1. Mark E. Brezinski

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    1. Mentioned In 52 Articles

    2. High-resolution imaging of progressive articular cartilage degeneration

      High-resolution imaging of progressive articular cartilage degeneration
      The objective of this study was to develop and verify a new technique for monitoring the progression of osteoarthritis (OA) by combining a rat model with the imaging modality optical coherence tomography (OCT). Time-sequential, in vivo, OCT imaging was performed on the left femoral condyles of 12 Wistar rats following sodium-iodoacetic acid-induced OA progression. The right femoral condyles (untreated) were also imaged and served as controls. Imaging was performed on ...
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    3. High-resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery

      High-resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery
      Abstract  This study demonstrates the first real-time imaging in vivo of human cartilage in normal and osteoarthritic knee joints at a resolution of micrometers, using optical coherence tomography (OCT). This recently developed high-resolution imaging technology is analogous to B-mode ultrasound except that it uses infrared light rather than sound. Real-time imaging with 11-μm resolution at four frames per second was performed on six patients using a portable OCT system with ...
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    4. Fiber optic needle probes for optical coherence tomography imaging

      Fiber optic needle probes for optical coherence tomography imaging
      A fiber optic needle probe for measuring or imaging the internal structure of a specimen includes a needle defining a bore, an optical fiber substantially positioned within the bore, and a beam director in optical communication with the optical fiber. At least a portion of the wall of the needle is capable of transmitting light. The beam director directs light from the optical fiber to an internal structure being imaged ...
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    5. Fiber optic imaging endoscope interferometer with at least one faraday rotator

      Fiber optic imaging endoscope interferometer with at least one faraday rotator
      An imaging system for performing optical coherence tomography includes an optical radiation source; a reference optical reflector; a first optical path leading to the reference optical reflector; and a second optical path coupled to an endoscopic unit. The endoscopic unit preferably includes an elongated housing defining a bore; a rotatable single mode optical fiber having a proximal end and a distal end positioned within and extending the length of the ...
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    6. Methods and apparatus for forward-directed optical scanning instruments

      Methods and apparatus for forward-directed optical scanning instruments
      An imaging system for performing forward scanning imaging for application to therapeutic and diagnostic devises used in medical procedures. The imaging system includes forward directed optical coherence tomography (OCT), and non-retroreflected forward scanning OCT. Also interferometric imaging and ranging techniques and fluorescent, Raman, two-photon, and diffuse wave imaging can be used. The forward scanning mechanisms include a cam attached to a motor, pneumatic devices, a pivoting device, piezoelectric transducers, electrostatic ...
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    7. Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope

      Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope
      An imaging system for performing optical coherence tomography includes an optical radiation source; a reference optical reflector; a first optical path leading to the reference optical reflector; and a second optical path coupled to an endoscopic unit. The endoscopic unit preferably includes an elongated housing defining a bore; a rotatable single mode optical fiber having a proximal end and a distal end positioned within and extending the length of the ...
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    8. 46-52 of 52 « 1 2 3 4
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  2. About Mark E. Brezinski

    Mark E. Brezinski

    Mark Edward Brezinski MD, PhD primary appointments are as faculty at Harvard Medical and Brigham and Women’s Hospital. His efforts span that of a scientist (bench to beside: engineering/physics to clinical trials) to a cardiologist. He has gained international recognition for pioneering efforts and advancing the field of optical coherence tomography (OCT), the micron-scale imaging technology. Since 2000, much of his efforts have been on adjuvant technologies including PS-OCT, OCT elastography, combined OCT-ultrasound, index matching, and quantum second order correlations with OCT. Dr. Brezinski has also made paradigm shifting advances in disciplines ranging from inflammatory cell regulation to quantum mechanical cell interactions to macroscopic quantum systems, with substantial potential impact to medicine beyond orthopedics and cardiology.

    Mark Brezinski MD, PhD is an internationally respected researcher most widely recognized as a pioneer of the OCT field (over 19 years). His work is truly translational research, spanning technology development, physical theory, bench top studies, and clinical trials. His work (along with collaborators and team members) in cardiology, in particular, translated a concept to an FDA approved interventional imaging technology. This was done in part through co-founding Lightlab Imaging that now sells cardiovascular OCT systems as a subsidiary of St. Jude Medical. For over 13 years, a primary focus has been to advance OCT for the diagnosis and treatment of musculoskeletal disease (MSD) and cardiology. In addition, he has made considerable contributions of applying quantum mechanical principles to medicine, both through technology development and understanding quantum cellular interactions. His efforts are also focused on quantum effects from indistinguishable paths rather than quantum entanglement.

    He is the author of over 150 publications, winner of many awards, including the Presidential Award from President Clinton, and routinely advises numerous Federal Agencies.

  3. Quotes

    1. Now that people are living longer, we want them to live healthier...As someone in the field since the original paper describing its utility, I think OCT has great potential to be high impact technology in managing cardiovascular disease.
      In With OCT, Image is Everything