal Epithelial Healing Under Bandage Contact Lens Using Ultrahigh-Resolution Optical Coherence Tomography After Pterygium Surgery

      Monitor Corneal Epithelial Healing Under Bandage Contact Lens Using Ultrahigh-Resolution Optical Coherence Tomography After Pterygium Surgery
      Objective: To monitor corneal epithelial healing under bandage contact lens (BCL) using ultrahigh-resolution optical coherence tomography (UHR-OCT) after pterygium surgery. Methods: Thirty-nine eyes of 39 patients undergoing pterygium excision and conjunctival autografting were randomly allocated into 2 groups: 20 eyes were covered with silicone hydrogel BCLs at the end of surgery and 19 eyes served as a control. Ultrahigh-resolution optical coherence tomography scans of the cornea were performed sequentially at ...
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    15. Repeatability and Reproducibility of Eight Macular Intra-Retinal Layer Thicknesses Determined by an Automated Segmentation Algorithm Using Two SD-OCT Instrument

      Repeatability and Reproducibility of Eight Macular Intra-Retinal Layer Thicknesses Determined by an Automated Segmentation Algorithm Using Two SD-OCT Instrument
      Purpose To evaluate the repeatability, reproducibility, and agreement of thickness profile measurements of eight intra-retinal layers determined by an automated algorithm applied to optical coherence tomography (OCT) images from two different instruments. Methods Twenty normal subjects (12 males, 8 females; 24 to 32 years old) were enrolled. Imaging was performed with a custom built ultra-high resolution OCT instrument (UHR-OCT, ~3 m resolution) and a commercial RTVue100 OCT (~5 m resolution ...
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    16. Agreement of Corneal Epithelial Profiles Produced by Automated Segmentation of SD-OCT Images Having Different Optical Resolutions

      Agreement of Corneal Epithelial Profiles Produced by Automated Segmentation of SD-OCT Images Having Different Optical Resolutions
      Objective: Using a custom-developed segmentation algorithm, agreement of corneal epithelial thickness profile measurements between two spectral domain optical coherence tomography (SD-OCT) systems was assessed. Methods: Eighteen left eyes (18 subjects; mean+/-standard deviation; age, 23.2+/-0.9 years) were imaged twice on nonconsecutive days by a custom-built ultra-high resolution OCT (UHR-OCT) system and a commercial RTVue OCT system. A segmentation algorithm based on axial gradient information and a shortest ...
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  2. About Meixiao Shen

    Meixiao Shen is with the School of Ophthalmology and Optometry at Wenzhou Medical College in China.