1. Ludwig Maximilian University of Munich

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    1. Mentioned In 155 Articles

    2. Corneal optical density in Fuchs endothelial dystrophy determined by anterior segment optical coherence tomography

      Corneal optical density in Fuchs endothelial dystrophy determined by anterior segment optical coherence tomography
      Purpose: In this study, we propose a method to grade corneal stromal opacity using optical density measurements by anterior segment optical coherence tomography (AS-OCT) and validate the approach in Fuchs endothelial corneal dystrophy (FECD). Methods: A retrospective analysis of human corneal OCT scans was performed on 48 eyes of 32 patients with FECD and 33 control eyes of 21 patients using the Carl Zeiss Cirrus HD-OCT 5000. In addition, corneal ...
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    3. In vivo Imaging of Sarcoptes scabiei infestation using Line‐field Confocal Optical Coherence Tomography

      In vivo Imaging of Sarcoptes scabiei infestation using Line‐field Confocal Optical Coherence Tomography
      Scabies remains a worldwide spread disease of considerable health and economic burden with repeated outbreaks in community settings.(1) Scabies agent is the ectoparasite Sarcoptes scabiei var. hominis ; this invisible mite causes a progressive rash, which can be misdiagnosed with eczema or pruritus sine materia . Diagnosis is based on characteristic clinical features (intense nightly itch, inflammatory excoriated papules in typical sites) and history of contact to infected patients.
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    4. OCT angiography in optic disc drusen: comparison with structural and functional parameters

      OCT angiography in optic disc drusen: comparison with structural and functional parameters
      Background Optic disc drusen (ODD) can cause retinal nerve fibre layer (RNFL) defects with progressive visual field (VF) loss. Microvascular changes are discussed as a cause. We measured the vessel density (VD) of the optic disc in ODD using optical coherence tomography angiography and compared it with a normal population. Another intent was to determine the sensitivity and correlations in comparison with functional (VF) and structural parameters (RNFL, minimum rim ...
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    5. Effects of Flavanol-Rich Dark Chocolate on Visual Function and Retinal Perfusion Measured With Optical Coherence Tomography Angiography

      Effects of Flavanol-Rich Dark Chocolate on Visual Function and Retinal Perfusion Measured With Optical Coherence Tomography Angiography
      Importance A recently reported randomized clinical trial suggested beneficial effects of vasodilating flavanols in dark chocolate on visual function without objective quantification of retinal perfusion. Objective To assess the effects of dark chocolate flavanols on subjective visual function and retinal perfusion objectively quantified on optical coherence tomography (OCT) angiography. Design, Setting, and Participants This randomized, masked double-blind crossover clinical trial analyzed 22 healthy participants at the Department of Ophthalmology, Ludwig ...
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    6. Nickel contact dermatitis evaluated by means of optical coherence tomography: first impressions

      Nickel contact dermatitis evaluated by means of optical coherence tomography: first impressions
      Nickel contact allergy, a major health problem in the general population, is usually diagnosed through appropriate clinical history and patch testing.(1, 2) Patch‐test results are not fully objectivable and are influenced by the observer's experience.(3) Moreover, not every individual with nickel‐sensitization develops a clinically visible contact allergy. We hypothesized that non‐invasive diagnostic techniques such as optical coherence tomography (OCT) could provide further details in ...
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    7. Vitrectomy for diabetic macular edema: optical coherence tomography criteria and pathology of the vitreomacular interface

      Vitrectomy for diabetic macular edema: optical coherence tomography criteria and pathology of the vitreomacular interface
      Purpose To correlate spectral-domain optical coherence tomography (SD-OCT) criteria and clinical data with pathology of the vitreomacular interface (VMI) in eyes with diabetic macular edema (DME). Design Retrospective cross-sectional study and laboratory investigation. Methods We included specimens of 27 eyes of 26 patients with center-involved DME that underwent vitrectomy with peeling of the internal limiting membrane (ILM). Selection of specimens was consecutive and in retrospect using our register of the ...
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    8. Neoatherosclerosis in Patients With Coronary Stent Thrombosis: Findings From Optical Coherence Tomography Imaging (A Report of the PRESTIGE Consortium)

      Neoatherosclerosis in Patients With Coronary Stent Thrombosis: Findings From Optical Coherence Tomography Imaging (A Report of the PRESTIGE Consortium)
      Objectives The purpose of this study was to assess neoatherosclerosis in a registry of prospectively enrolled patients presenting with stent thrombosis using optical coherence tomography . Background In-stent neoatherosclerosis was recently identified as a novel disease manifestation of atherosclerosis after coronary stent implantation. Methods Angiography and intravascular optical coherence tomography were used to investigate etiologic factors of neoatherosclerosis in patients presenting with stent thrombosis 1 year after implantation (very late stent ...
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    9. The Relationship Between Blue-Fundus Autofluorescence and Optical Coherence Tomography in Eyes With Lamellar Macular Holes

      The Relationship Between Blue-Fundus Autofluorescence and Optical Coherence Tomography in Eyes With Lamellar Macular Holes
      Purpose : The purpose of this study was to evaluate the relationship between blue-fundus autofluorescence (B-FAF) and optical coherence tomography (OCT) in eyes with lamellar macular holes (LMHs). Methods : this was a multicenter, observational case series. Ninety-two eyes with LMH associated with the standard epiretinal membrane (ERM) or lamellar holeassociated epiretinal proliferation (LHEP) were evaluated. The eyes must also present an area of increased autofluorescence on B-FAF. Results : The ERM-alone group ...
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    10. Swept source OCT system and method with phase-locked detection

      Swept source OCT system and method with phase-locked detection
      A swept source OCT system and related method are disclosed. The system comprises a control device for operating a tunable light source in response to an electronic sweep control signal such that the tunable light source carries out wave length sweeps with a repetition rate f.sub.sweep, which depends on the frequency of the sweep control signal. The system further comprises a detection device for the time-resolved detection of ...
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    11. Impact of Preinjection Spectral Domain Optical Coherence Tomography Findings in the Use of Intravitreal Ocriplasmin in a Clinical Setting

      Impact of Preinjection Spectral Domain Optical Coherence Tomography Findings in the Use of Intravitreal Ocriplasmin in a Clinical Setting
      To investigate the impact of spectral domain optical coherence tomography (SD-OCT) morphological predictive markers on visual acuity and outcome using ocriplasmin for macular hole and vitreomacular traction syndrome. Methods: A series of 40 patients in a retrospective study received intravitreal ocriplasmin. The primary endpoint was defined as morphological resolution of vitreomacular traction or closure of a macular hole. We analyzed the impact of pre- and postinjection SD-OCT findings on the ...
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    12. Optical Coherence Tomography Findings in Patients with Coronary Stent Thrombosis: A Report of the PREvention of Late Stent Thrombosis by an Interdisciplinary Global European Effort (PRESTIGE) Consortium

      Optical Coherence Tomography Findings in Patients with Coronary Stent Thrombosis: A Report of the PREvention of Late Stent Thrombosis by an Interdisciplinary Global European Effort (PRESTIGE) Consortium
      Background Stent thrombosis (ST) is a serious complication following coronary stenting. Intravascular optical coherence tomography (OCT) may provide insights into mechanistic processes leading to ST. We performed a prospective, multicenter study to evaluate OCT findings in patients with ST. Methods Consecutive patients presenting with ST were prospectively enrolled in a registry using a centralized telephone registration system. After angiographic confirmation of ST, OCT imaging of the culprit vessel was performed ...
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    13. Method for reducing the dimensionality of a spatially registered signal derived from the optical properties of a sample, and device therefor

      Method for reducing the dimensionality of a spatially registered signal derived from the optical properties of a sample, and device therefor
      At least one embodiment of the method is designed to create a two-dimensional image of a three-dimensional sample. The method comprises the following steps: provision of a wave-length-tunable light source (1) that emits primary radiation (P) with wavelengths that vary over time; sampling of location points of the sample (2) with the primary radiation (P); collection of secondary radiation (S), wherein the secondary radiation (S) is a part of the ...
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    14. ReLayNet: Retinal Layer and Fluid Segmentation of Macular Optical Coherence Tomography using Fully Convolutional Network

      ReLayNet: Retinal Layer and Fluid Segmentation of Macular Optical Coherence Tomography using Fully Convolutional Network
      Optical coherence tomography (OCT) is extensively used for diagnosis of diabetic macular edema due to its non-invasive imaging based assessment of the retinal layers. In this paper, we propose a new fully convolutional deep learning architecture, termed ReLayNet, for segmentation of retinal layers and fluid masses in eye OCT scans. ReLayNet uses a contracting path of convolutional blocks (encoders) to learn a heirarchy of contextual features, followed by an expansive ...
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    15. Detection of cervical intraepithelial neoplasia by using optical coherence tomography in combination with microscopy

      Detection of cervical intraepithelial neoplasia by using optical coherence tomography in combination with microscopy
      Optical coherence tomography (OCT) is a noninvasive high-resolution imaging technique that permits the detection of cancerous and precancerous lesions of the uterine cervix. The purpose of this study was to evaluate a new system that integrates an OCT device into a microscope. OCT images were taken from loop electrosurgical excision procedure (LEEP) specimens under microscopic guidance. The images were blinded with respect to their origin within the microscopic image and ...
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    16. Corneal Epithelial Remodeling Induced by Small Incision Lenticule Extraction (SMILE)

      Corneal Epithelial Remodeling Induced by Small Incision Lenticule Extraction (SMILE)
      Purpose : To assess the reactive changes of the corneal epithelial thickness (ET) profile induced by small incision lenticule extraction (SMILE) for treatment of myopia. Methods : This prospective observational study included 46 eyes of 23 patients that were scheduled for myopic SMILE. High-resolution spectral-domain optical coherence tomography (SD-OCT) and a custom image segmentation algorithm were applied to measure corneal ET at multiple time points within the central 5-mm zone. Postoperative ET ...
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  2. About Ludwig Maximilian University of Munich

    Ludwig Maximilian University of Munich (Ludwig-Maximilians-Universität München), also known as LMU, is a university in Munich and, with more than 44,000 students, is the second-largest university in Germany. The majority of foreign exchanges at the University of Munich are with European universities. The main building is situated in Ludwigstrasse. The university's main campus is served by the Munich U-Bahn's Universität station.