1. Laser Zentrum Hannover

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    1. Mentioned In 25 Articles

    2. Adaptive optics assisted and optical coherence tomography guided fs-laser system for ophthalmic surgery in the posterior eye

      Adaptive optics assisted and optical coherence tomography guided fs-laser system for ophthalmic surgery in the posterior eye
      While fs-lasers are clinically established for surgery in the anterior eye, their use in the posterior eye is impeded by aberrations and focus position errors. We implemented a laboratory system to investigate whether fs-laser surgery in the posterior eye is made more feasible by aberration correction and tomographic image guidance. Aberration correction is obtained by adaptive optics (AO) and the image guidance is accomplished by optical coherence tomography (OCT). System ...
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    3. Effect of saline inhalation on vocal fold epithelial morphology evaluated by optical coherence tomography

      Effect of saline inhalation on vocal fold epithelial morphology evaluated by optical coherence tomography
      Objectives/Hypothesis Examination of tissue structures by optical coherence tomography (OCT) has been shown to be useful on mucous membranes of the vocal folds, but so far its application to the human larynx has been limited because it is technically cumbersome and usually needs to be performed with sedation. Here a newly developed, noninvasive combined laryngoscopy and OCT procedure is described and its suitability for ambulatory OCT studies evaluated. Because ...
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    4. Automated working distance adjustment enables optical coherence tomography of the human larynx in awake patients

      Automated working distance adjustment enables optical coherence tomography of the human larynx in awake patients
      Optical coherence tomography (OCT) provides structural information of laryngeal tissue which is comparable to histopathological analysis of biopsies taken under general anesthesia. In awake patients, movements impede clinically useful OCT acquisition. Therefore, an automatic compensation of movements was implemented into a swept source OCT-laryngoscope. Video and OCT beam path were combined in one tube of 10-mm diameter. Segmented OCT images served as distance sensor and a feedback control adjusted the ...
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    5. Towards femtosecond laser surgery guidance in the posterior eye: utilization of optical coherence tomography and adaptive optics for focus positioning and shaping

      Towards femtosecond laser surgery guidance in the posterior eye: utilization of optical coherence tomography and adaptive optics for focus positioning and shaping
      Although fs-laser surgery is clinically established in the field of corneal flap cutting for laser in situ keratomileusis, surgery with fs-laser in the posterior part of the eye is impaired by focus degradation due to aberrations. Precise targeting and keeping of safety distance to the retina also relies on an intraoperative depth resolved imaging. We demonstrate a concept for image guided fs-laser surgery in the vitreous body combining adaptive optics ...
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    6. In situ optical coherence tomography of percutaneous implant-tissue interfaces in a murine model

      In situ optical coherence tomography of percutaneous implant-tissue interfaces in a murine model
      Novel surface coatings of percutaneous implants need to be tested in biocompatibility studies. The use of animal models for testing usually involves numerous lethal biopsies for the analysis of the implant-tissue interface. In this study, optical coherence tomography (OCT) was used to monitor the reaction of the skin to a percutaneous implant in an animal model of hairless but immunocompetent mice. In vivo optical biopsies with OCT were taken at ...
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    7. Compensating Motion Artifacts of 3D in vivo SD-OCT Scans

      Compensating Motion Artifacts of 3D in vivo SD-OCT Scans
      We propose a probabilistic approach for compensating motion artifacts in 3D in vivo SD-OCT (spectral-domain optical coherence tomography) tomographs. Subject movement causing axial image shifting is a major problem for in vivo imaging. Our technique is applied to analyze the tissue at percutaneous implants recorded with SD-OCT in 3D. The key challenge is to distinguish between motion and the natural 3D spatial structure of the scanned subject. To achieve this ...
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    8. Feature Of The Week 12/4/11: Researchers in Hannover Germany Utilize OCT to Measure Skin Swelling Along Percutaneous Implants

      Feature Of The Week 12/4/11: Researchers in Hannover Germany Utilize OCT to Measure Skin Swelling Along Percutaneous Implants
      ... in hairless mice", Proc. SPIE 7554, 75540S (2010) Researchers from the Leibniz University of Hannover (LUH), Laser Zentrum Hannover (LZH), and the Hannover Medical School (MHH) used OCT to measure skin swelling along pe...
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    9. Model Based 3D Segmentation and OCT Image Undistortion of Percutaneous Implants

      Model Based 3D Segmentation and OCT Image Undistortion of Percutaneous Implants
      Optical Coherence Tomography (OCT) is a noninvasive im-aging technique which is used here for in vivo biocompatibility studies of percutaneous implants. A prerequisite for a morphometric analysis of the OCT images is the correction of optical distortions caused by the index of refraction in the tissue. We propose a fully automatic approach for 3D segmentation of percutaneous implants using Markov random fields. Refraction correction is done by using the subcutaneous ...
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    10. Holoscopy: holographic optical coherence tomography

      Holoscopy: holographic optical coherence tomography
      We demonstrate Holoscopy -- a combination of full-field swept-source optical coherence tomography and digital holography. By using a simple Michelson interferometer setup, a rapidly tunable laser and combining scalar diffraction theory with standard Fourier-domain OCT signal processing we obtain depth invariant imaging quality.
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    11. A laryngoscope for office-based imaging of human vocal folds using OCT

      We developed a laryngoscope with an integrated OCT beam path for office-based non-contact imaging of human vocal folds. In combination with conventional videolaryngoscopy superficial and subsurface lesions can be detected. For error-free interpretation of OCT images obtained in office-based examination motion artifacts have to be considered. To demonstrate the implications on OCT images we simulated probe and patient movements for different commercial systems representing the three OCT modalities and analyzed ...
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  2. About Laser Zentrum Hannover

    Laser Zentrum Hannover

    Laser Zentrum Hannover e.V. is involved in research, development and consulting. On June 20, 1986 the Laser Zentrum Hannover e.V. (LZH) was founded under the patronage of the German State Ministry of Trade, Industry, Technology, and Transportation in Lower Saxony. The institution’s legal form is that of a registered association. The association’s main task is to support applied research in laser technology on a non-profit basis. The LZH is involved in: R&D projects in the field of laser development and laser applications; Technical and scientific consulting to link research and practice.  Industry-oriented training of experts for applying and operating laser systems.  The Department Biophotonics/Lasermedicine at the Laser Zentrum Hannover e.V. is a leading research group on lasers and biophotonics. The Biomedical Optics Department focuses on lasers and optics in the field of laser medicine and biophotonics. Currently, the department has two groups: Laser Medicine and Biophotonics. The main research subjects of the group of Medical Laser Application are in the field of online monitoring and diagnostics as well as the development of new therapheutic methods. The main focus in research is based upon the use of ultrashort (fs) laser pulses.