OCT was invented at Massachusetts Institute of Technology (MIT) in the early 1990's and has become the largest revenue generator i...
It's like looking inside an artery with a microscope. That's how Dr. Sandeep Nathan describes St. Jude Medical's Ilummien Optis technology. "You can see clumps of cells, little bits of blood clot," he said. "It is an unprecedented look, a detailed look at what's going on inside the coronary arteries." Nathan, director of interventional cardiology at the University of Chicago Medical Center, is among the first doctors to get hands-on experience with the latest generation of St. Jude's optical technology for looking inside arteries. The new system, recently approved by the U.S. Food and ...
Spectral domain optical coherence tomography (SD-OCT) is a high resolution imaging technique that generates excellent contrast based on intrinsic optical properties of the tissue, such as neurons and fibers. The SD-OCT data acquisition is performed directly on the tissue block, diminishing the need for cutting, mounting and staining. We utilized SD-OCT to visualize the laminar structure of the isocortex and compared cortical cytoarchitecture with the gold standard Nissl staining, both qualitatively and quantitatively. In histological processing, distortions routinely affect registration to the blockface image and prevent accurate 3D reconstruction of regions of tissue. We compared blockface registration to SD-OCT and ...
The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was recently developed as a method for imaging blood flow in the human retina without the use of phase information. In order to enable absolute blood velocity quantification, in vitro phantom experiments are performed to correlate the SSADA signal at multiple time scales with various preset velocities. A linear model relating SSADA measurements to absolute flow velocities is derived using the phantom data. The operating range for the linear model is discussed along with its implication for velocity quantification with SSADA in a clinical setting.
We present an endoscopic probe for optical coherence tomography (OCT) equipped with a miniaturized hollow ultrasonic motor that rotates the objective lens and provides an internal channel for the fiber to pass through, enabling 360 deg unobstructed circumferential scanning. This probe has an outer diameter of 1.5 mm, which is ultra-small for motorized probes with an unobstructed view in distal scanning endoscopic OCT. Instead of a mirror or prism, a customized aspheric right-angle lens is utilized, leading to an enlargement of the numerical aperture and thus high transverse resolution. Spectral-domain OCT imaging of bio-tissue and a phantom are demonstrated ...
MIT Technology Review today revealed its prestigious annual list of 35 top young innovators , which includes Electrical Engineering Assistant Professor Christine Fleming. Selected from hundreds of nominations, she is being honored as an outstanding inventor on the list for her work in the field of biotechnology and medicine. "I am thrilled to receive such a notable recognition of my work," says Fleming, whose research is focused on developing optical imaging and spectroscopy instruments for applications in cardiac electrophysiology and interventional cardiology. "I hope this will draw attention to cardiovascular disease, which is the leading cause of mortality in the United ...
James Fujimoto , the Elihu Thomson Professor of Electrical Engineering at MIT has been selected for the 2014 IEEE Photonics Award . The award, which is sponsored by the IEEE Photonics Society, is given in recognition of outstanding achievements in photonics. Prof. Fujimoto is cited “for pioneering the development and commercialization of optical coherence tomography for medical diagnostics.” James Fujimoto joined the MIT faculty in 1985 as Assistant Professor of Electrical Engineering after completing his SB, SM and PhD at MIT. He also holds the position of Adjunct Professor of Ophthalmology at Tufts University. As principal investigator in the Research Laboratory of ...
Massachusetts Institute of Technology (MIT) is a private, coeducational research university located in Cambridge, Massachusetts. MIT has five schools and one college, containing 32 academic departments, with a strong emphasis in theoretical, applied, and interdisciplinary scientific and technological research. Laser Medicine and Medical Imaging Group at MIT. The RLE Laser Medicine and Medical Imaging Group and its close collaborators were the originators of optical coherence tomography (OCT), a diagnostic technology now used in a growing number of medical fields. The group currently works to further understand and exploit the capabilities of OCT technology, with ongoing investigations in topics related to optical coherence microscopy development and optical biopsy using OCT.