1. Maciej Szkulmowski

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    1. Mentioned In 59 Articles

    2. Optical coherence microscopy as a novel, non-invasive method for the 4D live imaging of early mammalian embryos

      Optical coherence microscopy as a novel, non-invasive method for the 4D live imaging of early mammalian embryos
      Imaging of living cells based on traditional fluorescence and confocal laser scanning microscopy has delivered an enormous amount of information critical for understanding biological processes in single cells. However, the requirement for a high numerical aperture and fluorescent markers still limits researchers ability to visualize the cellular architecture without causing short- and long-term photodamage. Optical coherence microscopy (OCM) is a promising alternative that circumvents the technical limitations of fluorescence imaging ...
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    3. Spectrometer calibration for spectroscopic Fourier domain optical coherence tomography

      Spectrometer calibration for spectroscopic Fourier domain optical coherence tomography
      We propose a simple and robust procedure for Fourier domain optical coherence tomography (FdOCT) that allows to linearize the detected FdOCT spectra to wavenumber domain and, at the same time, to determine the wavelength of light for each point of detected spectrum. We show that in this approach it is possible to use any measurable physical quantity that has linear dependency on wavenumber and can be extracted from spectral fringes ...
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    4. Extended-focus optical coherence microscopy for high-resolution imaging of the murine brain

      Extended-focus optical coherence microscopy for high-resolution imaging of the murine brain
      We propose a new method and optical instrumentation for mouse brain imaging based on extended-focus optical coherence microscopy. This in vivo imaging technique allows the evaluation of the cytoarchitecture at cellular level and the circulation system dynamics in three dimensions. This minimally invasive and non-contact approach is performed without the application of contrasting agents. The optical design achieved a resolution of 2.2 m over a distance of 800 m ...
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    5. Method and apparatus for imaging of semi-transparent matter

      Method and apparatus for imaging of semi-transparent matter
      The invention relates to a method and apparatus for measuring the spatial and velocity distribution of scattering structures of a sample in semi-transparent matter. The acquired spectral data I(k, t) are transformed in two steps to image data I(z, v). A Doppler shift is imposed on the light to a separate real and mirror images in the v space to suppress the complex ambiguity artifact.
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    6. Image capturing apparatus, image capturing method, and storage medium

      Image capturing apparatus, image capturing method, and storage medium
      An image capturing apparatus includes a dividing unit configured to divide light from a light source into reference light and measurement light; a first dichroic mirror arranged in a measurement optical path for guiding the measurement light to an object to be examined; a second dichroic mirror arranged in a reference optical path for guiding the reference light to a reference object; and a light receiving unit configured to receive ...
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    7. Imaging of the stroke-related changes in the vascular system of the mouse brain with the use of extended focus Optical Coherence Microscopy

      Imaging of the stroke-related changes in the vascular system of the mouse brain with the use of extended focus Optical Coherence Microscopy
      We used Optical Coherence Microscopy (OCM) to monitor structural and functional changes due to ischemic stroke in small animals brains in vivo. To obtain lateral resolution of 2.2 m over the range of 600 m we used extended focus configuration of OCM instrument involving Bessel beam. It provided access to detailed 3D information about the changes in brain vascular system up to the level of capillaries across I and ...
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    8. Spectral optical coherence tomography

      Spectral optical coherence tomography
      The invention relates to an apparatus for generating a scannable optical delay for a beam of light and an apparatus for Fourier domain optical coherence tomography having said apparatus for generating a scannable optical delay in its reference arm (15). The light beam is directed to a pivotably driven mirror (10) from where it is reflected to a fixed mirror (12), and from there back retro reflected along the reference ...
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    9. Multimodal instrument for high-sensitivity autofluorescence and spectral optical coherence tomography of the human eye fundus

      Multimodal instrument for high-sensitivity autofluorescence and spectral optical coherence tomography of the human eye fundus
      ...ojtkowski »View Author Affiliations Katarzyna Komar,^1,^2 Patrycjusz Stremplewski,^1,^2 Marta Motoczyńska,^1 Maciej Szkulmowski,^1 and Maciej Wojtkowski^1,^* ^1Institute of Physics, Faculty of Physics, Astronomy and I...
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    10. Assessment of the flow velocity of blood cells in a microfluidic device using joint spectral and time domain optical coherence tomography

      Assessment of the flow velocity of blood cells in a microfluidic device using joint spectral and time domain optical coherence tomography
      ...and Maciej Wojtkowski »View Author Affiliations Danuta M. Bukowska,^1 Ladislav Derzsi,^2 Szymon Tamborski,^1 Maciej Szkulmowski,^1 Piotr Garstecki,^2 and Maciej Wojtkowski^1,^* ^1Institute of Physics, Faculty of Physi...
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    11. Quantitative lateral and axial flow imaging with optical coherence microscopy and tomography

      Quantitative lateral and axial flow imaging with optical coherence microscopy and tomography
      Optical coherence tomography (OCT) and optical coherence microscopy (OCM) allow the acquisition of quantitative three-dimensional axial flow by estimating the Doppler shift caused by moving scatterers. Measuring the velocity of red blood cells is currently the principal application of these methods. In many biological tissues, blood flow is often perpendicular to the optical axis, creating the need for a quantitative measurement of lateral flow. Previous work has shown that lateral ...
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    12. Angio-OCT as a noninvasive tool for three-dimensional vascular network visualization in retinal diseases

      Angio-OCT as a noninvasive tool for three-dimensional vascular network visualization in retinal diseases
      In this paper we demonstrate applicability of intensity-based optical coherence tomography technique for noninvasive visualization of 3D retinal microcapillary network. The study was performed with ultra high resolution and high speed (180,000 Ascans/sec) spectral optical coherence tomography (SOCT). New scanning protocols and data processing algorithms have been introduced to visualize microcapillary network. Moreover, results obtained in the eyes of healthy volunteers and patients with eye diseases were compared ...
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    13. Averaging techniques for OCT imaging

      Averaging techniques for OCT imaging
      State-of-the-art Fourier-domain optical coherence tomography (OCT) allows for the acquisition of up to millions of spectral fringes per second. This large amount of data can be used to improve the quality of structural tomograms after effective averaging. Here, we compare three OCT image improvement techniques: magnitude averaging, complex averaging, and spectral and time domain OCT (STdOCT). We evaluate the performance for images on both linear and logarithmic intensity scales and ...
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    14. Feature Of The Week 11/25/12: Nicolaus Copernicus University Presents Work on Four-Dimensional OCT Imaging Using Graphics Processing Units

      Feature Of The Week 11/25/12: Nicolaus Copernicus University Presents Work on Four-Dimensional OCT Imaging Using Graphics Processing Units
      Nicolaus Copernicus University present the application of graphics processing unit (GPU) programming for real-time three-dimensional (3-D) Fourier domain optical coherence tomography (FdOCT) imaging with implementation of flow visualization algorithms. One of the limitations of FdOCT is data processing time, which is generally longer than data acquisition time. Utilizing additional algorithms, such as Doppler analysis, further increases computation time. The general purpose computing on GPU (GPGPU) has been used successfully for ...
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    15. 1-15 of 59 1 2 3 4 »
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  2. About Maciej Szkulmowski

    Maciej Szkulmowski is an Assistant Professor in the Medical Physics Group at the Institute of Physics at Nicolaus Copernicus University.