1. Medical University of Vienna

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    1. Mentioned In 418 Articles

    2. Assessment of pathological features in Alzheimer’s disease brain tissue with a large field-of-view visible-light optical coherence microscope

      Assessment of pathological features in Alzheimer’s disease brain tissue with a large field-of-view visible-light optical coherence microscope
      We implemented a wide field-of-view visible-light optical coherence microscope (OCM) for investigating ex-vivo brain tissue of patients diagnosed with Alzheimers disease (AD) and of a mouse model of AD. A submicrometer axial resolution in tissue was achieved using a broad visible light spectrum. The use of various objective lenses enabled reaching micrometer transversal resolution and the acquisition of images of microscopic brain features, such as cell structures, vessels, and white ...
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    3. Comparison of Optical Coherence Tomography Angiography to Indocyanine Green Angiography and Slit Lamp Photography for Corneal Vascularization in an Animal Model

      Comparison of Optical Coherence Tomography Angiography to Indocyanine Green Angiography and Slit Lamp Photography for Corneal Vascularization in an Animal Model
      Corneal neovascularization (CoNV) could be treated by novel anti-angiogenic therapies, though reliable and objective imaging tools to evaluate corneal vasculature and treatment efficacy is still lacking. Optical coherence tomography angiography (OCTA) currently designed as a retinal vascular imaging system has been recently adapted for anterior-segment and showed good potential for successful imaging of CoNV. However, further development requires an animal model where parameters can be studied more carefully with histological ...
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    4. Non-Destructive Classification of Diversely Stained Capsicum annuum Seed Specimens of Different Cultivars Using Near-Infrared Imaging Based Optical Intensity Detection

      Non-Destructive Classification of Diversely Stained Capsicum annuum Seed Specimens of Different Cultivars Using Near-Infrared Imaging Based Optical Intensity Detection
      The non-destructive classification of plant materials using optical inspection techniques has been gaining much recent attention in the field of agriculture research. Among them, a near-infrared (NIR) imaging method called optical coherence tomography (OCT) has become a well-known agricultural inspection tool since the last decade. Here we investigated the non-destructive identification capability of OCT to classify diversely stained (with various staining agents) Capsicum annuum seed specimens of different cultivars. A ...
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    5. Multiple Wavelength Optical Coherence Tomography Assessments for Enhanced Ex Vivo Intra-Cochlear Microstructural Visualization

      Multiple Wavelength Optical Coherence Tomography Assessments for Enhanced Ex Vivo Intra-Cochlear Microstructural Visualization
      The precise identification of intra-cochlear microstructures is an essential otorhinolaryngological requirement to diagnose the progression of cochlea related diseases. Thus, we demonstrated an experimental procedure to investigate the most optimal wavelength range, which can enhance the visualization of ex vivo intra-cochlear microstructures using multiple wavelengths (i.e., 860 nm, 1060 nm, and 1300 nm) based optical coherence tomography (OCT) systems. The high-resolution tomograms, volumetric, and quantitative evaluations obtained from Basilar ...
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    6. Handheld multi‐modal imaging for point‐of‐care skin diagnosis based on akinetic integrated optics optical coherence tomography

      Handheld multi‐modal imaging for point‐of‐care skin diagnosis based on akinetic integrated optics optical coherence tomography
      A handheld skin imaging system with joint optical coherence tomography (OCT) at 1300 nm and digital epiluminescence microscopy (EM) is presented. The two modalities are physically co‐registered in a common‐path configuration. The instrument is enabled by a dedicated planar lightwave circuit with a footprint of only 1.1 x 19.5 mm 2 that provides akinetic axial OCT scanning at speeds up to 24 kHz. Lateral scanning is ...
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    7. Endoscopic optical coherence tomography with a flexible fiber bundle

      Endoscopic optical coherence tomography with a flexible fiber bundle
      We demonstrate in vivo endoscopic optical coherence tomography (OCT) imaging in the forward direction using a flexible fiber bundle (FB). In comparison to current conventional forward-looking probe schemes, our approach simplifies the endoscope design by avoiding the integration of any beam steering components in the distal probe end due to two-dimensional scanning of a focused light beam over the proximal FB surface. We describe the challenges that arise when OCT ...
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    8. Quality assessment of the optical thin films using line field spectral domain optical coherence tomography

      Quality assessment of the optical thin films using line field spectral domain optical coherence tomography
      Cross-sectional and three-dimensional images show the effectiveness of the system. In this study, the industrial inspection of optical thin film on touch screen panels was demonstrated using line field spectral domain optical coherence tomography. The conventional Fourier domain optical coherence tomography system requires a single scanner for two-dimensional cross-sectional images and two scanners for volumetric images. Our developed line field spectral domain optical coherence tomography has the advantage of needing ...
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    9. Adaptable switching schemes for time-encoded multichannel optical coherence tomography

      Adaptable switching schemes for time-encoded multichannel optical coherence tomography
      We introduce the approach of variable time encoding for multichannel optical coherence tomography (OCT). High-speed fiber optical switches are applied for sequential sample arm switching to enable quasisimultaneous image acquisition from three different orientation angles. In comparison with previous multichannel OCT (using simultaneous sample illumination), time-encoded multichannel OCT has no need for division of illumination power among the respective channels to satisfy laser safety requirements. Especially for ophthalmic applicationsin particular ...
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    10. Fully Automated Segmentation of Hyperreflective Foci in Optical Coherence Tomography Images

      Fully Automated Segmentation of Hyperreflective Foci in Optical Coherence Tomography Images
      The automatic detection of disease related entities in retinal imaging data is relevant for disease- and treatment monitoring. It enables the quantitative assessment of large amounts of data and the corresponding study of disease characteristics. The presence of hyperreflective foci (HRF) is related to disease progression in various retinal diseases. Manual identification of HRF in spectral-domain optical coherence tomography (SD-OCT) scans is error-prone and tedious. We present a fully automated ...
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    11. Comparison of SD-Optical Coherence Tomography Angiography and Indocyanine Green Angiography in Type 1 and 2 Neovascular Age-related Macular Degeneration

      Comparison of SD-Optical Coherence Tomography Angiography and Indocyanine Green Angiography in Type 1 and 2 Neovascular Age-related Macular Degeneration
      Purpose : The purpose of this study is to compare the ability of spectral domain optical coherence tomography angiography (SD-OCTA) and indocyanine green angiography (ICGA) to detect and measure lesion area in patients with type 1 and 2 choroidal neovascularization (CNV). Methods : Types 1 and 2 neovascular AMD (nAMD) were included in this prospective and observational case series. ETDRS best-corrected visual acuity (BCVA), ophthalmic examination with funduscopy, OCTA (AngioVue), fluorescein angiography ...
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    12. In Vivo Characterization of Spontaneous Retinal Neovascularization in the Mouse Eye by Multifunctional Optical Coherence Tomography

      In Vivo Characterization of Spontaneous Retinal Neovascularization in the Mouse Eye by Multifunctional Optical Coherence Tomography
      Purpose : To investigate the early development of spontaneous retinal neovascularization in the murine retina by a multifunctional optical coherence tomography approach. To characterize involved tissue changes in vivo and describe structural and functional changes over time. Methods : A multifunctional optical coherence tomography (OCT) system providing 3-fold contrast comprising reflectivity, polarization sensitivity, and OCT angiography (OCTA) was utilized to image very-low-density lipoprotein receptor (VLDLR) knockout mice. Baseline measurements were acquired as ...
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    13. Compact akinetic swept source optical coherence tomography angiography at 1060 nm supporting a wide field of view and adaptive optics imaging modes of the posterior eye

      Compact akinetic swept source optical coherence tomography angiography at 1060 nm supporting a wide field of view and adaptive optics imaging modes of the posterior eye
      Imaging of the human retina with high resolution is an essential step towards improved diagnosis and treatment control. In this paper, we introduce a compact, clinically user-friendly instrument based on swept source optical coherence tomography (SS-OCT). A key feature of the system is the realization of two different operation modes. The first operation mode is similar to conventional OCT imaging and provides large field of view (FoV) images (up to ...
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    14. Large field of view adaptive optics scanning laser ophthalmoscopy and optical coherence tomography

      Large field of view adaptive optics scanning laser ophthalmoscopy and optical coherence tomography
      Adaptive Optics (AO) retinal imaging is revealing microscopic structures of the eye in a non-invasive way. Due to anisoplanatism, conventional AO systems are efficient on small 1x1 field of view (FoV). We present a lens-based AO scanning laser ophthalmoscope (SLO) set-up with 2 deformable mirrors (DM), providing high-resolution retinal imaging on a 4x4 FoV, for an eye pupil diameter of 7 mm. The first DM is in a pupil plane ...
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  2. About Medical University of Vienna

    Medical University of Vienna

    Medical University of Vienna.  In its structuring and alignment the Medical University of Vienna relies on the "triple track" strategy. Research, education and patient care represent the three cornerstones of the university's system. Center for Biomedical Engineering and Physics, Medical University of Vienna, Austria.  The Biomedical Engineering Group at the Department of Biomedical Engineering of the Medical School, University of Vienna, is situated in the University Hospital of Vienna, which is the biggest hospital of Austria, and one of the biggest in Europe. The Biomedical Engineering Group was concentrated here to promote medical research with modern technical means.