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    1. Mentioned In 59 Articles

    2. A novel alignment procedure to assess calcified coronary plaques in histopathology, post-mortem computed tomography angiography and optical coherence tomography

      A novel alignment procedure to assess calcified coronary plaques in histopathology, post-mortem computed tomography angiography and optical coherence tomography
      Purpose Improve mapping and registration of longitudinal view on histopathology vessels in a three-dimensional alignment procedure for postmortem quantitative coronary plaque analyses. This new procedure is applied and results shown using calcified coronary plaque analyses within post-mortem computed tomography angiography (PMCTA), optical coherence tomography (OCT) and the gold standard of histopathology. Results In total, 338 annotated histopathology images were included, 166 PMCTA transversal images and 285 OCT images were aligned ...
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    3. Fusion of X-ray angiography and optical coherence tomography for coronary flow simulation

      Fusion of X-ray angiography and optical coherence tomography for coronary flow simulation
      In conclusion, this thesis proposes a new approach for reconstruction of coronary artery and the implanted BRS by fusion of OCT and X-ray angiography to analyze intracoronary ESS in vivo. The studies conducted in this thesis demonstrate the feasibility of the proposed approach to analyze the detailed local coronary hemodynamics in patients, including the SS patterns after BRS implantation in coronary bifurcations. We observed that in vivo assessment of ESS ...
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    4. OPTICAL COHERENCE TOMOGRAPHY FOR CORONARY ARTERY DISEASE (Thesis)

      OPTICAL COHERENCE TOMOGRAPHY FOR CORONARY ARTERY DISEASE (Thesis)
      The aim of this thesis was to develop a software pipeline for tissue analysis in IVOCT by systematically addressing different open questions for analysis. In Chapter 2, we report on a first attempt to quantify the correlation between the position of the catheter with respect to the luminal wall and the image intensities. We implemented the Depth-Resolved (DR) model for IVOCT images in Chapter 3. In addition to the attenuation ...
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    5. Correlation between redefined optical coherence tomography parameters and best-corrected visual acuity in non-resolving central serous chorioretinopathy treated with half-dose photodynamic therapy

      Correlation between redefined optical coherence tomography parameters and best-corrected visual acuity in non-resolving central serous chorioretinopathy treated with half-dose photodynamic therapy
      ...ho were treated with half-dose PDT between March 2014 and November 2016 at the Department of Ophthalmology of Leiden University Medical Center (Leiden, the Nederlands), were analysed. The diagnosis of non-resolving CSC w...
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    6. Histogram‐Based Standardization of Intravascular Optical Coherence Tomography Images Acquired from Different Imaging Systems

      Histogram‐Based Standardization of Intravascular Optical Coherence Tomography Images Acquired from Different Imaging Systems
      Purpose Intravascular optical coherence tomography (OCT) is widely used for analysis of the coronary artery disease. Its high spatial resolution allows for visualization of arterial tissue components in detail. There are different OCT systems on the market, each of which produces data characterized by its own intensity range and distribution. These differences should be taken into account for the development of image processing algorithms. In order to overcome this difference ...
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    7. Age-related Changes in Human Schlemm’s Canal: An In Vivo Optical Coherence Tomography-based Study

      Age-related Changes in Human Schlemm’s Canal: An In Vivo Optical Coherence Tomography-based Study
      Purpose: To investigate age-related changes in human Schlemms canal (SC) using spectral-domain optical coherence tomography (SD-OCT). Methods: A total of 125 normal eyes were imaged using SD-OCT nasally and temporally. The age-related variations of SC sagittal diameter and cross-sectional area (CSA) from four age groups [A (1620 years), B (2140 years), C (4160 years), and D (6180 years)] were analyzed with Spearman correlation. Results: The positive detection rates of SC ...
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    8. Quality difference of neointima following the implantation of bioresorbable scaffold and metallic stent in patients with ST elevation myocardial infarction: quantitative assessments by light intensity, light attenuation, and backscatter on optical coheren

      Quality difference of neointima following the implantation of bioresorbable scaffold and metallic stent in patients with ST elevation myocardial infarction: quantitative assessments by light intensity, light attenuation, and backscatter on optical coheren
      Aims: We aimed to assess possible difference of the neointimal quality after everolimus-eluting bioresorbable scaffold (BVS) implantation in comparison with cobalt chromium everolimus-eluting scaffold (CoCr-EES) by optical frequency domain imaging (OFDI). Methods and results: This study is a post-hoc analysis of TROFI II trial assessing neointimal quality 6-month after the implantation of BVS(N=82) and CoCr-EES(N=87) in STEMI patients. Neointimal light property analysis by OFDI full-automatically computed ...
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    9. Safeguarding ovarian tissue autotransplantation in cancer patients (Thesis)

      Safeguarding ovarian tissue autotransplantation in cancer patients (Thesis)
      Autotransplantation of ovarian tissue can be used to restore fertility in cancer patients following gonadotoxic treatment. Whether this procedure is safe remains unclear, as current tumor detection methods (e.g. PCR analysis, immunohistochemistry) render the ovarian tissue unsuitable for transplantation. As a result, the current tumor detection approach includes assessment of only one or two cortical ovarian fragments that are not transplanted, whereas cortical ovarian tissue fragments that are placed ...
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    10. In-stent fractional flow reserve variations and related optical coherence tomography findings: the FFR–OCT co-registration study

      In-stent fractional flow reserve variations and related optical coherence tomography findings: the FFR–OCT co-registration study
      We sought to assess in-stent variations in fractional flow reserve (FFR) in patients with previous percutaneous coronary intervention (PCI) and to associate any drop in FFR with findings by optical coherence tomography (OCT) imaging. Suboptimal post-PCI FFR values were previously associated with poor outcomes. It is not known to which extent in-stent pressure loss contributes to reduced FFR. In this single-arm observational study, 26 patients who previously underwent PCI with ...
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    11. Detection of early changes in the coronary artery microstructure after heart transplantation: A prospective optical coherence tomography study

      Detection of early changes in the coronary artery microstructure after heart transplantation: A prospective optical coherence tomography study
      Objectives To describe and characterize changes in the coronary artery microstructure during the first year following heart transplantation (HTx) by serial optical coherence tomography (OCT) scans. Background OCT enables in-vivo cardiac allograft vasculopathy (CAV) microstructure characterization. Early coronary artery microstructure changes after HTx may provide important mechanistic information regarding CAV development. Methods Twenty-six patients were enrolled at routine baseline coronary angiography 3 months after HTx. Coronary OCT scans were performed ...
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    12. Serial Assessment of Tissue Precursors and Progression of Coronary Calcification Analyzed by Fusion of IVUS and OCT

      Serial Assessment of Tissue Precursors and Progression of Coronary Calcification Analyzed by Fusion of IVUS and OCT
      Objectives The aim of this study was to assess calcium growth with fused grayscale intravascular ultrasound (IVUS), IVUSvirtual histology, and optical coherence tomography (OCT) from baseline to 5-year follow-up in patients treated with bioresorbable vascular scaffolds. Background IVUS and OCT have individual strengths in assessing plaque composition and volume. Fusion of images obtained using these methods could potentially aid in coronary plaque assessment. Methods Anatomic landmarks and endoluminal radiopaque markers ...
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    13. Tissue characterization with depth-resolved attenuation coefficient and backscatter term in intravascular optical coherence tomography images

      Tissue characterization with depth-resolved attenuation coefficient and backscatter term in intravascular optical coherence tomography images
      An important application of intravascular optical coherence tomography (IVOCT) for atherosclerotic tissue analysis is using it to estimate attenuation and backscatter coefficients. This work aims at exploring the potential of the attenuation coefficient, a proposed backscatter term, and image intensities in distinguishing different atherosclerotic tissue types with a robust implementation of depth-resolved (DR) approach. Therefore, the DR model is introduced to estimate the attenuation coefficient and further extended to estimate ...
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    14. Invasive assessment of coronary artery disease

      Invasive assessment of coronary artery disease
      oronary artery disease is associated to high mortality and morbidity rates and an accurate diagnostic assessment during heart catheterization has a fundamental role in prognostic stratification and treatment choices. Coronary angiography has been integrated by intravascular imaging modalities, namely intravascular ultrasound and optical coherence tomography, which allow the precise quantification of the atherosclerotic burden of coronary arteries. The hemodynamic relevance of a given coronary stenosis can be assessed using stress ...
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  2. About Leiden University

    Leiden University

    Leiden University is one of Europe's foremost research universities. This prominent position gives our graduates a leading edge in applying for academic posts and for functions outside academia.

     

    Leiden University Medical Center. The LUMC is a modern knowledge centre. The more than 7000 staff members of the LUMC are passionate about improving patient care through scientific research. We offer courses of instruction and continuing education to train doctors for this purpose. The LUMC focuses on top clinical and highly specialised care: the complex medical issues for which there are often not yet any answers. With patient care and research labs under one roof, patients, doctors and researchers collaborate to develop new treatment methods.