1. Massachusetts General Hospital

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    1. Mentioned In 862 Articles

    2. Optical design, optimization and validation of an extended-depth-of-field optical coherence tomography probe based on mirror-tunneling

      Optical design, optimization and validation of an extended-depth-of-field optical coherence tomography probe based on mirror-tunneling
      We present results from optimizing mirror-tunnel based optical coherence tomography probes, achieving extended depth of field at high resolution. We achieved 6 m spot diameter over 1 mm depth in simulations and validated experimentally.
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    3. Scalable mapping of myelin and neuron density in the human brain with micrometer resolution

      Scalable mapping of myelin and neuron density in the human brain with micrometer resolution
      Optical coherence tomography (OCT) is an emerging 3D imaging technique that allows quantification of intrinsic optical properties such as scattering coefficient and back-scattering coefficient, and has proved useful in distinguishing delicate microstructures in the human brain. The origins of scattering in brain tissues are contributed by the myelin content, neuron size and density primarily; however, no quantitative relationships between them have been reported, which hampers the use of OCT in ...
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    4. Massachusetts General Hospital Receive NIH Grant for A tethered capsule endoscopic-endomicroscopic (TEEM) approach for improving upper GI tract diagnosis

      Massachusetts General Hospital Receive NIH Grant for A tethered capsule endoscopic-endomicroscopic (TEEM) approach for improving upper GI tract diagnosis
      ...irements for upper GI tract screening (Aim 3).

      Massachusetts General Hospital Received a 2022 NIH Grant for $480,931 for A tethered capsule endoscopic-endomi...

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    5. Washington University Receives NIH Grant for High-throughput integrated live imaging and optogenetic pacing platform to assess hypoxia responsiveness in the fly heart

      Washington University Receives NIH Grant for High-throughput integrated live imaging and optogenetic pacing platform to assess hypoxia responsiveness in the fly heart
      ...o higher organisms, including humans. Working in collaboration with Drs. Airong Li and Rudolph Tanzi from the Massachusetts General Hospital, we demonstrated non-invasive optogenetic pacing and concurrent optical coheren...
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    6. THE RELATIONSHIP BETWEEN AXIAL RESOLUTION AND SIGNAL-TO-NOISE RATIO IN OPTICAL COHERENCE TOMOGRAPHY

      THE RELATIONSHIP BETWEEN AXIAL RESOLUTION AND SIGNAL-TO-NOISE RATIO IN OPTICAL COHERENCE TOMOGRAPHY
      In optical coherence tomography (OCT), axial resolution and signal-to-noise ratio (SNR) are typically viewed as uncoupled parameters. We show that this is only true for mirror-like surfaces, and that in diffuse scattering samples such as tissue there is an inherent coupling between axial resolution and measurement SNR. We explain the origin of this coupling and demonstrate that it can be used to achieve increased imaging penetration depth at the expense ...
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    7. Layered Plaque Characteristics and Layer Burden in Acute Coronary Syndromes

      Layered Plaque Characteristics and Layer Burden in Acute Coronary Syndromes
      Recently, layered plaque, an optical coherence tomography equivalent of healed plaque, has been gaining attention. However, detailed layered plaque characteristics including the burden of plaque layer have not been investigated. Patients with acute coronary syndromes who underwent preintervention optical coherence tomography imaging of culprit lesion were included. Layer index, a product of the mean layer arc and layer length, was correlated with the pattern of layer and culprit pathology. In ...
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    8. Imaging Technologies for Pre-surgical Margin Assessment of Basal Cell Carcinoma

      Imaging Technologies for Pre-surgical Margin Assessment of Basal Cell Carcinoma
      Basal cell carcinoma is the most common cancer worldwide, necessitating the development of techniques to decrease treatment costs through efficiency and efficacy. Mohs micrographic surgery, a specialized surgical technique involving staged resection of the tumor with complete histologic evaluation of the peripheral margins, is highly utilized. Reducing stages by even 5-10% would result in significant improvement in care and economic benefits. Non-invasive imaging could aid in both establishing the diagnosis ...
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    9. Advances in Imaging of Subbasal Corneal Nerves With Micro–Optical Coherence Tomography

      Advances in Imaging of Subbasal Corneal Nerves With Micro–Optical Coherence Tomography
      Purpose: To investigate the most peripheral corneal nerve plexus using high-resolution micro-optical coherence tomography (OCT) imaging and to assess OCT's clinical potential as a screening tool for corneal and systemic diseases. Methods: An experimental high-resolution (1.5 1.5 1 m) OCT setup was applied for three-dimensional imaging of the subbasal nerve plexus in nonhuman primates (NHPs) and swine within 3 hours postmortem. Morphologic features of subbasal nerves in ...
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    10. Apparatus and method for providing mesoscopic spectroscopy co-registered with optical frequency domain imaging

      Apparatus and method for providing mesoscopic spectroscopy co-registered with optical frequency domain imaging
      An apparatus can be provided according to certain exemplary embodiments. For example, the apparatus can include a waveguiding first arrangement providing at least one electromagnetic radiation. A configuration can be provided that receives and splits the at least one electromagnetic radiation into a first radiation and a second radiation. The apparatus can further include a waveguiding second arrangement which has a first waveguide and a second waveguide, whereas the first ...
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    11. Transient-mode photothermal optical coherence tomography

      Transient-mode photothermal optical coherence tomography
      Photothermal optical coherence tomography (PT-OCT) is an emerging extension of OCT, which forms images based on both scattering and absorption of light. The speed of PT-OCT, however, has been limited by the necessity for lock-in detection with extensive temporal sampling of the samples PT response. Here, we demonstrate transient-mode PT-OCT (TM-PT-OCT), which increases the effective A-line rate by orders of magnitude from 10100 Hz to 1.57.5 kHz, by ...
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    12. Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography

      Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography
      Polarization-sensitive optical coherence tomography (PS-OCT) reveals the subsurface microstructure of biological tissue and provides information regarding the polarization state of light backscattered from tissue. Complementing OCT's structural signal with molecular imaging requires strategies to simultaneously detect multiple exogenous contrast agents with high specificity in tissue. Specific detection of molecular probes enables the parallel visualization of physiological, cellular, and molecular processes. Here we demonstrate that, by combining PS-OCT and spectral ...
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    13. 1-15 of 862 1 2 3 4 ... 56 57 58 »
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  2. About Massachusetts General Hospital

    Massachusetts General Hospital

    Massachusetts General Hospital is a teaching hospital of Harvard Medical School and biomedical research facility in Boston, Massachusetts. It is owned and operated by Partners HealthCare (which also owns Brigham and Women's Hospital and North Shore Medical Center).

  3. Quotes about Massachusetts General Hospital

    1. We are excited to see the publication of this data from our collaborators at Massachusetts General Hospital that clearly demonstrate the imaging technology can produce valuable images of esophageal tissue...We look forward to moving ahead with continued development of this exciting new technology.
      In NinePoint Medical Imaging Technology Highlighted in Nature Medicine