1. Mark E. Brezinski

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    1. Mentioned In 50 Articles

    2. A Quantum Field Approach for Advancing Optical Coherence Tomography Part I: First Order Correlations, Single Photon Interference, and Quantum Noise

      A Quantum Field Approach for Advancing Optical Coherence Tomography Part I: First Order Correlations, Single Photon Interference, and Quantum Noise
      Optical coherence tomography has become an important imaging technology in cardiology and ophthalmology, with other applications under investigations. Major advances in optical coherence tomography (OCT) imaging are likely to occur through a quantum field approach to the technology. In this paper, which is the first part in a series on the topic, the quantum basis of OCT first order correlations is expressed in terms of full field quantization. Specifically first ...
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    3. System and method for calibrated spectral domain optical coherence tomography and low coherence interferometry

      System and method for calibrated spectral domain optical coherence tomography and low coherence interferometry
      Systems and methods for enhancing spectral domain optical coherence tomography (OCT] are provided. In particular, a system and method for calibration of spectral interference signals using an acquired calibration signal are provided. The calibration signal may be logarithmically amplified to further improve the accuracy of the calibration. From the calibration signal, a series of more accurate calibration data are calculated. An acquired spectral interference signal is calibrated using these calibration ...
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    4. Determination of a material characteristic with the use of second-order photon correlation

      Determination of a material characteristic with the use of second-order photon correlation
      An optical system and method for characterizing an object is provided. The system includes at least one light source configured to direct photons toward an object and an interferometer configured to receive photons from the object. The system also includes at least one detector system adapted to detect an optical signal at an output of the interferometer and to remove, from the detected optical signal, a signal portion representing first ...
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    5. Serving Unmet Needs with Optical Coherence Tomography WebCast with Dr. Mark Brezinski

      Serving Unmet Needs with Optical Coherence Tomography WebCast with Dr. Mark Brezinski
      What Steve Jobs referred to as the unmet need is a barrier to effective treatment, scientific discoveryand equipment sales. Traditionally, developers (engineers) strive for precision, elegance, and maximum theoretical performance (e.g. resolution), whereas the end user (physician or researcher) often has very different requirements. Unfortunately, efforts to bridge this gap can easily become confused. In this webcast, biophotonics pioneer Mark Brezinski MD explores unmet needs in biomedicine, using examples ...
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    6. Practical Challenges of Current Video Rate OCT Elastography: Accounting for Dynamic and Static Tissue Properties

      Practical Challenges of Current Video Rate OCT Elastography: Accounting for Dynamic and Static Tissue Properties
      Optical coherence tomography (OCT) elastography (OCTE) has the potential to be an important diagnostic tool for pathologies including coronary artery disease, osteoarthritis, malignancies, and even dental caries. Many groups have performed OCTE, including our own, using a wide range of approaches. However, we will demonstrate current OCTE approaches are not scalable to real-time, in vivo imaging. As will be discussed, among the most important reasons is current designs focus on ...
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    7. Longitudinal necrotic shafts near TCFAs—A potential novel mechanism for plaque rupture to trigger ACS?

      Comment "We have previously seen these shafts and at the very least, one other group has noted them. But this is ..." - mebrezin
      Longitudinal necrotic shafts near TCFAs—A potential novel mechanism for plaque rupture to trigger ACS?
      ...crotic shafts near TCFAs—A potential novel mechanism for plaque rupture to trigger ACS? Mark E. Brezinski x Mark E. Brezinski Search for articles by this author Affiliations * Center for Optics and Modern Physics, ...
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    8. Matching human pathology is essential for validating OCT imaging to detect high-risk plaques

      Comment "As my comments in Nature Cardiology Reviews show, I strongly disagree with many aspects of the article Otsuka et al. ..." - mebrezin
      Matching human pathology is essential for validating OCT imaging to detect high-risk plaques
      We thank Mark Brezinski for his Correspondence ( Capabilities, limitations, and misconceptions of using OCT to assess vulnerable plaques . Nat. Rev. Cardiol. doi:10.1038/nrcardio.2014.62-c1 ) 1 on our Review ( Clinical classification of plaque morphology in coronary disease . Nat. Rev. Cardiol. 11 , 379 389 ; 2014 ), 2 and for his comments and clarifications. We agree that the phenomenon
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    9. Capabilities, limitations, and misconceptions of using OCT to assess vulnerable plaques

      Comment "Several comments on cardiovascular OCT 1. With OCT, to identify TCFA, in addition to cap thickness you need to identify ..." - mebrezin
      Capabilities, limitations, and misconceptions of using OCT to assess vulnerable plaques
      Serious concerns exist about the Review by Otsuka et al . (Clinical classification of plaque morphology in coronary disease. Nat. Rev. Cardiol. 11, 379389; 2014 ), 1 some of which are discussed in this Correspondence. The concerns are predominately about the authors' understanding of the principles and application of optical coherence tomography (OCT),
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    10. A Quantum Field Approach for Advancing Optical Coherence Tomography Part I: First Order Correlations, Single Photon Interference, And Quantum Noise

      Comment "We believe advancing OCT through quantum mechanics is very important to the future of the technology. Related articles: http://www.hindawi.com/journals/jamp/2012/469043/ http://pra.aps.org/abstract/PRA/v78/i6/e063824 ..." - mebrezin
      A Quantum Field Approach for Advancing Optical Coherence Tomography Part I: First Order Correlations, Single Photon Interference, And Quantum Noise
      Optical coherence tomography has become an important imaging technology in cardiology and ophthalmology, with other applications under investigations. Major advances in optical coherence tomography (OCT) imaging are likely to occur through a quantum field approach to the technology. In this paper, which is the first part in a series on the topic, the quantum basis of OCT first order correlations is expressed in terms of full field quantization. Specifically first ...
      Read Full Article
    11. Brigham and Women's Hospital Receives NIH Grant for Coronary Plaque Characterization Utilizing Quantum Optics Approaches with OCT

      Brigham and Women's Hospital Receives NIH Grant for Coronary Plaque Characterization Utilizing Quantum Optics Approaches with OCT
      Brigham and Women's Hospital Received a 2013 NIH Grant for $163,958 for Coronary Plaque Characterization Utilizing Quantum Optics Approaches with OCT. The principal investigator is Mark Brezinski. The program began in 2012 and ends in 2014. Below is a summary of the proposed work. Myocardial infarctions (MI), the leading cause of mortality in industrialized countries, almost exclusively result from the rupture of small, thin walled, lipid filled plaques ...
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    12. Fossilized Teeth as a New Robust and Reproducible Standard for Polarization-Sensitive Optical Coherence Tomography

      Comment "After looking at many synthetic and some biological material for over a decade, we were surprised the Megalodon met our ..." - mebrezin
      Fossilized Teeth as a New Robust and Reproducible Standard for Polarization-Sensitive Optical Coherence Tomography
      A clinical need exists for a cheap and efficient standard for polarization sensitive optical coherence tomography (PS-OCT). We utilize prehistoric fossilized teeth from the Megalodon shark and European horse as an unconventional, yet robust standard. Given their easy accessibility and the microstructural consistency conferred by the process of fossilization, they provide a means of calibration to reduce error from sources such as catheter bending and temperature changes. We tested the ...
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    13. The Application of Optical Coherence Tomography in Musculoskeletal Disease

      The Application of Optical Coherence Tomography in Musculoskeletal Disease
      Many musculoskeletal disorders (MDs) are associated with irreversible bone and cartilage damage; this is particularly true for osteoarthritis (OA). Therefore, a clinical need exists for modalities which can detect OA and other MDs at early stages. Optical coherence tomography (OCT) is an infrared-based imaging, currently FDA approved in cardiology and ophthalmology, which has a resolution greater than 10 microns and acquisition rate of 120 frames/second. It has shown feasibility ...
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    14. 1-15 of 50 1 2 3 4 »
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  2. About Mark E. Brezinski

    Mark E. Brezinski

    Mark Edward Brezinski MD, PhD primary appointments are as faculty at Harvard Medical and Brigham and Women’s Hospital. His efforts span that of a scientist (bench to beside: engineering/physics to clinical trials) to a cardiologist. He has gained international recognition for pioneering efforts and advancing the field of optical coherence tomography (OCT), the micron-scale imaging technology. Since 2000, much of his efforts have been on adjuvant technologies including PS-OCT, OCT elastography, combined OCT-ultrasound, index matching, and quantum second order correlations with OCT. Dr. Brezinski has also made paradigm shifting advances in disciplines ranging from inflammatory cell regulation to quantum mechanical cell interactions to macroscopic quantum systems, with substantial potential impact to medicine beyond orthopedics and cardiology.

    Mark Brezinski MD, PhD is an internationally respected researcher most widely recognized as a pioneer of the OCT field (over 19 years). His work is truly translational research, spanning technology development, physical theory, bench top studies, and clinical trials. His work (along with collaborators and team members) in cardiology, in particular, translated a concept to an FDA approved interventional imaging technology. This was done in part through co-founding Lightlab Imaging that now sells cardiovascular OCT systems as a subsidiary of St. Jude Medical. For over 13 years, a primary focus has been to advance OCT for the diagnosis and treatment of musculoskeletal disease (MSD) and cardiology. In addition, he has made considerable contributions of applying quantum mechanical principles to medicine, both through technology development and understanding quantum cellular interactions. His efforts are also focused on quantum effects from indistinguishable paths rather than quantum entanglement.

    He is the author of over 150 publications, winner of many awards, including the Presidential Award from President Clinton, and routinely advises numerous Federal Agencies.

  3. Quotes

    1. Now that people are living longer, we want them to live healthier...As someone in the field since the original paper describing its utility, I think OCT has great potential to be high impact technology in managing cardiovascular disease.
      In With OCT, Image is Everything