1. Linbo Liu

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    1. Mentioned In 51 Articles

    2. Estimation of refractive index for biological tissue using micro-optical coherence tomography

      Estimation of refractive index for biological tissue using micro-optical coherence tomography
      The refractive index of biological tissue is required for investigating the tissue's optical properties. Efforts have been made to characterize refractive indices of biological tissues at a single wavelength, but it is more convenient to know the Cauchy's coefficients, which provide refractive index over a wide range of wavelengths. We demonstrate a method to noninvasively provide the Cauchy's dispersion coefficients of biological tissues using micro-optical coherence tomography ...
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    3. Imaging cellular structures of atherosclerotic coronary arteries using circumferentially scanning micro-optical coherence tomography fiber probe ex vivo

      Imaging cellular structures of atherosclerotic coronary arteries using circumferentially scanning micro-optical coherence tomography fiber probe ex vivo
      Development and progression of coronary atherosclerotic lesions is mediated by a number of cellular components, which are not readily visualized using the current clinical investigation tools. Visualizing these cellular components in situ and in vivo may allow early detection of the vulnerable plaques, with implications for coronary artery disease (CAD) therapy and for the prevention of acute myocardial infarction (AMI). In this study, we have developed a fiber-optic micro-optical coherence ...
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    4. Novel application of In Vivo Micro-Optical Coherence Tomography to assess Cornea scarring in an Animal Model

      Novel application of In Vivo Micro-Optical Coherence Tomography to assess Cornea scarring in an Animal Model
      This pilot study uses a micro-optical coherence tomography (micro-OCT) system with ~1m axial resolution specifically to image the cornea and corneal scars in vivo . We used an established murine corneal scar model by irregular phototherapeutic keratectomy in ten C57BL/6 mice, with serial imaging using the micro-OCT and compared to anterior segment (AS-OCT) (RTvue, Optovue, Fremont, CA) before and after scar induction. Main outcome was agreement between the AS-OCT and ...
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    5. Extending the depth of focus of fiber-optic optical coherence tomography using a chromatic dual-focus design

      Extending the depth of focus of fiber-optic optical coherence tomography using a chromatic dual-focus design
      We report a dual-focus fiber-optic probe designed to extend depth of focus (DOF) in high-resolution endoscopic optical coherence tomography. We exploited the broad spectral bandwidth of a supercontinuum source and, in the fiber probe, the foci of the 7501000 nm and 11001450 nm inputs were axially chromatically shifted. The interference signals from the two spectral bands were measured with a Si camera-based spectrometer and an InGaAs camera-based spectrometer, respectively. We ...
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    6. Multiscale skin imaging in vivo using optical coherence tomography

      Multiscale skin imaging in vivo using optical coherence tomography
      Optical coherence tomography (OCT) is a noninvasive high-resolution diagnostic imaging modality that plays an increasingly important role in dermatology. Diagnosis of skin diseases using OCT requires both cellular-level high resolution and large area skin coverage. In practice, however, there exists a trade-off between the achievable spatial resolutions and the transverse scanning range. In this study, we report a Micro-OCT ( OCT) system that is capable of providing three-dimensional images of the ...
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    7. Evaluating micro-optical coherence tomography (μOCT) as a feasible imaging tool for pancreatic disease diagnosis

      Evaluating micro-optical coherence tomography (μOCT) as a feasible imaging tool for pancreatic disease diagnosis
      Pancreatic cancer is one of the leading causes of cancer mortality worldwide due to the lack of reliable tools for early diagnosis of this cancer. In this study, we evaluated the feasibility of micro-optical coherence tomography (OCT) as an imaging tool for the diagnosis of pancreatic cancers. Specifically, we constructed a OCT device that achieves a resolution of 1.67 m and 1.79 m in axial and lateral directions ...
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    8. Extending axial focus of optical coherence tomography using parallel multiple aperture synthesis

      Extending axial focus of optical coherence tomography using parallel multiple aperture synthesis
      Compromising the inherent trade-off between transverse resolution and depth of focus (DOF) remains a long-standing issue in optical coherence tomography (OCT). In this work, we report a novel techniqueparallel multiple aperture synthesis (pMAS) to simultaneously generate multiple optical apertures in an OCT sample arm by employing a two-surface coated mirror. In the proposed pMAS, the DOF is extended by a factor of 16.49 without sacrificing the transverse resolution for ...
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    9. Multiple aperture synthetic optical coherence tomography for biological tissue imaging

      Multiple aperture synthetic optical coherence tomography for biological tissue imaging
      An inherent compromise must be made between transverse resolution and depth of focus (DOF) in spectral domain optical coherence tomography (SD-OCT). Thus far, OCT has not been capable of providing a sufficient DOF to stably acquire cellular-resolution images. We previously reported a novel technique named multiple aperture synthesis (MAS) to extend the DOF in high-resolution OCT [Optica4, 701 (2017)]. In this technique, the illumination beam is scanned across the objective ...
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    10. Visualizing Micro-anatomical Structures of the Posterior Cornea with Micro-optical Coherence Tomography

      Visualizing Micro-anatomical Structures of the Posterior Cornea with Micro-optical Coherence Tomography
      Diagnosis of corneal disease and challenges in corneal transplantation require comprehensive understanding of corneal anatomy, particularly that of the posterior cornea. Micro-optical coherence tomography (OCT) is a potentially suitable tool to meet this need, owing to its ultrahigh isotropic spatial resolution, high image acquisition rate and depth priority scanning mode. In this study, we explored the ability of OCT to visualize micro-anatomical structures of the posterior cornea ex vivo and ...
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    11. Endomicroscopic optical coherence tomography for cellular resolution imaging of gastrointestinal tracts

      Endomicroscopic optical coherence tomography for cellular resolution imaging of gastrointestinal tracts
      Our ability to detect neoplastic changes in gastrointestinal (GI) tracts is limited by the lack of an endomicroscopic imaging tool that provides cellular-level structural details of GI mucosa over a large tissue area. In this paper, we report a fiber-optic based micro-optical coherence tomography (OCT) system and demonstrate its capability to acquire cellular-level details of GI tissue through circumferential scanning. The system achieves an axial resolution of 2.48m in ...
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    12. Polarization management to mitigate misalignment-induced fringe fading in fiber-based optical coherence tomography

      Polarization management to mitigate misalignment-induced fringe fading in fiber-based optical coherence tomography
      In fiber-based optical coherence tomography (OCT), the interference fringes suffer from the fading effect due to misalignment of the light polarization states between the reference and sample arms, resulting in sensitivity degradation and image intensity variation. We theoretically and experimentally analyzed the relation between the misalignment and the fading coefficient. Assuming that the variation of the light polarization in single-mode fiber (SMF) was a random process, we statistically quantified the ...
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    13. Depth-of-focus extension in optical coherence tomography via multiple aperture synthesis

      Depth-of-focus extension in optical coherence tomography via multiple aperture synthesis
      In this paper, we report what we believe is a novel technique to overcome the depth-of-focus (DOF) limitation in optical coherence tomography (OCT). Using confocal optics on a sample arm, we scanned the illumination beam across the under-filled objective lens pupil plane by steering the beam at the pinhole using a microcylindrical lens. The detected interferometric signals from multiple distinctive apertures were digitally refocused, which is analogous to synthetic aperture ...
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    14. Iron-oxide nanoparticles powered micro optical coherence tomography for in situ imaging the penetration and swelling of polymeric microneedles in skin

      Iron-oxide nanoparticles powered micro optical coherence tomography for in situ imaging the penetration and swelling of polymeric microneedles in skin
      In recent years, polymeric microneedles (MNs) have attracted keen interests among researchers for their applicability in transdermal drug delivery and interstitial skin fluid (ISF) extraction. When design and characterize such devices, it is critical to monitor their real-time in vitro and in vivo performances to optimize the desired effects, yet most of the existing methods are incapable of such functions. To address this unmet need, we develop a real-time non-invasive ...
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      Mentions: Linbo Liu
    15. Illuminating dynamic neutrophil trans-epithelial migration with micro-optical coherence tomography

      Illuminating dynamic neutrophil trans-epithelial migration with micro-optical coherence tomography
      A model of neutrophil migration across epithelia is desirable to interrogate the underlying mechanisms of neutrophilic breach of mucosal barriers. A co-culture system consisting of a polarized mucosal epithelium and human neutrophils can provide a versatile model of trans-epithelial migration in vitro , but observations are typically limited to quantification of migrated neutrophils by myeloperoxidase correlation, a destructive assay that precludes direct longitudinal study. Our laboratory has recently developed a new ...
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  2. About Linbo Liu

    Linbo Liu

    Linbo Liu received B.Eng in Precision Instrument in 2001, and M. Eng. in Optical Engineering in 2004, from Tianjin University, China. He received PhD in Graduate Programme in Bioengineering (GPBE) in 2008 from School of Medicine, National University of Singapore. From 2008-2011, he received his postdoctoral training in Wellman Center in Photomedicine, Harvard Medical School (HMS) and Massachusetts General Hospital (MGH) where he developed and established a new generation of OCT technology termed micro-Optical Coherence Tomography (µOCT). Dr Liu was promoted as an Instructor in Dermatology at HMS before he joined the School of Electrical and Electronic Engineering and School of Chemical and Biomedical Engineering as a Nanyang Assistant Professor in 2012.