1. Massachusetts General Hospital

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    1. Mentioned In 660 Articles

    2. Spectral-domain optical coherence phase microscopy for quantitative biological studies (Thesis)

      Spectral-domain optical coherence phase microscopy for quantitative biological studies (Thesis)
      Conventional phase-contrast and differential interference contrast microscopy produce high contrast images of transparent specimens such as cells. However, they do not provide quantitative information or do not have enough sensitivity to detect nanometerlevel structural alterations. We have developed spectral-domain optical coherence phase microscopy (SD-OCPM) for highly sensitive quantitative phase imaging in 3D. This technique employs common-path spectral-domain optical coherence reflectometry to produce depth-resolved reflectance and quantitative phase images with high ...
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    3. Volumetric sub-surface imaging using spectrally encoded endoscopy

      D. Yelin, B. E. Bouma, G. J. Tearney Endoscopic imaging below tissue surfaces and through turbid media may provide improved diagnostic capabilities and visibility in surgical settings. Spectrally encoded endoscopy (SEE) is a recently developed method that utilizes a single optical fiber, miniature optics and a diffractive grating for ... [Opt. Express 16, 1748-1757 (2008)]
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    4. Monitoring mouse retinal degeneration with high-resolution spectral-domain optical coherence tomography

      Progression of retinal degeneration in a mouse model was studied in vivo with high-resolution spectral-domain optical coherence tomography (SD-OCT). Imaging in 3D with high depth resolution (<3 μm), SD-OCT resolved all the major layers of the retina of control C57BL/6J mice. Images of transgenic mice having a null mutation of the rhodopsin gene revealed the anatomical consequences of retinal degeneration: thinning of the outer retina, including the outer plexiform ...
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    5. High-speed polarization sensitive optical frequency domain imaging with frequency multiplexing

      W.Y. Oh, S.H. Yun, B.J. Vakoc, M. Shishkov, A.E. Desjardins, B.H. Park, J.F. de Boer, G.J. Tearney, B.E. Bouma. Polarization sensitive optical coherence tomography (PS-OCT) provides a cross-sectional image of birefringence in biological samples that is complementary in many applications to the standard reflectance-based image. Recent ex vivo studies have demonstrated that birefringence mapping enables the ... [Opt. Express 16, 1096-1103 (2008)]
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    6. Two-axis magnetically-driven MEMS scanning catheter for endoscopic high-speed optical coherence tomography

      Ki Hean Kim, B. H. Park, Gopi N. Maguluri, Tom W. Lee, Fran J. Rogomentich, Mirela G. Bancu, Brett E. Bouma, Johannes F. de Boer, Jonathan J. Bernstein A two-axis scanning catheter was developed for 3D endoscopic imaging with spectral domain optical coherence tomography (SD-OCT). The catheter incorporates a micro-mirror scanner implemented with microelectromechanical systems (MEMS) technology: the micro-mirror is mounted on a two-axis gimbal ... [Opt. Express 15, 18130-18140 (2007)]
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    7. Apparatus and method for low coherence ranging

      A system, apparatus and method for performing low coherence ranging of a sample with high transverse resolution and large depth of focus can be provided. For example, an optical ranging system including a light source can be used. Certain exemplary arrangement can be provided, e.g., a first arrangement for directing light from the light source to the sample, a second arrangement for directing reflected light from the sample to ...
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    8. Phase-resolved optical coherence tomography and optical Doppler tomography for imaging blood flow in human skin with fast scanning speed and high velocity sensitivity.

      We have developed a novel phase-resolved optical coherence tomography (OCT) and optical Doppler tomography (ODT) system that uses phase information derived from a Hilbert transformation to image blood flow in human skin with fast scanning speed and high velocity sensitivity. Using the phase change between sequential scans to construct flow-velocity imaging, this technique decouples spatial resolution and velocity sensitivity in flow images and increases imaging speed by more than 2 ...
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    9. High-speed fiber based polarization-sensitive optical coherence tomography of in vivo human skin.

      A high-speed single-mode fiber-based polarization-sensitive optical coherence tomography (PS OCT) system was developed. With a polarization modulator, Stokes parameters of reflected flight for four input polarization states are measured as a function of depth. A phase modulator in the reference arm of a Michelson interferometer permits independent control of the axial scan rate and carrier frequency. In vivo PS OCT images of human skin are presented, showing subsurface structures that ...
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    10. Power-efficient nonreciprocal interferometer and linear-scanning fiber-optic catheter for optical coherence tomography.

      A nonreciprocal fiber-optic interferometer is demonstrated in an optical coherence tomography (OCT) system. The increased power efficiency of this system provides a 4.1-dB advantage over standard Michelson implementations. In addition, a new linear-scanning fiber-optic catheter is demonstrated that avoids the rotary optical junction that is required in circumferential scanning systems. These advancements have permitted the clinical implementation of OCT imaging in the human gastrointestinal tract. PMID: 18071562 [PubMed - in ...
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    11. Three dimensional tracking for volumetric spectral-domain optical coherence tomography

      Gopi Maguluri, Mircea Mujat, B. H. Park, K. H. Kim, Wei Sun, N. V. Iftimia, R. D. Ferguson, Daniel X. Hammer, Teresa C. Chen, Johannes F. de BoerWe present a three-dimensional (3D) tracker for a clinical ophthalmic spectral domain optical coherence tomography (SD-OCT) system that combines depth-tracking with lateral tracking, providing a stabilized reference frame for 3D data recording and post acquisition analysis. The depth-tracking ... [Opt. Express 15, 16808-16817 (2007)]
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    12. Spectrally balanced detection for optical frequency domain imaging

      In optical frequency domain imaging (OFDI) or swept-source optical coherence tomography, balanced detection is required to suppress relative intensity noise (RIN). A regular implementation of balanced detection by combining reference and sample arm signal in a 50/50 coupler and detecting the ... [Opt. Express 15, 16390-16399 (2007)]
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  2. About Massachusetts General Hospital

    Massachusetts General Hospital

    Massachusetts General Hospital is a teaching hospital of Harvard Medical School and biomedical research facility in Boston, Massachusetts. It is owned and operated by Partners HealthCare (which also owns Brigham and Women's Hospital and North Shore Medical Center).

  3. Quotes about Massachusetts General Hospital

    1. We are excited to see the publication of this data from our collaborators at Massachusetts General Hospital that clearly demonstrate the imaging technology can produce valuable images of esophageal tissue...We look forward to moving ahead with continued development of this exciting new technology.
      Charles Carignan in NinePoint Medical Imaging Technology Highlighted in Nature Medicine