1. Lawrence Livermore National Laboratory

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    1. Mentioned In 50 Articles

    2. Progress on Developing Adaptive Optics–Optical Coherence Tomography for In Vivo Retinal Imaging: Monitoring and Correction of Eye Motion Artifacts

      Progress on Developing Adaptive Optics–Optical Coherence Tomography for In Vivo Retinal Imaging: Monitoring and Correction of Eye Motion Artifacts
      Recent progress in retinal image acquisition techniques, including optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO), combined with improved performance of adaptive optics (AO) instrumentation, has resulted in improvement in the quality of in vivo images of cellular structures in the human retina. Here, we present a short review of progress on developing AO-OCT instruments. Despite significant progress in imaging speed and resolution, eye movements present during acquisition of ...
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    3. Performance of 97-elements ALPAO membrane magnetic deformable mirror in Adaptive Optics - Optical Coherence Tomography system for in vivo imaging of human retina

      Performance of 97-elements ALPAO membrane magnetic deformable mirror in Adaptive Optics - Optical Coherence Tomography system for in vivo imaging of human retina
      We present an evaluation of two different configurations of the ALPAO 97-actuator membrane magnetic deformable mirror for wavefront correction, using either 7 or 9 actuators across the eye pupil. These tests included monitoring of aberration correction for a human subject. This AO-sub system is part of the UC Davis high-resolution human retinal imaging adaptive optics - optical coherence tomography (AO-OCT) instrument. AO-OCT allows the three-dimensional (3D) visualization of different retinal structures ...
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    4. Integrated adaptive optics optical coherence tomography and adaptive optics scanning laser ophthalmoscope system for simultaneous cellular resolution in vivo retinal imaging

      Integrated adaptive optics optical coherence tomography and adaptive optics scanning laser ophthalmoscope system for simultaneous cellular resolution in vivo retinal imaging
      , , , , , , We describe an ultrahigh-resolution (UHR) retinal imaging system that combines adaptive optics Fourier-domain optical coherence tomography (AO-OCT) with an adaptive optics scanning laser ophthalmoscope (AO-SLO) to allow simultaneous data acquisition by the two modalities. The AO-SLO subsystem was ... [Biomed. Opt. Express 2, 1674-1686 (2011)]
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    5. Compact adaptive optic-optical coherence tomography system

      Compact adaptive optic-optical coherence tomography system
      Badal Optometer and rotating cylinders are inserted in the AO-OCT to correct large spectacle aberrations such as myopia, hyperopic and astigmatism for ease of clinical use and reduction. Spherical mirrors in the sets of the telescope are rotated orthogonally to reduce aberrations and beam displacement caused by the scanners. This produces greatly reduced AO registration errors and improved AO performance to enable high order aberration correction in a patient eyes.
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    6. Quantitative principal component model for skin chromophore mapping using multi-spectral images and spatial priors

      Quantitative principal component model for skin chromophore mapping using multi-spectral images and spatial priors
      We describe a novel reconstruction algorithm based on Principal Component Analysis (PCA) applied to multi-spectral imaging data. Using numerical phantoms, based on a two layered skin model developed previously, we found analytical expressions, which convert qualitative PCA results into quantitative blood volume and oxygenation values, assuming the epidermal thickness to be known. We also evaluate the limits of accuracy of this method when the value of the epidermal thickness is ...
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    7. Lantis Laser Seizes Unique Opportunity by Signing Letter of Intent to Merge With TAG Minerals Inc. and Its Wholly-Owned Operating Subsidiary TAG Minerals Zimbabwe Limited

      Lantis Laser Seizes Unique Opportunity by Signing Letter of Intent to Merge With TAG Minerals Inc. and Its Wholly-Owned Operating Subsidiary TAG Minerals Zimbabwe Limited
      ...clusive rights to the applications in dentistry of OCT technology under its exclusive license Agreements with Lawrence Livermore National Laboratory and with The Regents of the University of California for Near Infrared ...
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    8. AO-OCT with reference arm phase shifting for complex conjugate artifact-free imaging of in vivo retinal structures

      AO-OCT with reference arm phase shifting for complex conjugate artifact-free imaging of in vivo retinal structures
      We summarize the performance of an AO-OCT system with reference arm phase shifting for complex conjugate artifactfree imaging of in vivo retinal structures. As a complex conjugate artifact removal (CCR) method we used a previously reported technique requiring constant phase shifts between consecutive A-scans. In our system these shifts were generated by continuous beam path-length changes from offsetting the pivot point of the scanning mirror placed in the system reference ...
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    9. Sightseeing: Adaptive optics could peer deep into damaged eyes for earlier diagnoses

      Sightseeing: Adaptive optics could peer deep into damaged eyes for earlier diagnoses
      The earlier diabetic retinopathy, macular degeneration and glaucoma—the three most prevalent diseases causing blindness—can be diagnosed, the more successfully they can be treated. Obtaining high-res images of the retina is not so easy, however, due to aberrations caused by imperfections in the cornea and crystalline lens. Using the same adaptive optics principles that let astronomers see distant objects with such instruments as the Keck Telescope, researchers have created ...
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  2. About Lawrence Livermore National Laboratory

    Lawrence Livermore National Laboratory

    Lawrence Livermor National Laboratory (LLNL) is a United States Department of Energy (DOE) national laboratory, managed and operated by the University of California, in Livermore, California until September 30, 2007. As of October 1, 2007 the lab will be managed by Lawrence Livermore National Security, LLC (LLNS), a consortium comprised of the University of California, Bechtel National, BWX Technologies, Washington Group International, and Battelle Memorial Institute. Along with Los Alamos National Laboratory in New Mexico, it is one of the two United States laboratories whose founding mission was the design of nuclear weapons.

    LLNL is self-described as "a premier research and development institution for science and technology applied to national security." It is responsible for ensuring that the nation’s nuclear weapons remain "safe, secure, and reliable" through application of advances in science, engineering, and technology. The laboratory also applies its special expertise and multidisciplinary capabilities to preventing the [http://en.wiktionary.org/wiki/proliferation proliferation] and use of weapons of mass destruction, and to bolstering homeland security. Those capabilities are also utilized in programs in non-defense areas such as basic science, energy, environmental science, and biosciences.

    LLNL is home to many of the most powerful computer systems in the world, according to the TOP500 list — including Blue Gene/L, the world's fastest computer. Since 1978 the laboratory has received a total of 113 prestigious R&D; 100 Awards, including seven in 2006, the most for any institution. The awards are given annually by the editors of R&D; Magazine to the most innovative ideas of the year.

    LLNL's main facility is located on a one-square-mile site in Livermore, CA. Site 300, a ten-square-mile remote explosive/experiment testing site, is situated 18 miles to the east. Lawrence Livermore has an annual budget of about $1.6 billion and a staff of over 8,000 University of California employees, as well as 1,500 contract employees. Additionally, there are approximately 100 DOE employees stationed at the laboratory to provide federal oversight of LLNL's work for the DOE."