1. Linbo Liu

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    1. Mentioned In 65 Articles

    2. Feasibility evaluation of micro-optical coherence tomography (μOCT) for rapid brain tumor type and grade discriminations: μOCT images versus pathology

      Feasibility evaluation of micro-optical coherence tomography (μOCT) for rapid brain tumor type and grade discriminations: μOCT images versus pathology
      Background Precise identification, discrimination and assessment of central nervous system (CNS) tumors is of critical importance to brain neoplasm treatment. Due to the complexity and limited resolutions of the existing diagnostic tools, however, it is difficult to identify the tumors and their boundaries precisely in clinical practice, and thus, the conventional way of brain neoplasm treatment relies mainly on the experiences of neurosurgeons to make resection decisions in the surgery ...
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    3. Interferometer-in-Spectrometer for High-Resolution Optical Coherence Tomography

      Interferometer-in-Spectrometer for High-Resolution Optical Coherence Tomography
      Ultrahigh-resolution optical coherence tomography provides an axial resolution of 1-2 m for resolving cellular structures of biological tissues critical for the diagnosis of diseases. However, it requires a relatively large spectral bandwidth which is not supported by the key components of the imaging system. We propose a novel spectral-domain OCT design, termed interferometer-in-spectrometer, which is able to compensate the bandwidth limitations of the grating and the line scan sensor by ...
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    4. High-Resolution Optical Coherence Tomography (OCT) for Skin Imaging (Book Chapter)

      High-Resolution Optical Coherence Tomography (OCT) for Skin Imaging (Book Chapter)
      This important, timely book covers the latest understanding about today's major skin disorders, the development of imaging technologies for skin diagnosis, and the applications of micro/nano-technologies for the treatment of skin complications. It also places great emphasis on the critical role that interdisciplinary science occupies to achieve the requisite level of understanding of skin conditions and their management, which is essential to creating technologies that work. Imaging Technologies ...
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    5. Excess mucus viscosity and airway dehydration impact COPD airway clearance

      Excess mucus viscosity and airway dehydration impact COPD airway clearance
      The mechanisms by which cigarette smoking impairs airway mucus clearance are not well understood. We recently established a ferret model of cigarette smoke-induced chronic obstructive pulmonary disease (COPD) exhibiting chronic bronchitis. We investigated the effects of cigarette smoke on mucociliary transport (MCT). Adult ferrets were exposed to cigarette smoke for 6 months, with in vivo mucociliary clearance (MCC) measured by Tc-labeled DTPA (Tc-DTPA) retention. Excised tracheae were imaged with micro-optical ...
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    6. Constrained polarization evolution simplifies depth-resolved retardation measurements with polarization-sensitive optical coherence tomography

      Constrained polarization evolution simplifies depth-resolved retardation measurements with polarization-sensitive optical coherence tomography
      We observed that the polarization state of light after round-trip propagation through a birefringent medium frequently aligns with the employed input polarization state mirrored by the horizontal plane of the Poincar sphere. We explored the predisposition for this mirror state and evidence that it constrains the evolution of polarization states as a function of the round-trip depth into weakly scattering birefringent samples, as measured with polarization-sensitive optical coherence tomography (PS-OCT ...
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    7. Rapid, High-Resolution, Label-Free, and 3-Dimensional Imaging to Differentiate Colorectal Adenomas and Non-Neoplastic Polyps With Micro-Optical Coherence Tomography

      Rapid, High-Resolution, Label-Free, and 3-Dimensional Imaging to Differentiate Colorectal Adenomas and Non-Neoplastic Polyps With Micro-Optical Coherence Tomography
      INTRODUCTION: Resectanddiscard paradigmisoneofthemainstrategiestodealwithcolorectaldiminutivepolyps after optical diagnosis. However, there are risks that unrecognized potentially malignant lesions are discarded without accurate diagnosis. The purpose of this study is to validate the potential of micro- optical coherence tomography ( m OCT) to improve the diagnostic accuracy of colorectal lesions and help endoscopists make better clinical decision without additional pathology costs. METHODS: RESULTS: DISCUSSION: Fresh tissue samples were obtained from patients with colorectal polyps or ...
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    8. Automatic evaluation of stratum basale and dermal papillae using ultrahigh resolution optical coherence tomography

      Automatic evaluation of stratum basale and dermal papillae using ultrahigh resolution optical coherence tomography
      Diagnosis of many skin conditions requires evaluation of dermal papillae and stratum basale, such as vitiligo. In clinical practice, imaging dermal papillae structures relies on excisional biopsy followed by histological processing and analysis. As biopsy is invasive and associated with complications, a noninvasive imaging method such as optical coherence tomography (OCT) can complement the existing method by enabling large area scanning. However, because OCT image analysis requires training and it ...
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    9. Methods, systems, arrangements and computer-accessible medium for providing micro-optical coherence tomography procedures

      Methods, systems, arrangements and computer-accessible medium for providing micro-optical coherence tomography procedures
      Exemplary apparatus and method can be provided for obtaining data regarding a plurality of samples. For example, using at least one arrangement, it is possible to receive interferometric information that is based on radiations provided from a reference and the samples that are provided in respective chambers. Alternatively and/or in addition, based on the interferometric information, it is possible to discriminate between agents to identify a particular agent that ...
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    10. Are nuclei in stratified squamous epithelium high scattering or low scattering?

      Are nuclei in stratified squamous epithelium high scattering or low scattering?
      Imaging nuclei of keratinocytes in the stratified squamous epithelium has been a subject of intense research since nucleus associated cellular atypia is the key criteria for the screening and diagnosis of epithelial cancers and their precursors. However, keratinocyte nuclei have been reported to be either low scattering or high scattering, so that these inconsistent reports might have led to misinterpretations of optical images, and more importantly, hindered the establishment of ...
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    11. Single input state polarization-sensitive optical coherence tomography with high resolution and polarization distortion correction

      Single input state polarization-sensitive optical coherence tomography with high resolution and polarization distortion correction
      Abstract: In single input state polarization-sensitive optical coherence tomography (PS-OCT) with high resolution, the imperfections of quarter-wave plate (QWP) and the sensitivity roll-off mismatch between the two detection channels cause unpredictable polarization distortion. We present a correction method based on the Jones matrix modeling of the system. In a single input PS-OCT system working at 840 nm with an axial resolution of ~2.3 m, the method yielded better estimation ...
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    12. Optical coherence tomography with gapped spectrum

      Optical coherence tomography with gapped spectrum
      The axial resolution of optical coherence tomography (OCT) is determined by the spectral shape and bandwidth of the detected light, which are limited by the gaps in the wavelength range of illumination, transmission, and detection. In this work, we demonstrate that the axial resolution deteriorated by gaps in OCT spectra can be restored by adopting the gapped amplitude and phase estimation (GAPES) method. GAPES estimates the missing parts between separated ...
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    13. Nondestructive Measurement of Conformal Coating Thickness on Printed Circuit Board with Ultra-high Resolution Optical Coherence Tomography

      Nondestructive Measurement of Conformal Coating Thickness on Printed Circuit Board with Ultra-high Resolution Optical Coherence Tomography
      Conformal coating (CC) is widely used to protect printed circuit board (PCB) from corrosion, mould growth and electrical failures. To ensure an effective protection, the thickness of the conformal coating layer needs to be well controlled. However, to date, the coating thickness is usually measured in a destructive way under microscopes. In this study, we proposed to use optical coherence tomography (OCT) to measure the CC thickness nondestructively. Specifically, to ...
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    14. Cellular resolution corneal imaging with extended imaging range

      Cellular resolution corneal imaging with extended imaging range
      Current optical coherence tomography (OCT) technology, which is used for imaging the eyes anterior segment, has been established as a clinical gold standard for the diagnosis of corneal diseases. However, the cellular resolution level information that is critical for many clinical applications is still not available. The major technical challenges toward cellular resolution OCT imaging are the limited ranging depth and depth of focus (DOF). In this work, we present ...
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    15. Estimation of refractive index for biological tissue using micro-optical coherence tomography

      Estimation of refractive index for biological tissue using micro-optical coherence tomography
      The refractive index of biological tissue is required for investigating the tissue's optical properties. Efforts have been made to characterize refractive indices of biological tissues at a single wavelength, but it is more convenient to know the Cauchy's coefficients, which provide refractive index over a wide range of wavelengths. We demonstrate a method to noninvasively provide the Cauchy's dispersion coefficients of biological tissues using micro-optical coherence tomography ...
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  2. About Linbo Liu

    Linbo Liu

    Linbo Liu received B.Eng in Precision Instrument in 2001, and M. Eng. in Optical Engineering in 2004, from Tianjin University, China. He received PhD in Graduate Programme in Bioengineering (GPBE) in 2008 from School of Medicine, National University of Singapore. From 2008-2011, he received his postdoctoral training in Wellman Center in Photomedicine, Harvard Medical School (HMS) and Massachusetts General Hospital (MGH) where he developed and established a new generation of OCT technology termed micro-Optical Coherence Tomography (µOCT). Dr Liu was promoted as an Instructor in Dermatology at HMS before he joined the School of Electrical and Electronic Engineering and School of Chemical and Biomedical Engineering as a Nanyang Assistant Professor in 2012.