1. Massachusetts General Hospital

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    1. Mentioned In 815 Articles

    2. Micro Optical Coherence Tomography for Coronary Imaging

      Micro Optical Coherence Tomography for Coronary Imaging
      Intravascular optical coherence tomography (IVOCT) that produces images with 10 m resolution has emerged as a significant technology for evaluating coronary architectural morphology. Yet, many features that are relevant to coronary plaque pathogenesis can only be seen at the cellular level. This issue has motivated the development of a next-generation form of OCT imaging that offers higher resolution. One such technology that we review here is termed micro-OCT (OCT) that ...
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    3. Massachusetts General Hospital Receives NIH Grant for In Vivo Endobronchial OCT for IPF Diagnosis and Therapy

      Massachusetts General Hospital Receives NIH Grant for In Vivo Endobronchial OCT for IPF Diagnosis and Therapy
      ...ll permit earlier therapy initiation, earlier assessment of efficacy, and increase survival for IPF patients. Massachusetts General Hospital Receives a 2021 NIH Grant for $848,987 for In Vivo Endobronchial OCT for IPF Di...
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    4. Measuring myelin content and cell density in the human brain using optical coherence tomography

      Measuring myelin content and cell density in the human brain using optical coherence tomography
      Serial Sectioning Optical Coherence Tomography(serial sectioning OCT) has been widely used to investigate the structural and pathological features of brain samples. OCT is an optical imaging technique that provides both the 3D structure of the tissue as well as the optical properties including the scattering coefficient ( s ) and back-scattering coefficient ( b ). Serial sectioning OCT allows the reconstruction of distortion-free volumetric images at high contrast and high resolution, which has ...
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    5. Post Doctoral Opening in the Division of Pulmonary and Critical Care Medicine/Department of Pathology at Massachusetts General Hospital

      Post Doctoral Opening in the Division of Pulmonary and Critical Care Medicine/Department of Pathology at Massachusetts General Hospital
      ...assachusetts General Hospital The Hariri Optical Imaging Laboratory is a multidisciplinary research group at Massachusetts General Hospital. The focus of the laboratory is on the design, development and clinical transla...
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    6. Modeling, optimization, and validation of an extended-depth-of-field optical coherence tomography probe based on a mirror tunnel

      Modeling, optimization, and validation of an extended-depth-of-field optical coherence tomography probe based on a mirror tunnel
      The diagnostic capability of high-resolution optical coherence tomography (OCT) may be enhanced by using extended depth-of-field (EDOF) imaging that retains high transverse resolution over long depths. A recently developed mirror-tunnel optical probe design (single-mode fiber to multimode fiber to lens structure) that generates coaxially focused modes has been previously shown to enable EDOF for endoscopic OCT applications. Here, we present ray-tracing optical modeling of this optical configuration, which has the ...
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    7. Optical coherence tomography of arteriolar diameter and capillary perfusion during spreading depolarizations

      Optical coherence tomography of arteriolar diameter and capillary perfusion during spreading depolarizations
      Spreading depolarization (SD) is associated with profound oligemia and reduced oxygen availability in the mouse cortex during the depolarization phase. Coincident pial arteriolar constriction has been implicated as the primary mechanism for the oligemia. However, where in the vascular bed the hemodynamic response starts has been unclear. To resolve the origin of the hemodynamic response, we used optical coherence tomography (OCT) to simultaneously monitor changes in the vascular tree from ...
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    8. Improved sensitivity roll-off in dual reference, buffered spectral-domain optical coherence tomography

      Improved sensitivity roll-off in dual reference, buffered spectral-domain optical coherence tomography
      Significance: While spectral-domain optical coherence tomography (SD-OCT) is a preferred form of OCT imaging, sensitivity roll-off limits its applicability for certain biomedical imaging applications. Aim: The aim of this work is to extend the imaging range of conventional SD-OCT systems for imaging large luminal organs such as the gastrointestinal tract. Approach: We present an SD-OCT system operating at a center wavelength of 1300 nm that uses two delayed reference arms ...
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    9. Apparatus, devices and methods for in vivo imaging and diagnosis

      Apparatus, devices and methods for in vivo imaging and diagnosis
      Exemplary method and apparatus for diagnosing or characterizing an inflammation within an anatomical structure can be provided. For example, using at least one source arrangement, it is possible to provide at least one first electro-magnetic radiation to the anatomical structure at least one first wavelength in vivo. With at least one detector arrangement, it is possible to detect at least one second electro-magnetic radiation at least one second wavelength provided ...
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    10. Feasibility and safety of tethered capsule endomicroscopy in patients with Barrett’s esophagus in a multi-center study

      Feasibility and safety of tethered capsule endomicroscopy in patients with Barrett’s esophagus in a multi-center study
      Background Aims Tethered capsule endomicroscopy (TCE) involves swallowing small tethered pill that implements optical coherence tomography (OCT) imaging, procuring high resolution images of the whole esophagus. Here, we demonstrate and evaluate the feasibility and safety of TCE and a portable OCT imaging system in patients with Barretts esophagus (BE) in a multi-center (5-site) clinical study. Methods Untreated patients with BE as per endoscopic biopsy diagnosis were eligible to participate in ...
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    11. OCT-OCTA segmentation: combining structural and blood flow information to segment Bruch's membrane

      OCT-OCTA segmentation: combining structural and blood flow information to segment Bruch's membrane
      In this paper we present a fully automated graph-based segmentation algorithm that jointly uses optical coherence tomography (OCT) and OCT angiography (OCTA) data to segment Bruch's membrane (BM). This is especially valuable in cases where the spatial correlation between BM, which is usually not visible on OCT scans, and the retinal pigment epithelium (RPE), which is often used as a surrogate for segmenting BM, is distorted by pathology. We ...
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    12. Multi-beam OCT imaging based on an integrated, free-space interferometer

      Multi-beam OCT imaging based on an integrated, free-space interferometer
      While it is a common practice to increase the speed of swept-source optical coherence tomography (OCT) systems by using a high-speed source, this approach may not always be optimal. Parallelization in the form of multiple imaging beams is an alternative approach, but scalable and low-loss multi-beam OCT architectures are needed to capitalize on its advantages. In this study, we demonstrate an eight-beam OCT system using an interferometer architecture comprising planar ...
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    13. 1-15 of 815 1 2 3 4 ... 53 54 55 »
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  2. About Massachusetts General Hospital

    Massachusetts General Hospital

    Massachusetts General Hospital is a teaching hospital of Harvard Medical School and biomedical research facility in Boston, Massachusetts. It is owned and operated by Partners HealthCare (which also owns Brigham and Women's Hospital and North Shore Medical Center).

  3. Quotes about Massachusetts General Hospital

    1. We are excited to see the publication of this data from our collaborators at Massachusetts General Hospital that clearly demonstrate the imaging technology can produce valuable images of esophageal tissue...We look forward to moving ahead with continued development of this exciting new technology.
      In NinePoint Medical Imaging Technology Highlighted in Nature Medicine