1. Massachusetts Institute of Technology

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    1. Mentioned In 650 Articles

    2. High speed, long range, deep penetration swept source OCT for structural and angiographic imaging of the anterior eye

      High speed, long range, deep penetration swept source OCT for structural and angiographic imaging of the anterior eye
      This study reports the development of prototype swept-source optical coherence tomography (SS-OCT) technology for imaging the anterior eye. Advances in vertical-cavity surface-emitting laser (VCSEL) light sources, signal processing, optics and mechanical designs, enable a unique combination of high speed, long range, and deep penetration that addresses the challenges of anterior eye imaging. We demonstrate SS-OCT with a 325 kHz A-scan rate, 12.2 m axial resolution (in air), and 15 ...
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    3. Cross-free in both lateral and axial directions Fourier-domain full-field optical coherence tomography

      Cross-free in both lateral and axial directions Fourier-domain full-field optical coherence tomography
      Fourier-domain full-field optical coherence tomography (FD-FF-OCT) has the advantages of high resolution and parallel detection. However, using parallel detection can result in optical crosstalk. Toward minimizing crosstalk, we implemented a very fast deformable membrane (DM) that introduces random phase illumination, which can effectively reduce the crosstalk by washing out fringes originating from multiply scattered light. However, for one thing, although the application of DM has reduced the crosstalk problem in ...
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    4. An inverse method for mechanical characterization of heterogeneous diseased arteries using intravascular imaging

      An inverse method for mechanical characterization of heterogeneous diseased arteries using intravascular imaging
      The increasing prevalence of finite element (FE) simulations in the study of atherosclerosis has spawned numerous inverse FE methods for the mechanical characterization of diseased tissue in vivo. Current approaches are however limited to either homogenized or simplified material representations. This paper presents a novel method to account for tissue heterogeneity and material nonlinearity in the recovery of constitutive behavior using imaging data acquired at differing intravascular pressures by incorporating ...
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    5. OCT Angiography-based Evaluation of the Choriocapillaris in Neovascular Age-related Macular Degeneration

      OCT Angiography-based Evaluation of the Choriocapillaris in Neovascular Age-related Macular Degeneration
      Neovascular age-related macular degeneration (AMD) can lead to rapid, irreversible vision loss in untreated eyes. While the pathogenesis of neovascular AMD remains incompletely understood, the choriocapillaris has been hypothesized as the initial site of injury. Due to limitations of dye-based angiography, in vivo imaging of the choriocapillaris has been a longstanding challenge. However, the clinical introduction of optical coherence tomography angiography (OCTA) has enabled researchers and clinicians to noninvasively image ...
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    6. A platform for high-fidelity patient-specific structural modelling of atherosclerotic arteries: from intravascular imaging to three-dimensional stress distributions

      A platform for high-fidelity patient-specific structural modelling of atherosclerotic arteries: from intravascular imaging to three-dimensional stress distributions
      The pathophysiology of atherosclerotic lesions, including plaque rupture triggered by mechanical failure of the vessel wall, depends directly on the plaque morphology-modulated mechanical response. The complex interplay between lesion morphology and structural behaviour can be studied with high-fidelity computational modelling. However, construction of three-dimensional (3D) and heterogeneous models is challenging, with most previous work focusing on two-dimensional geometries or on single-material lesion compositions. Addressing these limitations, we here present a ...
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    7. Quantification of volumetric morphometry and optical property in the cortex of human cerebellum at micrometer resolution

      Quantification of volumetric morphometry and optical property in the cortex of human cerebellum at micrometer resolution
      The surface of the human cerebellar cortex is much more tightly folded than the cerebral cortex. Volumetric analysis of cerebellar morphometry in magnetic resonance imaging studies suffers from insufficient resolution, and therefore has had limited impact on disease assessment. Automatic serial polarization-sensitive optical coherence tomography (as-PSOCT) is an emerging technique that offers the advantages of microscopic resolution and volumetric reconstruction of large-scale samples. In this study, we reconstructed multiple cubic ...
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    8. Arterial wall characterization in optical coherence tomography imaging

      Arterial wall characterization in optical coherence tomography imaging
      A method, including: obtaining, by a processor, imaging data from a vessel; detecting, using the processor, an inner wall of the vessel based on the imaging data; identifying, using the processor, a plurality of visible edge portions of an outer wall of the vessel based on the imaging data; fitting, using the processor, a continuous surface model to the plurality of identified visible edge portions of the outer wall; and ...
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    9. Refractive-index matching enhanced polarization-sensitive optical coherence tomography quantification in human brain tissue

      Refractive-index matching enhanced polarization-sensitive optical coherence tomography quantification in human brain tissue
      The importance of polarization-sensitive optical coherence tomography (PS-OCT) has been increasingly recognized in human brain imaging. Despite the recent progress of PS-OCT in revealing white matter architecture and orientation, quantification of fine-scale fiber tracts in the human brain cortex has been a challenging problem, due to a low birefringence in the gray matter. In this study, we investigated the effect of refractive index matching by 2,2'-thiodiethanol (TDE) immersion ...
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    10. Multiscale correlation of microvascular changes on optical coherence tomography angiography with retinal sensitivity in diabetic retinopathy

      Multiscale correlation of microvascular changes on optical coherence tomography angiography with retinal sensitivity in diabetic retinopathy
      Purpose: To assess global, zonal, and local correlations between vessel density changes measured by optical coherence tomography angiography (OCTA) and retinal sensitivity measured by microperimetry across diabetic retinopathy severity. Methods: Diabetic patients and non-diabetic controls underwent OCTA imaging and microperimetry testing. Pearson's correlation was used to assess associations between average sensitivity and skeletonized vessel density (SVD) or FAZ area centrally. Linear mixed effects modeling was used to assess relationships ...
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    11. Analysis of correlations between local geographic atrophy growth rates and local OCT angiography-measured choriocapillaris flow deficits

      Analysis of correlations between local geographic atrophy growth rates and local OCT angiography-measured choriocapillaris flow deficits
      The purpose of this study is to quantitatively assess correlations between local geographic atrophy (GA) growth rates and local optical coherence tomography angiography (OCTA)-measured choriocapillaris (CC) flow deficits. Thirty-eight eyes from 27 patients with GA secondary to age-related macular degeneration (AMD) were imaged with a commercial 1050 nm swept-source OCTA instrument at 3 visits, each separated by 6 months. Pearson correlations were computed between local GA growth rates, estimated ...
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    12. Layer-based, depth-resolved computation of attenuation coefficients and backscattering fractions in tissue using optical coherence tomography

      Layer-based, depth-resolved computation of attenuation coefficients and backscattering fractions in tissue using optical coherence tomography
      Structural optical coherence tomography (OCT) images of tissue stand to benefit from greater functionalization and quantitative interpretation. The OCT attenuation coefficient , an analogue of the imaged samples scattering coefficient, offers potential functional contrast based on the relationship of to sub-resolution physical properties of the sample. Attenuation coefficients are computed either by fitting a representative over several depth-wise pixels of a samples intensity decay, or by using previously-developed depth-resolved attenuation algorithms ...
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    13. Massachusetts Institute of Technology Receives NIH Grant for Novel Optical Diagnostics with Optical Coherence Tomography

      Massachusetts Institute of Technology Receives NIH Grant for Novel Optical Diagnostics with Optical Coherence Tomography
      ...xt-align: justify;">This proposal is a renewal of an ongoing collaborative program among investigators at the Massachusetts Institute of Technology (MIT) and New England Eye Center (NEEC). The program focuses on the deve...
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    14. Three dimensional reconstruction of coronary artery stents from optical coherence tomography: experimental validation and clinical feasibility

      Three dimensional reconstruction of coronary artery stents from optical coherence tomography: experimental validation and clinical feasibility
      The structural morphology of coronary stents (e.g. stent expansion, lumen scaffolding, strut apposition, tissue protrusion, side branch jailing, strut fracture), and the local hemodynamic environment after stent deployment are key determinants of procedural success and subsequent clinical outcomes. High-resolution intracoronary imaging has the potential to enable the geometrically accurate three-dimensional (3D) reconstruction of coronary stents. The aim of this work was to present a novel algorithm for 3D stent ...
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    15. Post-doctoral Associate Positions in Biophotonics at Washington University in St. Louis

      Post-doctoral Associate Positions in Biophotonics at Washington University in St. Louis
      ...sp; After graduation, he joined Professor James G. Fujimoto's Laser Medicine and Medical Imaging Group at the Massachusetts Institute of Technology (MIT) as a postdoctoral associate. In 2012, Dr. Zhou joined the faculty ...
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    16. 1-15 of 650 1 2 3 4 ... 42 43 44 »
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  2. About Massachusetts Institute of Technology

    Massachusetts Institute of Technology

    Massachusetts Institute of Technology (MIT) is a private, coeducational research university located in Cambridge, Massachusetts. MIT has five schools and one college, containing 32 academic departments, with a strong emphasis in theoretical, applied, and interdisciplinary scientific and technological research.  Laser Medicine and Medical Imaging Group at MIT.  The RLE Laser Medicine and Medical Imaging Group and its close collaborators were the originators of optical coherence tomography (OCT), a diagnostic technology now used in a growing number of medical fields. The group currently works to further understand and exploit the capabilities of OCT technology, with ongoing investigations in topics related to optical coherence microscopy development and optical biopsy using OCT.