1. Lehigh University

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    1. Mentioned In 28 Articles

    2. Wide-field high-speed space-division multiplexing optical coherence tomography using an integrated photonic device

      Wide-field high-speed space-division multiplexing optical coherence tomography using an integrated photonic device
      Space-division multiplexing optical coherence tomography (SDM-OCT) is a recently developed parallel OCT imaging method in order to achieve multi-fold speed improvement. However, the assembly of fiber optics components used in the first prototype system was labor-intensive and susceptible to errors. Here, we demonstrate a high-speed SDM-OCT system using an integrated photonic chip that can be reliably manufactured with high precisions and low per-unit cost. A three-layer cascade of 1 2 ...
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    3. Optical coherence tomography detects necrotic regions and volumetrically quantifies multicellular tumor spheroids

      Optical coherence tomography detects necrotic regions and volumetrically quantifies multicellular tumor spheroids
      hree-dimensional (3D) tumor spheroid models have gained increased recognition as important tools in cancer research and anti-cancer drug development. However, currently available imaging approaches employed in high-throughput screening drug discovery platforms e.g. bright field, phase contrast, and fluorescence microscopies, are unable to resolve 3D structures deep inside (50 m) tumor spheroids. In this study, we established a label-free, non-invasive optical coherence tomography (OCT) imaging platform to characterize 3D morphological ...
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    4. Optical Coherence Tomography for Brain Imaging and Developmental Biology

      Optical Coherence Tomography for Brain Imaging and Developmental Biology
      Optical coherence tomography (OCT) is a promising research tool for brain imaging and developmental biology. Serving as a three-dimensional optical biopsy technique, OCT provides volumetric reconstruction of brain tissues and embryonic structures with micrometer resolution and video rate imaging speed. Functional OCT enables label-free monitoring of hemodynamic and metabolic changes in the brain in vitro and in vivo in animal models. Due to its noninvasiveness nature, OCT enables longitudinal imaging ...
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    5. Apparatus and method for space-division multiplexing optical coherence tomography

      Apparatus and method for space-division multiplexing optical coherence tomography
      A space-division multiplexing optical coherence tomography apparatus and system is provided. In one embodiment, the system includes a light source, a reference arm, and a sample arm. The sample arm splits the sampling light into a plurality of sampling beams which may be scanned simultaneously onto a surface of a sample. An optical delay may be introduced into the sampling beams before scanning. A plurality of reflected light signals returned ...
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    6. Label-Free Imaging of Eosinophilic Esophagitis Mouse Models Using Optical Coherence Tomography

      Label-Free Imaging of Eosinophilic Esophagitis Mouse Models Using Optical Coherence Tomography
      Eosinophilic esophagitis (EoE) is an immune-mediated disorder characterized by esophageal inflammation and related structural changes causing symptoms such as feeding difficulties and food impaction. The pathophysiological mechanisms underlying EoE remain poorly understood. Preclinical studies using mouse models have been critical in comprehending human disease mechanisms and associated pathways. In this chapter, we describe an experimental method using a noninvasive label-free optical imaging technique, optical coherence tomography, to characterize the pathophysiological ...
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    7. Post-doctoral Associate Position in Biophotonics/Biomedical Optical Imaging at Lehigh University

      Post-doctoral Associate Position in Biophotonics/Biomedical Optical Imaging at Lehigh University
      ...ubject. Interviews will be arranged on a rolling basis until the position is filled. About Lehigh University: Lehigh University is a private university located in Bethlehem, Pennsylvania , with easy access to Philadelphi...
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    8. Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University

      Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University
      ...ubject. Interviews will be arranged on a rolling basis until the position is filled. About Lehigh University: Lehigh University is a private university located in Bethlehem, Pennsylvania , with easy access to Philadelphi...
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    9. Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University

      Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University
      ...at to Dr. Chao Zhou ( chaozhou@lehigh.edu ) with Postdoc Application in the subject. About Lehigh University: Lehigh University is a private university located in Bethlehem, Pennsylvania , with easy access to Philadelphi...
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    10. Optogenetic pacing in Drosophila melanogaster

      Optogenetic pacing in Drosophila melanogaster
      Electrical stimulation is currently the gold standard for cardiac pacing. However, it is invasive and nonspecific for cardiac tissues. We recently developed a noninvasive cardiac pacing technique using optogenetic tools, which are widely used in neuroscience. Optogenetic pacing of the heart provides high spatial and temporal precisions, is specific for cardiac tissues, avoids artifacts associated with electrical stimulation, and therefore promises to be a powerful tool in basic cardiac research ...
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    11. A Circadian Clock Gene, Cry, Affects Heart Morphogenesis and Function in Drosophila as Revealed by Optical Coherence Microscopy

      A Circadian Clock Gene, Cry, Affects Heart Morphogenesis and Function in Drosophila as Revealed by Optical Coherence Microscopy
      ...evant data are within the paper and its Supporting Information files. Funding: This work was supported by the Lehigh University Start-up Fund, National Institutes of Health [R00EB010071 to C.Z., R15EB019704 to C.Z. and A...
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    12. Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University

      Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University
      ...at to Dr. Chao Zhou ( chaozhou@lehigh.edu ) with Postdoc Application in the subject. About Lehigh University: Lehigh University is a private university located in Bethlehem, Pennsylvania , with easy access to Philadelphi...
      Read Full Article
    13. Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University

      Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University
      ...ws will be scheduled as early as during the Photonics West conferences in Feb. 2015. About Lehigh University: Lehigh University is a private university located in Bethlehem, Pennsylvania , with easy access to Philadelphi...
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    14. SPACE-DIVISION Multiplexing Optical Coherence Tomography Apparatus

      SPACE-DIVISION Multiplexing Optical Coherence Tomography Apparatus
      A space-division multiplexing optical coherence tomography apparatus arid system is provided, in one embodiment, the system includes a light source, a reference arm. and a sample arm. The sample arm splits the sampling light into a plurality of sampling beams which may be scanned simultaneously onto a surface of a sample. An optical delay may be introduced into the sampling beams before scanning. A plurality of reflected light signals returned ...
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    15. System And Method For Parallel Imaging Optical Coherence Tomography

      System And Method For Parallel Imaging Optical Coherence Tomography
      A parallel imaging optical coherence tomography system. In one embodiment, the system includes a light source, a movable scan unit, and an interferometer comprising a reference arm and a sample arm. The scan unit includes a plurality of apertures illuminated by incident light from the light source. The scan unit produces a plurality of light beams transmitted to the interferometer. The light beams are each split producing a plurality of ...
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    16. 1-15 of 28 1 2 »
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  2. About Lehigh University

    Lehigh University

    Lehigh University is a premier residential research university, ranked in the top tier of national research universities each year. We are a coeducational, nondenominational, private university that offers a distinct academic environment of undergraduate and graduate students from across the globe. The university offers majors and programs in four colleges: The College of Arts and Sciences, The College of Business and Economics, The College of Education and The P.C. Rossin College of Engineering and Applied Science. More than 4,700 undergraduate and 2,000 graduate students call Lehigh "home." Located in Pennsylvania’s scenic Lehigh Valley, the campus is situated on 1,600 acres in close proximity to both New York City and Philadelphia.