1. Lotte Themstrup

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    1. Mentioned In 28 Articles

    2. Optical coherence tomography of onychomycosis: proposed terminology and a suggestion of practical usage

      Optical coherence tomography of onychomycosis: proposed terminology and a suggestion of practical usage
      Onychomycosis is the most common cause of nail changes accounting for about half of all nail diseases. It is important to diagnose the fungal pathogen to prescribe adequate treatment, but as genus- and species-specific diagnostic tests can be time consuming and expensive, it is crucial to obtain representative tissue during nail scrapings. Optical coherence tomography (OCT) is a non-invasive imaging tool enabling real-time imaging of skin and tissue. Pilot studies ...
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    3. The vascular morphology of melanoma is related to Breslow index: an in vivo study with dynamic optical coherence tomography

      The vascular morphology of melanoma is related to Breslow index: an in vivo study with dynamic optical coherence tomography
      Background Malignant melanoma is an aggressive skin cancer, which can lead to metastasis development. Vascularization enhancement is fundamental for tumor growth, worsening the prognosis. Dynamic Optical Coherence Tomography (D‐OCT) enables the in vivo evaluation of vascular patterns in skin lesions. Objective In vivo evaluation of the melanoma vessel morphology by means of D‐OCT and correlation with Breslow index. Methods Retrospective analysis of histologically proven melanomas, evaluated by D ...
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    4. Dynamic optical coherence tomography of histamine induced wheals

      Dynamic optical coherence tomography of histamine induced wheals
      Background Dynamic optical coherence tomography (D‐OCT) is a noninvasive imaging technique providing images of the skin and detecting movement in the tissue ie, measuring blood flow. The attenuation coefficient describes light absorption and scattering abilities of the tissue, while the dynamic signal provides a quantitative measure of the blood flow. Aim The study objective is to describe the dynamic changes of the skin and skin vessels during histamine release ...
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    5. Dynamic optical coherence tomography of skin blood vessels – proposed terminology and practical guidelines

      Dynamic optical coherence tomography of skin blood vessels – proposed terminology and practical guidelines
      Background Dynamic optical coherence tomography (D-OCT) has recently been introduced in dermatology. In contrast to Standard OCT imaging, which exclusively relies on the morphological analysis of the tissue, D-OCT allows the in-vivo visualisation of blood flow. Preliminary D-OCT data showed differences in the vascularisation of nevus to melanoma transition, suggesting that this technology may help to differentiate between benign and malignant lesions. Objective Several factors may influence the quality of ...
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    6. In vivo measurements of blood vessels’ distribution in non-melanoma skin cancer by dynamic optical coherence tomography — a new quantitative measure?

      In vivo measurements of blood vessels’ distribution in non-melanoma skin cancer by dynamic optical coherence tomography — a new quantitative measure?
      Background Skin biopsies only provide point-in-time data making longitudinal studies difficult. Using Dynamic optical coherence tomography (D-OCT) in vivo , non-invasive imaging of the microvasculature becomes possible. The current OCT literature is almost exclusively based on qualitative information but quantitative data may offer additional advantages, for example, by reducing observer variation. The objective of this study was to evaluate the in vivo superficial distribution of blood vessels, defined as the surface-to-first-vessel ...
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    7. In vivo microvascular imaging of cutaneous actinic keratosis, Bowen's disease and squamous cell carcinoma using Dynamic optical coherence tomography

      In vivo microvascular imaging of cutaneous actinic keratosis, Bowen's disease and squamous cell carcinoma using Dynamic optical coherence tomography
      Background A clear distinction between actinic keratosis (AK), Bowen's disease (BD) and squamous cell carcinoma (SCC) cannot reliably be made by clinical and dermoscopic evaluation alone. Dynamic optical coherence tomography (D-OCT) is a novel angiographic variant of OCT that allows for non-invasive, in vivo evaluation of the cutaneous microvascular morphology. Objective To investigate the microvascular structures of AK, BD and invasive SCC using D-OCT in order to gain insights ...
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    8. Optical coherence tomography in the diagnosis of actinic keratosis – A systematic review

      Optical coherence tomography in the diagnosis of actinic keratosis – A systematic review
      Background Optical coherence tomography (OCT) is a real-time non-invasive imaging tool, introduced in dermatology in the late 1990s. OCT uses near-infrared light impulses to produce images which can be displayed in cross-sectional and en-face mode. The technique has been used to image skin diseases especially non-melanoma skin cancer including actinic keratosis (AK). Morphological characteristics of AK can be visualized in OCT images and can be used for diagnosis as well ...
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    9. Diagnostic accuracy of optical coherence tomography in actinic keratosis and basal cell carcinoma

      Diagnostic accuracy of optical coherence tomography in actinic keratosis and basal cell carcinoma
      Background Early diagnosis of non-melanoma skin cancer (NMSC) is potentially possible using optical coherence tomography (OCT) which provides non-invasive, real-time images of skin with micrometre resolution and an imaging depth of up to 2 mm. OCT technology for skin imaging has undergone significant developments, improving image quality substantially. The diagnostic accuracy of any method is influenced by continuous technological development making it necessary to regularly re-evaluate methods. Objective The objective ...
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    10. Dynamic Optical Coherence Tomography Capillaroscopy A New Imaging Tool in Autoimmune Connective Tissue Disease

      Dynamic Optical Coherence Tomography Capillaroscopy A New Imaging Tool in Autoimmune Connective Tissue Disease
      Importance Vasculopathy characterized by functional and structural abnormalities of the microcirculation plays an important role in systemic sclerosis and dermatomyositis. Although there are several advantages in using capillaroscopy, the method does not offer insight on the skin architecture, flow status, or morphology of the deeper dermal vessels. Dynamic optical coherence tomography (D-OCT) is a recently developed OCT technique that enables detection of high-speed changes in back-scattered light caused by moving ...
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    11. Optical coherence tomography of basal cell carcinoma: density and signal attenuation

      Optical coherence tomography of basal cell carcinoma: density and signal attenuation
      Background Basal cell carcinoma (BCC) is the most prevalent malignancy in Caucasians. Optical coherence tomography (OCT) is a non-invasive optical imaging technology using the principle of interferometry. OCT has shown a great potential in diagnosing, monitoring, and follow-up of BCC. So far most OCT studies on the subject of BCC have had a qualitative focus, i.e. on morphological analysis of the OCT images. The aim of this study was ...
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    12. Validation of Dynamic optical coherence tomography for non-invasive, in vivo microcirculation imaging of the skin

      Validation of Dynamic optical coherence tomography for non-invasive, in vivo microcirculation imaging of the skin
      Objectives Dynamic optical coherence tomography (D-OCT) is anangiographic variation of OCT that non-invasively provides images of the in vivo microvasculature of the skin by combining conventional OCT images with flow data. The objective of this study was to investigate and report on the D-OCT technique for imaging of the vascular networks in skin as well as to validate the method by comparing the results against already accepted blood flow measuring ...
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    13. Adjunct use of optical coherence tomography increases the detection of recurrent basal cell carcinoma over clinical and dermoscopic examination alone

      Adjunct use of optical coherence tomography increases the detection of recurrent basal cell carcinoma over clinical and dermoscopic examination alone
      Background Basal cell carcinoma (BCC) is a locally destructive form of skin cancer, mainly affecting Caucasians. In the last few years non-surgical treatments of BCC have become widely used and non-invasive methods for treatment monitoring and follow-up are therefore becoming increasingly warranted. The objective of this study was to investigate the utility of adjunct use of non-invasive optical coherence tomography (OCT) imaging for the detection of recurrent BCC over clinical ...
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    14. Dynamic Optical Coherence Tomography in Dermatology

      Dynamic Optical Coherence Tomography in Dermatology
      Optical coherence tomography (OCT) represents a non-invasive imaging technology, which may be applied to the diagnosis of non-melanoma skin cancer and which has recently been shown to improve the diagnostic accuracy of basal cell carcinoma. Technical developments of OCT continue to expand the applicability of OCT for different neoplastic and inflammatory skin diseases. Of these, dynamic OCT (D-OCT) based on speckle variance OCT is of special interest as it allows ...
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    15. In vivo, micro-morphological vascular changes induced by topical brimonidine studied by Dynamic optical coherence tomography

      In vivo, micro-morphological vascular changes induced by topical brimonidine studied by Dynamic optical coherence tomography
      Background Brimonidine is a selective 2 adrenergic receptor agonist with potent vasoconstrictive activity topically used for treatment of facial flushing and erythema caused by rosacea. Direct evidence for the in vivo morphology changes in skin vessels induced by topical application of brimonidine is limited. Dynamic optical coherence tomography is a novel technology that combines conventional OCT with information on flow and thereby provides supplementary information about the microvasculature. Dynamic OCT ...
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    16. Optical coherence tomography in dermatology

      Optical coherence tomography in dermatology
      BACKGROUND: Optical coherence tomography (OCT) was first used in skin imaging in 1997, and since then the technology has undergone significant technological development. With its high resolution and moderate penetration depth OCT fills the imaging gap between High Frequency Ultrasound and Reflectance Confocal Microscopy. Different modalities of OCT have been developed either focusing on higher image resolution or special visualization of tissue with distinct optical properties, including collagen and blood ...
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  2. About Lotte Themstrup

    Lotte Themstrup is with the Department of Dermatology, Roskilde Hospital, Health Sciences Faculty, University of Copenhagen.