1. Linda M. Zangwill

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    1. Mentioned In 59 Articles

    2. Deep Learning Approaches Predict Glaucomatous Visual Field Damage from Optical Coherence Tomography Optic Nerve Head Enface Images and Retinal Nerve Fiber Layer Thickness Maps

      Deep Learning Approaches Predict Glaucomatous Visual Field Damage from Optical Coherence Tomography Optic Nerve Head Enface Images and Retinal Nerve Fiber Layer Thickness Maps
      Purpose To develop and evaluate a deep learning system for differentiating between eyes with and without glaucomatous visual field damage (GVFD) and predicting the severity of GFVD from spectral domain optical coherence tomography (SDOCT) optic nerve head images. Design Evaluation of a diagnostic technology Participants 9,765 visual field (VF)SDOCT pairs collected from 1,194 participants with and without GVFD (1909 eyes). Methods Deep learning models were trained to ...
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    3. Association of Macular and Circumpapillary Microvasculature with Visual Field Sensitivity in Advanced Glaucoma

      Association of Macular and Circumpapillary Microvasculature with Visual Field Sensitivity in Advanced Glaucoma
      Purpose To evaluate the association between optical coherence tomography angiography (OCTA) macular and circumpapillary vessel density and visual field mean deviation (MD) in advanced primary open angle glaucoma (POAG). Design Cross-sectional study. Methods Macula (superficial layer) and optic nerve head [ONH, with (capillary density :CD) and without (vessel density: VD) automated removal of large vessels] OCTA of 34 eyes (34 patients, MD -10 dB) were investigated as macula whole image ...
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    4. Measurement floors and dynamic ranges of optical coherence tomography and angiography in glaucoma

      Measurement floors and dynamic ranges of optical coherence tomography and angiography in glaucoma
      Purpose To determine if optical coherence tomography angiography (OCTA)derived vessel density measurements can extend the available dynamic range for detecting glaucoma compared to spectral-domain optical coherence tomography (SDOCT)derived thickness measurements. Design Observational, cross-sectional study. Participants A total of 509 eyes from 38 healthy participants, 63 glaucoma suspects and 193 glaucoma patients enrolled in the Diagnostic Innovations in Glaucoma Study. Methods Relative vessel density and tissue thickness measurement floors ...
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    5. UC San Diego Receives NIH Grant for Diagnostic Innovations in Glaucoma Study (DIGS): High Myoptia and Advanced Diseas

      UC San Diego Receives NIH Grant for Diagnostic Innovations in Glaucoma Study (DIGS): High Myoptia and Advanced Diseas
      ...nostic Innovations in Glaucoma Study (DIGS): High Myoptia and Advanced Disease. The principal investigator is Linda Zangwill. The program began in 2017 and ends in 2022. Below is a summary of the proposed work. This new...
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    6. Repeatability and Reproducibility of Corneal Epithelial Thickness Mapping with Spectral Domain Optical Coherence Tomography in Normal and Diseased Cornea Eyes

      Repeatability and Reproducibility of Corneal Epithelial Thickness Mapping with Spectral Domain Optical Coherence Tomography in Normal and Diseased Cornea Eyes
      Purpose To evaluate the performance of the epithelial thickness mapping (ETM) of the iVue spectral domain optical coherence tomography (SD-OCT) (Optovue Inc., Fremont, CA) in normal and diseased cornea eyes. Design Reliability and validity analysis. Methods Sixty eyes of 60 subjects were recruited for the study that included normal subjects (n=12) and patients with corneal diseases (12 each with dry eye syndrome (DES), contact lens (CL) wear, post laser ...
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    7. Optic disc microvasculature dropout in primary open-angle glaucoma measured with optical coherence tomography angiography

      Optic disc microvasculature dropout in primary open-angle glaucoma measured with optical coherence tomography angiography
      Purpose To evaluate microvasculature dropout in the optic disc (Mvd-D) using optical coherence tomography angiography (OCTA) and investigate factors associated with Mvd-D in primary open-angle glaucoma (POAG) eyes. Methods One hundred twenty-three eyes of 123 POAG patients were included from the Diagnostic Innovations in Glaucoma Study. The 3.03.0-mm optic nerve head OCTA scans were acquired using a spectral-domain OCT instrument. Images with whole-signal-mode were evaluated. Eyes were classified ...
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    8. Retinal Nerve Fiber Layer Features Identified by Unsupervised Machine Learning on Optical Coherence Tomography Scans Predict Glaucoma Progression

      Retinal Nerve Fiber Layer Features Identified by Unsupervised Machine Learning on Optical Coherence Tomography Scans Predict Glaucoma Progression
      Purpose : To apply computational techniques to wide-angle swept-source optical coherence tomography (SS-OCT) images to identify novel, glaucoma-related structural features and improve detection of glaucoma and prediction of future glaucomatous progression. Methods : Wide-angle SS-OCT, OCT circumpapillary retinal nerve fiber layer (cpRNFL) circle scans spectral-domain (SD)-OCT, standard automated perimetry (SAP), and frequency doubling technology (FDT) visual field tests were completed every 3 months for 2 years from a cohort of 28 ...
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    9. Deep-Layer Microvasculature Dropout by Optical Coherence Tomography Angiography and Microstructure of Parapapillary Atrophy

      Deep-Layer Microvasculature Dropout by Optical Coherence Tomography Angiography and Microstructure of Parapapillary Atrophy
      Purpose : To investigate the association between the microstructure of -zone parapapillary atrophy (PPA) and parapapillary deep-layer microvasculature dropout assessed by optical coherence tomography angiography (OCT-A). Methods : Thirty-seven eyes with PPA devoid of the Bruch's membrane (BM) (PPA) ranging between completely absent and discontinuous BM were matched by severity of the visual field (VF) damage with 37 eyes with fully intact BM (PPA +BM ) based on the spectral-domain (SD) OCT ...
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    10. Optical Coherence Tomography Angiography Macular Vascular Density Measurements and the Central 10-2 Visual Field in Glaucoma

      Optical Coherence Tomography Angiography Macular Vascular Density Measurements and the Central 10-2 Visual Field in Glaucoma
      Purpose: To evaluate the association between macula vascular density assessed by optical coherence tomography angiography (OCT-A) and central visual field (VF) threshold sensitivities in healthy, glaucoma suspect and glaucoma patients. Methods: A total of 185 eyes from 38 healthy participants, 31 glaucoma suspects, 72 mild glaucoma patients, and 44 moderate/severe glaucoma patients from the Diagnostic Innovations in Glaucoma Study who underwent OCT-A images of the macula and 10-2 VF ...
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    11. Inter-eye Asymmetry of Optical Coherence Tomography Angiography Vessel Density in Bilateral Glaucoma, Glaucoma Suspect, and Healthy Eyes

      Inter-eye Asymmetry of Optical Coherence Tomography Angiography Vessel Density in Bilateral Glaucoma, Glaucoma Suspect, and Healthy Eyes
      Purpose To investigate inter-eye retinal vessel density asymmetry in healthy, glaucoma suspect, and mild to moderate glaucoma subjects, and its potential utility for early detection of glaucomatous damage. Design Cross-sectional study. Methods 153 subjects including 55 healthy, 32 glaucoma suspect, and 66 glaucoma subjects enrolled in the Diagnostic Innovations in Glaucoma Study(DIGS). Vessel density was obtained from optical coherence tomography angiography (OCT-A) macular and optic nerve head scans. Thickness ...
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    12. The Association Between Macula and ONH Optical Coherence Tomography Angiography (OCT-A) Vessel Densities in Glaucoma, Glaucoma Suspect, and Healthy Eyes

      The Association Between Macula and ONH Optical Coherence Tomography Angiography (OCT-A) Vessel Densities in Glaucoma, Glaucoma Suspect, and Healthy Eyes
      Purpose: To evaluate strength of associations between optical coherence tomography (OCT)-angiography vessel density (VD) measurements in the macula and peripapillary region of the optic nerve head (ONH) with standard structural OCT thickness measures. Materials and Methods: This cross-sectional study included 333 eyes of 219 primary open-angle glaucoma patients, 41 glaucoma suspects, and 73 healthy participants from the Diagnostic Innovations in Glaucoma Study (DIGS) with good quality OCT angiography images ...
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    13. The Association between Macula and ONH Optical Coherence Tomography Angiography (OCT-A) Vessel Densities in Glaucoma, Glaucoma Suspect and Healthy Eyes

      The Association between Macula and ONH Optical Coherence Tomography Angiography (OCT-A) Vessel Densities in Glaucoma, Glaucoma Suspect and Healthy Eyes
      Purpose: To evaluate strength of associations between Optical Coherence Tomography-Angiography (OCT-A) vessel density (VD) measurements in the macula and peripapillary region of the optic nerve head (ONH) with standard structural OCT thickness measures. Methods: This cross-sectional study included 333 eyes of 219 primary open angle glaucoma patients, 41 glaucoma suspects, and 73 healthy participants from the Diagnostics Innovations in Glaucoma Study (DIGS) with good quality OCT-A images. The strength of ...
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    14. Reproducibility of Optical Coherence Tomography Angiography Macular and Optic Nerve Head Vascular Density in Glaucoma and Healthy Eyes

      Reproducibility of Optical Coherence Tomography Angiography Macular and Optic Nerve Head Vascular Density in Glaucoma and Healthy Eyes
      Purpose: Optical coherence tomography angiography (OCT-A) is a non-invasive technology that allows visualization of retinal blood vessels. It is important to determine reproducibility of measurements as low precision can impair its diagnostic capabilities. The purpose of this study is to determine intra-visit and inter-visit reproducibility of optic nerve head (ONH) and macular vessel density measurements with OCT-A. Patients and Methods: Fifteen healthy volunteers and fourteen glaucoma patients completed two OCT-A ...
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    15. Comparing optical coherence tomography radial and cube scan patterns for measuring Bruch's membrane opening minimum rim width (BMO-MRW) in glaucoma and healthy eyes: cross-sectional and longitudinal analysis

      Comparing optical coherence tomography radial and cube scan patterns for measuring Bruch's membrane opening minimum rim width (BMO-MRW) in glaucoma and healthy eyes: cross-sectional and longitudinal analysis
      Aim To compare the cube and radial scan patterns of the spectral domain optical coherence tomography (SD-OCT) for quantifying the Bruch's membrane opening minimum rim width (BMO-MRW). Methods Sixty healthy eyes and 189 glaucomatous eyes were included. The optic nerve head cube and radial pattern scans were acquired using Spectralis SD-OCT. BMO-MRWs were automatically delineated using the San Diego Automated Layer Segmentation Algorithm. The BMO-MRW diagnostic accuracy for glaucoma ...
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    16. Automated circumferential construction of first-order aqueous humor outflow pathways using spectral-domain optical coherence tomography

      Automated circumferential construction of first-order aqueous humor outflow pathways using spectral-domain optical coherence tomography
      The purpose was to create a three-dimensional (3-D) model of circumferential aqueous humor outflow (AHO) in a living human eye with an automated detection algorithm for Schlemms canal (SC) and first-order collector channels (CC) applied to spectral-domain optical coherence tomography (SD-OCT). Anterior segment SD-OCT scans from a subject were acquired circumferentially around the limbus. A Bayesian Ridge method was used to approximate the location of the SC on infrared confocal ...
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  2. About Linda M. Zangwill

    Linda M. Zangwill

    Linda M. Zangwill is an Associate Professor in Epidemiology and Biostatistics at the University of California San Diego, Hamilton Glaucoma Center and at the Shirley Eye Center.