1. Medical University of Vienna

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    1. Mentioned In 615 Articles

    2. Ultra-widefield OCT Angiography

      Ultra-widefield OCT Angiography
      Optical Coherence Tomography Angiography (OCTA), a functional extension of OCT, has the potential to replace most invasive fluorescein angiography (FA) exams in ophthalmology. So far, OCTAs field of view is however still lacking behind fluorescence fundus photography techniques. This is problematic, because many retinal diseases manifest at an early stage by changes of the peripheral retinal capillary network. It is therefore desirable to expand OCTAs field of view to match ...
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    3. Detection of diabetic neovascularisation using single-capture 65°-widefield optical coherence tomography angiography

      Detection of diabetic neovascularisation using single-capture 65°-widefield optical coherence tomography angiography
      Aim: To assess the detection rate of retinal neovascularisation (NV) in eyes with proliferative diabetic retinopathy (PDR) using widefield optical coherence tomography angiography (WF-OCTA) in comparison to ultrawidefield fluorescein angiography (UWF-FA). Methods: Single-capture 65-WF-OCTA-imaging was performed in patients with NV at the disc or elsewhere (NVE) detected on UWF-FA using a modified PlexElite system and B-scans were examined for blood flow signals breaching the internal limiting membrane. Sensitivity of WF-OCTA ...
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    4. OCT Meets micro-CT: A Subject-Specific Correlative Multimodal Imaging Workflow for Early Chick Heart Development Modeling

      OCT Meets micro-CT: A Subject-Specific Correlative Multimodal Imaging Workflow for Early Chick Heart Development Modeling
      Structural and Doppler velocity data collected from optical coherence tomography have already provided crucial insights into cardiac morphogenesis. X-ray microtomography and other ex vivo methods have elucidated structural details of developing hearts. However, by itself, no single imaging modality can provide comprehensive information allowing to fully decipher the inner workings of an entire developing organ. Hence, we introduce a specimen-specific correlative multimodal imaging workflow combining OCT and micro-CT imaging which ...
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    5. Birefringent Properties of the Peripapillary Retinal Nerve Fiber Layer in Healthy and Glaucoma Subjects Analyzed by Polarization-Sensitive OCT

      Birefringent Properties of the Peripapillary Retinal Nerve Fiber Layer in Healthy and Glaucoma Subjects Analyzed by Polarization-Sensitive OCT
      Purpose: To study the circumpapillary retinal nerve fiber layer (RNFL) birefringence (BIR) of early glaucoma and age-matched healthy eyes using polarization-sensitive optical coherence tomography (PS-OCT). Methods: In this prospective cross-sectional study, we compared virtual circular PS-OCT B-scans with a diameter of 3.5 mm centered on the optic disc (OD) acquired with a PS-OCT prototype (860 nm center wavelength). Early glaucoma was defined by the glaucomatous appearance of the OD ...
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    6. Segmentation of Bruch's Membrane in retinal OCT with AMD using anatomical priors and uncertainty quantification

      Segmentation of Bruch's Membrane in retinal OCT with AMD using anatomical priors and uncertainty quantification
      Bruch's membrane (BM) segmentation on optical coherence tomography (OCT) is a pivotal step for the diagnosis and follow-up of age-related macular degeneration (AMD), one of the leading causes of blindness in the developed world. Automated BM segmentation methods exist, but they usually do not account for the anatomical coherence of the results, neither provide feedback on the confidence of the prediction. These factors limit the applicability of these systems ...
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    7. Are Macula or Optic Nerve Head Structures better at Diagnosing Glaucoma? An Answer using AI and Wide-Field Optical Coherence Tomography

      Are Macula or Optic Nerve Head Structures better at Diagnosing Glaucoma? An Answer using AI and Wide-Field Optical Coherence Tomography
      Purpose : (1) To develop a deep learning algorithm to automatically segment connective and neural tissue structures of the optic nerve head (ONH) and macula in 3D wide - field optical coherence tomography (OCT) scans; (2) To exploit such information, to assess whether 3D macula or ONH structures (or the combination of both) provide the best diagnostic power for glaucoma. Methods: A cross - sectional comparative study was performe d which included wide ...
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    8. Degeneration of Melanin-Containing Structures Observed Longitudinally in the Eyes of SOD1-/- Mice Using Intensity, Polarization, and Spectroscopic OCT

      Degeneration of Melanin-Containing Structures Observed Longitudinally in the Eyes of SOD1-/- Mice Using Intensity, Polarization, and Spectroscopic OCT
      Purpose: Melanin plays an important function in maintaining eye health, however there are few metrics that can be used to study retinal melanin content in vivo. Methods: The slope of the spectral coefficient of variation (SSCoV) is a novel biomarker that measures chromophore concentration by analyzing the local divergence of spectral intensities using optical coherence tomography (OCT). This metric was validated in a phantom and applied in a longitudinal study ...
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    9. Investigating the macular choriocapillaris in early primary open-angle glaucoma using swept-source optical coherence tomography angiography

      Investigating the macular choriocapillaris in early primary open-angle glaucoma using swept-source optical coherence tomography angiography
      Introduction: There has been a growing interest in the role of vascular factors in glaucoma. Studies have looked at the characteristics of macular choriocapillaris in patients with glaucoma but with conflicting results. Our study aims to use swept-source optical coherence tomography angiography (SS-OCTA) to evaluate macular choriocapillaris metrics in normal participants and compare them with patients with early primary open-angle glaucoma (POAG) (mean deviation better than -6dB). Methods: In this ...
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    10. Optical coherence tomography and OCT angiography characteristics of indocyanine green angiographic plaques in nonexudative age-related macular degeneration

      Optical coherence tomography and OCT angiography characteristics of indocyanine green angiographic plaques in nonexudative age-related macular degeneration
      Purpose: To describe characteristics of indocyanine green (ICG) angiographic plaques in the nonexudative fellow eye of Caucasian patients with unilateral treatment-nave exudative neovascular age-related macular degeneration (nAMD) through optical coherence tomography (OCT) and OCT angiography (OCTA). Methods: In this retrospective cross-sectional study, nonexudative eyes with ICG angiographic plaques were analyzed by OCT B-scans for the sensitivity of a double-layer sign (DLS), a pigment epithelium detachment (PED), outer retinal atrophy (ORA ...
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    11. Longitudinal investigation of a xenograft tumor zebrafish model using polarization-sensitive optical coherence tomography

      Longitudinal investigation of a xenograft tumor zebrafish model using polarization-sensitive optical coherence tomography
      Breast cancer is a leading cause of death in female patients worldwide. Further research is needed to get a deeper insight into the mechanisms involved in the development of this devastating disease and to find new therapy strategies. The zebrafish is an established animal model, especially in the field of oncology, which has shown to be a promising candidate for pre-clinical research and precision-based medicine. To investigate cancer growth in ...
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    12. Evaluation of Generative Adversarial Networks for High-Resolution Synthetic Image Generation of Circumpapillary Optical Coherence Tomography Images for Glaucoma

      Evaluation of Generative Adversarial Networks for High-Resolution Synthetic Image Generation of Circumpapillary Optical Coherence Tomography Images for Glaucoma
      Importance: Deep learning (DL) networks require large data sets for training, which can be challenging to collect clinically. Generative models could be used to generate large numbers of synthetic optical coherence tomography (OCT) images to train such DL networks for glaucoma detection. Objective: To assess whether generative models can synthesize circumpapillary optic nerve head OCT images of normal and glaucomatous eyes and determine the usability of synthetic images for training ...
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    13. Predicting treat-and-extend outcomes and treatment intervals in neovascular age-related macular degeneration from retinal optical coherence tomography using artificial intelligence

      Predicting treat-and-extend outcomes and treatment intervals in neovascular age-related macular degeneration from retinal optical coherence tomography using artificial intelligence
      Purpose: To predict visual outcomes and treatment needs in a treat extend (TE) regimen in neovascular age-related macular degeneration (nAMD) using a machine learning model based on quantitative optical coherence tomography (OCT) imaging biomarkers. Materials and methods: Study eyes of 270 treatment-nave subjects, randomized to receiving ranibizumab therapy in the TE arm of a randomized clinical trial were considered. OCT volume scans were processed at baseline and at the first ...
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    14. New Eurostars project to develop novel multi-model OCT device for improving cataract surgery outcome

      New Eurostars project to develop novel multi-model OCT device for improving cataract surgery outcome
      ...0, Vienna 1190, Austria Email: abhishek.kumar@wavesenseengineering.com About Medical University of Vienna The Medical University of Vienna is one of the most traditional medical educational establishments with 8,000 stud...
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    15. Retinal Layer Thinning After Optic Neuritis is Associated With Future Relapse Remission in Relapsing Multiple Sclerosis

      Retinal Layer Thinning After Optic Neuritis is Associated With Future Relapse Remission in Relapsing Multiple Sclerosis
      Introduction: Remission of relapses is an important contributor to both short- and long-term prognosis in relapsing multiple sclerosis (RMS). In MS-associated acute optic neuritis (MS-ON), retinal layer thinning measured by optical coherence tomography (OCT) is a reliable biomarker of both functional recovery and the degree of neuroaxonal damage. However, prediction of non-ON relapse remission is challenging. We aimed to investigate whether retinal thinning after ON is associated with relapse remission ...
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  2. About Medical University of Vienna

    Medical University of Vienna

    Medical University of Vienna.  In its structuring and alignment the Medical University of Vienna relies on the "triple track" strategy. Research, education and patient care represent the three cornerstones of the university's system. Center for Biomedical Engineering and Physics, Medical University of Vienna, Austria.  The Biomedical Engineering Group at the Department of Biomedical Engineering of the Medical School, University of Vienna, is situated in the University Hospital of Vienna, which is the biggest hospital of Austria, and one of the biggest in Europe. The Biomedical Engineering Group was concentrated here to promote medical research with modern technical means.