1. Marc D. Feldman

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    1. Mentioned In 47 Articles

    2. Clinical utility of quantitative bright spots analysis in patients with acute coronary syndrome: an optical coherence tomography study

      Clinical utility of quantitative bright spots analysis in patients with acute coronary syndrome: an optical coherence tomography study
      To investigate the clinical significance of bright spots in coronary plaque detected by optical coherence tomography (OCT) in patients with coronary artery disease. We identified 112 patients [acute coronary syndromes (ACS): n = 50, stable angina pectoris (SAP): n = 62] who underwent OCT imaging of the culprit lesion. A novel OCT algorithm was applied to detect bright spots representing the juxtaposition of a variety of plaque components including macrophages. The density ...
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    3. Translating Intravascular Optical Coherence Tomography from a Research to a Clinical Tool

      Translating Intravascular Optical Coherence Tomography from a Research to a Clinical Tool
      Intravascular optical coherence tomography (IVOCT) continues to be a hot topic as a method for studying vulnerable plaque in research laboratories across the globe. It is also growing in popularity as a tool for interventional cardiologists to guide percutaneous coronary intervention (PCI). The power of IVOCT for diagnosis of thin-capped fibroatheromas (TCFAs) has yet to receive mainstream clinical attention due to the fact that clinicians still do not have a ...
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    4. Can Multimodal Invasive Imaging Be Used to Predict Periprocedural Myocardial Infarctions?

      Can Multimodal Invasive Imaging Be Used to Predict Periprocedural Myocardial Infarctions?
      More than 1 million percutaneous coronary interventions (PCIs) are performed per year in the United States. Although technological advances have significantly improved outcomes following PCI, 5% to 44% of PCI patients still experience periprocedural myocardial infarction (PMI). PMI can be either macro-sized (coronary dissection or occlusion of a side branch) or microvascular such as distal embolization and/or microvascular plugging. PMIs have recently been defined as Type 4a: cardiac troponin ...
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    5. Detection of plaque structure and composition using OCT combined with two-photon luminescence (TPL) imaging

      Detection of plaque structure and composition using OCT combined with two-photon luminescence (TPL) imaging
      Background and Objectives Atherosclerosis and plaque rupture leads to myocardial infarction and stroke. A novel hybrid optical coherence tomography (OCT) and two-photon luminescence (TPL) fiber-based imaging system was developed to characterize tissue constituents in the context of plaque morphology. Study Design/Materials and Methods Ex vivo coronary arteries (34 regions of interest) from three human hearts with atherosclerotic plaques were examined by OCTTPL imaging. Histological sections (4m in thickness) were ...
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    6. Simultaneous morphological and biochemical endogenous optical imaging of atherosclerosis

      Simultaneous morphological and biochemical endogenous optical imaging of atherosclerosis
      Aims The aim of this study was to validate novel imaging technology for simultaneous morphological and biochemical endogenous optical imaging of coronary atherosclerotic plaque. Methods and results Optical coherence tomography (OCT) generates high-resolution 3D images of plaque morphology and endogenous fluorescence lifetime imaging microscopy (FLIM) characterizes biochemical composition. Both imaging modalities rely on plaque's intrinsic optical characteristics, making contrast agents unnecessary. A multimodal OCT/FLIM system was utilized to ...
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    7. Intravascular optical coherence tomography light scattering artifacts: merry-go-rounding, blooming, and ghost struts

      Intravascular optical coherence tomography light scattering artifacts: merry-go-rounding, blooming, and ghost struts
      We sought to elucidate the mechanisms underlying two common intravascular optical coherence tomography (IV-OCT) artifacts that occur when imaging metallic stents: merry-go-rounding (MGR), which is an increase in strut arc length (SAL), and blooming, which is an increase in the strut reflection thickness (blooming thickness). Due to uncontrollable variables that occur in vivo , we performed an in vitro assessment of MGR and blooming in stented vessel phantoms. Using Xience V ...
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    8. Macrophages and intravascular optical coherence tomography bright spots: a quantitative study

      Macrophages and intravascular optical coherence tomography bright spots: a quantitative study
      Objectives We hypothesized that bright spots in intravascular optical coherence tomography (IVOCT) images may originate by co-localization of plaque materials of differing indices of refraction (IR). To quantitatively identify bright spots, we developed an algorithm that accounts for factors including tissue depth, distance from light source, and signal-to-noise ratio. We used this algorithm to perform a bright spot analysis of IVOCT images, and compared these results with histologic examination of ...
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    9. Apparatus And Methods For Optical Coherence Tomography And TWO-PHOTON Luminescence Imaging

      Apparatus And Methods For Optical Coherence Tomography And TWO-PHOTON Luminescence Imaging
      Exemplary embodiments of the present disclosure include a combined catheter- based optical coherence tomography - two-photon luminescence (OCT-TPL) imaging system. Exemplary embodiments further include methods to detect, and further characterize the distribution of cellular components (e.g., macrophage, collagen/elastin fiber, lipid droplet) in thin-cap fibroatheromas with high spatial resolution in vivo.
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    10. Optical Coherent Tomography to guide below-the-knee endovascular interventions

      Optical Coherent Tomography to guide below-the-knee endovascular interventions
      Peripheral arterial disease remains a common cause of leg amputations causing significant morbidity and mortality. Data regarding below-the-knee endovascular interventions is scarce while long-term patency rates via different endovascular revascularization modalities remain limited. OCT offers excellent three dimension endothelial visualization; however its value to guide peripheral interventions has not been studied. We describe the use of OCT to guide endovascular below-the-knee interventions in order to achieve excellent OCT results.
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    11. Expert consensus statement on the use of fractional flow reserve, intravascular ultrasound, and optical coherence tomography a consensus statement of the society of cardiovascular angiography and interventions

      Expert consensus statement on the use of fractional flow reserve, intravascular ultrasound, and optical coherence tomography a consensus statement of the society of cardiovascular angiography and interventions
      ...nterventions 1. Amir Lotfi MD, FSCAI^1, 2. Allen Jeremias MD, FSCAI^2, 3. William F. Fearon MD, FSCAI^3, 4. Marc D. Feldman MD, FSCAI^4, 5. Roxana Mehran MD^5, 6. John C. Messenger MD, FSCAI^6, 7. Cindy L. Grines MD, F...
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  2. About Marc D. Feldman

    Marc D. Feldman

    Marc D. Feldman, M.D., Interventional cardiologist and researcher at the Health Science Center at the University of Texas in San Antonio. Also co-founder of CardioSpectra acquired by Volcano in 2007.

  3. Quotes

    1. The Clayton Foundation allows its investigators wider latitude in their research than traditional grant-funding agencies...As a result, rather than focusing on research that will lead to the next funded grant application, investigators can focus on what is most exciting and most likely to impact patient care.
      In Researchers Receive $300,000 Award to Advance Technology With Potential to Predict Heart Attacks