1. Lawrence A. Yannuzzi

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    1. Mentioned In 22 Articles

    2. CHARACTERIZING RETINAL–CHOROIDAL ANASTOMOSIS IN MACULAR TELANGIECTASIA TYPE 2 WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      CHARACTERIZING RETINAL–CHOROIDAL ANASTOMOSIS IN MACULAR TELANGIECTASIA TYPE 2 WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
      Purpose: To characterize structural and angiographic findings in macular telangiectasia Type 2 (MacTel 2) and examine associations with visual acuity. Methods: MacTel 2 patients with complete ophthalmologic examination, including fundus photography, autofluorescence, spectral-domain optical coherence tomography, and projection-resolved optical coherence tomography angiography , were retrospectively evaluated. Results: There were 43 eyes of 22 patients with a mean age 63.9 (10.3) years. Six patients had diabetes. Twenty-one eyes (48.8 ...
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    3. Filigree vascular pattern in Combined Hamartoma of Retina and Retinal Pigment Epithelium on Optical Coherence Tomography Angiography

      Filigree vascular pattern in Combined Hamartoma of Retina and Retinal Pigment Epithelium on Optical Coherence Tomography Angiography
      Objective To evaluate the vascular structure within combined hamartoma of retina and retinal pigment epithelium (CHRRPE) lesions using optical coherence tomography angiography (OCT-A). Design: Multicentre retrospective observational analysis Subjects: 20 eyes of patients diagnosed with CHRRPE Methods Retrospective analysis of color fundus photographs, optical coherence tomography (OCT) and OCT-A of 20 eyes with CHRRPE. Morphological characteristics of CHRRPE and the OCT features were correlated with the density of the filigree ...
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    4. Peripapillary versus macular combined hamartoma of the retina and retinal pigment epithelium: Imaging characteristics

      Peripapillary versus macular combined hamartoma of the retina and retinal pigment epithelium: Imaging characteristics
      Purpose To compare clinical, optical coherence tomography (OCT), and fundus autofluorescence (FAF) characteristics of peripapillary versus (vs.) macular variants of combined hamartoma of the retina and retinal pigment epithelium (combined hamartoma). Design Retrospective observational, comparative case series Methods:Setting Multicentre collaborative study Study Population 50 eyes with a clinical diagnosis of combined hamartoma Observational Analysis A comparative analysis of color fundus photographs (CFPs), OCT and FAF was performed for peripapillary ...
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    5. Imaging Of Pigment Epithelial Detachments With Optical Coherence Tomography Angiography

      Imaging Of Pigment Epithelial Detachments With Optical Coherence Tomography Angiography
      Purpose: To investigate the utility of optical coherence tomography angiography (OCTA) for detecting pathologic vascularization within pigment epithelial detachments (PEDs). Methods: This was a retrospective, cross-sectional, consecutive case series. Multimodal imaging (structural OCT, fluorescein, and indocyanine green angiography) was used as the gold standard to classify PEDs as nonvascularized or vascularized. Optical coherence tomography angiography imaging of the PED was subsequently and independently evaluated to classify PEDs as vascularized or ...
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    6. The Evolution of the Plateau, an Optical Coherence Tomography Signature Seen in Geographic Atrophy

      The Evolution of the Plateau, an Optical Coherence Tomography Signature Seen in Geographic Atrophy
      Purpose : Histologic details of progression routes to geographic atrophy (GA) in AMD are becoming available through optical coherence tomography (OCT). We studied the origins and evolution of an OCT signature called plateau in eyes with GA and suggested a histologic correlate. Methods : Serial eye-tracked OCT scans and multimodal imaging were acquired from eight eyes of seven patients with GA and plateau signatures over a mean follow-up of 7.7 years ...
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    7. Histologic and Optical Coherence Tomographic Correlates in Drusenoid Pigment Epithelium Detachment in Age-Related Macular Degeneration

      Histologic and Optical Coherence Tomographic Correlates in Drusenoid Pigment Epithelium Detachment in Age-Related Macular Degeneration
      Purpose Drusenoid pigment epithelium detachment (DPED) is a known precursor to geographic atrophy in age-related macular degeneration (AMD). We sought histologic correlates for spectral-domain (SD) optical coherence tomography (OCT) signatures in DPED and determined the frequency and origin of these OCT signatures in a clinical cohort of DPED eyes. Design Laboratory imaging and histologic comparison, and retrospective, observational cohort study. Participants Four donor eyes with histopathologic diagnosis of AMD (2 ...
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    8. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF CHORIORETINAL LESIONS DUE TO IDIOPATHIC MULTIFOCAL CHOROIDITIS

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF CHORIORETINAL LESIONS DUE TO IDIOPATHIC MULTIFOCAL CHOROIDITIS
      Purpose: To evaluate the spectrum of macular chorioretinal lesions occurring in idiopathic multifocal choroiditis using optical coherence tomography angiography (OCTA) to evaluate those showing neovascular flow. Methods: This was a descriptive, retrospective study of 18 eyes of 14 patients with multifocal choroiditis. Macular lesions were characterized as subretinal pigment epithelium, subretinal, or mixed and evaluated during active and presumed inactive states of multifocal choroiditis. Correlations between structural optical coherence tomography ...
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    9. TYPE 3 NEOVASCULARIZATION IMAGED WITH CROSS-SECTIONAL AND EN FACE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      TYPE 3 NEOVASCULARIZATION IMAGED WITH CROSS-SECTIONAL AND EN FACE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
      Purpose: To study the cross-sectional and en face optical coherence tomography angiography (OCTA) findings in Type 3 neovascularization (NV). Methods: Optical coherence tomography angiography imaging of 27 eyes of 23 patients with Type 3 NV was analyzed with 9 eyes having consecutive follow-up OCTA studies. Results: Type 3 NV appeared as a linear high-flow structure on cross-sectional OCTA corresponding to a high-flow tuft of vessels seen on en face OCTA ...
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    10. VOLUME-RENDERED ANGIOGRAPHIC AND STRUCTURAL OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF MACULAR TELANGIECTASIA TYPE 2

      VOLUME-RENDERED ANGIOGRAPHIC AND STRUCTURAL OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF MACULAR TELANGIECTASIA TYPE 2
      Purpose: To evaluate multimodal imaging including volume-rendered angiographic and structural optical coherence tomography of macular telangiectasia Type 2 (MacTel2) for right-angle vein complexes, macular cavitations, and signs of deeper retinal vascular invasion. Methods: Retrospective review of imaging performed in a community-based retinal referral center. The eyes were scanned using optical coherence tomography using split-spectrum amplitude-decorrelation techniques to derive flow information. These data were extracted and used to create volume-rendered images ...
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    11. Fractal Dimensional Analysis of Optical Coherence Tomography Angiography in Eyes With Diabetic Retinopathy

      Fractal Dimensional Analysis of Optical Coherence Tomography Angiography in Eyes With Diabetic Retinopathy
      Purpose : We used fractal dimensional analysis to analyze retinal vascular disease burden in eyes with diabetic retinopathy using spectral-domain optical coherence tomography angiography (OCTA). Methods : A retrospective study was performed of 13 eyes with diabetic retinopathy without diabetic macular edema and 56 control eyes. Optical coherence tomography angiography images were acquired using the RTVue XR Avanti. Automated segmentation was obtained through the superficial and deep capillary plexuses for each eye ...
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    12. Subretinal hyperreflective material imaged with optical coherence tomography angiography

      Subretinal hyperreflective material imaged with optical coherence tomography angiography
      Purpose The range of subretinal hyperreflective material (SHRM) seen in macular disease includes type 2 macular neovascularization, fibrosis, exudation, vitelliform material and hemorrhage. The prognostic significance of SHRM has been evaluated retrospectively in clinical trials but discriminating SHRM subtypes traditionally requires multiple imaging modalities. The purpose of this study is to describe optical coherence tomography angiography (OCTA) flow characteristics and artifacts which might help to distinguish SHRM subtypes. Design Validity ...
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    13. Volume-Rendering Optical Coherence Tomography Angiography of Macular Telangiectasia Type 2

      Volume-Rendering Optical Coherence Tomography Angiography of Macular Telangiectasia Type 2
      Purpose To evaluate the vascular structure of eyes with macular telangiectasia type 2 (MacTel2) using volume-rendered optical coherence tomography angiography (OCTA). Design Retrospective cross-sectional study. Participants A total of 14 consecutive patients (20 eyes) with MacTel2 who had a signal strength score 55 and could maintain fixation during the scan process. Methods The eyes were scanned using optical coherence tomography with split-spectrum amplitude decorrelation techniques to derive flow information. Data ...
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    14. A case of acute exudative polymorphous vitelliform maculopathy: follow-up and wide-field spectral-domain optical coherence tomography

      A case of acute exudative polymorphous vitelliform maculopathy: follow-up and wide-field spectral-domain optical coherence tomography
      To present a case of an HIV-positive patient with acute exudative polymorphous vitelliform maculopathy (AEPVM) and evaluate the presence of specific spectral-domain optical coherence tomography (SD-OCT) findings. Case report. We reviewed the AEPVM cases reported in the literature and compared those to our patient to determine if there is a correspondence between the etiology that leads to the onset of AEPVM and clinical and SD-OCT findings. Acute exudative polymorphous vitelliform ...
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  2. About Lawrence A. Yannuzzi

    Lawrence A. Yannuzzi

    Lawrence A. Yannuzzi is founder and chairman of the Viterous-Retina-Macular Consultants of New York. Larry Yannuzzi is a graduate of Harvard College and Boston University Medical School, where he was honored as a distinguished alumnus. He is a professor of clinical ophthalmology at Columbia University Medical School, vice–chairman and director of The Retinal Research Center of the Manhattan Eye, Ear & Throat Hospital, and founder and president of The Macula Foundation, Inc. He is a world renowned retinal specialist who has published more than 300 scientific papers and 11 textbooks, with particular interest in diseases of the macula, such as diabetic retinopathy and age–related macular degeneration. He has also been given awards and distinctions in his field for contributions on retinal imaging drug development, ophthalmic laser, and the diagnosis and treatment of macular and retinal diseases. His achievements have gained worldwide respect and admiration. Most recently, he was given an honorary doctorate at the University of Ancona, the Michelson Award for Retinal Vascular Disease in Gent, the Alcon Research Institution Award, a distinguished alumnus award at Boston University, and a lifetime achievement award by the American Academy of Ophthalmology.