1. Laura J. Balcer

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    1. Mentioned In 44 Articles

    2. The Latest on Optical Coherence Tomography

      The Latest on Optical Coherence Tomography
      Beginning almost 25 years ago, optical coherence tomography (OCT) began its journey into the mainstream of ophthalmology. Initially developed for retinal an vitro-retinal interface disease and glaucoma, this revolutionary technology has proven to ultimately have broader applications in neuro-ophthalmology and neurology, 2 specialties in which a better understating of OCT has led to more widespread investigation and clinical use.
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    3. Clinical trials to clinical use: using vision as a model for multiple sclerosis and beyond

      Clinical trials to clinical use: using vision as a model for multiple sclerosis and beyond
      Optical coherence tomography (OCT) has made possible the structurefunction correlations that uniquely characterize the afferent visual pathway as a model for understanding multiple sclerosis (MS) and for developing new treatments. During the past decade, OCT measures of retinal nerve fiber layer (RNFL) and ganglion cell/inner plexiform layer (GCL + IPL) thickness have evolved from being a means to validate visual function tests, such as low-contrast letter acuity, to provide a ...
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    4. Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria

      Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria
      Background: Retinal optical coherence tomography (OCT) permits quantification of retinal layer atrophy relevant to assessment of neurodegeneration in multiple sclerosis (MS). Measurement artefacts may limit the use of OCT to MS research. Objective: An expert task force convened with the aim to provide guidance on the use of validated quality control (QC) criteria for the use of OCT in MS research and clinical trials. Methods: A prospective multi-centre ( n = 13 ...
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    5. Monocular and binocular low-contrast visual acuity and optical coherence tomography in pediatric multiple sclerosis

      Monocular and binocular low-contrast visual acuity and optical coherence tomography in pediatric multiple sclerosis
      Background Low-contrast letter acuity and optical coherence tomography (OCT) capture visual dysfunction and axonal loss in adult-onset multiple sclerosis (MS), and have been proposed as secondary outcome metrics for therapeutic trials. Clinical trials will soon be launched in pediatric MS, but such outcome metrics have not been well-validated in this population. Objectives To determine whether MS onset during childhood and adolescence is associated with measurable loss of visual acuity and ...
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    6. Baseline Retinal Nerve Fiber Layer Thickness and Macular Volume Quantified by OCT in the North American Phase 3 Fingolimod Trial for Relapsing-Remitting Multiple Sclerosis

      Baseline Retinal Nerve Fiber Layer Thickness and Macular Volume Quantified by OCT in the North American Phase 3 Fingolimod Trial for Relapsing-Remitting Multiple Sclerosis
      Background: Patients with multiple sclerosis (MS) demonstrate thinning of peripapillary retinal nerve fiber layer (RNFL) and decreased macular volume as measured by optical coherence tomography (OCT). To our knowledge, there are no previous reports from a large MS OCT database with strict quality control measures that quantitate RNFL and macula in patients with relapsing-remitting multiple sclerosis. Methods: The University of California Davis OCT Reading Center gathered OCT data at baseline ...
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    7. Vision in Multiple Sclerosis: The Story, Structure-Function Correlations, and Models for Neuroprotection

      Vision in Multiple Sclerosis: The Story, Structure-Function Correlations, and Models for Neuroprotection
      Abstract: Visual dysfunction is one of the most common clinical manifestations of multiple sclerosis (MS). Just over a decade ago, MS clincial trials did not include visual outcomes, but experts recognized the need for more sensitive measures of visual function. Low-contrast letter acuity emerged as the leading candidate to measure visual disability in MS, and subsequent studies found low-contrast acuity testing to correlate well with brain MRI lesion burden, visual-evoked ...
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    8. The Impact of Utilizing Different Optical Coherence Tomography Devices for Clinical Purposes and in Multiple Sclerosis Trials

      The Impact of Utilizing Different Optical Coherence Tomography Devices for Clinical Purposes and in Multiple Sclerosis Trials
      ...iewicz Girish Hiremath Sheena K. Farrell Ciprian M. Crainiceanu Amy Conger Teresa C. Frohman Esther R. Bisker Laura J. Balcer Elliot M. Frohman Peter A. Calabresi Shiv Saidha 1 Department of Neurology, Johns Hopkins Univ...
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    9. Retinal Ganglion Cell Layer Volumetric Assessment by Spectral-Domain Optical Coherence Tomography in Multiple Sclerosis: Application of a High-Precision Manual Estimation Technique

      Retinal Ganglion Cell Layer Volumetric Assessment by Spectral-Domain Optical Coherence Tomography in Multiple Sclerosis: Application of a High-Precision Manual Estimation Technique
      Background: Neuronal loss in the retina has been demonstrated pathologically in eyes of patients with multiple sclerosis (MS). In vivo, MS eyes have reduced total macular volumes by optical coherence tomography (OCT). Using a high-resolution spectral-domain OCT, this pilot study used a manual method to measure ganglion cell layer (GCL) volumes and to determine the relation of these volumes to visual function in MS eyes. Methods: Sixteen eyes of 8 ...
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    10. Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography

      Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography
      Optical coherence tomography studies in multiple sclerosis have primarily focused on evaluation of the retinal nerve fibre layer. The aetiology of retinal changes in multiple sclerosis is thought to be secondary to optic nerve demyelination. The objective of this study was to use optical coherence tomography to determine if a subset of patients with multiple sclerosis exhibit primary retinal neuronopathy, in the absence of retrograde degeneration of the retinal nerve ...
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    11. Cup to disc ratio by optical coherence tomography is abnormal in multiple sclerosis

      Cup to disc ratio by optical coherence tomography is abnormal in multiple sclerosis
      Publication year: 2011Source: Journal of the Neurological Sciences, In Press, Corrected Proof, Available online 11 January 2011S.B., Syc , C.V., Warner , S., Saidha , S.K., Farrell , A., Conger , ... Objective: To identify and characterize cup to disc ratio (CDR) and related optic nerve head abnormalities in multiple sclerosis (MS) using spectral domain optical coherence tomography (OCT). Background: While CDR is routinely assessed by ophthalmologists in the evaluation of glaucoma, CDR ...
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    12. Associations between retinal nerve fiber layer abnormalities and optic nerve examination

      Associations between retinal nerve fiber layer abnormalities and optic nerve examination
      Objective: Retinal nerve fiber layer (RNFL) abnormalities detected by optical coherence tomography (OCT) are useful markers for axonal loss and visual dysfunction in multiple sclerosis (MS), but their role in routine clinical management is not well-studied. Methods: Clinical and OCT examinations were performed on 240 patients attending a neurology clinic. Using OCT 5th percentile to define abnormal RNFL thickness, we compared eyes classified by neurologists as having optic atrophy to ...
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    13. 16-30 of 44 « 1 2 3 »
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  2. About Laura J. Balcer

    Laura J. Balcer

    Laura J. Balcer, MD, MSCE, is an Associate Professor of Neurology Hospital of the University of Pennsylvania. Neuro-ophthalmologist.

  3. Quotes

    1. Multiple Sclerosis researchers are very excited about OCT.
      In Eyes reveal health secrets of the brain