Method for quantitative assessment of retinal vessel tortuosity in optical coherence tomography angiography applied to sickle cell retinopathy

Tortuosity is an important geometric vessel parameter and among the first microvascular alterations observed in various retinopathies. In the current study, a quantitative vessel tortuosity index (VTI) based on a combination of local and global centerline features is presented. Performance of VTI and previously established tortuosity indices were compared against human observers evaluation of tortuosity. An imageprocessing pipeline was developed for application of VTI in retinal vessels imaged by optical ...
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