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1. Mentioned In 146 Articles
2. Retinal applications of swept source optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA)
  
  Explore ScienceDirect Feb 1 2021 Ophthalmology
  
  The advent of optical coherence tomography (OCT) revolutionized both clinical assessment and research of vitreoretinal conditions. Since then, extraordinary advances have been made in this imaging technology, including the relatively recent development of swept-source OCT (SS-OCT). SS-OCT enables a fast scan rate and utilizes a tunable swept laser at longer wavelengths than conventional spectral-domain devices. These features enable imaging of larger areas with reduced motion artifact, and a better visualization ...
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  Mentions: Harvard University Massachusetts Eye and Ear Infirmary University of Milan
3. Quantitative evaluation of the human vocal fold extracellular matrix using multiphoton microscopy and optical coherence tomography
  
  Explore Nature Publishing Group Feb 1 2021 Otolaryngology
  
  Identifying distinct normal extracellular matrix (ECM) features from pathology is of the upmost clinical importance for laryngeal diagnostics and therapy. Despite remarkable histological contributions, our understanding of the vocal fold (VF) physiology remains murky. The emerging field of non-invasive 3D optical imaging may be well-suited to unravel the complexity of the VF microanatomy. This study focused on characterizing the entire VF ECM in length and depth with optical imaging. A ...
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  Mentions: Harvard University Massachusetts Eye and Ear Infirmary
4. Detection of neovascularisation in the vitreoretinal interface slab using widefield swept-source optical coherence tomography angiography in diabetic retinopathy
  
  Explore BJO Online Dec 24 2020 Ophthalmology
  
  Aims To compare the efficacy of diabetic retinal neovascularisation (NV) detection using the widefield swept-source optical coherence tomography angiography (WF SS-OCTA) vitreoretinal interface (VRI) Angio slab and SS-OCT VRI Structure slab. Methods A prospective, observational study was performed at Massachusetts Eye and Ear from January 2019 to June 2020. Patients with proliferative diabetic retinopathy (PDR), patients with non-proliferative diabetic retinopathy and patients with diabetes but without diabetic retinopathy were included ...
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  Mentions: Harvard University Wenzhou Medical College Massachusetts Eye and Ear Infirmary
5. Disorganisation of retinal inner layers is associated with reduced contrast sensitivity in retinal vein occlusion
  
  Explore BJO Online Nov 10 2020 Ophthalmology
  
  Background/Aims To determine if disorganisation of retinal inner layers (DRIL) is associated with reduced contrast sensitivity (CS) in patients with retinal vein occlusion (RVO) with a history of macular oedema (ME). Methods Prospective, observational cohort study. Patients with a history of ME secondary to central retinal vein occlusion (CRVO) or branch retinal vein occlusion (BRVO) from October 2017 to July 2019 at a single institution were included. Patients underwent ...
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  Mentions: Harvard University Massachusetts Eye and Ear Infirmary
6. Artifact Rates for 2D Retinal Nerve Fiber Layer Thickness Versus 3D Neuroretinal Rim Thickness Using Spectral-Domain Optical Coherence Tomography
  
  Explore TVST Journal Sep 26 2020 Ophthalmology
  
  Purpose : To compare the rates of clinically significant artifacts for two-dimensional peripapillary retinal nerve fiber layer (RNFL) thickness versus three-dimensional (3D) neuroretinal rim thickness using spectral-domain optical coherence tomography (SD-OCT). Methods : Only one eye per patient was used for analysis of 120 glaucoma patients and 114 normal patients. For RNFL scans and optic nerve scans, 15 artifact types were calculated per B-scan and per eye. Neuroretinal rim tissue was quantified ...
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  Mentions: Brett E. Bouma Johannes F. de Boer Massachusetts General Hospital
7. A quantitative comparison of four optical coherence tomography angiography devices in healthy eyes
  
  Explore Home - Springer Sep 25 2020 Ophthalmology
  
  Purpose Optical coherence tomography angiography (OCT-A) is a novel imaging modality for the diagnosis of chorioretinal diseases. A number of FDA-approved OCT-A devices are currently commercially available, each with unique algorithms and scanning protocols. Although several published studies have compared different combinations of OCT-A machines, there is a lack of agreement on the consistency of measurements across OCT-A devices. Therefore, we conducted a prospective quantitative comparison of four available OCT-A ...
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  Mentions: Optovue Heidelberg Engineering Topcon Medical Systems
8. An Artificial Intelligence Approach to Assess Spatial Patterns of Retinal Nerve Fiber Layer Thickness Maps in Glaucoma
  
  Explore TVST Journal Sep 12 2020 Ophthalmology
  
  Purpose : The purpose of this study was to classify the spatial patterns of retinal nerve fiber layer thickness (RNFLT) and assess their associations with visual field (VF) loss in glaucoma. Methods : We used paired reliable 24-2 VFs and optical coherence tomography scans of 691 eyes from 691 patients. The RNFLT maps were used to determine the RNFLT patterns (RPs) by non-negative matrix factorization (NMF). The RPs were correlated with mean ...
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  Mentions: Brigham and Women’s Hospital Harvard University Massachusetts Eye and Ear Infirmary
9. Comparison of SDOCT Scan Types for Grading Disorganization of Retinal Inner Layers and Other Morphologic Features of Diabetic Macular Edema
  
  Explore TVST Journal Aug 29 2020 Ophthalmology
  
  Purpose : To assess grading reproducibility of disorganization of the retinal inner layers (DRIL) and other morphologic features of diabetic macular edema (DME) across spectral domain optical coherence tomography (SDOCT) instruments and scan types. Methods : A cross-sectional study enrolled participants with current or recent center-involved DME. In group A (27 eyes), we obtained two Cirrus scans (512 128 macular cube [Cube] and high-definition five-line raster [HD 5-Line]) and two Spectralis scans ...
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  Mentions: Optovue Case Western Reserve University Medical University of Vienna
10. Optical coherence tomographic measurements of the sound-induced motion of the ossicular chain in chinchillas: Additional modes of ossicular motion enhance the mechanical response of the chinchilla middle ear at higher frequencies
  
  Explore ScienceDirect Aug 17 2020 Otolaryngology
  
  Wavelength-swept optical coherence tomography (OCT) was used to scan the structure of cadaveric chinchilla ears in three dimensions with high spatial resolution and measure the sound-induced displacements of the entire OCT-visible lateral surfaces of the ossicles in the lateral-to-medial direction. The simultaneous measurement of structure and displacement allowed a precise match between the observed motion and its structural origin. The structure and measured displacements are consistent with previously published data ...
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  Mentions: Seok-Hyun Yun Harvard University Massachusetts Eye and Ear Infirmary
11. Widefield Swept-Source OCTA in Vogt-Koyanagi-Harada Disease
  
  Explore Healio.com Jul 29 2020 Ophthalmology
  
  Herein, the authors describe an initial case report of widefield swept-source optical coherence tomography angiography (SS-OCTA) in Vogt-Koyanagi-Harada (VKH) disease. When compared to fluorescent angiography, indocyanine green angiography, and enhanced-depth OCT upon which the revised criteria for VHK are based widefield SS-OCTA enables detection of vitreous inflammation, noninvasive identification of characteristic areas of flow void at the level of choriocapillaris in the acute phase and may be a novel valuable ...
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  Mentions: Harvard University Wenzhou Medical College Massachusetts Eye and Ear Infirmary
12. Detection of Venous Loops in Diabetic Retinopathy using Widefield Swept-Source Optical Coherence Tomography Angiography
  
  Explore IOVS Journal Jul 27 2020 Ophthalmology
  
  Purpose : Retinal venous loops (RVL) are rare manifestations of diabetic retinopathy (DR) usually identified by color fundus photography. The prevalence and its predictive value reported in the literature may be underestimated due to the limitations of detection techniques. This study investigated the prevalence of RVL and their associated microvascular changes using widefield swept-source optical coherence tomography angiography (WF SS-OCTA). Methods : In this retrospective, observational study at Mass Eye and Ear ...
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  Mentions: Harvard University Massachusetts Eye and Ear Infirmary
13. Advances in Optical Imaging Technique (Textbook)
  
  Explore scirp.org Jul 14 2020 Textbooks
  
  Optical imaging is a pillar in biomedical research from super-resolution microscopy to whole-body imaging in animal models. Optical imaging covers such a large field that it is difficult to decide what was the first medical application .Could it be said that the introduction of spectacles in 1270, in Florence, Italy was the first use of optical imaging in medicine? Or the introduction in 1590 of the compound microscope by the ...
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  Mentions: Harvard University Massachusetts Eye and Ear Infirmary
14. Comparison of widefield swept-source optical coherence tomography angiography with ultra-widefield colour fundus photography and fluorescein angiography for detection of lesions in diabetic retinopathy
  
  Explore BJO Online Jun 30 2020 Ophthalmology
  
  Aims To compare widefield swept-source optical coherence tomography angiography (WF SS-OCTA) with ultra-widefield colour fundus photography (UWF CFP) and fluorescein angiography (UWF FA) for detecting diabetic retinopathy (DR) lesions. Methods This prospective, observational study was conducted at Massachusetts Eye and Ear from December 2018 to October 2019. Proliferative DR, non-proliferative DR and diabetic patients with no DR were included. All patients were imaged with a WF SS-OCTA using a Montage ...
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  Mentions: Johns Hopkins University Harvard University Boston University
15. Retinal Microvasculature Changes After Repair of Macula-off Retinal Detachment Assessed with Optical Coherence Tomography Angiography
  
  Explore Medical Journals Publisher Jun 26 2020 Ophthalmology
  
  ...edical School, 243 Charles St, Boston, MA 02114 Tel +1 (617) 573-3750 Fax +1 (617) 573-3698 Email john_miller@meei.harvard.edu Objective: To characterize the microvascular retinal changes after repair of macula-off rhegm...
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  Mentions: Cornell University Harvard University Massachusetts Eye and Ear Infirmary
16. Future Directions of Optical Coherence Tomography in Otology: A Morphological and Functional Approach
  
  Explore e-ceo.org May 12 2020 Otolaryngology
  
  Optical coherence tomography (OCT) is a real-time optical imaging modality that enables tomographic imaging at the submicron scale. Basic research into applications of OCT systems in the field of otology has been conducted. For instance, Oh et al. [1] recently reported that OCT provided noninvasive, nondestructive two-dimensional cross-sectional and three-dimensional volumetric images of middle-ear and inner ear structures in rodents. Anatomical depth-resolved imaging has shown promising potential for morphological measurements ...
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  Mentions: Harvard University Massachusetts Eye and Ear Infirmary Jeong Hun Jang
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