1. Massachusetts General Hospital

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    1. Mentioned In 640 Articles

    2. Volumetric non-local-means based speckle reduction for optical coherence tomography

      Volumetric non-local-means based speckle reduction for optical coherence tomography
      We present a novel tomographic non-local-means based despeckling technique, TNode, for optical coherence tomography. TNode is built upon a weighting similarity criterion derived for speckle in a three-dimensional similarity window. We present an implementation using a two-dimensional search window, enabling the despeckling of volumes in the presence of motion artifacts, and an implementation using a three-dimensional window with improved performance in motion-free volumes. We show that our technique provides effective ...
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    3. NinePoint Medical Appoints Eman Namati, Ph.D., to Chief Executive Officer

      NinePoint Medical Appoints Eman Namati, Ph.D., to Chief Executive Officer
      ...ing system. Prior to his time at NinePoint, Dr. Namati was a researcher developing optical imaging systems at Massachusetts General Hospital. He worked with Professors Guillermo Tearney, M.D., Ph.D., and Brett Bouma, Ph....
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    4. Ruptures and Thickening : Optical Coherence Tomography as the Arbiter of the Fibrous Cap

      Ruptures and Thickening : Optical Coherence Tomography as the Arbiter of the Fibrous Cap
      Coronary artery disease remains a leading cause of mortality worldwide, primarily through acute events mediated by progression and disruption of thrombosis-provoking atheroma. The necrotic core of advanced atheroma harbors highly prothrombotic material, including components of tissue factor, von Willebrand factor, and plasminogen activator inhibitor1. Exposure of these contents to flowing blood can spur thrombosis and is a critical feature of many acute coronary syndromes (ACS). It is therefore vital that ...
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    5. Wide dynamic range high-speed three-dimensional quantitative OCT angiography with a hybrid-beam scan

      Wide dynamic range high-speed three-dimensional quantitative OCT angiography with a hybrid-beam scan
      We demonstrate a novel hybrid-beam scanning-based quantitative optical coherence tomography angiography (OCTA) that provides high-speed wide dynamic range blood flow speed imaging. The hybrid-beam scanning scheme enables multiple OCTA image acquisitions with a wide range of multiple time intervals simultaneously providing wide dynamic range blood flow speed imaging independent of the blood vessel orientation, which was quantified over a speed range of 0.6 104 mm / s 0.6104mm/s ...
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    6. Apparatus and method for providing diffuse spectroscopy co-registered with optical frequency domain imaging

      Apparatus and method for providing diffuse spectroscopy co-registered with optical frequency domain imaging
      An apparatus can be provided according to certain exemplary embodiments. For example, the apparatus can include a waveguiding first arrangement providing at least one electromagnetic radiation. A configuration can be provided that receives and splits the at least one electromagnetic radiation into a first radiation and a second radiation. The apparatus can further include a waveguiding second arrangement which has a first waveguide and a second waveguide, whereas the first ...
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    7. Needle-based Optical Coherence Tomography to Guide Transbronchial Lymph Node Biopsy

      Needle-based Optical Coherence Tomography to Guide Transbronchial Lymph Node Biopsy
      Background: Transbronchial needle aspiration (TBNA), often used to sample lymph nodes for lung cancer staging , is subject to sampling error even when performed with endobronchial ultrasound. Optical coherence tomography (OCT) is a high-resolution imaging modality that rapidly generates helical cross-sectional images. We aim to determine if needle-based OCT can provide microstructural information in lymph nodes that may be used to guide TBNA, and improve sampling error. Methods: We performed ex ...
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    8. Robust wavenumber and dispersion calibration for Fourier-domain optical coherence tomography

      Robust wavenumber and dispersion calibration for Fourier-domain optical coherence tomography
      Many Fourier-domain optical coherence tomography (FD-OCT) systems sample the interference fringes with a non-uniform wavenumber ( k ) interval, introducing a chirp to the signal that depends on the path length difference underlying each fringe. A dispersion imbalance between sample and reference arms also generates a chirp in the fringe signal which, in contrast, is independent of depth. Fringe interpolation to obtain a signal linear in k and compensate dispersion imbalance is ...
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    9. Optical coherence tomography (OCT) imaging of dynamic airway behavior in an asthma model

      Optical coherence tomography (OCT) imaging of dynamic airway behavior in an asthma model
      To better understand bronchoconstriction in asthma, it is critical to dynamically visualize airway behavior in vivo. However, currently available imaging techniques do not have sufficient temporal and spatial resolution to investigate airway dynamics. We propose to use endobronchial Optical Coherence Tomography (OCT) to provide real-time cross-sectional images of airway dynamics with a high spatial resolution. Our aim was to study the structure and function of spatially distinct airways during tidal ...
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    10. Visualizing cellular markers of sensorineural hearing loss in the murine cochlea using micro-optical coherence tomography

      Visualizing cellular markers of sensorineural hearing loss in the murine cochlea using micro-optical coherence tomography
      Although sensorineural hearing loss (SNHL) affects 600 million people globally and its prevalence is increasing, therapies remain limited. Advances in therapy development for SNHL are slow because we do not possess a method for visualizing the cochleas interior in living humans and relating visualized pathology to a patients hearing ability. To this end, we are investigating the ability of micro-optical coherence tomography (OCT), a low-coherence interferometric imaging technique that requires ...
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    11. Optical coherence tomography angiography based biomarkers to assess the safety of peripheral nerve electrostimulation

      Optical coherence tomography angiography based biomarkers to assess the safety of peripheral nerve electrostimulation
      Peripheral nerves connect and relay information between the central nervous system and its target organs. Small arteries traverse the epineurium and are responsible for supplying blood to the axons and cells within the nerves. Constriction or damage to these vessels can reduce perfusion leading to ischemic insults. Peripheral nerve electrostimulation has been approved for the treatment of epilepsy, depression and migraines, and is also being studied for the treatment of ...
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    12. Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy

      Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy
      Tethered capsule endomicroscopy (TCE) is a new method for performing comprehensive microstructural OCT imaging of gastrointestinal (GI) tract in unsedated patients in a well-tolerated and cost-effective manner. These features of TCE bestow it with significant potential to improve the screening, surveillance and management of various upper gastrointestinal diseases. To achieve clinical adoption of this imaging technique, it is important to validate it with co-registered histology, the current diagnostic gold standard ...
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    13. Contrast enhancement of microscopic birefringent crystals using polarization sensitive micro-optical coherence tomography

      Contrast enhancement of microscopic birefringent crystals using polarization sensitive micro-optical coherence tomography
      Background: Birefringent crystals such as cholesterol and monosodium urate have recently been identified as possible pharmacologic targets for the treatment of coronary artery disease. The size of these crystals can be very small (on the order of 1 m), making them difficult to identify. To image these microscopic crystals and enhance contrast, we modified existing micro optical coherence tomography system so that it was capable of obtaining polarization-sensitive images (PS-OCT ...
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    14. Cellular-resolution, extended depth of focus optical coherence tomography catheter toward in vivo cardiovascular imaging

      Cellular-resolution, extended depth of focus optical coherence tomography catheter toward in vivo cardiovascular imaging
      Optical coherence tomography (OCT) has been a useful clinical tool for diagnosing coronary artery disease through a flexible catheter, but its full promise relies on resolving cellular and sub-cellular structures in vivo. Previously, visualizing cellular structures through an imaging catheter is not possible due to limited depth of focus (DOF) of a tightly focused Gaussian beam: typically, a Gaussian beam with 2-3 m resolution has a DOF within 100 m ...
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    15. 1-15 of 640 1 2 3 4 ... 41 42 43 »
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  2. About Massachusetts General Hospital

    Massachusetts General Hospital

    Massachusetts General Hospital is a teaching hospital of Harvard Medical School and biomedical research facility in Boston, Massachusetts. It is owned and operated by Partners HealthCare (which also owns Brigham and Women's Hospital and North Shore Medical Center).

  3. Quotes about Massachusetts General Hospital

    1. We are excited to see the publication of this data from our collaborators at Massachusetts General Hospital that clearly demonstrate the imaging technology can produce valuable images of esophageal tissue...We look forward to moving ahead with continued development of this exciting new technology.
      Charles Carignan in NinePoint Medical Imaging Technology Highlighted in Nature Medicine