1. Massachusetts Institute of Technology

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    1. Mentioned In 579 Articles

    2. Colocalization of neurons in optical coherence microscopy and Nissl-stained histology in Brodmann’s area 32 and area 21

      Colocalization of neurons in optical coherence microscopy and Nissl-stained histology in Brodmann’s area 32 and area 21
      Optical coherence tomography is an optical technique that uses backscattered light to highlight intrinsic structure, and when applied to brain tissue, it can resolve cortical layers and fiber bundles. Optical coherence microscopy (OCM) is higher resolution (i.e., 1.25 m) and is capable of detecting neurons. In a previous report, we compared the correspondence of OCM acquired imaging of neurons with traditional Nissl stained histology in entorhinal cortex layer ...
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    3. Optic axis mapping with catheter-based polarization-sensitive optical coherence tomography

      Optic axis mapping with catheter-based polarization-sensitive optical coherence tomography
      Birefringence offers an intrinsic contrast mechanism related to the microstructure and arrangement of fibrillary tissue components. Here we present a reconstruction strategy to recover not only the scalar amount of birefringence, but also its optic axis orientation as a function of depth in tissue from measurements with catheter-based polarization-sensitive optical coherence tomography. A polarization symmetry constraint, intrinsic to imaging in the backscatter direction, facilitates the required compensation for wavelength-dependent transmission ...
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    4. Extended coherence length and depth ranging using a Fourier domain mode-locked frequency comb and circular interferometric ranging

      Extended coherence length and depth ranging using a Fourier domain mode-locked frequency comb and circular interferometric ranging
      Fourier domain mode-locking (FDML) has been a popular laser design for high speed optical frequency domain imaging (OFDI) but achieving long coherence lengths, and therefore imaging range, has been challenging. The narrow instantaneous linewidth of a frequency comb (FC) FDML laser could provide an attractive platform for high speed as well as long range OFDI. Unfortunately, aliasing artifacts arising from signals beyond the principle measurement depth of the free spectral ...
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    5. Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University

      Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University
      ...ust 2007, Dr. Zhou joined Professor James G. Fujimoto’s Laser Medicine and Medical Imaging Group at the Massachusetts Institute of Technology (MIT) as a postdoctoral associate. Since then, he has been working on th...
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    6. Feature Of The Week 10/08/2018: Clinical Utility of Ultrahigh-Speed Endoscopic Optical Coherence Tomography in Gastroenterology

      Feature Of The Week 10/08/2018: Clinical Utility of Ultrahigh-Speed Endoscopic Optical Coherence Tomography in Gastroenterology
      ...enesis. For more information see recent Article1 , Article2 , and Article3 . Courtesy Osman O. Ahsen from the Massachusetts Institute of Technology . Barrett’s esophagus (BE) surveillance is limited by biopsy sampling er...
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    7. Assessment of Barrett’s esophagus and dysplasia with ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography

      Assessment of Barrett’s esophagus and dysplasia with ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography
      Background This study aimed to evaluate the use of ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography (OCT) with micromotor catheters for the in vivo assessment of Barretts esophagus and dysplasia. Methods 74 OCT datasets with correlated biopsy/endoscopic mucosal resection histology (49 nondysplastic Barretts esophagus [NDBE], 25 neoplasia) were obtained from 14 patients with Barretts esophagus and a history of dysplasia and 30 with NDBE. The associations between ...
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    8. Volumetric non-local-means based speckle reduction for optical coherence tomography

      Volumetric non-local-means based speckle reduction for optical coherence tomography
      We present a novel tomographic non-local-means based despeckling technique, TNode, for optical coherence tomography. TNode is built upon a weighting similarity criterion derived for speckle in a three-dimensional similarity window. We present an implementation using a two-dimensional search window, enabling the despeckling of volumes in the presence of motion artifacts, and an implementation using a three-dimensional window with improved performance in motion-free volumes. We show that our technique provides effective ...
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    9. A Quantum Field Approach for Advancing Optical Coherence Tomography Part I: First Order Correlations, Single Photon Interference, and Quantum Noise

      A Quantum Field Approach for Advancing Optical Coherence Tomography Part I: First Order Correlations, Single Photon Interference, and Quantum Noise
      Optical coherence tomography has become an important imaging technology in cardiology and ophthalmology, with other applications under investigations. Major advances in optical coherence tomography (OCT) imaging are likely to occur through a quantum field approach to the technology. In this paper, which is the first part in a series on the topic, the quantum basis of OCT first order correlations is expressed in terms of full field quantization. Specifically first ...
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    10. Robust wavenumber and dispersion calibration for Fourier-domain optical coherence tomography

      Robust wavenumber and dispersion calibration for Fourier-domain optical coherence tomography
      Many Fourier-domain optical coherence tomography (FD-OCT) systems sample the interference fringes with a non-uniform wavenumber ( k ) interval, introducing a chirp to the signal that depends on the path length difference underlying each fringe. A dispersion imbalance between sample and reference arms also generates a chirp in the fringe signal which, in contrast, is independent of depth. Fringe interpolation to obtain a signal linear in k and compensate dispersion imbalance is ...
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    11. Polymeric endovascular strut and lumen detection algorithm for intracoronary optical coherence tomography images

      Polymeric endovascular strut and lumen detection algorithm for intracoronary optical coherence tomography images
      Polymeric endovascular implants are the next step in minimally invasive vascular interventions. As an alternative to traditional metallic drug-eluting stents, these often-erodible scaffolds present opportunities and challenges for patients and clinicians. Theoretically, as they resorb and are absorbed over time, they obviate the long-term complications of permanent implants, but in the short-term visualization and therefore positioning is problematic. Polymeric scaffolds can only be fully imaged using optical coherence tomography (OCT ...
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    12. 1-15 of 579 1 2 3 4 ... 37 38 39 »
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  2. About Massachusetts Institute of Technology

    Massachusetts Institute of Technology

    Massachusetts Institute of Technology (MIT) is a private, coeducational research university located in Cambridge, Massachusetts. MIT has five schools and one college, containing 32 academic departments, with a strong emphasis in theoretical, applied, and interdisciplinary scientific and technological research.  Laser Medicine and Medical Imaging Group at MIT.  The RLE Laser Medicine and Medical Imaging Group and its close collaborators were the originators of optical coherence tomography (OCT), a diagnostic technology now used in a growing number of medical fields. The group currently works to further understand and exploit the capabilities of OCT technology, with ongoing investigations in topics related to optical coherence microscopy development and optical biopsy using OCT.