1. Martin J. Leahy

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    1. Mentioned In 46 Articles

    2. Feature Of The Week 6/22/14: Feasibility of Intracoronary Frequency Domain Optical Coherence Tomography Derived Fractional Flow Reserve for the Assessment of Coronary Artery Stenosis

      Feature Of The Week 6/22/14: Feasibility of Intracoronary Frequency Domain Optical Coherence Tomography Derived Fractional Flow Reserve for the Assessment of Coronary Artery Stenosis

      Frequency domain optical coherence tomography (FD-OCT) provides cross-sectional images of coronary arteries and deployed stents with micron resolution and measures lumen dimensions with excellent reproducibility. FD-OCT combined with blood flow resistances model can overcome many limitations of conventional measures of stenosis severity based on quantitative coronary angiography (QCA) and intravascular ultrasound (IVUS). The aim of this feasibility study was to investigate the relationship between pressure derived fractional flow reserve (FFR) and FD-OCT derived FFR, a new method for quantitative measure of stenosis severity that estimates the blood flow resistance and microvascular resistance of the vessel segments imaged by FD-OCT. 26 ...

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    3. Feasibility of Intracoronary Frequency Domain Optical Coherence Tomography Derived Fractional Flow Reserve for the Assessment of Coronary Artery Stenosis

      Feasibility of Intracoronary Frequency Domain Optical Coherence Tomography Derived Fractional Flow Reserve for the Assessment of Coronary Artery Stenosis

      Frequency domain optical coherence tomography (FD-OCT) provides cross-sectional images of coronary arteries and deployed stents with micron resolution and measures lumen dimensions with excellent reproducibility. FD-OCT combined with a blood flow resistances model can overcome many limitations of conventional measures of stenosis severity based on quantitative coronary angiography (QCA) and intravascular ultrasound (IVUS). The aim of this feasibility study was to investigate the relationship between pressure derived fractional flow reserve (FFR) and FD-OCT derived FFR, a new method for quantitative measure of stenosis severity that estimates the blood flow resistance and microvascular resistance of the vessel segments imaged by FD-OCT ...

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    4. High resolution coherence domain depth-resolved nailfold capillaroscopy based on correlation mapping optical coherence tomography

      High resolution coherence domain depth-resolved nailfold capillaroscopy based on correlation mapping optical coherence tomography
      ...based on correlation mapping optical coherence tomography Hrebesh M. Subhash ; Sean O'Gorman ; Kai Neuhaus ; Martin Leahy; High resolution coherence domain depth-resolved nailfold capillaroscopy based on correlation map...
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    5. Variation in cross-correlation as a discriminator for microvessel imaging using clinical intravascular optical coherence tomography systems

      Variation in cross-correlation as a discriminator for microvessel imaging using clinical intravascular optical coherence tomography systems
      ...al intravascular optical coherence tomography systems Shiju Joseph ; Clément Rousseau ; Hrebesh M. Subhash ; Martin Leahy ; David Adlam; Variation in cross-correlation as a discriminator for microvessel imaging using cl...
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    6. Comparison of frequency domain optical coherence tomography and quantitative coronary angiography for the assessment of coronary lesions

      Comparison of frequency domain optical coherence tomography and quantitative coronary angiography for the assessment of coronary lesions
      ... and quantitative coronary angiography for the assessment of coronary lesions Haroon Zafar ; Faisal Sharif ; Martin J. Leahy; Comparison of frequency domain optical coherence tomography and quantitative coronary angiogr...
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    7. Photothermal optical coherence tomography for depth-resolved imaging of mesenchymal stem cells via single wall carbon nanotube

      Photothermal optical coherence tomography for depth-resolved imaging of mesenchymal stem cells via single wall carbon nanotube
      ...m cells via single wall carbon nanotubes Hrebesh M. Subhash ; Emma Connolly ; Mary Murphy ; Valerie Barron ; Martin Leahy; Photothermal optical coherence tomography for depth-resolved imaging of mesenchymal stem cells v...
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    8. Imaging mesenchymal stem cells containing single wall nanotube nanoprobes in a 3D scaffold using photo-thermal optical coherence tomography

      Imaging mesenchymal stem cells containing single wall nanotube nanoprobes in a 3D scaffold using photo-thermal optical coherence tomography
      ...robes in a 3D scaffold using photo-thermal optical coherence tomography Emma Connolly ; Hrebesh M. Subhash ; Martin J. Leahy ; Niall Rooney ; Frank Barry ; Mary Murphy ; Valerie Barron; Imaging mesenchymal stem cells co...
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    9. The design, development and application of a dual-beam spectral-domain optical coherence tomography system for the non-invasive assessment of vascular dynamics by statistical means (Thesis)

      The design, development and application of a dual-beam spectral-domain optical coherence tomography system for the non-invasive assessment of vascular dynamics by statistical means (Thesis)

      This assertion underscores the importance of haematological dynamic assessment, which can benefit greatly from non-invasive high-resolution imaging of blood flow especially at the microvascular level. This importance is further highlighted in oncological applications with recent emphasis on tumour vasculature, angiogenic processes and developments of anti-angiogenic therapies. Optical coherence tomography (OCT) has established itself a firm foothold in the realm of non-invasive optical medical diagnostic imaging, enabling in vivo cross-sectional tomographic visualisation of the internal microstructure of biological systems, and is now considered an optical analogue to CT or MRI, but with microscopic resolution. The original concept of OCT was to ...

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    10. Feature Of The Week 1/19/14: Feature Of The Week: Irish Researchers Investigate Correlation of FFR and OCT Measured Parameters for Identifying Coronary Stenosis

      Feature Of The Week 1/19/14: Feature Of The Week: Irish Researchers Investigate Correlation of FFR and OCT Measured Parameters for Identifying Coronary Stenosis

      The usefulness of fractional flow reserve (FFR) in the functional evaluation of intermediate coronary stenosis is well established. Similarly, intracoronary optical coherence tomography (OCT) continues to be a promising imaging technique for the assessment of coronary artery disease. The frequency domain OCT (FD-OCT) provides faster image acquisition speeds, higher frame rates and greater scan depths as compared to time domain OCT while preserving the image quality. The main aim of this study was to determine the correlation between FFR and frequency domain OCT (FD-OCT) measured anatomical parameters that include minimal lumen area (MLA), minimal lumen diameter (MLD) and percent lumen ...

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  2. About Martin J. Leahy

    Martin J. Leahy

    Martin Leahy is the Chair of Applied Physics and Head of the Tissue Optics and Microcirculation Imaging group at the School of Physics, National University of Ireland, Galway. Martin Leahy completed a DPhil at the University of Oxford and he and a colleague established Oxford Optronix Ltd., where he was Director of R&D. From 1995 he had various research and teaching posts at the University of Oxford. He then joined the Stokes Research Institute where he conducted industry led R&D and later the Physics Department at the University of Limerick where led research groups in energy and biophotonics and lectured in physics. He has secured more than €7M in external R&D funding since 2003. He is an adjunct professor at the Royal College of Surgeons, Fellow of the Institute of Physics in Ireland, Fellow of the Royal Academy of Medicine in Ireland and Fellow of SPIE. He is a co-chair, executive organizing committee member and panel moderator for SPIE Photonics West BiOS in San Francisco and host of the BioPIC European Bioimaging conference. Editorial Board member of the Journal of Biomedical Optics. Prof Leahy was founding MD of Limerick West Windfarms Ltd. and Millstream Energy and PI on the research projects that spun out Biomass Heating Solutions Ltd. and Wheelsbridge AB. Since his return to full-time academia, he has played a leading role in graduate biophotonics education through NBIP, UL and the Biophotonics and Imaging Graduate Summer School. In 2010 he delivered a dozen international invited lectures and published more than a dozen ISI journal articles. He is currently Chair of Applied Physics at NUI Galway.

  3. Quotes

    1. Physics has delivered extraordinary advances in almost every facet of modern life...From the humble thermometer and stethoscope to X-Ray, CT, MRI, ultrasound, PET and radiotherapy, our health has been transformed by these advances. Photonics promises to bring healthcare to the next level, as it is the only means to see cells and molecules in small, accessible, low cost and safe imaging systems. Compact Imaging’s multiple-reference OCT technology has the potential to harness all these advantages, delivering solutions to health and security markets with a distinct edge..
      In Compact Imaging Reaches Agreement On Research Collaboration with Irish Universities