1. Marc D. Feldman

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    1. Mentioned In 41 Articles

    2. Macrophages and intravascular optical coherence tomography bright spots: a quantitative study

      Macrophages and intravascular optical coherence tomography bright spots: a quantitative study

      Objectives We hypothesized that bright spots in intravascular optical coherence tomography (IVOCT) images may originate by co-localization of plaque materials of differing indices of refraction (IR). To quantitatively identify bright spots, we developed an algorithm that accounts for factors including tissue depth, distance from light source, and signal-to-noise ratio. We used this algorithm to perform a bright spot analysis of IVOCT images, and compared these results with histologic examination of matching tissue sections. Background Although bright spots are thought to represent macrophages in IVOCT images, studies of alternative etiologies have not been reported. Methods Fresh human coronary arteries (n=14 ...

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    3. Apparatus And Methods For Optical Coherence Tomography And TWO-PHOTON Luminescence Imaging

      Apparatus And Methods For Optical Coherence Tomography And TWO-PHOTON Luminescence Imaging

      Exemplary embodiments of the present disclosure include a combined catheter- based optical coherence tomography - two-photon luminescence (OCT-TPL) imaging system. Exemplary embodiments further include methods to detect, and further characterize the distribution of cellular components (e.g., macrophage, collagen/elastin fiber, lipid droplet) in thin-cap fibroatheromas with high spatial resolution in vivo.

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    4. Optical Coherent Tomography to guide below-the-knee endovascular interventions

      Optical Coherent Tomography to guide below-the-knee endovascular interventions

      Peripheral arterial disease remains a common cause of leg amputations causing significant morbidity and mortality. Data regarding below-the-knee endovascular interventions is scarce while long-term patency rates via different endovascular revascularization modalities remain limited. OCT offers excellent three dimension endothelial visualization; however its value to guide peripheral interventions has not been studied. We describe the use of OCT to guide endovascular below-the-knee interventions in order to achieve excellent OCT results.

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    5. Expert consensus statement on the use of fractional flow reserve, intravascular ultrasound, and optical coherence tomography a consensus statement of the society of cardiovascular angiography and interventions

      Expert consensus statement on the use of fractional flow reserve, intravascular ultrasound, and optical coherence tomography a consensus statement of the society of cardiovascular angiography and interventions
      ...nterventions 1. Amir Lotfi MD, FSCAI^1, 2. Allen Jeremias MD, FSCAI^2, 3. William F. Fearon MD, FSCAI^3, 4. Marc D. Feldman MD, FSCAI^4, 5. Roxana Mehran MD^5, 6. John C. Messenger MD, FSCAI^6, 7. Cindy L. Grines MD, F...
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    6. Intravascular optical coherence tomography measurement of size and apposition of metallic stents

      Intravascular optical coherence tomography measurement of size and apposition of metallic stents

      Effect of beam size and catheter position on the apparent size and apposition of metallic stent struts in IVOCT images were examined. Micro-CT data was employed to determine light - stent strut interactions. Simulated results suggest that location of the reflecting regions depend on relative orientation and position of stent struts to the IVOCT beam. Erroneous stent apposition measurements can occur when the IVOCT catheter is at an eccentric position. A method that mitigates stent strut apposition measurement errors is proposed.

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    7. Development and application of optical imaging techniques in diagnosing cardiovascular disease (Thesis)

      Development and application of optical imaging techniques in diagnosing cardiovascular disease (Thesis)

      Atherosclerosis and specifically rupture of vulnerable plaques account for 23% of all deaths worldwide, far surpassing both infectious diseases and cancer. Plaque-based macrophages, often associated with lipid deposits, contribute to atherogenesis from initiation through progression, plaque rupture and ultimately, thrombosis. Therefore, the macrophage is an important early cellular marker related to vulnerability of atherosclerotic plaques. The objective of my research is to assess the ability of multiple optical imaging modalities to detect, and further characterize the distribution of macrophages (having taken up plasmonic gold nanoparticles as a contrast agent) and lipid deposits in atherosclerotic plaques. Tissue phantoms and macrophage cell ...

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  2. About Marc D. Feldman

    Marc D. Feldman

    Marc D. Feldman, M.D., Interventional cardiologist and researcher at the Health Science Center at the University of Texas in San Antonio. Also co-founder of CardioSpectra acquired by Volcano in 2007.

  3. Quotes

    1. The Clayton Foundation allows its investigators wider latitude in their research than traditional grant-funding agencies...As a result, rather than focusing on research that will lead to the next funded grant application, investigators can focus on what is most exciting and most likely to impact patient care.
      In Researchers Receive $300,000 Award to Advance Technology With Potential to Predict Heart Attacks