1. LLTech

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    1. Mentioned In 70 Articles

    2. Use of high‐resolution full‐field optical coherence tomography and dynamic cell imaging for rapid intraoperative diagnosis during breast cancer surgery

      Use of high‐resolution full‐field optical coherence tomography and dynamic cell imaging for rapid intraoperative diagnosis during breast cancer surgery
      Background Although traditional intraoperative assessments (ie, frozen sections) may lower reoperation rates in patients with breast cancer, time/tissue limitations and accuracy concerns have discouraged their routine clinical use. Full‐field optical coherence tomography (FFOCT) and dynamic cell imaging (DCI) are novel optical imaging techniques offering rapid histologic approximations that are unfettered by requisite handling steps. This study was conducted to determine the feasibility and diagnostic utility of FFOCT and ...
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      Mentions: LLTech
    3. Full-field optical coherence tomography: novel imaging technique for extemporaneous high-resolution analysis of mucosal architecture in human gut biopsies

      Full-field optical coherence tomography: novel imaging technique for extemporaneous high-resolution analysis of mucosal architecture in human gut biopsies
      Full-field optical coherence tomography (FFOCT) is an imaging technique of biological tissue based on tissue light reflectance analysis. We evaluated the feasibility of imaging fresh digestive mucosal biopsies after a quick mounting procedure (5min) using two distinct modalities of FFOCT. In static FFOCT mode, we gained high-resolution images of general gut tissue-specific architecture, such as oesophageal papillae, gastric pits, duodenal villi and colonic crypts. In dynamic FFOCT mode, we imaged ...
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    4. Diagnostic Efficacy of FFOCT Imaging for Tissue Sample Obtained by EUSFNB

      Diagnostic Efficacy of FFOCT Imaging for Tissue Sample Obtained by EUSFNB
      In most Asian medical centers, rapid on-site cytology evaluation is not available, the number of needle passes of EUS-FNA is decided by endoscopists. Full-field optical coherence tomography (FF-OCT) is a new optical imaging technique that could generate sectioning tomogram from fresh tissue and provide close-to-pathology depiction of the morphological structure and pathological changes in minutes without conventional tissue preparation, slicing, and staining, and dynamic cell imaging (DCI) added the viability ...
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      Mentions: LLTech
    5. Endoscopic Optical Imaging for Precision Oncology Treatment Applied to Colorectal Tumours (Elios-Color-on-Specimen)

      Endoscopic Optical Imaging for Precision Oncology Treatment Applied to Colorectal Tumours (Elios-Color-on-Specimen)
      The Institute of Image-Guided Surgery (IHU) of Strasbourg is a translational research Institute aiming to develop hybrid surgery techniques. The IHU-SPECTRA research unit, entirely dedicated to the development of fluorescence-guided surgery, was set up to test several innovations as part of a large-scale project (ELIOS: Endoscopic Luminescent Imaging for Precision Oncology Surgery), funded by the ARC Foundation for Cancer Research. The proposed research protocol is part of the ELIOS project ...
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      Mentions: LLTech
    6. Quantitative measures of corneal transparency, derived from objective analysis of depth-resolved corneal images, demonstrated with full-field optical coherence tomographic microscopy

      Quantitative measures of corneal transparency, derived from objective analysis of depth-resolved corneal images, demonstrated with full-field optical coherence tomographic microscopy
      ...hotographs of the FF-OCT system used in this study. (A) Photograph of the commercial FF-OCT device (Light-CT, LLTech, Paris, France). (B) Schematic and optical setup of the device. (C) Photograph of corneal tissue in the...
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    7. Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT

      Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT
      We describe recent technological progress in multimodal en face full-field optical coherence tomography that has allowed detection of slow and fast dynamic processes in the eye. We show that by combining static, dynamic and fluorescence contrasts we can achieve label-free high-resolution imaging of the retina and anterior eye with temporal resolution from milliseconds to several hours, allowing us to probe biological activity at subcellular scales inside 3D bulk tissue. Our ...
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    8. Light-CT in the Diagnosis of Breast Tumor and Lymph Node

      Light-CT in the Diagnosis of Breast Tumor and Lymph Node
      Intraoperative pathological diagnosis such as frozen section and imprint cytology is not routinely recommended in clinical practice because of time and accuracy concerns. Full-field optical coherence tomography (FF-OCT) is a new optical imaging technique that could generate sectioning tomogram from fresh tissue and provide close-to-pathology depiction of the morphological structure and pathological changes in minutes without conventional tissue preparation, slicing, and staining, and dynamic cell imaging (DCI) added the viability ...
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    9. In vivo imaging through the entire thickness of human cornea by full-field optical coherence tomography

      In vivo imaging through the entire thickness of human cornea by full-field optical coherence tomography
      Despite obvious improvements in visualization of the in vivo cornea through the faster imaging speeds and higher axial resolutions, cellular imaging stays unresolvable task for OCT, as en face viewing with a high lateral resolution is required. The latter is possible with FFOCT, a method that relies on a camera, moderate numerical aperture (NA) objectives and an incoherent light source to provide en face images with a micrometer-level resolution. Recently ...
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    10. Full-Field Optical Coherence Tomography as a Diagnosis Tool: Recent Progress with Multimodal Imaging

      Full-Field Optical Coherence Tomography as a Diagnosis Tool: Recent Progress with Multimodal Imaging
      Full-field optical coherence tomography (FF-OCT) is a variant of OCT that is able to register 2D en face views of scattering samples at a given depth. Thanks to its superior resolution, it can quickly reveal information similar to histology without the need to physically section the sample. Sensitivity and specificity levels of diagnosis performed with FF-OCT are 80% to 95% of the equivalent histological diagnosis performances and could therefore benefit ...
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    11. Quality control and primo-diagnosis of transurethral bladder resections with full-field OCT

      Quality control and primo-diagnosis of transurethral bladder resections with full-field OCT
      Transurethral resections are commonly used for bladder cancer diagnosis, treatment and follow-up. Cancer staging relies largely on the analysis of muscle in the resections; however, muscle presence is uncertain at the time of the resection. An extemporaneous quality control tool would be of great use to certify the presence of muscle in the resection, and potentially formulate a primo-diagnosis, in order to ensure optimum patient care. Full-field optical coherence tomography ...
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  2. About LLTech

    LLTech

    LLTech is a privately owned company founded in 2007. LLTech vision is to become the leader in real time, safe, non-destructive optical biopsies and cellular level tissue imaging for research and clinical applications (micro biopsies assessment, surgical margins…). Using the properties of white light and optics the Light-CT research scanner generates DICOM 3D high-resolution three-dimensional images of tissue microstructure, without introducing artifacts.

  3. Quotes about LLTech

    1. It is hard to access private capital in France for early stage startups without a proof-of-concept completed. Access to grants for LLTech directly or access for grants from 3rd parties that use LLTech equipment have been greatly beneficial for moving our vision of digital pathology forward. For the future it would be beneficial to reduce the amount of paper work and the long process.
      Bertrand de Poly in Optical Coherence Tomography Used $500M of Federally Funded Research Over The Past Decade: How was it Used, What was Accomplished, and What’s to Come?