1. Massachusetts General Hospital

    0 Comments Leave a Comment

    1-15 of 786 1 2 3 4 ... 51 52 53 »

    1. Mentioned In 786 Articles

    2. New prediction tools and treatment for ACS patients with plaque erosion

      Explore atherosclerosis-journal.com Cardiology
      New prediction tools and treatment for ACS patients with plaque erosion
      For decades, we have known from autopsy observations that the proximate cause of the majority of acute coronary syndromes (ACS) is occlusive thrombosis generated by plaque rupture or, less frequently, superficial erosion.1-3 Mounting evidence supports the concept that these two substrates are separate entities, with distinct pathogenesis, clinical presentation, and prognosis.4-9 Yet, when ACS patients present to the emergency department with ischemic symptoms, we still triage them exclusively ...
      Read Full Article
      Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University

    4. Micro-optical coherence tomography for high-resolution morphologic imaging of cellular and nerval corneal micro-structures

      Explore OSA | OSA Publishing Ophthalmology
      Micro-optical coherence tomography for high-resolution morphologic imaging of cellular and nerval corneal micro-structures
      We demonstrate the highest resolution (1.51.51 m) micrometer optical coherence tomography (OCT) imaging of the morphologic micro-structure of excised swine and non-human primate corneas. Besides epithelial, stromal, and endothelial cell morphology, this report focuses on investigating the most peripheral corneal nerve fibers, the nerve fibers of the subbasal plexus (SBP). Alterations of SBP nerve density and composition are reportedly linked to major neurologic disorders, such as diabetic neuropathy ...
      Read Full Article
      Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

    5. Linear-in-wavenumber actively-mode-locked wavelength-swept laser

      Explore OSA | OSA Publishing Tunable Sources
      Linear-in-wavenumber actively-mode-locked wavelength-swept laser
      We report on an akinetic actively-mode-locked wavelength-swept laser (ASL) with a sweep that is highly linear in wavenumber. By tailoring the drive waveform of the intracavity modulator, the wavenumber sweep was further linearized to enable high fidelity frequency-domain interferometric ranging without resampling of the acquired data. Used for catheter-based optical coherence tomography, the ASL showed comparable imaging performance to a state-of-the-art polygon-based wavelength-swept source at a matching sweep rate of ...
      Read Full Article
      Mentions: Brett E. Bouma Massachusetts Institute of Technology Massachusetts General Hospital

    6. Intravascular Polarimetry: Clinical Translation and Future Applications of Catheter-Based Polarization Sensitive Optical Frequency Domain Imaging

      Explore Frontiers Cardiology
      Intravascular Polarimetry: Clinical Translation and Future Applications of Catheter-Based Polarization Sensitive Optical Frequency Domain Imaging
      Optical coherence tomography (OCT) and optical frequency domain imaging (OFDI) visualize the coronary artery wall and plaque morphology in great detail. The advent of these high-resolution intracoronary imaging modalities has propelled our understanding of coronary atherosclerosis and provided enhanced guidance for percutaneous coronary intervention. Yet, the lack of contrast between distinct tissue types and plaque compositions impedes further elucidation of the complex mechanisms that contribute to acute coronary syndrome (ACS ...
      Read Full Article
      Mentions: Brett E. Bouma Massachusetts General Hospital Harvard University

    7. Study of Gastrointestinal Dysfunction and Enteric Neural Pathology in Patients With Parkinson's Disease

      Explore Home - ClinicalTrials.gov Gastroenterology , Clinical Trials
      Study of Gastrointestinal Dysfunction and Enteric Neural Pathology in Patients With Parkinson's Disease
      The purpose of this study is to establish the esophageal pathology findings as imaged with tethered capsule microscopy in subjects with Parkinson Disease. Images from patients with Parkinson disease will be compared to our previously obtained images in healthy subjects to establish the spectrum of esophageal pathologies occurring in patients with Parkinson disease by OCT imaging. In the case of imaging internal luminal organs, like the esophagus, OCT light is ...
      Read Full Article
      Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

    8. Artifact Rates for 2D Retinal Nerve Fiber Layer Thickness Versus 3D Neuroretinal Rim Thickness Using Spectral-Domain Optical Coherence Tomography

      Explore TVST Journal Ophthalmology
      Artifact Rates for 2D Retinal Nerve Fiber Layer Thickness Versus 3D Neuroretinal Rim Thickness Using Spectral-Domain Optical Coherence Tomography
      Purpose : To compare the rates of clinically significant artifacts for two-dimensional peripapillary retinal nerve fiber layer (RNFL) thickness versus three-dimensional (3D) neuroretinal rim thickness using spectral-domain optical coherence tomography (SD-OCT). Methods : Only one eye per patient was used for analysis of 120 glaucoma patients and 114 normal patients. For RNFL scans and optic nerve scans, 15 artifact types were calculated per B-scan and per eye. Neuroretinal rim tissue was quantified ...
      Read Full Article
      Mentions: Brett E. Bouma Johannes F. de Boer Massachusetts General Hospital

    9. Feasibility Study to Assess a Trans-nasal Intestinal Potential Difference Probe

      Explore Home - ClinicalTrials.gov Clinical Trials , Probes
      Feasibility Study to Assess a Trans-nasal Intestinal Potential Difference Probe
      Increased gastrointestinal (GI) permeability is associated to several GI conditions that affect millions of people worldwide. Healthy intestinal walls limit only specific molecules to cross into the body. "Leaky gut" is a condition of unregulated and increased gut permeability that allows unwanted antigens, pathogens and microbial toxins into the bloodstream(1). This in turn leads to a subsequent immune response that includes the production of inflammatory mediators. Leaky gut is ...
      Read Full Article
      Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

    10. Optical Imaging of Gastrointestinal Biopsy Samples and Their Correlation With Histology

      Explore Home - ClinicalTrials.gov Gastroenterology , Clinical Trials
      Optical Imaging of Gastrointestinal Biopsy Samples and Their Correlation With Histology
      The investigators have previously developed optical imaging systems that have been able to provide highly detailed images of tissue structures in multiple application areas including Cardiology, Gastroenterology, and Pulmonology. They are looking to continue the advancement of these various technologies under development. The population will include subjects who are undergoing elective esophagogastroduodenoscopy with biopsy, colonoscopy with biopsy, and/or endo-mucosal resection.The endoscopist will take no more than 3 biopsies ...
      Read Full Article
      Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

    11. Evaluation of Tethered Capsule Endomicroscopy as a Screening Tool for Barrett's Esophagus in the Primary Care Setting

      Explore Home - ClinicalTrials.gov Gastroenterology , Clinical Trials
      Evaluation of Tethered Capsule Endomicroscopy as a Screening Tool for Barrett's Esophagus in the Primary Care Setting
      The investigators have developed a tethered capsule OCT device intended as an inexpensive screening tool for BE. The capsule, which is attached to a thin, flexible tether, is reusable after being processed by a standard disinfection technique. Used without sedation, the capsule is swallowed by the participant and travels in the esophagus to the gastroesophageal junction (GEJ) via peristalsis. Cross-sectional microscopic OCT images of the entire esophagus are collected during ...
      Read Full Article
      Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

    12. Efficacy and Safety of Laser‐Assisted Combination Chemotherapy: An Explorative Imaging‐Guided Treatment With 5‐Fluorouracil and Cisplatin for Basal Cell Carcinoma

      Explore Wiley Online Library Dermatology
      Efficacy and Safety of Laser‐Assisted Combination Chemotherapy: An Explorative Imaging‐Guided Treatment With 5‐Fluorouracil and Cisplatin for Basal Cell Carcinoma
      Background and Objectives Rising incidences of basal cell carcinoma (BCC) have increased the need for effective topical therapies. By enhancing cutaneous uptake of the chemotherapeutic agents, cisplatin and 5‐fluorouracil (5‐FU), laser‐assisted delivery may provide a new combination treatment for BCC. Accordingly, this study aimed to evaluate tumor response, safety, and drug biodistribution in tumors and blood after topical laser‐assisted 5‐FU+CIS treatment in BCC patients ...
      Read Full Article
      Mentions: Massachusetts General Hospital Harvard University Mette Mogensen

    13. Influence of tissue fixation on depth-resolved birefringence of oral cavity tissue samples

      Explore SPIE Digital Library Dentistry
      Influence of tissue fixation on depth-resolved birefringence of oral cavity tissue samples
      Significance: To advance our understanding of the contrast observed when imaging with polarization-sensitive optical coherence tomography (PS-OCT) and its correlation with oral cancerous pathologies, a detailed comparison with histology provided via ex vivo fixed tissue is required. The effects of tissue fixation, however, on such polarization-based contrast have not yet been investigated. Aim: A study was performed to assess the impact of tissue fixation on depth-resolved (i.e., local) birefringence ...
      Read Full Article
      Mentions: Massachusetts General Hospital Harvard University David D. Sampson

    14. Tethered capsule en face optical coherence tomography for imaging Barrett’s oesophagus in unsedated patients

      Explore BMJ Open Gastroenterology Gastroenterology , Probes
      Tethered capsule en face optical coherence tomography for imaging Barrett’s oesophagus in unsedated patients
      Objective Barretts oesophagus (BE) screening outside the endoscopy suite can identify patients for surveillance and reduce mortality. Tethered capsule optical coherence tomography (OCT) can volumetrically image oesophageal mucosa in unsedated patients and detect features of BE. We investigated ultrahigh-speed tethered capsule swept-source OCT (SS-OCT), improved device design, developed procedural techniques and measured capsule contact, longitudinal pullback non-uniformity and patient toleration. Design OCT was performed in 16 patients prior to endoscopic ...
      Read Full Article
      Mentions: Thorlabs Massachusetts General Hospital Hiroshi Mashimo

    15. In vivo imaging of the depth-resolved optic axis of birefringence in human skin

      Explore OSA | OSA Publishing
      In vivo imaging of the depth-resolved optic axis of birefringence in human skin
      Recent progress has enabled the reconstruction of the local (i.e., depth-resolved) optic axis (OAx) of biological tissue from measurements made with polarization-sensitive optical coherence tomography (PS-OCT). Here we demonstrate local OAx imaging in healthy human skin in vivo . The images reveal dense, weaving patterns that are imperceptible in OCT intensity tomograms or conventional PS-OCT metrics and that suggest a mesh-like tissue organization, consistent with the morphology of dermal collagen ...
      Read Full Article
      Mentions: Massachusetts General Hospital Harvard University David D. Sampson
    17. 1-15 of 786 1 2 3 4 ... 51 52 53 »
  1. Search:

  2. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology

    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents

    3. Technology:

      Broadband Sources, Probes, Tunable Sources

    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks

  4. About Massachusetts General Hospital

    Massachusetts General Hospital

    Massachusetts General Hospital is a teaching hospital of Harvard Medical School and biomedical research facility in Boston, Massachusetts. It is owned and operated by Partners HealthCare (which also owns Brigham and Women's Hospital and North Shore Medical Center).

  5. Related Topics

    1. Optical methods for tissue analysis
      682 articles also mentioned Harvard University
    2. Optical coherence tomography (OCT) can successfully identify the characteristics of coronary plaques
      151 articles also mentioned Ik-Kyung Jang
    3. Power-efficient nonreciprocal interferometer and linear-scanning fiber-optic catheter for optical coherence tomography.
      98 articles also mentioned Massachusetts Institute of Technology
    4. High-speed polarization sensitive optical frequency domain imaging with frequency multiplexing
      85 articles also mentioned Benjamin J. Vakoc
    5. Optical Technique Provides Improved 'Virtual Biopsies' Of Internal Surfaces
      81 articles also mentioned National Institutes of Health

  6. Quotes about Massachusetts General Hospital

    1. We are excited to see the publication of this data from our collaborators at Massachusetts General Hospital that clearly demonstrate the imaging technology can produce valuable images of esophageal tissue...We look forward to moving ahead with continued development of this exciting new technology.
      Charles Carignan in NinePoint Medical Imaging Technology Highlighted in Nature Medicine