1. Linbo Liu

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    1. Mentioned In 66 Articles

    2. Micro-Optical Coherence Tomography Tracking of Magnetic Gene Transfection via Au-Fe3O4 Dumbbell Nanoparticles

      Micro-Optical Coherence Tomography Tracking of Magnetic Gene Transfection via Au-Fe3O4 Dumbbell Nanoparticles
      Heterogeneous Au-Fe3O4 dumbbell nanoparticles (NPs) are composed of Au NP and Fe3O4 NP that brings in optical and magnetic property respectively. This article reports the engineering of Au-Fe3O4 NPs as gene carriers for magnetic gene transfection as well as contrast agents for micro-optical coherence tomography (OCT). As a proof-of-concept, Au-Fe3O4 NPs are used to deliver green fluorescent protein to HEK 293T cells and their entrance into the cells is monitored ...
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      Mentions: Linbo Liu
    3. High Resolution Optical Coherence Tomography for Bio-Imaging

      High Resolution Optical Coherence Tomography for Bio-Imaging
      Optical coherence tomography (OCT) is a low-coherence interferometry based bio-imaging technology. It has attracted extensive research interests in recent years for its non-invasive, high-speed and high-resolution properties. Numerous schemes for improving OCT resolutions have been demonstrated in literature. This chapter gives a comprehensive review of the recent developments of spectral domain (SD)-OCT systems with either high axial-resolution or lateral resolution, and then highlights the wide applications of such high-resolution ...
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    4. Gravity-driven membrane filtration as pretreatment for seawater reverse osmosis: Linking biofouling layer morphology with flux stabilization

      Gravity-driven membrane filtration as pretreatment for seawater reverse osmosis: Linking biofouling layer morphology with flux stabilization
      In this study gravity-driven membrane (GDM) ultrafiltration is investigated for the pretreatment of seawater before reverse osmosis (RO). The impacts of temperature (21 1 and 29 1 C) and hydrostatic pressure (40 and 100 mbar) on dynamic flux development and biofouling layer structure were studied. The data suggested pore constriction fouling was predominant at the early stage of filtration, during which the hydrostatic pressure and temperature had negligible effects on ...
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    5. Postdoctoral research fellowships and studentship (optical coherence tomography) at Nanyang Technological University

      Postdoctoral research fellowships and studentship (optical coherence tomography) at Nanyang Technological University
      ...Remuneration package will be negotiable and commensurate with experiences. Contact: Address correspondence Dr Liu Linbo ( liulinbo@ntu.edu.sg ) One PhD fellowship and 2 research staff position are available in the area o...
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    6. Innovations in Microscopic Imaging of Atherosclerosis and Valvular Disease (Book Chapter)

      Innovations in Microscopic Imaging of Atherosclerosis and Valvular Disease (Book Chapter)
      Calcific aortic valve disease (CAVD) is still an unsolved medical problem, because the pathogenesis of CAVD is poorly understood and early calcification is hard to identify. The lack of high-resolution imaging tools to study early stage disease further hampers the search for therapeutic targets. Micro-optical coherence tomography (OCT), which is a new form of OCT, is the highest-resolution cross-sectional OCT technology available today with 1 m resolution. We used OCT ...
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    7. Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution

      Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution
      Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one portion of a sample. For example, at least one first radiation can be forwarded to the portion through at least one optical arrangement. At least one second radiation can be received from the portion which is based on the first radiation. Based on an interaction between the optical arrangement and the first ...
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    8. Optical Coherence Tomography in Coronary Artery Disease: Toward Sub cellular Imaging

      Optical Coherence Tomography in Coronary Artery  Disease: Toward Sub cellular Imaging
      Intracoronary optical coherence tomography (OCT) is an interferometric imaging technology that uses near-infrared light to provide cross-sectional images with an axial resolution of 10 m and a transverse of 20-40 m in vivo. The imaging capabilities of OCT have enabled visualization of important features of coronary plaque, including thrombus, macrophage, neovascularization, stent implantation and stent strut coverage, which have provided new insights for better understanding of this disease. Frequency domain ...
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    9. A Functional Anatomic Defect of the Cystic Fibrosis Airway

      A Functional Anatomic Defect of the Cystic Fibrosis Airway
      Rationale: The mechanisms underlying cystic fibrosis (CF) lung disease pathogenesis are unknown. Objective: To establish mechanisms linking anion transport with the functional microanatomy, we evaluated normal and CF piglet trachea, as well as adult swine trachea in the presence of selective anion inhibitors. Methods: We investigated airway functional microanatomy using micro-optical coherence tomography, a new imaging modality that concurrently quantifies multiple functional parameters of airway epithelium in a co-localized fashion ...
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    10. 46-60 of 66 « 1 2 3 4 5 »
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  2. About Linbo Liu

    Linbo Liu

    Linbo Liu received B.Eng in Precision Instrument in 2001, and M. Eng. in Optical Engineering in 2004, from Tianjin University, China. He received PhD in Graduate Programme in Bioengineering (GPBE) in 2008 from School of Medicine, National University of Singapore. From 2008-2011, he received his postdoctoral training in Wellman Center in Photomedicine, Harvard Medical School (HMS) and Massachusetts General Hospital (MGH) where he developed and established a new generation of OCT technology termed micro-Optical Coherence Tomography (µOCT). Dr Liu was promoted as an Instructor in Dermatology at HMS before he joined the School of Electrical and Electronic Engineering and School of Chemical and Biomedical Engineering as a Nanyang Assistant Professor in 2012.