1. Lehigh University

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    1. Mentioned In 39 Articles

    2. Full-range space-division multiplexing optical coherence tomography angiography

      Full-range space-division multiplexing optical coherence tomography angiography
      Abstract In this study, we demonstrated a full-range space-division multiplexing optical coherence tomography (FR-SDM-OCT) system. Utilizing the galvanometer-based phase modulation full-range technique, the total imaging range of FR-SDM-OCT can be extended to 20 mm in tissue, with a digitizer sampling rate of 500 MS/s and a laser sweeping rate of 100 kHz. Complex conjugate terms were suppressed in FR-SDM-OCT images with a measured rejection ratio of up to 46 ...
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    3. Red-light Heartbeat Control and Optical Coherence Microscopy (OCM) Imaging in Drosophila (Thesis)

      Red-light Heartbeat Control and Optical Coherence Microscopy (OCM) Imaging in Drosophila (Thesis)
      would like to thank my advisor Prof. Chao Zhou, who gave me the opportunity to pursue a higher-level education in the United States, and led me to the field of biomedical engineering. I still have the impression that I was attracted by the fast heartbeat of a Drosophila Prof. Zhou showed with a video in his presentation in Peking University in 2014. I was curious that how the fast heartbeat ...
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    4. Functional High-Speed Optical Coherence Tomography (Thesis)

      Functional High-Speed Optical Coherence Tomography (Thesis)
      Optical coherence tomography (OCT) is a high speed, high resolution, noninvasive imaging technique that has seen applications across many clinical and biological research fields, with a particular focus in ophthalmic, cardiologic and dermatologic imaging. Ultrahigh speed OCT imaging has become of interest for high resolution, widefield in vivo imaging. Space division multiplexing optical coherence tomography (SDM-OCT) is a novel optical coherence tomography system which utilizes a parallel imaging approach to ...
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    5. Post-doctoral Associate Positions in Biophotonics / Biomedical Optical Imaging at Washington University in St. Louis

      Post-doctoral Associate Positions in Biophotonics / Biomedical Optical Imaging at Washington University in St. Louis
      ...(2011), the Libsch Early Career Research Award (2016) and the Alfred Noble Robinson Faculty Award (2018) from Lehigh University, and the National Innovation Award (2017) from TechConnect World Innovation Conference and N...
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    6. Post-doctoral Associate Positions in Biophotonics / Biomedical Optical Imaging at Washington University in St. Louis

      Post-doctoral Associate Positions in Biophotonics / Biomedical Optical Imaging at Washington University in St. Louis
      ...(2011), the Libsch Early Career Research Award (2016) and the Alfred Noble Robinson Faculty Award (2018) from Lehigh University, and the National Innovation Award (2017) from TechConnect World Innovation Conference and N...
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    7. Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography

      Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography
      Optical coherence tomography (OCT), a three-dimensional imaging technology, was used to monitor and characterize the growth kinetics of multicellular tumor spheroids. Precise volumetric quantification of tumor spheroids using a voxel counting approach, and label-free dead tissue detection in the spheroids based on intrinsic optical attenuation contrast, were demonstrated.
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    8. Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University

      Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University
      ...ubject. Interviews will be arranged on a rolling basis until the position is filled. About Lehigh University: Lehigh University is a private university located in Bethlehem, Pennsylvania , with easy access to Philadelphi...
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    9. Computer-Aided Diagnosis of Label-Free 3-D Optical Coherence Microscopy Images of Human Cervical Tissue

      Computer-Aided Diagnosis of Label-Free 3-D Optical Coherence Microscopy Images of Human Cervical Tissue
      : Ultrahigh-resolution optical coherence microscopy (OCM) has recently demonstrated its potential for accurate diagnosis of human cervical diseases. One major challenge for clinical adoption, however, is the steep learning curve clinicians need to overcome to interpret OCM images. Developing an intelligent technique for computer-aided diagnosis (CADx) to accurately interpret OCM images will facilitate clinical adoption of the technology and improve patient care. Methods: 497 high-resolution 3-D OCM volumes (600 cross-sectional images ...
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    10. Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University

      Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University
      ...ubject. Interviews will be arranged on a rolling basis until the position is filled. About Lehigh University: Lehigh University is a private university located in Bethlehem, Pennsylvania , with easy access to Philadelphi...
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    11. Feature Of The Week 10/15/2017: Optical coherence tomography detects necrotic regions and volumetrically quantifies multicellular tumor spheroids

      Feature Of The Week 10/15/2017: Optical coherence tomography detects necrotic regions and volumetrically quantifies multicellular tumor spheroids
      ...tential for high-throughput drug screening. For more information see recent Article . Courtesy Chao Zhou from Lehigh University . Three-dimensional (3D) tumor spheroid models have gained increased recognition as importan...
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    12. Wide-field high-speed space-division multiplexing optical coherence tomography using an integrated photonic device

      Wide-field high-speed space-division multiplexing optical coherence tomography using an integrated photonic device
      Space-division multiplexing optical coherence tomography (SDM-OCT) is a recently developed parallel OCT imaging method in order to achieve multi-fold speed improvement. However, the assembly of fiber optics components used in the first prototype system was labor-intensive and susceptible to errors. Here, we demonstrate a high-speed SDM-OCT system using an integrated photonic chip that can be reliably manufactured with high precisions and low per-unit cost. A three-layer cascade of 1 2 ...
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    13. Optical coherence tomography detects necrotic regions and volumetrically quantifies multicellular tumor spheroids

      Optical coherence tomography detects necrotic regions and volumetrically quantifies multicellular tumor spheroids
      hree-dimensional (3D) tumor spheroid models have gained increased recognition as important tools in cancer research and anti-cancer drug development. However, currently available imaging approaches employed in high-throughput screening drug discovery platforms e.g. bright field, phase contrast, and fluorescence microscopies, are unable to resolve 3D structures deep inside (50 m) tumor spheroids. In this study, we established a label-free, non-invasive optical coherence tomography (OCT) imaging platform to characterize 3D morphological ...
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    14. Optical Coherence Tomography for Brain Imaging and Developmental Biology

      Optical Coherence Tomography for Brain Imaging and Developmental Biology
      Optical coherence tomography (OCT) is a promising research tool for brain imaging and developmental biology. Serving as a three-dimensional optical biopsy technique, OCT provides volumetric reconstruction of brain tissues and embryonic structures with micrometer resolution and video rate imaging speed. Functional OCT enables label-free monitoring of hemodynamic and metabolic changes in the brain in vitro and in vivo in animal models. Due to its noninvasiveness nature, OCT enables longitudinal imaging ...
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  2. About Lehigh University

    Lehigh University

    Lehigh University is a premier residential research university, ranked in the top tier of national research universities each year. We are a coeducational, nondenominational, private university that offers a distinct academic environment of undergraduate and graduate students from across the globe. The university offers majors and programs in four colleges: The College of Arts and Sciences, The College of Business and Economics, The College of Education and The P.C. Rossin College of Engineering and Applied Science. More than 4,700 undergraduate and 2,000 graduate students call Lehigh "home." Located in Pennsylvania’s scenic Lehigh Valley, the campus is situated on 1,600 acres in close proximity to both New York City and Philadelphia.