Live imaging of normal and abnormal vascular development in mammalian embryos is important tool in embryonic research, which can potentially contribute to understanding, prevention and treatment of cardiovascular birth defects. Here, we used speckle variance analysis of swept source optical coherence tomography (OCT) data sets acquired from live mouse embryos to reconstruct the 3-D structure of the embryonic vasculature. Both Doppler OCT and speckle variance algorithms were used to reconstruct the vascular structure. The results demonstrates that speckle variance imaging provides more accurate representation of the vascular structure, as it is not sensitive to the blood flow direction, while the ...
Mark Dickenson is a Physicist in the School of Astronomy and Physics at the University of Manchester. Dr Mark Dickinson graduated in Physics from the University of Manchester in 1981 and carried on to research into multi-oscillator ring laser gyroscopes for his PhD in 1984. He was appointed as lecturer in the School of Physics and Astronomy in 1989. His research covers a number of areas, the core of which is Laser Physics. More recently he has been specialising in medical and biological applications of lasers. Recent projects include laser tweezing, blood flow measurements in the microcirculation, laser nerve stimulation for human pain studies, optical coherence tomography and a range of dental applications for lasers. He has worked in collaboration with a number of medical/dental groups and has been involved with industrial partners, including University spin-off companies. Dr Dickinson is an author, member and one of the key organisers of the new Photon Science Institute at the University of Manchester.
But when Andrew approached me, I thought that this would be perfect for the frogs - it can show us what is happening in the frogs' skin but it is non-invasive.In Sunbathing Frog May Hold Clue To Deadly Disease
It will dramatically speed up the diagnosis process, meaning we do not need to take tissue samples and wait for them to be tested, and in some cases, avoid the need for exploratory surgery.In Laser that 'sees' through skin