1. Linbo Liu

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    1. Mentioned In 36 Articles

    2. Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia

      Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia
      We report the design and fabrication of a flexible, longitudinally scanning high-resolution micro-optical coherence tomography (OCT) endobronchial probe, optimized for micro-anatomical imaging in airways. The 2.4 mm diameter and flexibility of the probe allows it to be inserted into the instrument channel of a standard bronchoscope, enabling real-time video guidance of probe placement. To generate a depth-of-focus enhancing annular beam, we utilized a new fabrication method, whereby a hollow ...
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    3. Multifiber angular compounding optical coherence tomography for speckle reduction

      Multifiber angular compounding optical coherence tomography for speckle reduction
      We report on an integrated fiber optic design to implement multifiber angular compounding optical coherence tomography, which enables angular compounding for speckle reduction. A multi-facet fiber array delivers three light beams to the sample with different incident angles. Back-reflective/back-scattered signals from these channels were simultaneously detected by a three-channel spectrometer. The axial and lateral resolution was measured to be 3 3 and 3.5 m 3.5m , respectively, in ...
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    4. Contrast Enhanced Subsurface Fingerprint Detection using High-speed Optical Coherence Tomography

      Contrast Enhanced Subsurface Fingerprint Detection using High-speed Optical Coherence Tomography
      Spectral-domain optical coherence tomography (SDOCT) has been demonstrated to be a viable tool in forensic science for fingerprint detection, yet it still suffers from certain practical issues, e.g., the limited scanning speed and low image contrast. In this letter, we report a high-speed SD-OCT together with an image contrast enhancement mechanism for reliable subsurface fingerprint detection. The constructed SDOCT system achieves a scanning rate up to 60K A-lines/s ...
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    5. Spectral domain optical coherence tomography with extended depth-of-focus by aperture synthesis

      Spectral domain optical coherence tomography with extended depth-of-focus by aperture synthesis
      We developed a spectral domain optical coherence tomography (SD-OCT) with an extended depth-of-focus (DOF) by synthetizing aperture. For a designated Gaussian-shape light source, the lateral resolution was determined by the numerical aperture (NA) of the objective lens and can be approximately maintained over the confocal parameter, which was defined as twice the Rayleigh range. However, the DOF was proportional to the square of the lateral resolution. Consequently, a trade-off existed ...
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    6. Particle-Tracking Microrheology Using Micro-Optical Coherence Tomography

      Particle-Tracking Microrheology Using Micro-Optical Coherence Tomography
      Clinical manifestations of cystic fibrosis (CF) result from an increase in the viscosity of the mucus secreted by epithelial cells that line the airways. Particle-tracking microrheology (PTM) is a widely accepted means of determining the viscoelastic properties of CF mucus, providing an improved understanding of this disease as well as an avenue to assess the efficacies of pharmacologic therapies aimed at decreasing mucus viscosity. Among its advantages, PTM allows the ...
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    7. Evaluation of a Micro-Optical Coherence Tomography for the Corneal Endothelium in an Animal Model

      Evaluation of a Micro-Optical Coherence Tomography for the Corneal Endothelium in an Animal Model
      Recent developments in optical coherence tomography (OCT) systems for the cornea have limited resolution or acquisition speed. In this study we aim to evaluate the use of a micro-OCT (OCT ~1m axial resolution) compared to existing imaging modalities using animal models of corneal endothelial disease. We used established cryoinjury and bullous keratopathy models in Sprague Dawley rats comparing ex vivo OCT imaging in normal and diseased eyes to (1) histology ...
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    8. Toward High-Speed Imaging of Cellular Structures in Rat Colon Using Micro-optical Coherence Tomography

      Toward High-Speed Imaging of Cellular Structures in Rat Colon Using Micro-optical Coherence Tomography
      The mucosal microanatomy of the large intestine is characterized by the presence of crypts of Lieberkhn, which is associated predominantly with goblet cells. Such cellular-level intestinal microstructures undergo morphological changes during the progression of bowel diseases, such as colon cancer or ulcerative colitis. As an indicator of gastric cancers, intestinal metaplasia in the large intestine is characterized by the appearance of goblet cells in gastric epithelium, and therefore, visualization of ...
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    9. In vivo imaging of airway cilia and mucus clearance with micro-optical coherence tomography

      In vivo imaging of airway cilia and mucus clearance with micro-optical coherence tomography
      We have designed and fabricated a 4 mm diameter rigid endoscopic probe to obtain high resolution micro-optical coherence tomography (OCT) images from the tracheal epithelium of living swine. Our common-path fiber-optic probe used gradient-index focusing optics, a selectively coated prism reflector to implement a circular-obscuration apodization for depth-of-focus enhancement, and a common-path reference arm and an ultra-broadbrand supercontinuum laser to achieve high axial resolution. Benchtop characterization demonstrated lateral and axial ...
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    10. Postdoctoral research fellowship, research associate position, and PhD scholarship (optical coherence tomography) at Nanyang Technological University

      Postdoctoral research fellowship, research associate position, and PhD scholarship (optical coherence tomography) at Nanyang Technological University
      One research fellow position, one research associate position, and one PhD scholarship is available at School of Electrical Electronic Engineering. The successful candidates will join a multidisciplinary team of 10 research staff and 10 PhD students and work on collaborative research projects with a focus on microscopic/endoscopic technology development and translational studies. These positions are supported by multiple active grants (Funding amount: $10M; Funding period: 2015-2020) for developing ultrahigh ...
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    11. Spectral domain optical coherence tomography with dual-balanced detection

      Spectral domain optical coherence tomography with dual-balanced detection
      We developed a spectral domain optical coherence tomography (SD-OCT) system employing dual-balanced detection (DBD) for direct current term suppression and SNR enhancement, especially for auto-autocorrelation artifacts reduction. The DBD was achieved by using a beam splitter to building a free-space Michelson interferometer, which generated two interferometric spectra with a phase difference of . These two phase-opposed spectra were guided to the spectrometer through two single mode fibers of the 8 fiber ...
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    12. Combination Therapy with Cystic Fibrosis Transmembrane Conductance Regulator Modulators Augment the Airway Functional Microanatomy

      Combination Therapy with Cystic Fibrosis Transmembrane Conductance Regulator Modulators Augment the Airway Functional Microanatomy
      Recently approved therapies that modulate CFTR function have shown significant clinical benefit, but recent investigations regarding their molecular mechanism when used in combination have not been consistent with clinical results. We employed Micro-Optical Coherence Tomography (OCT) as a novel means to assess the mechanism of action of CFTR modulators, focusing on the effects on mucociliary clearance. Primary human airway monolayers from patients with a G551D mutation responded to ivacaftor treatment ...
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    13. High-resolution extended source optical coherence tomography

      High-resolution extended source optical coherence tomography
      High resolution optical coherence tomography (OCT) is capable of providing detailed tissue microstructures that are critical for disease diagnosis, yet its sensitivity is usually degraded since the system key components are typically not working at their respective center wavelengths. We developed a novel imaging system that achieves enhanced sensitivity without axial resolution degradation by the use of a spectrally encoded extended source (SEES) technique; it allows larger sample power without ...
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    14. Spectral estimation optical coherence tomography for axial super-resolution

      Spectral estimation optical coherence tomography for axial super-resolution
      The depth reflectivity profile of Fourier domain optical coherence tomography (FD-OCT) is estimated from the inverse Fourier transform of the spectral interference signals (interferograms). As a result, the axial resolution is fundamentally limited by the coherence length of the light source. We demonstrate that using the autoregressive spectral estimation technique instead of the inverse Fourier transform, to analyze the spectral interferograms can improve the axial resolution. We name this method ...
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    15. Spectral-domain optical coherence tomography with dual-balanced detection for auto-correlation artifacts reduction

      Spectral-domain optical coherence tomography with dual-balanced detection for auto-correlation artifacts reduction
      We developed a spectral domain optical coherence tomography (SD-OCT) to reduce auto-correlation artifacts (AC) using dual-balanced detection (DBD). AC were composed of the interference signals between different sample tissue depths, and shown up as artifacts in OCT images. This system employed a free-space Michelson interferometer, at the refraction plane of whose beam splitter, the light reflected experienced a /2 phase shift with respect to the light transmitted. Then two phase-opposed ...
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    16. 1-15 of 36 1 2 3 »
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  2. About Linbo Liu

    Linbo Liu

    Linbo Liu received B.Eng in Precision Instrument in 2001, and M. Eng. in Optical Engineering in 2004, from Tianjin University, China. He received PhD in Graduate Programme in Bioengineering (GPBE) in 2008 from School of Medicine, National University of Singapore. From 2008-2011, he received his postdoctoral training in Wellman Center in Photomedicine, Harvard Medical School (HMS) and Massachusetts General Hospital (MGH) where he developed and established a new generation of OCT technology termed micro-Optical Coherence Tomography (µOCT). Dr Liu was promoted as an Instructor in Dermatology at HMS before he joined the School of Electrical and Electronic Engineering and School of Chemical and Biomedical Engineering as a Nanyang Assistant Professor in 2012.