1. Massachusetts General Hospital

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    1. Mentioned In 848 Articles

    2. Quantification of volumetric morphometry and optical property in the cortex of human cerebellum at micrometer resolution

      Explore bioRxiv.org Neurology
      Quantification of volumetric morphometry and optical property in the cortex of human cerebellum at micrometer resolution
      The surface of the human cerebellar cortex is much more tightly folded than the cerebral cortex. Volumetric analysis of cerebellar morphometry in magnetic resonance imaging studies suffers from insufficient resolution, and therefore has had limited impact on disease assessment. Automatic serial polarization-sensitive optical coherence tomography (as-PSOCT) is an emerging technique that offers the advantages of microscopic resolution and volumetric reconstruction of large-scale samples. In this study, we reconstructed multiple cubic ...
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      Mentions: Massachusetts Institute of Technology Massachusetts General Hospital Harvard University

    3. Optical Coherence Tomography of Plaque Vulnerability and Rupture: JACC Focus Seminar Part 1/3

      Explore ScienceDirect Cardiology
      Optical Coherence Tomography of Plaque Vulnerability and Rupture: JACC Focus Seminar Part 1/3
      Plaque rupture is the most common cause of acute coronary syndromes and sudden cardiac death. Characteristics and pathobiology of vulnerable plaques prone to plaque rupture have been studied extensively over 2 decades in humans using optical coherence tomography (OCT), an intravascular imaging technique with micron scale resolution. OCT studies have identified key features of plaque vulnerability and described the in vivo characteristics and spatial distribution of thin cap fibroatheromas as ...
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      Mentions: Johns Hopkins University Mount Sinai School of Medicine Massachusetts General Hospital

    4. Optical Coherence Tomography of Plaque Erosion: JACC Focus Seminar Part 2/3

      Explore ScienceDirect Cardiology
      Optical Coherence Tomography of Plaque Erosion: JACC Focus Seminar Part 2/3
      Plaque erosion, a distinct histopathological and clinical entity, accounts for over 30% of acute coronary syndromes (ACS). Optical coherence tomography allows in vivo diagnosis of plaque erosion. Local flow perturbation with activation of Toll-like receptor 2 and CD8 + T cells and subsequent desquamation of endothelium and neutrophil extracellular trap formation contribute to mechanisms of plaque erosion. Compared with ACS patients with plaque rupture, those with plaque erosion are younger, have ...
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      Mentions: Brigham and Women’s Hospital Mount Sinai School of Medicine Massachusetts General Hospital

    5. Optical Coherence Tomography of Coronary Plaque Progression and Destabilization: JACC Focus Seminar Part 3/3

      Explore ScienceDirect Cardiology
      Optical Coherence Tomography of Coronary Plaque Progression and Destabilization: JACC Focus Seminar Part 3/3
      The development of optical coherence tomography (OCT) has revolutionized our understanding of coronary artery disease. In vivo OCT research has paralleled with advances in computational fluid dynamics, providing additional insights in the various hemodynamic factors influencing plaque growth and stability. Recent OCT studies introduced a new concept of plaque healing in relation to clinical presentation. In addition to known mechanisms of acute coronary syndromes such as plaque rupture and plaque ...
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      Mentions: Mount Sinai School of Medicine Massachusetts General Hospital Harvard University

    6. Refractive-index matching enhanced polarization-sensitive optical coherence tomography quantification in human brain tissue

      Explore bioRxiv.org Neurology
      Refractive-index matching enhanced polarization-sensitive optical coherence tomography quantification in human brain tissue
      The importance of polarization-sensitive optical coherence tomography (PS-OCT) has been increasingly recognized in human brain imaging. Despite the recent progress of PS-OCT in revealing white matter architecture and orientation, quantification of fine-scale fiber tracts in the human brain cortex has been a challenging problem, due to a low birefringence in the gray matter. In this study, we investigated the effect of refractive index matching by 2,2'-thiodiethanol (TDE) immersion ...
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      Mentions: Massachusetts Institute of Technology Massachusetts General Hospital Harvard University

    7. Systems, methods, and media for multiple reference arm spectral domain optical coherence tomography

      Explore uspto.gov Patents , Tunable Sources
      Systems, methods, and media for multiple reference arm spectral domain optical coherence tomography
      In some embodiments, systems, methods, and media for multiple reference arm spectral domain optical coherence tomography are provided which, in some embodiments, includes: a sample arm coupled to a light source; a first reference arm having a first path length; a second reference arm having a longer second path length; a first optical coupler that combines light from the sample arm and the first reference arm; a second coupler that ...
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      Mentions: Massachusetts General Hospital Harvard University Wasatch Photonics

    8. Endomicroscopy of the human cochlea using a micro-optical coherence tomography catheter

      Explore Nature Publishing Group Otolaryngology
      Endomicroscopy of the human cochlea using a micro-optical coherence tomography catheter
      Sensorineural hearing loss (SNHL) is one of the most profound public health concerns of the modern era, affecting 466 million people today, and projected to affect 900 million by the year 2050. Advances in both diagnostics and therapeutics for SNHL have been impeded by the human cochlea's inaccessibility for in vivo imaging, resulting from its extremely small size, convoluted coiled configuration, fragility, and deep encasement in dense bone. Here ...
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      Mentions: Massachusetts General Hospital Stanford University Harvard University

    9. Massachusetts General Hospital Receives NIH Grant for Volumetric mapping of tissue microstructure with OCT for enhanced dysplasia detection

      Explore Optical Coherence Tomography News Gastroenterology , Funding
      Massachusetts General Hospital Receives NIH Grant for Volumetric mapping of tissue microstructure with OCT for enhanced dysplasia detection
      ... proactive treatment of disease, and im- proved outcomes in at-risk patients.

      Massachusetts General Hospital Receives a 2021 NIH Grant for $46,036 for Volumetric mapping of tissue microstr...

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      Mentions: National Institutes of Health Massachusetts General Hospital

    10. Massachusetts General Hospital Receives NIH Grant for Lithium Niobate on Insulator (LNOI) Photonic Circuit Lasers for High-Speed, Wide-field OCT

      Explore Optical Coherence Tomography News Funding
      Massachusetts General Hospital Receives NIH Grant for Lithium Niobate on Insulator (LNOI) Photonic Circuit Lasers for High-Speed, Wide-field OCT
      Massachusetts General Hosptial Receives a 2021 NIH Grant for $199,976 for Lithium Niobate on Insulator (LNOI) Photonic Circuit Lasers for High-Speed, Wide-field OCT. The principal investigator is Benjamin Vakoc. Below is a summary of the proposed work. Despite advances in OCT technology over the past two decades, retinal OCT systems are still limited by their speed. This has many consequences on how OCT is used. Perhaps most significantly, current ...
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      Mentions: National Institutes of Health Massachusetts General Hospital

    11. Rapid non-destructive volumetric tumor yield assessment in fresh lung core needle biopsies using polarization sensitive optical coherence tomography

      Explore OSA | OSA Publishing Pulmonology
      Rapid non-destructive volumetric tumor yield assessment in fresh lung core needle biopsies using polarization sensitive optical coherence tomography
      Adequate tumor yield in core-needle biopsy (CNB) specimens is essential in lung cancer for accurate histological diagnosis, molecular testing for therapeutic decision-making, and tumor biobanking for research. Insufficient tumor sampling in CNB is common, primarily due to inadvertent sampling of tumor-associated fibrosis or atelectatic lung, leading to repeat procedures and delayed diagnosis. Currently, there is no method for rapid, non-destructive intraprocedural assessment of CNBs. Polarization-sensitive optical coherence tomography (PS-OCT) is ...
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      Mentions: University of Michigan Massachusetts General Hospital Harvard University

    12. High-Speed, Long-Range Swept-Source Optical Coherence Tomography for the Anterior Segment of the Eye

      Explore IOVS Journal Ophthalmology
      High-Speed, Long-Range Swept-Source Optical Coherence Tomography for the Anterior Segment of the Eye
      Purpose : The anterior segment (AS) of the eye is of interest in multiple diseases and procedures, including glaucoma, ocular surface inflammation, and refractive / cataract surgeries. Visualizing the anterior eye using optical coherence tomography (OCT) has unique challenges, and AS OCT technology is less developed than retinal imaging. We developed next generation swept-source OCT (SS-OCT) technology to enable high-speed and long-range AS structural and angiographic imaging in clinical settings. Methods : We ...
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      Mentions: Thorlabs Massachusetts General Hospital Oregon Health & Science University

    13. Coronary plaque and clinical characteristics of South Asian (Indian) patients with acute coronary syndromes: An optical coherence tomography study

      Explore International Journal of Cardiology Cardiology
      Coronary plaque and clinical characteristics of South Asian (Indian) patients with acute coronary syndromes: An optical coherence tomography study
      Background South Asians, and Indians in particular, are known to have a higher incidence of premature atherosclerosis and acute coronary syndromes (ACS) with worse clinical outcomes, compared to populations with different ethnic backgrounds. However, the underlying pathobiology accounting for these differences has not been fully elucidated. Methods ACS patients who had culprit lesion optical coherence tomography (OCT) imaging were enrolled. Culprit plaque characteristics were evaluated using OCT. Results Among 1315 ...
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      Mentions: Massachusetts General Hospital Harvard University Kitasato University
    17. 1-15 of 848 1 2 3 4 ... 55 56 57 »
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  4. About Massachusetts General Hospital

    Massachusetts General Hospital

    Massachusetts General Hospital is a teaching hospital of Harvard Medical School and biomedical research facility in Boston, Massachusetts. It is owned and operated by Partners HealthCare (which also owns Brigham and Women's Hospital and North Shore Medical Center).

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  6. Quotes about Massachusetts General Hospital

    1. We are excited to see the publication of this data from our collaborators at Massachusetts General Hospital that clearly demonstrate the imaging technology can produce valuable images of esophageal tissue...We look forward to moving ahead with continued development of this exciting new technology.
      In NinePoint Medical Imaging Technology Highlighted in Nature Medicine