1. Mathias Fink

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    1. Mentioned In 16 Articles

    2. Real-time, non-contact, cellular imaging and angiography of human cornea and limbus with common-path Full-field/SD OCT

      Real-time, non-contact, cellular imaging and angiography of human cornea and limbus with common-path Full-field/SD OCT
      In todays clinics, a cellular-resolution view of the cornea can be achieved only with an in vivo confocal microscope (IVCM) in contact with the eye. Here, we present a common-path Full-field/Spectral-domain OCT microscope (FF/SD OCT), which, for the first time, enables cell-detail imaging of the entire ocular surface (central and peripheral cornea, limbus, sclera, tear film) without contact and in real time. The device, that has been successfully ...
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    3. Curved-Full-Field OCT for high-resolution imaging of living human retina over a large field-of-view

      Curved-Full-Field OCT for high-resolution imaging of living human retina over a large field-of-view
      Allying high-resolution with a large field-of-view (FOV) is of great importance in the fields of biology and medicine [1, 2, 3], but particularly challenging when imaging non-flat living samples such as the human retina. Indeed, high-resolution is normally achieved with adaptive optics (AO) and scanning methods, which considerably reduce the useful FOV and increase the system complexity. An alternative technique is time-domain Full-Field Optical Coherence Tomography (FF-OCT) [4, 5], which ...
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    4. Dynamic full-field optical coherence tomography: 3D live-imaging of retinal organoids

      Dynamic full-field optical coherence tomography: 3D live-imaging of retinal organoids
      Optical coherence tomography offers astounding opportunities to image the complex structure of living tissue, but lacks functional information. We present dynamic full-field optical coherence tomography to image living human induced pluripotent stem cell-derived retinal organoids non-invasively. Colored images with an endogenous contrast linked to organelle motility are generated, with sub-micrometer spatial resolution and millisecond temporal resolution, opening an avenue to identify specific cell types in living tissue via their function.
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    5. Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT

      Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT
      We describe recent technological progress in multimodal en face full-field optical coherence tomography that has allowed detection of slow and fast dynamic processes in the eye. We show that by combining static, dynamic and fluorescence contrasts we can achieve label-free high-resolution imaging of the retina and anterior eye with temporal resolution from milliseconds to several hours, allowing us to probe biological activity at subcellular scales inside 3D bulk tissue. Our ...
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    6. In vivo imaging through the entire thickness of human cornea by full-field optical coherence tomography

      In vivo imaging through the entire thickness of human cornea by full-field optical coherence tomography
      Despite obvious improvements in visualization of the in vivo cornea through the faster imaging speeds and higher axial resolutions, cellular imaging stays unresolvable task for OCT, as en face viewing with a high lateral resolution is required. The latter is possible with FFOCT, a method that relies on a camera, moderate numerical aperture (NA) objectives and an incoherent light source to provide en face images with a micrometer-level resolution. Recently ...
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    7. In vivo high resolution human corneal imaging using full-field optical coherence tomography

      In vivo high resolution human corneal imaging using full-field optical coherence tomography
      We present the first full-field optical coherence tomography (FFOCT) device capable of in vivo imaging of the human cornea. We obtained images of the epithelial structures, Bowmans layer, sub-basal nerve plexus (SNP), anterior and posterior stromal keratocytes, stromal nerves, Descemets membrane and endothelial cells with visible nuclei. Images were acquired with a high lateral resolution of 1.7 m and relatively large field-of-view of 1.26 mm x 1.26 ...
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    8. The multiple scattering limit in optical microscopy

      The multiple scattering limit in optical microscopy
      Optical microscopy offers a unique insight of biological structures with a sub-micrometer resolution and a minimum invasiveness. However, the inhomogeneities of the specimen itself can induce multiple scattering of light and optical aberrations which limit the observation to depths close to the surface. To predict quantitatively the penetration depth in microscopy, we theoretically derive the single-to-multiple scattering ratio in reflection. From this key quantity, the multiple scattering limit is deduced ...
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    9. Cell Motility as Contrast Agent in Retinal Explant Imaging With Full-Field Optical Coherence Tomography

      Cell Motility as Contrast Agent in Retinal Explant Imaging With Full-Field Optical Coherence Tomography
      Purpose : To use cell motility as a contrast agent in retinal explants. Methods : Macaque and mouse retinal explants were imaged with high resolution full field optical coherence tomography (FFOCT) and dynamic FFOCT, coupled with fluorescence imaging. Results : Static and dynamic FFOCT create complementary contrast from different structures within a cell. When imaging in vitro samples, static FFOCT detects steep refractive index gradients to reveal stationary structures including fibers, vessels, collagen ...
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    10. Full-Field Optical Coherence Tomography as a Diagnosis Tool: Recent Progress with Multimodal Imaging

      Full-Field Optical Coherence Tomography as a Diagnosis Tool: Recent Progress with Multimodal Imaging
      Full-field optical coherence tomography (FF-OCT) is a variant of OCT that is able to register 2D en face views of scattering samples at a given depth. Thanks to its superior resolution, it can quickly reveal information similar to histology without the need to physically section the sample. Sensitivity and specificity levels of diagnosis performed with FF-OCT are 80% to 95% of the equivalent histological diagnosis performances and could therefore benefit ...
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    11. Retinal imaging with adaptive optics full-field OCT

      Retinal imaging with adaptive optics full-field OCT
      Adaptive optics full-filed OCT (FFOCT) with a transmissive liquid crystal spatial light modulator (LCSLM) as wavefront corrector is used without strict plane conjugation for low order aberrations corrections. We validated experimentally that FFOCT resolution is independent of aberrations and only reduce the signal level. A signal based sensorless algorithm was thus applied for wavefront distortion compensation. Image quality improvements by the wavefront sensorless control of the LCSLM were evaluated on ...
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    12. Dynamic multimodal full-field optical coherence tomography and fluorescence structured illumination microscopy

      Dynamic multimodal full-field optical coherence tomography and fluorescence structured illumination microscopy
      We report on the development of a configuration of a multimodal full-field optical coherence tomography (FF-OCT) and fluorescence microscope. Our system can simultaneously acquire FF-OCT and structured illumination microscopy images. Dynamic parallel evolution of tissue microstructures and biochemical environments can be visualized. We use high numerical aperture objectives to optimize the combination of the two modalities. We imaged the propagation of mechanical waves initiated by calcium waves in a heart ...
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    13. Diffuse shear wave imaging: toward passive elastography using low-frame rate spectral-domain optical coherence tomography

      Diffuse shear wave imaging: toward passive elastography using low-frame rate spectral-domain optical coherence tomography
      Optical coherence tomography (OCT) can map the stiffness of biological tissue by imaging mechanical perturbations (shear waves) propagating in the tissue. Most shear wave elastography (SWE) techniques rely on active shear sources to generate controlled displacements that are tracked at ultrafast imaging rates. Here, we propose a noise-correlation approach to retrieve stiffness information from the imaging of diffuse displacement fields using low-frame rate spectral-domain OCT. We demonstrated the method on ...
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    14. Adaptive optics full-field optical coherence tomography

      Adaptive optics full-field optical coherence tomography
      We describe a simple and compact full-field optical coherence tomography (FFOCT) setup coupled to a transmissive liquid crystal spatial light modulator (LCSLM) to induce or correct aberrations. To reduce the system complexity, strict pupil conjugation was abandoned because low-order aberrations are often dominant. We experimentally confirmed a recent theoretical and experimental demonstration that the image resolution was almost insensitive to aberrations that mostly induce a reduction of the signal level ...
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    15. Full-field spatially incoherent illumination interferometry: a spatial resolution almost insensitive to aberrations

      Full-field spatially incoherent illumination interferometry: a spatial resolution almost insensitive to aberrations
      We show that with spatially incoherent illumination, the point spread function (PSF) width/spatial resolution of an imaging interferometer like that used in full-field optical coherence tomography (OCT) is almost insensitive to aberrations. In these systems, aberrations mostly induce a reduction of the signal level that leads to a loss of the signal-to-noise ratio without broadening the system PSF. This is demonstrated by comparison with traditional scanning OCT and wide-field ...
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    16. Feature Of The Week: Feature Of The Week 1/26/14: ESPCI-ParisTech Investigates Full-Field Optical Coherence Tomograpy (FF-OCT) Shear Wave Elastography

      Feature Of The Week: Feature Of The Week 1/26/14: ESPCI-ParisTech Investigates Full-Field Optical Coherence Tomograpy (FF-OCT) Shear Wave Elastography
      Elasticity maps of tissue have proved to be particularly useful in providing complementary contrast to ultrasonic imaging, e.g., for cancer diagnosis at the millimeter scale. Optical coherence tomography (OCT) offers an endogenous contrast based on singly backscattered optical waves. Adding complementary contrast to OCT images by recording elasticity maps could also be valuable in improving OCT-based diagnosis at the microscopic scale. Static elastography has been successfully coupled with full-field ...
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  2. About Mathias Fink

    Mathias Fink received the Ph.D. degree in solid-state physics in 1970 and received the doctorat es-sciences degree in 1978 from Paris University. His current research interests include medical ultrasonic imaging, ultrasonic therapy; nondestructive testing; underwater acoustics; telecommunications; seismology; active control of sound and vibration; analogies between optics, quantum mechanics, and acoustics; wave coherence in multiply scattering media; and time-reversal in physics. He holds 28 patents, and he has published more than 300 articles.