1. Linbo Liu

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    1. Mentioned In 70 Articles

    2. Towards Indicating Human Skin State In Vivo Using Geometry-Dependent Spectroscopic Contrast Imaging

      Towards Indicating Human Skin State In Vivo Using Geometry-Dependent Spectroscopic Contrast Imaging
      Skin plays a significant role in human body function and its collagen states change during the human skin ageing process, which affects skin function. We previously reported on geometry-dependent spectroscopic contrast achieved by spectroscopic micro-optical coherence tomography ( S OCT), which discovered that transversely oriented and regularly arranged nano-cylinders selectively backscatter the long-wavelength lights and generate spectral centroid (SC) shifts towards the long wavelengths within a spectral window of 700 950 ...
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    3. Automatic differentiation of nonkeratinized stratified squamous epithelia and columnar epithelia through feature structure extraction using OCT

      Automatic differentiation of nonkeratinized stratified squamous epithelia and columnar epithelia through feature structure extraction using OCT
      As a type of precancerous lesion, metaplasia is usually considered to be associated with developing cancer. In clinical practice, surveillance of metaplastic cases usually relies on excisional biopsy followed by histological processing and analysis. As it is an invasive method accompanied by other complications, non-invasive imaging methods such as optical coherence tomography (OCT) can complement the existing method by enabling large area scanning. However, because it takes time to review ...
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    4. Resolution enhancement and realistic speckle recovery with generative adversarial modeling of micro-optical coherence tomography

      Resolution enhancement and realistic speckle recovery with generative adversarial modeling of micro-optical coherence tomography
      A resolution enhancement technique for optical coherence tomography (OCT), based on Generative Adversarial Networks (GANs), was developed and investigated. GANs have been previously used for resolution enhancement of photography and optical microscopy images. We have adapted and improved this technique for OCT image generation. Conditional GANs (cGANs) were trained on a novel set of ultrahigh resolution spectral domain OCT volumes, termed micro-OCT, as the high-resolution ground truth (1 m isotropic ...
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    5. Dual-side view optical coherence tomography for thickness measurement on opaque materials

      Dual-side view optical coherence tomography for thickness measurement on opaque materials
      Optical coherence tomography (OCT), as an optical interferometric imaging technique, has found wide applications in various fields. In principle, OCT is well suited for imaging layered structures, and thus, one of the typical applications is thickness measurement. However, due to the limited imaging depth resulting from light attenuation, thickness measurement by OCT is limited to non-opaque materials. In this study, we developed a novel (to the best of our knowledge ...
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    6. Feasibility evaluation of micro-optical coherence tomography (μOCT) for rapid brain tumor type and grade discriminations: μOCT images versus pathology

      Feasibility evaluation of micro-optical coherence tomography (μOCT) for rapid brain tumor type and grade discriminations: μOCT images versus pathology
      Background Precise identification, discrimination and assessment of central nervous system (CNS) tumors is of critical importance to brain neoplasm treatment. Due to the complexity and limited resolutions of the existing diagnostic tools, however, it is difficult to identify the tumors and their boundaries precisely in clinical practice, and thus, the conventional way of brain neoplasm treatment relies mainly on the experiences of neurosurgeons to make resection decisions in the surgery ...
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    7. Interferometer-in-Spectrometer for High-Resolution Optical Coherence Tomography

      Interferometer-in-Spectrometer for High-Resolution Optical Coherence Tomography
      Ultrahigh-resolution optical coherence tomography provides an axial resolution of 1-2 m for resolving cellular structures of biological tissues critical for the diagnosis of diseases. However, it requires a relatively large spectral bandwidth which is not supported by the key components of the imaging system. We propose a novel spectral-domain OCT design, termed interferometer-in-spectrometer, which is able to compensate the bandwidth limitations of the grating and the line scan sensor by ...
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    8. High-Resolution Optical Coherence Tomography (OCT) for Skin Imaging (Book Chapter)

      High-Resolution Optical Coherence Tomography (OCT) for Skin Imaging (Book Chapter)
      This important, timely book covers the latest understanding about today's major skin disorders, the development of imaging technologies for skin diagnosis, and the applications of micro/nano-technologies for the treatment of skin complications. It also places great emphasis on the critical role that interdisciplinary science occupies to achieve the requisite level of understanding of skin conditions and their management, which is essential to creating technologies that work. Imaging Technologies ...
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    9. Excess mucus viscosity and airway dehydration impact COPD airway clearance

      Excess mucus viscosity and airway dehydration impact COPD airway clearance
      The mechanisms by which cigarette smoking impairs airway mucus clearance are not well understood. We recently established a ferret model of cigarette smoke-induced chronic obstructive pulmonary disease (COPD) exhibiting chronic bronchitis. We investigated the effects of cigarette smoke on mucociliary transport (MCT). Adult ferrets were exposed to cigarette smoke for 6 months, with in vivo mucociliary clearance (MCC) measured by Tc-labeled DTPA (Tc-DTPA) retention. Excised tracheae were imaged with micro-optical ...
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    10. Constrained polarization evolution simplifies depth-resolved retardation measurements with polarization-sensitive optical coherence tomography

      Constrained polarization evolution simplifies depth-resolved retardation measurements with polarization-sensitive optical coherence tomography
      We observed that the polarization state of light after round-trip propagation through a birefringent medium frequently aligns with the employed input polarization state mirrored by the horizontal plane of the Poincar sphere. We explored the predisposition for this mirror state and evidence that it constrains the evolution of polarization states as a function of the round-trip depth into weakly scattering birefringent samples, as measured with polarization-sensitive optical coherence tomography (PS-OCT ...
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    11. Rapid, High-Resolution, Label-Free, and 3-Dimensional Imaging to Differentiate Colorectal Adenomas and Non-Neoplastic Polyps With Micro-Optical Coherence Tomography

      Rapid, High-Resolution, Label-Free, and 3-Dimensional Imaging to Differentiate Colorectal Adenomas and Non-Neoplastic Polyps With Micro-Optical Coherence Tomography
      INTRODUCTION: Resectanddiscard paradigmisoneofthemainstrategiestodealwithcolorectaldiminutivepolyps after optical diagnosis. However, there are risks that unrecognized potentially malignant lesions are discarded without accurate diagnosis. The purpose of this study is to validate the potential of micro- optical coherence tomography ( m OCT) to improve the diagnostic accuracy of colorectal lesions and help endoscopists make better clinical decision without additional pathology costs. METHODS: RESULTS: DISCUSSION: Fresh tissue samples were obtained from patients with colorectal polyps or ...
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    12. Automatic evaluation of stratum basale and dermal papillae using ultrahigh resolution optical coherence tomography

      Automatic evaluation of stratum basale and dermal papillae using ultrahigh resolution optical coherence tomography
      Diagnosis of many skin conditions requires evaluation of dermal papillae and stratum basale, such as vitiligo. In clinical practice, imaging dermal papillae structures relies on excisional biopsy followed by histological processing and analysis. As biopsy is invasive and associated with complications, a noninvasive imaging method such as optical coherence tomography (OCT) can complement the existing method by enabling large area scanning. However, because OCT image analysis requires training and it ...
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    13. Methods, systems, arrangements and computer-accessible medium for providing micro-optical coherence tomography procedures

      Methods, systems, arrangements and computer-accessible medium for providing micro-optical coherence tomography procedures
      Exemplary apparatus and method can be provided for obtaining data regarding a plurality of samples. For example, using at least one arrangement, it is possible to receive interferometric information that is based on radiations provided from a reference and the samples that are provided in respective chambers. Alternatively and/or in addition, based on the interferometric information, it is possible to discriminate between agents to identify a particular agent that ...
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    14. Are nuclei in stratified squamous epithelium high scattering or low scattering?

      Are nuclei in stratified squamous epithelium high scattering or low scattering?
      Imaging nuclei of keratinocytes in the stratified squamous epithelium has been a subject of intense research since nucleus associated cellular atypia is the key criteria for the screening and diagnosis of epithelial cancers and their precursors. However, keratinocyte nuclei have been reported to be either low scattering or high scattering, so that these inconsistent reports might have led to misinterpretations of optical images, and more importantly, hindered the establishment of ...
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  2. About Linbo Liu

    Linbo Liu

    Linbo Liu received B.Eng in Precision Instrument in 2001, and M. Eng. in Optical Engineering in 2004, from Tianjin University, China. He received PhD in Graduate Programme in Bioengineering (GPBE) in 2008 from School of Medicine, National University of Singapore. From 2008-2011, he received his postdoctoral training in Wellman Center in Photomedicine, Harvard Medical School (HMS) and Massachusetts General Hospital (MGH) where he developed and established a new generation of OCT technology termed micro-Optical Coherence Tomography (µOCT). Dr Liu was promoted as an Instructor in Dermatology at HMS before he joined the School of Electrical and Electronic Engineering and School of Chemical and Biomedical Engineering as a Nanyang Assistant Professor in 2012.