1. Massachusetts Institute of Technology

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    1. Mentioned In 443 Articles

    2. High-Speed Ultrahigh-Resolution OCT of Bruch's Membrane in Membranoproliferative Glomerulonephritis Type 2

      High-Speed Ultrahigh-Resolution OCT of Bruch's Membrane in Membranoproliferative Glomerulonephritis Type 2
      ...SPR, JSD); and Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts (JJL, JGF). Supported in part by a Research t...
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    3. NinePoint Medical Appoints Christopher von Jako, Ph.D., to Chief Executive Officer

      NinePoint Medical Appoints Christopher von Jako, Ph.D., to Chief Executive Officer
      ...LifeSciences, Covidien, Medtronic, and Radionics. He earned a double B.S. from Bates College, a M.S. from the Massachusetts Institute of Technology, and a Ph.D. from the University of Pécs Medical School. <...
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    4. Ultrahigh speed endoscopic optical coherence tomography for gastroenterology

      Ultrahigh speed endoscopic optical coherence tomography for gastroenterology

      We describe an ultrahigh speed endoscopic swept source optical coherence tomography (OCT) system for clinical gastroenterology using a vertical-cavity surface-emitting laser (VCSEL) and micromotor imaging catheter. The system had a 600 kHz axial scan rate and 8 µm axial resolution in tissue. Imaging was performed with a 3.2 mm diameter imaging catheter at 400 frames per second with a 12 µm spot size. Three-dimensional OCT (3D-OCT) imaging was performed in patients with a cross section of pathologies undergoing upper and lower endoscopy. The use of distally actuated imaging catheters enabled OCT imaging with more flexibility, such as volumetric imaging ...

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    5. Depth-encoded all-fiber swept source polarization sensitive OCT

      Depth-encoded all-fiber swept source polarization sensitive OCT

      Polarization sensitive optical coherence tomography (PS-OCT) is a functional extension of conventional OCT and can assess depth-resolved tissue birefringence in addition to intensity. Most existing PS-OCT systems are relatively complex and their clinical translation remains difficult. We present a simple and robust all-fiber PS-OCT system based on swept source technology and polarization depth-encoding. Polarization multiplexing was achieved using a polarization maintaining fiber. Polarization sensitive signals were detected using fiber based polarization beam splitters and polarization controllers were used to remove the polarization ambiguity. A simplified post-processing algorithm was proposed for speckle noise reduction relaxing the demand for phase stability. We ...

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    6. Dual modality intravascular optical coherence tomography (OCT) and near-infrared fluorescence (NIRF) imaging: a fully automated algorithm for the distance-calibration of NIRF signal intensity for quantitative molecular imaging

      Dual modality intravascular optical coherence tomography (OCT) and near-infrared fluorescence (NIRF) imaging: a fully automated algorithm for the distance-calibration of NIRF signal intensity for quantitative molecular imaging
      ... Department of Pathology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA Harvard-Massachusetts Institute of Technology Health Sciences and Technology, Cambridge, MA, USA ...
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    7. All-fiber wavelength swept ring laser based on Fabry-Perot filter for optical frequency domain imaging

      All-fiber wavelength swept ring laser based on  Fabry-Perot filter for optical frequency domain  imaging

      Innovations in laser engineering have yielded several novel configurations for high repetition rate, broad sweep range, and long coherence length wavelength swept lasers. Although these lasers have enabled high performance frequency-domain optical coherence tomography, they are typically complicated and costly and many require access to proprietary materials or devices. Here, we demonstrate a simplified ring resonator configuration that is straightforward to construct from readily available materials at a low total cost. It was enabled by an insight regarding the significance of isolation against bidirectional operation and by configuring the sweep range of the intracavity filter to exceed its free spectral ...

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    8. Longitudinal necrotic shafts near TCFAs—A potential novel mechanism for plaque rupture to trigger ACS?

      Longitudinal necrotic shafts near TCFAs—A potential novel mechanism for plaque rupture to trigger ACS?
      ...Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA * Department of Electrical Engineering, Massachusetts Institute of Technology, 77 MA Avenue, Cambridge, MA 02139, USA Correspondence * Correspondi...
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    9. Praevium Research Receives NIH Grant for VCSEL Technology for Ultrahigh Speed OCT Retinal and Anterior Eye Imaging.

      Praevium Research Receives NIH Grant for VCSEL Technology for Ultrahigh Speed OCT Retinal and Anterior Eye Imaging.
      ...ically pumped VCSELs for OCT at both 1310nm and 1050nm obtained by Praevium Research and collaborators at the Massachusetts Institute of Technology (MIT). This prior work has demonstrated numerous performance advantages ...
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    10. Quantitative technique for robust and noise-tolerant speed measurements based on speckle decorrelation in optical coherence tomography

      Quantitative technique for robust and noise-tolerant speed measurements based on speckle decorrelation in optical coherence tomography

      Intensity-based techniques in optical coherence tomography (OCT), such as those based on speckle decorrelation, have attracted great interest for biomedical and industrial applications requiring speed or flow information. In this work we present a rigorous analysis of the effects of noise on speckle decorrelation, demonstrate that these effects frustrate accurate speed quantitation, and propose new techniques that achieve quantitative and repeatable measurements. First, we derive the effect of background noise on the speckle autocorrelation function, finding two detrimental effects of noise. We propose a new autocorrelation function that is immune to the main effect of background noise and permits quantitative ...

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    11. Clinical Guide to Angio-OCT (Non Invasive, Dyeless OCT Angiography) (Textbook)

      Clinical Guide to Angio-OCT (Non Invasive, Dyeless OCT Angiography)  (Textbook)

      The book discusses the clinical possibilities of Angio-OCT. Most imaging in the book (77 figures in Chapters 5, 7.1 and 10) has been performed with XR-Avanti Optovue SD-OCT device using SSADA algorithm. A few figures in chapters 3, 7.2 and 8 have been performed with a swept source OCT prototype using SSADA algorithm. Another technique is described in chapter 11, using ultrahigh speed, SS-OCT and its applications to optical coherence tomography-angiography (OCTA). Key Features Angio-OCT (Dyeless OCT Angiography) is a new TECHNOLOGY that gives already useful results, that can be applied to day-to-day clinical ophthalmology. Several different OCT ...

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    12. Spectral-Domain and Swept-Source OCT Imaging of Asteroid Hyalosis: A Case Report

      Spectral-Domain and Swept-Source OCT Imaging of Asteroid Hyalosis: A Case Report

      A 72-year-old man with diabetes was referred to the retina clinic for diabetic retinopathy. Detailed funduscopic examination of the left eye was limited by prominent asteroid hyalosis. Spectral-domain (SD) and swept-source (SS) optical coherence tomography (OCT) were utilized to examine the vitreous, vitreoretinal interface, and the morphology of the retina. Asteroid hyalosis induced artifacts of the OCT images, which resolved when the appropriate imaging protocols were applied. SS-OCT may show superior diagnostic and preoperative capabilities when compared to SD-OCT in the settings of asteroid hyalosis-induced media opacity.

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    13. 1-15 of 443 1 2 3 4 ... 28 29 30 »
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  2. About Massachusetts Institute of Technology

    Massachusetts Institute of Technology

    Massachusetts Institute of Technology (MIT) is a private, coeducational research university located in Cambridge, Massachusetts. MIT has five schools and one college, containing 32 academic departments, with a strong emphasis in theoretical, applied, and interdisciplinary scientific and technological research.  Laser Medicine and Medical Imaging Group at MIT.  The RLE Laser Medicine and Medical Imaging Group and its close collaborators were the originators of optical coherence tomography (OCT), a diagnostic technology now used in a growing number of medical fields. The group currently works to further understand and exploit the capabilities of OCT technology, with ongoing investigations in topics related to optical coherence microscopy development and optical biopsy using OCT.