1. Matthew Brenner

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    1. Mentioned In 30 Articles

    2. Optical coherence tomography imaging to analyze biofilm thickness from distal to proximal regions of the endotracheal tubes

      Optical coherence tomography imaging to analyze biofilm thickness from distal to proximal regions of the endotracheal tubes
      The development of nosocomial ventilator-associated pneumonia (VAP) has been linked to the presence of specific bacteria found in the biofilm that develops in intubated endotracheal tubes of critical care patients. Presence of biofilm has been difficult to assess clinically. Here, we use Optical coherence tomography (OCT), to visualize the biofilm at both the proximal and distal tips. Ultimately, the goal will be to determine if OCT can be a tool ...
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    3. Visualizing biofilm formation in endotracheal tubes using endoscopic three-dimensional optical coherence tomography

      Visualizing biofilm formation in endotracheal tubes using endoscopic three-dimensional optical coherence tomography
      Biofilm formation has been linked to ventilator-associated pneumonia, which is a prevalent infection in hospital intensive care units. Currently, there is no rapid diagnostic tool to assess the degree of biofilm formation or cellular biofilm composition. Optical coherence tomography (OCT) is a minimally invasive, nonionizing imaging modality that can be used to provide high-resolution cross-sectional images. Biofilm deposited in critical care patients endotracheal tubes was analyzed in vitro . This study ...
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    4. Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components

      Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components
      ... Ng Endoscopic Microscopy X; and Optical Techniques in Pulmonary Medicine II Melissa J. Suter; Stephen Lam; Matthew Brenner; Guillermo J. Tearney; Thomas D. Wang San Francisco, California, United States | February 07,...
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    5. UC Irvine Receives at 2014 NIH Grant for Evaluation of Obstructive Sleep Apnea with Long Range 3D Endoscopic FD-OCT

      UC Irvine Receives at 2014 NIH Grant  for Evaluation of Obstructive Sleep Apnea with Long Range 3D Endoscopic FD-OCT
      ...ablished track record in the development of optical imaging methods and translational research. Co-mentor Dr. Matthew Brenner, Professor and Chief of Pulmonary Medicine at the Lung Center at the University of California ...
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    6. In vivo detection of inhalation injury in large airway using three-dimensional long-range swept-source optical coherence tomography

      In vivo detection of inhalation injury in large airway using three-dimensional long-range swept-source optical coherence tomography
      We report on the feasibility of using long-range swept-source optical coherence tomography (OCT) to detect airway changes following smoke inhalation in a sheep model. The long-range OCT system (with axial imaging range of 25 mm) and probe are capable of rapidly obtaining a series of high-resolution full cross-sectional images and three-dimensional reconstructions covering 20-cm length of tracheal and bronchial airways with airway diameter up to 25 mm, regardless of the ...
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    7. Integrated IVUS-OCT for Real-Time Imaging of Coronary Atherosclerosis

      Integrated IVUS-OCT for Real-Time Imaging of Coronary Atherosclerosis
      Accurate assessment of atherosclerotic plaque characteristics and the subsequent tailoring of optimal therapy holds great promise for preventing acute coronary syndromes (ACS) and life-threatening sequelae 1 . Combined use of optical coherence tomography (OCT) and intravascular ultrasound (IVUS) was proposed as a potential method for accurate assessment of plaque characteristics and vulnerability ( 2 , ). However, significant challenges remain in trying to adapt an integrated OCT-IVUS system for clinical applications. We report here ...
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    8. Endoscopic long range fourier domain optical coherence tomography (LR-FD-OCT)

      Endoscopic long range fourier domain optical coherence tomography (LR-FD-OCT)
      An endoscopic swept-source Fourier Domain optical coherence tomographic system (FDOCT system) for imaging of tissue structure includes a Fourier Domain mode locked (FDML), high speed, narrow line-width, wavelength swept source, an OCT interferometer having a sample arm, a reference arm, a detection arm, and a source arm coupled to the swept source, an endoscopic probe coupled to the sample arm, and a data processing circuit coupled to the detection arm ...
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    9. Integrated intravascular optical coherence tomography (OCT) - ultrasound (US) catheter for characterization of atherosclerotic plaques in vivo

      Integrated intravascular optical coherence tomography (OCT) - ultrasound (US) catheter for characterization of atherosclerotic plaques in vivo
      A miniature integrated intravascular optical coherence tomography (OCT) - ultrasound (US) catheter for real-time imaging of atherosclerotic plaques has been developed, providing high resolution and deep tissue penetration at the same time. This catheter, with an outer diameter of 1.18mm, is suitable for imaging in human coronary arteries. The first in vivo 3D imaging of atherosclerotic microstructure in a rabbit abdominal aorta obtained by an integrated OCT-US catheter is presented ...
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    10. Investigating in vivo airway wall mechanics during tidal breathing with optical coherence tomography

      Investigating in vivo airway wall mechanics during tidal breathing with optical coherence tomography
      Optical coherence tomography (OCT) is a nondestructive imaging technique offering high temporal and spatial resolution, which makes it a natural choice for assessing tissue mechanical properties. We have developed methods to mechanically analyze the compliance of the rabbit trachea in vivo using tissue deformations induced by tidal breathing, offering a unique tool to assess the behavior of the airways during their normal function. Four-hundred images were acquired during tidal breathing ...
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    11. Recent advances in optical coherence tomography for the diagnoses of lung disorders

      Recent advances in optical coherence tomography for the diagnoses of lung disorders
      There have been many advances in the field of diagnostic and therapeutic pulmonary medicine in the past several years, with major progress in the field of imaging. Optical coherence tomography (OCT) is a high-resolution (micron level) imaging modality currently being advanced with the potential to image airway wall structures in real time and at higher resolution than previously possible. OCT has the potential to increase the sensitivity and specificity of ...
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    12. UC Irvine Receives NIH Award for Evaluation of Obstructive Sleep Apnea with Long Range 3D Endoscopic Fourier Domain OCT

      UC Irvine Receives NIH Award for Evaluation of Obstructive Sleep Apnea with Long Range 3D Endoscopic Fourier Domain OCT
      ...ablished track record in the development of optical imaging methods and translational research. Co-mentor Dr. Matthew Brenner, Professor and Chief of Pulmonary Medicine at the Lung Center at the University of California ...
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    13. 1-15 of 30 1 2 »
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  2. About Matthew Brenner

    Matthew Brenner

    Matthew Brenner, MD, is a Professor of Medicine and Chief, Pulmonary and Critical Care Medicine at the Lung Center at the University of California Irvine.