1. Mark C. Pierce

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    1. Mentioned In 5 Articles

    2. Morphomechanics of dermis-A method for non-destructive testing of collagenous tissues

      Morphomechanics of dermis-A method for non-destructive testing of collagenous tissues
      Background Collagenous tissues store, transmit and dissipate elastic energy during mechanical deformation. In skin, mechanical energy is stored during loading and then is dissipated, which protects skin from mechanical failure. Thus, energy storage (elastic properties) and dissipation (viscous properties) are important characteristics of extracellular matrices (ECMs) that support the cyclic loading of ECMs without tissue failure. Methods Uniaxial stress-strain measurements on decellularized human dermis have been made and compared to ...
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      Mentions: Mark C. Pierce
    3. Large area 3-D optical coherence tomography imaging of lumpectomy specimens for radiation treatment planning

      Large area 3-D optical coherence tomography imaging of lumpectomy specimens for radiation treatment planning
      Our long term goal is to develop a high-resolution imaging method for comprehensive assessment of tissue removed during lumpectomy procedures. By identifying regions of high-grade disease within the excised specimen, we aim to develop patient-specific post-operative radiation treatment regimens. We have assembled a benchtop spectral-domain optical coherence tomography (SD-OCT) system with 1320 nm center wavelength. Automated beam scanning enables sub-volumes spanning 5 mm x 5 mm x 2 mm (500 ...
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      Mentions: Mark C. Pierce
    4. Snapshot 3D optical coherence tomography system using image mapping spectrometry

      Snapshot 3D optical coherence tomography system using image mapping spectrometry
      A snapshot 3-Dimensional Optical Coherence Tomography system was developed using Image Mapping Spectrometry. This system can give depth information (Z) at different spatial positions (XY) within one camera integration time to potentially reduce motion artifact and enhance throughput. The current (x,y, ) datacube of (85356117) provides a 3D visualization of sample with 400 m depth and 13.4 m in transverse resolution. Axial resolution of 16.0 m can also ...
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    5. In vivo imaging of human burn injuries with polarization-sensitive optical coherence tomography

      In vivo imaging of human burn injuries with polarization-sensitive optical coherence tomography
      The accurate determination of burn depth is critical in the clinical management of burn wounds. Polarization-sensitive optical coherence tomography (PS-OCT) has been proposed as a potentially non-invasive method for determining burn depth by measuring thermally induced changes in the structure and birefringence of skin, and has been investigated in pre-clinical burn studies with animal models and ex vivo human skin. In this study, we applied PS-OCT to the in-vivo imaging ...
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    6. Low-cost, portable optical imaging systems for cancer diagnosis

      Low-cost, portable optical imaging systems for cancer diagnosis
      Worldwide incidence and mortality rates due to cancer continue to rise, with the burden of disease increasingly shifting to developing countries. Several optical diagnostic methods such as diffuse optical tomography, wide-field autofluorescence imaging, confocal microscopy, and optical coherence tomography, are currently under development to enable earlier detection of cancer. However, these are primarily intended for use in healthcare facilities in industrialized countries. Using knowledge gained from early clinical studies with ...
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  2. About Mark C. Pierce

    Mark C. Pierce

    Mark C. Pierce is at the was a visiting professor at Wellman Center for Photomedicine and is currently an Assistant Professor in the Bioengineering Department at Rice University.