1. Massachusetts General Hospital

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    1. Mentioned In 576 Articles

    2. Introduction to the feature issue on the 25 year anniversary of optical coherence tomography

      Introduction to the feature issue on the 25 year anniversary of optical coherence tomography
      This feature issue commemorates the approximately 25 year history of Optical Coherence Tomography (OCT), one of the most successful biophotonic technologies. While OCT has technological origins traceable to ultrafast laser development and fiber optic system test instrumentation of the 1980s, innovations in low coherence interferometry for optical ranging and imaging for biomedical applications in the U.S., Europe and Japan by the early 1990s led to coinage of the now ...
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    3. System, apparatus and method for utilizing optical dispersion for fourier-domain optical coherence tomography

      System, apparatus and method for utilizing optical dispersion for fourier-domain optical coherence tomography
      An apparatus can be provided which can include a laser arrangement which can be configured to provide a laser radiation, and can include an optical cavity. The optical cavity can include a dispersive optical first arrangement which can be configured to receive and disperse at least one first electro-magnetic radiation so as to provide at least one second electro-magnetic radiation. Such cavity can also include an active optical modulator second ...
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    4. Methods and systems for performing angle-resolved Fourier-domain optical coherence tomography

      Methods and systems for performing angle-resolved Fourier-domain optical coherence tomography
      Arrangements, apparatus and methods are provided according to exemplary embodiments of the present invention. In particular, at least one first electro-magnetic radiation may be received and at least one second electro-magnetic radiation within a solid angle may be forwarded to a sample. The second electro-magnetic radiation may be associated with the first electro-magnetic radiation. A plurality of third electro-magnetic radiations can be received from the sample which is associated with ...
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    5. Intravascular optical coherence tomography [Invited]

      Intravascular optical coherence tomography [Invited]
      Shortly after the first demonstration of optical coherence tomography for imaging the microstructure of the human eye, work began on developing systems and catheters suitable for intravascular imaging in order to diagnose and investigate atherosclerosis and potentially to monitor therapy. This review covers the driving considerations of the clinical application and its constraints, the major engineering milestones that enabled the current, high-performance commercial imaging systems, the key studies that laid ...
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    6. Imaging system, method and distal attachment for multidirectional field of view endoscopy

      Imaging system, method and distal attachment for multidirectional field of view endoscopy
      An exemplary apparatus for imaging at least one anatomical structure can be provided. For example, the apparatus can include an endoscopic first arrangement, a radiation source second arrangement which provides at least one electro-magnetic radiation, and a third arrangement attached to at least one portion of the endoscopic arrangement. The third arrangement can contain an optical arrangement which, upon impact by the at least one electro-magnetic radiation and based thereon ...
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    7. Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

      Endoscopic optical coherence tomography: technologies and clinical applications [Invited]
      In this paper, we review the current state of technology development and clinical applications of endoscopic optical coherence tomography (OCT). Key design and engineering considerations are discussed for most OCT endoscopes, including side-viewing and forward-viewing probes, along with different scanning mechanisms (proximal-scanning versus distal-scanning). Multi-modal endoscopes that integrate OCT with other imaging modalities are also discussed. The review of clinical applications of endoscopic OCT focuses heavily on diagnosis of diseases ...
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    8. Endoscopic biopsy apparatus, system and method

      Endoscopic biopsy apparatus, system and method
      Exemplary embodiments of apparatus, method and system for determining a position on or in a biological tissue can be provided. For example, using such exemplary embodiment, it is possible to control the focus of an optical imaging probe. In another exemplary embodiment, it is possible to implement a marking apparatus together with or into an optical imaging probe. According to one exemplary embodiment, it is possible (using one or more ...
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    9. Laser speckle microrheometer for measuring mechanical properties of biological tissue

      Laser speckle microrheometer for measuring mechanical properties of biological tissue
      Volumetric distribution of a micromechanical parameter of a biological tissue, such as viscoelastic parameter or tissue stiffness, is determined, with microscopic resolution, from optical data representing light scattered by sequential layers of the tissue and, optionally, displayed to visualization. A particular layer of the tissue is defined through coherence-gating of light received at the optical detector. Coherence-gating is achieved with the use of an interferometer the sample arm of which ...
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    10. Illuminating dynamic neutrophil trans-epithelial migration with micro-optical coherence tomography

      Illuminating dynamic neutrophil trans-epithelial migration with micro-optical coherence tomography
      A model of neutrophil migration across epithelia is desirable to interrogate the underlying mechanisms of neutrophilic breach of mucosal barriers. A co-culture system consisting of a polarized mucosal epithelium and human neutrophils can provide a versatile model of trans-epithelial migration in vitro , but observations are typically limited to quantification of migrated neutrophils by myeloperoxidase correlation, a destructive assay that precludes direct longitudinal study. Our laboratory has recently developed a new ...
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    11. Extended bandwidth wavelength swept laser source for high resolution optical frequency domain imaging

      Extended bandwidth wavelength swept laser source for high resolution optical frequency domain imaging
      Improving the axial resolution by providing wider bandwidth wavelength swept lasers remains an important issue for optical frequency domain imaging (OFDI). Here, we demonstrate a wide tuning range, all-fiber wavelength swept laser at a center wavelength of 1250 nm by combining two ring cavities that share a single Fabry-Perot tunable filter. The two cavities contain semiconductor optical amplifiers with central wavelengths of 1190 nm and 1292 nm, respectively. To avoid ...
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    12. Assessment of ciliary phenotype in primary ciliary dyskinesia by micro-optical coherence tomography

      Assessment of ciliary phenotype in primary ciliary dyskinesia by micro-optical coherence tomography
      Ciliary motion defects cause defective mucociliary transport (MCT) in primary ciliary dyskinesia (PCD). Current diagnostic tests do not assess how MCT is affected by perturbation of ciliary motion. In this study, we sought to use micro-optical coherence tomography (OCT) to delineate the mechanistic basis of cilia motion defects of PCD genes by functional categorization of cilia motion. Tracheae from three PCD mouse models were analyzed using OCT to characterize ciliary ...
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    13. Postdoctoral Research Fellowships in Optical Coherence Tomography at Massachusetts General Hosptial

      Postdoctoral Research Fellowships in Optical Coherence Tomography at Massachusetts General Hosptial
      ... of optical coherence tomography (OCT) is available in the Tearney Lab at the Massachusetts General Hospital (MGH) in the Wellman Center for Photomedicine. This appointment will be made at the rank of postdoctoral fellow...
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    14. Management and Outcome of Patients With Acute Coronary Syndrome Caused by Plaque Rupture Versus Plaque Erosion: An Intravascular Optical Coherence Tomography Study

      Management and Outcome of Patients With Acute Coronary Syndrome Caused by Plaque Rupture Versus Plaque Erosion: An Intravascular Optical Coherence Tomography Study
      ...s who underwent optical coherence tomography ( OCT ) imaging of the culprit lesion prior to stenting from the Massachusetts General Hospital OCT Registry. Management (stent versus no stent), poststent OCT findings, and o...
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    15. 1-15 of 576 1 2 3 4 ... 37 38 39 »
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  2. About Massachusetts General Hospital

    Massachusetts General Hospital

    Massachusetts General Hospital is a teaching hospital of Harvard Medical School and biomedical research facility in Boston, Massachusetts. It is owned and operated by Partners HealthCare (which also owns Brigham and Women's Hospital and North Shore Medical Center).

  3. Quotes about Massachusetts General Hospital

    1. We are excited to see the publication of this data from our collaborators at Massachusetts General Hospital that clearly demonstrate the imaging technology can produce valuable images of esophageal tissue...We look forward to moving ahead with continued development of this exciting new technology.
      Charles Carignan in NinePoint Medical Imaging Technology Highlighted in Nature Medicine