1. Maciej Szkulmowski

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    1. Mentioned In 65 Articles

    2. Spectral and time domain optical coherence spectroscopy

      Spectral and time domain optical coherence spectroscopy
      We propose a novel method for spectroscopic optical coherence tomography (OCT). This method uses the dependence of the Doppler frequency spectrum on the wavenumber. Controlled modulation of the light in the spectral OCT interferometer allows for an instantaneous depth-resolved reconstruction of the backscattered light spectrum from all depths. The feasibility of the spectroscopic analysis using the proposed scheme was confirmed experimentally.
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    3. Blood flow rate estimation in optic disc capillaries and vessels using Doppler optical coherence tomography with 3D fast phase unwrapping

      Blood flow rate estimation in optic disc capillaries and vessels using Doppler optical coherence tomography with 3D fast phase unwrapping
      The retinal volumetric flow rate contains useful information not only for ophthalmo-logy but also for the diagnosis of common civilization diseases such as diabetes, Alzheimer's disease, or cerebrovascular diseases. Non-invasive optical methods for quantitative flow assessment, such as Doppler optical coherence tomography (OCT), have certain limitations. One is the phase wrapping that makes simultaneous calculations of the flow in all human retinal vessels impossible due to a very large ...
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    4. In vivo brain imaging with multimodal optical coherence microscopy in a mouse model of thromboembolic photochemical stroke

      In vivo brain imaging with multimodal optical coherence microscopy in a mouse model of thromboembolic photochemical stroke
      We used a new multimodal imaging system that combines optical coherence microscopy and brightfield microscopy. Using this in vivo brain monitoring approach and cranial window implantation, we three-dimensionally visualized the vascular network during thrombosis, with high temporal (18 s) and spatial (axial, 2.5m; lateral, 2.2m) resolution. We used a modified mouse model of photochemical thromboembolic stroke in order to more accurately parallel human stroke. Specifically, we applied green ...
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    5. Computationally effective 2D and 3D fast phase unwrapping algorithms and their applications to Doppler optical coherence tomography

      Computationally effective 2D and 3D fast phase unwrapping algorithms and their applications to Doppler optical coherence tomography
      We propose a simplification for a robust and easy to implement fast phase unwrapping (FPU) algorithm that is used to solve the phase wrapping problem encountered in various fields of optical imaging and metrology. We show that the number of necessary computations using the algorithm can be reduced compared to its original version. FPU can be easily extended from two to three spatial dimensions. We demonstrate the applicability of the ...
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    6. Retina Tomography and Optical Coherence Tomography in Eye Diagnostic System

      Retina Tomography and Optical Coherence Tomography in Eye Diagnostic System
      Eye diagnostic, two-step method based on retina color image and Optical Coherence Tomography is presented in this paper. A new robust algorithm, by which various eye diseases can be diagnosed, was implemented as an essential part of the work. The approach comprises two steps. The first one deals with the analysis of retina color image. In this stage, an algorithm was implemented to especially search hard exudates. If the algorithm ...
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    7. Feature Of The Week 10/08/2017: Optical Coherence Microscopy as a Novel, Non-Invasive Method for the 4D Live Imaging of Early Mammalian Embryos

      Feature Of The Week 10/08/2017: Optical Coherence Microscopy as a Novel, Non-Invasive Method for the 4D Live Imaging of Early Mammalian Embryos
      Imaging of living cells based on traditional fluorescence and confocal laser scanning microscopy has delivered an enormous amount of information critical for understanding biological processes in single cells. However, the requirement for a high numerical aperture and fluorescent markers still limits researchers ability to visualize the cellular architecture without causing short- and long-term photodamage. Optical coherence microscopy (OCM) is a promising alternative that circumvents the technical limitations of fluorescence imaging ...
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    8. Optical coherence microscopy as a novel, non-invasive method for the 4D live imaging of early mammalian embryos

      Optical coherence microscopy as a novel, non-invasive method for the 4D live imaging of early mammalian embryos
      Imaging of living cells based on traditional fluorescence and confocal laser scanning microscopy has delivered an enormous amount of information critical for understanding biological processes in single cells. However, the requirement for a high numerical aperture and fluorescent markers still limits researchers ability to visualize the cellular architecture without causing short- and long-term photodamage. Optical coherence microscopy (OCM) is a promising alternative that circumvents the technical limitations of fluorescence imaging ...
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    9. Spectrometer calibration for spectroscopic Fourier domain optical coherence tomography

      Spectrometer calibration for spectroscopic Fourier domain optical coherence tomography
      We propose a simple and robust procedure for Fourier domain optical coherence tomography (FdOCT) that allows to linearize the detected FdOCT spectra to wavenumber domain and, at the same time, to determine the wavelength of light for each point of detected spectrum. We show that in this approach it is possible to use any measurable physical quantity that has linear dependency on wavenumber and can be extracted from spectral fringes ...
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    10. Extended-focus optical coherence microscopy for high-resolution imaging of the murine brain

      Extended-focus optical coherence microscopy for high-resolution imaging of the murine brain
      We propose a new method and optical instrumentation for mouse brain imaging based on extended-focus optical coherence microscopy. This in vivo imaging technique allows the evaluation of the cytoarchitecture at cellular level and the circulation system dynamics in three dimensions. This minimally invasive and non-contact approach is performed without the application of contrasting agents. The optical design achieved a resolution of 2.2 m over a distance of 800 m ...
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    11. Method and apparatus for imaging of semi-transparent matter

      Method and apparatus for imaging of semi-transparent matter
      The invention relates to a method and apparatus for measuring the spatial and velocity distribution of scattering structures of a sample in semi-transparent matter. The acquired spectral data I(k, t) are transformed in two steps to image data I(z, v). A Doppler shift is imposed on the light to a separate real and mirror images in the v space to suppress the complex ambiguity artifact.
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    12. Image capturing apparatus, image capturing method, and storage medium

      Image capturing apparatus, image capturing method, and storage medium
      An image capturing apparatus includes a dividing unit configured to divide light from a light source into reference light and measurement light; a first dichroic mirror arranged in a measurement optical path for guiding the measurement light to an object to be examined; a second dichroic mirror arranged in a reference optical path for guiding the reference light to a reference object; and a light receiving unit configured to receive ...
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    13. Imaging of the stroke-related changes in the vascular system of the mouse brain with the use of extended focus Optical Coherence Microscopy

      Imaging of the stroke-related changes in the vascular system of the mouse brain with the use of extended focus Optical Coherence Microscopy
      We used Optical Coherence Microscopy (OCM) to monitor structural and functional changes due to ischemic stroke in small animals brains in vivo. To obtain lateral resolution of 2.2 m over the range of 600 m we used extended focus configuration of OCM instrument involving Bessel beam. It provided access to detailed 3D information about the changes in brain vascular system up to the level of capillaries across I and ...
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    14. Spectral optical coherence tomography

      Spectral optical coherence tomography
      The invention relates to an apparatus for generating a scannable optical delay for a beam of light and an apparatus for Fourier domain optical coherence tomography having said apparatus for generating a scannable optical delay in its reference arm (15). The light beam is directed to a pivotably driven mirror (10) from where it is reflected to a fixed mirror (12), and from there back retro reflected along the reference ...
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  2. About Maciej Szkulmowski

    Maciej Szkulmowski is an Assistant Professor in the Medical Physics Group at the Institute of Physics at Nicolaus Copernicus University.