1. Linbo Liu

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    1. Mentioned In 43 Articles

    2. Visualizing Micro-anatomical Structures of the Posterior Cornea with Micro-optical Coherence Tomography

      Visualizing Micro-anatomical Structures of the Posterior Cornea with Micro-optical Coherence Tomography
      Diagnosis of corneal disease and challenges in corneal transplantation require comprehensive understanding of corneal anatomy, particularly that of the posterior cornea. Micro-optical coherence tomography (OCT) is a potentially suitable tool to meet this need, owing to its ultrahigh isotropic spatial resolution, high image acquisition rate and depth priority scanning mode. In this study, we explored the ability of OCT to visualize micro-anatomical structures of the posterior cornea ex vivo and ...
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    3. Endomicroscopic optical coherence tomography for cellular resolution imaging of gastrointestinal tracts

      Endomicroscopic optical coherence tomography for cellular resolution imaging of gastrointestinal tracts
      Our ability to detect neoplastic changes in gastrointestinal (GI) tracts is limited by the lack of an endomicroscopic imaging tool that provides cellular-level structural details of GI mucosa over a large tissue area. In this paper, we report a fiber-optic based micro-optical coherence tomography (OCT) system and demonstrate its capability to acquire cellular-level details of GI tissue through circumferential scanning. The system achieves an axial resolution of 2.48m in ...
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    4. Polarization management to mitigate misalignment-induced fringe fading in fiber-based optical coherence tomography

      Polarization management to mitigate misalignment-induced fringe fading in fiber-based optical coherence tomography
      In fiber-based optical coherence tomography (OCT), the interference fringes suffer from the fading effect due to misalignment of the light polarization states between the reference and sample arms, resulting in sensitivity degradation and image intensity variation. We theoretically and experimentally analyzed the relation between the misalignment and the fading coefficient. Assuming that the variation of the light polarization in single-mode fiber (SMF) was a random process, we statistically quantified the ...
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    5. Depth-of-focus extension in optical coherence tomography via multiple aperture synthesis

      Depth-of-focus extension in optical coherence tomography via multiple aperture synthesis
      In this paper, we report what we believe is a novel technique to overcome the depth-of-focus (DOF) limitation in optical coherence tomography (OCT). Using confocal optics on a sample arm, we scanned the illumination beam across the under-filled objective lens pupil plane by steering the beam at the pinhole using a microcylindrical lens. The detected interferometric signals from multiple distinctive apertures were digitally refocused, which is analogous to synthetic aperture ...
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    6. Iron-oxide nanoparticles powered micro optical coherence tomography for in situ imaging the penetration and swelling of polymeric microneedles in skin

      Iron-oxide nanoparticles powered micro optical coherence tomography for in situ imaging the penetration and swelling of polymeric microneedles in skin
      In recent years, polymeric microneedles (MNs) have attracted keen interests among researchers for their applicability in transdermal drug delivery and interstitial skin fluid (ISF) extraction. When design and characterize such devices, it is critical to monitor their real-time in vitro and in vivo performances to optimize the desired effects, yet most of the existing methods are incapable of such functions. To address this unmet need, we develop a real-time non-invasive ...
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      Mentions: Linbo Liu
    7. Illuminating dynamic neutrophil trans-epithelial migration with micro-optical coherence tomography

      Illuminating dynamic neutrophil trans-epithelial migration with micro-optical coherence tomography
      A model of neutrophil migration across epithelia is desirable to interrogate the underlying mechanisms of neutrophilic breach of mucosal barriers. A co-culture system consisting of a polarized mucosal epithelium and human neutrophils can provide a versatile model of trans-epithelial migration in vitro , but observations are typically limited to quantification of migrated neutrophils by myeloperoxidase correlation, a destructive assay that precludes direct longitudinal study. Our laboratory has recently developed a new ...
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    8. Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia

      Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia
      We report the design and fabrication of a flexible, longitudinally scanning high-resolution micro-optical coherence tomography (OCT) endobronchial probe, optimized for micro-anatomical imaging in airways. The 2.4 mm diameter and flexibility of the probe allows it to be inserted into the instrument channel of a standard bronchoscope, enabling real-time video guidance of probe placement. To generate a depth-of-focus enhancing annular beam, we utilized a new fabrication method, whereby a hollow ...
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    9. Multifiber angular compounding optical coherence tomography for speckle reduction

      Multifiber angular compounding optical coherence tomography for speckle reduction
      We report on an integrated fiber optic design to implement multifiber angular compounding optical coherence tomography, which enables angular compounding for speckle reduction. A multi-facet fiber array delivers three light beams to the sample with different incident angles. Back-reflective/back-scattered signals from these channels were simultaneously detected by a three-channel spectrometer. The axial and lateral resolution was measured to be 3 3 and 3.5 m 3.5m , respectively, in ...
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    10. Contrast Enhanced Subsurface Fingerprint Detection using High-speed Optical Coherence Tomography

      Contrast Enhanced Subsurface Fingerprint Detection using High-speed Optical Coherence Tomography
      Spectral-domain optical coherence tomography (SDOCT) has been demonstrated to be a viable tool in forensic science for fingerprint detection, yet it still suffers from certain practical issues, e.g., the limited scanning speed and low image contrast. In this letter, we report a high-speed SD-OCT together with an image contrast enhancement mechanism for reliable subsurface fingerprint detection. The constructed SDOCT system achieves a scanning rate up to 60K A-lines/s ...
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    11. Spectral domain optical coherence tomography with extended depth-of-focus by aperture synthesis

      Spectral domain optical coherence tomography with extended depth-of-focus by aperture synthesis
      We developed a spectral domain optical coherence tomography (SD-OCT) with an extended depth-of-focus (DOF) by synthetizing aperture. For a designated Gaussian-shape light source, the lateral resolution was determined by the numerical aperture (NA) of the objective lens and can be approximately maintained over the confocal parameter, which was defined as twice the Rayleigh range. However, the DOF was proportional to the square of the lateral resolution. Consequently, a trade-off existed ...
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    12. Particle-Tracking Microrheology Using Micro-Optical Coherence Tomography

      Particle-Tracking Microrheology Using Micro-Optical Coherence Tomography
      Clinical manifestations of cystic fibrosis (CF) result from an increase in the viscosity of the mucus secreted by epithelial cells that line the airways. Particle-tracking microrheology (PTM) is a widely accepted means of determining the viscoelastic properties of CF mucus, providing an improved understanding of this disease as well as an avenue to assess the efficacies of pharmacologic therapies aimed at decreasing mucus viscosity. Among its advantages, PTM allows the ...
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    13. Evaluation of a Micro-Optical Coherence Tomography for the Corneal Endothelium in an Animal Model

      Evaluation of a Micro-Optical Coherence Tomography for the Corneal Endothelium in an Animal Model
      Recent developments in optical coherence tomography (OCT) systems for the cornea have limited resolution or acquisition speed. In this study we aim to evaluate the use of a micro-OCT (OCT ~1m axial resolution) compared to existing imaging modalities using animal models of corneal endothelial disease. We used established cryoinjury and bullous keratopathy models in Sprague Dawley rats comparing ex vivo OCT imaging in normal and diseased eyes to (1) histology ...
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    14. Toward High-Speed Imaging of Cellular Structures in Rat Colon Using Micro-optical Coherence Tomography

      Toward High-Speed Imaging of Cellular Structures in Rat Colon Using Micro-optical Coherence Tomography
      The mucosal microanatomy of the large intestine is characterized by the presence of crypts of Lieberkhn, which is associated predominantly with goblet cells. Such cellular-level intestinal microstructures undergo morphological changes during the progression of bowel diseases, such as colon cancer or ulcerative colitis. As an indicator of gastric cancers, intestinal metaplasia in the large intestine is characterized by the appearance of goblet cells in gastric epithelium, and therefore, visualization of ...
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  2. About Linbo Liu

    Linbo Liu

    Linbo Liu received B.Eng in Precision Instrument in 2001, and M. Eng. in Optical Engineering in 2004, from Tianjin University, China. He received PhD in Graduate Programme in Bioengineering (GPBE) in 2008 from School of Medicine, National University of Singapore. From 2008-2011, he received his postdoctoral training in Wellman Center in Photomedicine, Harvard Medical School (HMS) and Massachusetts General Hospital (MGH) where he developed and established a new generation of OCT technology termed micro-Optical Coherence Tomography (µOCT). Dr Liu was promoted as an Instructor in Dermatology at HMS before he joined the School of Electrical and Electronic Engineering and School of Chemical and Biomedical Engineering as a Nanyang Assistant Professor in 2012.