1. Lida P. Hariri

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    1. Mentioned In 30 Articles

    2. Distinguishing Tumor from Associated Fibrosis to Increase Diagnostic Biopsy Yield with Polarization-Sensitive Optical Coherence Tomography

      Distinguishing Tumor from Associated Fibrosis to Increase Diagnostic Biopsy Yield with Polarization-Sensitive Optical Coherence Tomography
      Purpose: With recent advancements in personalized medicine, biopsies must contain sufficient tumor for histologic diagnosis and molecular testing. However, inadvertent biopsy of tumor-associated fibrosis compromises tumor yield, resulting in delayed diagnoses and/or repeat procedures when additional tumor is needed. The ability to differentiate tumor from fibrosis intraprocedurally during biopsy could significantly increase tumor yield. Polarization-sensitive optical coherence tomography (PS-OCT) is an imaging modality that is endoscope- and/or needle-compatible ...
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    3. In Vivo and Ex Vivo Microscopy: Moving Toward the Integration of Optical Imaging Technologies Into Pathology Practice

      In Vivo and Ex Vivo Microscopy: Moving Toward the Integration of Optical Imaging Technologies Into Pathology Practice
      The traditional surgical pathology assessment requires tissue to be removed from the patient, then processed, sectioned, stained, and interpreted by a pathologist using a light microscope. Today, an array of alternate optical imaging technologies allow tissue to be viewed at high resolution, in real time, without the need for processing, fixation, freezing, or staining. Optical imaging can be done in living patients without tissue removal, termed in vivo microscopy, or ...
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    4. Nano-optic endoscope for high-resolution optical coherence tomography in vivo

      Nano-optic endoscope for high-resolution optical coherence tomography in vivo
      Acquisition of high-resolution images from within internal organs using endoscopic optical imaging has numerous clinical applications. However, difficulties associated with optical aberrations and the trade-off between transverse resolution and depth of focus significantly limit the scope of applications. Here, we integrate a metalens, with the ability to modify the phase of incident light at subwavelength level, into the design of an endoscopic optical coherence tomography catheter (termed nano-optic endoscope) to ...
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    5. Needle-based Optical Coherence Tomography to Guide Transbronchial Lymph Node Biopsy

      Needle-based Optical Coherence Tomography to Guide Transbronchial Lymph Node Biopsy
      Background: Transbronchial needle aspiration (TBNA), often used to sample lymph nodes for lung cancer staging , is subject to sampling error even when performed with endobronchial ultrasound. Optical coherence tomography (OCT) is a high-resolution imaging modality that rapidly generates helical cross-sectional images. We aim to determine if needle-based OCT can provide microstructural information in lymph nodes that may be used to guide TBNA, and improve sampling error. Methods: We performed ex ...
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    6. Optical coherence tomography (OCT) imaging of dynamic airway behavior in an asthma model

      Optical coherence tomography (OCT) imaging of dynamic airway behavior in an asthma model
      To better understand bronchoconstriction in asthma, it is critical to dynamically visualize airway behavior in vivo. However, currently available imaging techniques do not have sufficient temporal and spatial resolution to investigate airway dynamics. We propose to use endobronchial Optical Coherence Tomography (OCT) to provide real-time cross-sectional images of airway dynamics with a high spatial resolution. Our aim was to study the structure and function of spatially distinct airways during tidal ...
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    7. Massachusetts General Hospital Receives NIH Grant for Low Risk In VIvo Optical Diagnosis of IPF with Optical Imaging

      Massachusetts General Hospital Receives NIH Grant for Low Risk In VIvo Optical Diagnosis of IPF with Optical Imaging
      ...or $179,120 for Low Risk In VIvo Optical Diagnosis of IPF with Optical Imaging. The principal investigator is Lida Hariri. The program began in 2016 and ends in 2021. Below is a summary of the proposed work.

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    8. Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo

      Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo
      The inability to visualize airway smooth muscle (ASM) cells in vivo is a major obstacle in understanding their role in normal physiology and diseases. At present, there is no imaging modality available to assess ASM in vivo. Confocal endomicroscopy lacks the penetration depth and field of view, and conventional optical coherence tomography (OCT) does not have sufficient contrast to differentiate ASM from surrounding tissues. We have developed a birefringence microscopy ...
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    9. Diagnosing Lung Carcinomas with Optical Coherence Tomography

      Diagnosing Lung Carcinomas with Optical Coherence Tomography
      Rationale: Lung carcinoma diagnosis on tissue biopsy can be challenging due to insufficient tumor and lack of architectural information. Optical coherence tomography (OCT) is a high-resolution imaging modality that visualizes tissue microarchitecture in volumes orders of magnitude larger than biopsy. It has been proposed that OCT could potentially replace tissue biopsy. Objectives: We aim to determine if OCT could replace histology in diagnosing lung carcinomas . We develop and validate OCT ...
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  2. About Lida P. Hariri

    Lida P. Hariri

    Lida Hariri, MD/PhD, is a resident in Pathology at Massachusetts General Hosptial.  She received her PhD in Biomedical Engineering in 2007 and MD in 2009 from the University of Arizona.