1. Mary E. Dickinson

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    1. Mentioned In 35 Articles

    2. Comparison and combination of rotational imaging optical coherence tomography and selective plane illumination microscopy for embryonic study

      Comparison and combination of rotational imaging optical coherence tomography and selective plane illumination microscopy for embryonic study
      Several optical imaging techniques have been applied for high-resolution embryonic imaging using different contrast mechanisms, each with their own benefits and limitations. In this study, we imaged the same E9.5 mouse embryo with rotational imaging optical coherence tomography (RI-OCT) and selective plane illumination microscopy (SPIM). RI-OCT overcomes optical penetration limits of traditional OCT imaging that prohibit full-body imaging of mouse embryos at later stages by imaging the samples from ...
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    3. A dual-modality optical coherence tomography and selective plane illumination microscopy system for mouse embryonic imaging

      A dual-modality optical coherence tomography and selective plane illumination microscopy system for mouse embryonic imaging
      Both optical coherence tomography (OCT) and selective plane illumination microscopy (SPIM) are frequently used in mouse embryonic research for high-resolution three-dimensional imaging. However, each of these imaging methods provide a unique and independent advantage: SPIM provides morpho-functional information through immunofluorescence and OCT provides a method for whole-embryo 3D imaging. In this study, we have combined rotational imaging OCT and SPIM into a single, dual-modality device to image E9.5 mouse ...
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    4. Optical Modalities for Embryonic Imaging

      Optical Modalities for Embryonic Imaging
      tudies of disease etiology often rely on the murine (mouse) model, which provides valuable genotypic information. Yet associated phenotypic information from murine embryos is often lacking. Of the various techniques that have been proposed for imaging such embryos, optical modalities may provide the best compromise among speed, penetration depth and resolution. This year, we developed approaches to improve embryonic imaging with optical coherence tomography (OCT), 1 and also provided a ...
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    5. Optical coherence tomography for embryonic imaging: a review

      Optical coherence tomography for embryonic imaging: a review
      Embryogenesis is a highly complex and dynamic process, and its visualization is crucial for understanding basic physiological processes during development and for identifying and assessing possible defects, malformations, and diseases. While traditional imaging modalities, such as ultrasound biomicroscopy, micro-magnetic resonance imaging, and micro-computed tomography, have long been adapted for embryonic imaging, these techniques generally have limitations in their speed, spatial resolution, and contrast to capture processes such as cardiodynamics during ...
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    6. Applicability, usability, and limitations of murine embryonic imaging with optical coherence tomography and optical projection tomography

      Applicability, usability, and limitations of murine embryonic imaging with optical coherence tomography and optical projection tomography
      ...posure,” Dev. Dyn. 244(4), 607–618 (2015). [CrossRef] [PubMed] C. Wu, N. Sudheendran, M. Singh, I. V. Larina, M. E. Dickinson, and K. V. Larin, “Rotational Imaging OCT for Full-Body Mouse Embryonic Imaging,” J. Biomed. O...
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    7. Comparison of rotational imaging optical coherence tomography and selective plane illumination microscopy for embryonic study

      Comparison of rotational imaging optical coherence tomography and selective plane illumination microscopy for embryonic study
      The mouse is a common model for studying developmental diseases. Different optical techniques have been developed to investigate mouse embryos, but each has its own set of limitations and restrictions. In this study, we imaged the same E9.5 mouse embryo with rotational imaging Optical Coherence Tomography (RI-OCT) and Selective Plane Illumination Microscopy (SPIM), and compared the two techniques. Results demonstrate that both methods can provide images with micrometer-scale spatial ...
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    8. Rotational imaging optical coherence tomography for full-body mouse embryonic imaging

      Rotational imaging optical coherence tomography for full-body mouse embryonic imaging
      Optical coherence tomography (OCT) has been widely used to study mammalian embryonic development with the advantages of high spatial and temporal resolutions and without the need for any contrast enhancement probes. However, the limited imaging depth of traditional OCT might prohibit visualization of the full embryonic body. To overcome this limitation, we have developed a new methodology to enhance the imaging range of OCT in embryonic day (E) 9.5 ...
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    9. Quantification of Mouse Embryonic Eye Development with Optical Coherence Tomography In Utero

      Quantification	of	Mouse	Embryonic	Eye	Development	with	 Optical	Coherence	Tomography	In	Utero
      Mouse models are commonly used as research tools to understand regulatory pathways affected by human diseases and disorders. Live imaging tools for visualization of mouse embryonic ocular tissues would be beneficial in research associated with developmental ocular defects. In this study, in utero quantitative assessment of ocular structures in mouse embryos was performed with a swept-source optical coherence tomography (SSOCT). To define developmental changes in eye morphology in live embryos ...
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    10. Comparison of optical projection tomography and optical coherence tomography for assessment of murine embryonic development

      Comparison of optical projection tomography and optical coherence tomography for assessment of murine embryonic development
      ...mohan Singh ; Achuth Nair ; Tegy Vadakkan ; Victor Piazza ; Ryan Udan ; Michael V. Frazier ; Trevor Janecek ; Mary E. Dickinson ; Kirill V. Larin; Comparison of optical projection tomography and optical coherence tomogra...
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    11. 4D Reconstruction of the Beating Embryonic Heart From Two Orthogonal Sets of Parallel Optical Coherence Tomography Slice-Sequences

      4D Reconstruction of the Beating Embryonic Heart From Two Orthogonal Sets of Parallel Optical Coherence Tomography Slice-Sequences
      Current methods to build dynamic optical coherence tomography (OCT) volumes of the beating embryonic heart involve synchronization of 2D+time slice-sequences acquired over separate heartbeats. Temporal registration of these sequences is performed either through gating or post-processing. While synchronization algorithms that exclusively rely on image-intrinsic signals allow forgoing external gating hardware, they are prone to error accumulation, require operator-supervised correction, or lead to non-isotropic resolution. Here, we propose an imagebased ...
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  2. About Mary E. Dickinson

    Mary E. Dickinson

    Mary E. Dickinson is an Associate Professor in the Department of Molecular Physiology & Biophysics at Baylor College of Medicine.