1. Massachusetts Institute of Technology

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    1. Mentioned In 663 Articles

    2. MEMS-VCSEL swept-source optical coherence tomography for multi-MHz endoscopic ...

      MEMS-VCSEL swept-source optical coherence tomography for multi-MHz endoscopic ...
      Swept-source optical coherence tomography (SS-OCT) enables volumetric imaging of subsurface structure, but applications requiring wide fields of view, rapid imaging, and higher resolutions have been challenging because of the need for multi-MHz A-scan rates. Until now, achieving multi-MHz A-scan rates has been limited to Fourier-domain mode-locked lasers or stretched-pulse lasers. We describe a microelectromechanical-system, vertical-cavity surface-emitting laser (MEMS-VCSEL) for SS-OCT at A-scan rates of 2.4 and 3.0 MHz ...
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    3. Measuring collagen injury depth for burn severity determination using polarization sensitive optical coherence tomography

      Measuring collagen injury depth for burn severity determination using polarization sensitive optical coherence tomography
      Determining the optimal treatment course for a dermatologic burn wound requires knowledge of the wound's severity, as quantified by the depth of thermal damage. In current clinical practice, burn depth is inferred based exclusively on superficial visual assessment, a method which is subject to substantial error rates in the classification of partial thickness (second degree) burns. Here, we present methods for direct, quantitative determination of the depth extent of ...
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    4. Light-sheet photonic force optical coherence elastography for high-throughput quantitative 3D micromechanical imaging

      Light-sheet photonic force optical coherence elastography for high-throughput quantitative 3D micromechanical imaging
      Quantitative characterisation of micro-scale mechanical properties of the extracellular matrix (ECM) and dynamic cell-ECM interactions can significantly enhance fundamental discoveries and their translational potential in the rapidly growing field of mechanobiology. However, quantitative 3D imaging of ECM mechanics with cellular-scale resolution and dynamic monitoring of cell-mediated changes to pericellular viscoelasticity remain a challenge for existing mechanical characterisation methods. Here, we present light-sheet photonic force optical coherence elastography (LS-pfOCE) to address ...
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    5. A novel algorithm for multiplicative speckle noise reduction in ex vivo human brain OCT images

      A novel algorithm for multiplicative speckle noise reduction in ex vivo human brain OCT images
      Optical coherence tomography (OCT) images of ex vivo human brain tissue are corrupted by multiplicative speckle noise that degrades the contrast to noise ratio (CNR) of microstructural compartments. This work proposes a novel algorithm to reduce noise corruption in OCT images that minimizes the penalized negative log likelihood of gamma distributed speckle noise. The proposed method is formulated as a majorize-minimize problem that reduces to solving an iterative regularized least ...
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    6. Ultrahigh resolution spectral-domain optical coherence tomography using the 1000-1600 nm spectral band

      Ultrahigh resolution spectral-domain optical coherence tomography using the 1000-1600 nm spectral band
      Ultrahigh resolution optical coherence tomography (UHR-OCT) can image microscopic features that are not visible with the standard OCT resolution of 5-15 m. In previous studies, high-speed UHR-OCT has been accomplished within the visible (VIS) and near-infrared (NIR-I) spectral ranges, specifically within 550-950 nm. Here, we present a spectral domain UHR-OCT system operating in a short-wavelength infrared (SWIR) range from 1000 to 1600 nm using a supercontinuum light source and an ...
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    7. Optical coherence tomography in coronary atherosclerosis assessment and intervention

      Optical coherence tomography in coronary atherosclerosis assessment and intervention
      Since optical coherence tomography (OCT) was first performed in humans two decades ago, this imaging modality has been widely adopted in research on coronary atherosclerosis and adopted clinically for the optimization of percutaneous coronary intervention. In the past 10 years, substantial advances have been made in the understanding of in vivo vascular biology using OCT. Identification by OCT of culprit plaque pathology could potentially lead to a major shift in ...
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    8. Relationship between axial resolution and signal-to-noise ratio in optical coherence tomography

      Relationship between axial resolution and signal-to-noise ratio in optical coherence tomography
      In optical coherence tomography (OCT), axial resolution and signal-to-noise ratio (SNR) are typically viewed as uncoupled parameters. We show that this is true only for mirror-like surfaces and that in diffuse scattering samples such as biological tissues there is an inherent coupling between axial resolution and measurement SNR. We explain the origin of this coupling and demonstrate that it can be used to achieve increased imaging penetration depth at the ...
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    9. Impact and implications of mixed plaque class in automated characterization of complex atherosclerotic lesions

      Impact and implications of mixed plaque class in automated characterization of complex atherosclerotic lesions
      Atherosclerosis is a complex disease altering vasculature morphology, and subsequently flow, with progressive plaque formation, mural disruption, and lumen occlusion. Determination of clinically-relevant plaque componentsparticularly calcium, lipid, and fibrous tissuehas driven automated image-based tissue characterization. Atherosclerotic tissue of mixed composition type arises when these principal components interdigitate and combine during the course of progressive atherosclerosis. Nevertheless, such mixed plaque is treated non-uniformly, and often neglected, as a distinct class in ...
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    10. Is Real-Time Microscopy on the Horizon? A Brief Review of the Potential Future Directions in Clinical Breast Tumor Microscopy Implementation

      Is Real-Time Microscopy on the Horizon? A Brief Review of the Potential Future Directions in Clinical Breast Tumor Microscopy Implementation
      We will briefly review the current paradigm and some recent developments in the area of clinical breast microscopy, highlighting several promising commercially available, and research-based platforms. Confocal microscopy (reflectance, fluorescence, and spectrally encoded), optical coherence tomography (wide field and full field), stereomicroscopy, open-top light sheet microscopy, microscopy with ultraviolet surface excitation, nonlinear microscopy, Raman scattering microscopy, photoacoustic microscopy, and needle microendoscopy will be discussed. Non-microscopic methods for breast pathology assessment ...
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    11. Refractive-index matching enhanced polarization sensitive optical coherence tomography quantification in human brain tissue

      Refractive-index matching enhanced polarization sensitive optical coherence tomography quantification in human brain tissue
      The importance of polarization-sensitive optical coherence tomography (PS-OCT) has been increasingly recognized in human brain imaging. Despite the recent progress of PS-OCT in revealing white matter architecture and orientation, quantification of fine-scale fiber tracts in the human brain cortex has been a challenging problem, due to a low birefringence in the gray matter. In this study, we investigated the effect of refractive index matching by 2,2-thiodiethanol (TDE) immersion on ...
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    12. High speed, long range, deep penetration swept source OCT for structural and angiographic imaging of the anterior eye

      High speed, long range, deep penetration swept source OCT for structural and angiographic imaging of the anterior eye
      This study reports the development of prototype swept-source optical coherence tomography (SS-OCT) technology for imaging the anterior eye. Advances in vertical-cavity surface-emitting laser (VCSEL) light sources, signal processing, optics and mechanical designs, enable a unique combination of high speed, long range, and deep penetration that addresses the challenges of anterior eye imaging. We demonstrate SS-OCT with a 325 kHz A-scan rate, 12.2 m axial resolution (in air), and 15 ...
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    13. Cross-free in both lateral and axial directions Fourier-domain full-field optical coherence tomography

      Cross-free in both lateral and axial directions Fourier-domain full-field optical coherence tomography
      Fourier-domain full-field optical coherence tomography (FD-FF-OCT) has the advantages of high resolution and parallel detection. However, using parallel detection can result in optical crosstalk. Toward minimizing crosstalk, we implemented a very fast deformable membrane (DM) that introduces random phase illumination, which can effectively reduce the crosstalk by washing out fringes originating from multiply scattered light. However, for one thing, although the application of DM has reduced the crosstalk problem in ...
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    14. James Fujimoto named 2022 recipient of the IEEE Medal for Innovations in Healthcare Technology

      James Fujimoto named 2022 recipient of the IEEE Medal for Innovations in Healthcare Technology
      James Fujimoto, the Elihu Thomson Professor in Electrical Engineering, has been named the 2022 recipient of the IEEE Medal for Innovations in Healthcare Technology. In the award citation, the IEEE lauded Fujimoto for pioneering the development and commercialization of optical coherence tomography for medical imaging and diagnostics. Professor Fujimoto is a principal investigator in the Research Laboratory of Electronics (RLE). He received his S.B., S.M., and Ph.D ...
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    15. 1-15 of 663 1 2 3 4 ... 43 44 45 »
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  2. About Massachusetts Institute of Technology

    Massachusetts Institute of Technology

    Massachusetts Institute of Technology (MIT) is a private, coeducational research university located in Cambridge, Massachusetts. MIT has five schools and one college, containing 32 academic departments, with a strong emphasis in theoretical, applied, and interdisciplinary scientific and technological research.  Laser Medicine and Medical Imaging Group at MIT.  The RLE Laser Medicine and Medical Imaging Group and its close collaborators were the originators of optical coherence tomography (OCT), a diagnostic technology now used in a growing number of medical fields. The group currently works to further understand and exploit the capabilities of OCT technology, with ongoing investigations in topics related to optical coherence microscopy development and optical biopsy using OCT.