1. Kyoto University Graduate School of Medicine

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    1. Mentioned In 94 Articles

    2. Automated Assessment of Drusen Using Three-dimensional Spectral-domain Optical Coherence Tomography

      Automated Assessment of Drusen Using Three-dimensional Spectral-domain Optical Coherence Tomography

      Purpose: To compare automated assessment of macular drusen delineated by our originally-developed algorithm on 3-dimensional (3D) spectral-domain optical coherence tomography (SD-OCT) with the assessment by certificated graders on color fundus photographs in non-neovascular age-related macular degeneration (AMD). Design: Prospective case series. Methods: Automated assessment of macular drusen was performed using raster scan by 3D OCT-1000 (Topcon) in 18 eyes with non-neovascular AMD with at least one large druse (≥125μm) and predominantly soft indistinct drusen. We defined drusen as the regions that have the distance between the RPE and calculated Bruch's membrane lines > predefined threshold distances. We assessed the agreement ...

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    3. Characteristics of Optical Coherence Tomographic Hyperreflective Foci in Retinal Vein Occlusion

      Characteristics of Optical Coherence Tomographic Hyperreflective Foci in Retinal Vein Occlusion
      Purpose: To evaluate the hyperreflective foci in branch retinal vein occlusion and central retinal vein occlusion depicted by spectral-domain optical coherence tomography (OCT). Methods: Consecutive series of 73 eyes of 73 patients with retinal vein occlusion (58 branch retinal vein occlusion and 15 central retinal vein occlusion) who had Spectralis OCT images obtained were retrospectively reviewed, comparing color fundus photographs and fluorescein angiography. Results: Hyperreflective foci were detected in 54 eyes (74.0%) by spectral-domain OCT, and hard exudates were detected in 17 eyes (23.3%) by color fundus photography. Hard exudates on the color photographs corresponded to the confluence ...
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    4. Effects of Age, Sex, and Axial Length on the Three-Dimensional Profile of Normal Macular Layer Structures

      Effects of Age, Sex, and Axial Length on the Three-Dimensional Profile of Normal Macular Layer Structures
      Purpose. To identify sex-related differences and age-related changes in individual retinal layer thicknesses in a population of healthy eyes across the lifespan, using spectral domain optical coherence tomography (SD-OCT). Methods. In seven institutes in Japan, mean thicknesses of the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), photoreceptor inner segment (IS), and photoreceptor outer segment (OS) were measured using SD-OCT with a new automated segmentation protocol in 256 healthy subjects. Results. Interoperator coefficients of variability for measurements of each layer ranged from 0 ...
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    5. Detection of Localized Retinal Nerve Fiber Layer Defects in Glaucoma Using Enhanced Spectral-Domain Optical Coherence Tomography

      Detection of Localized Retinal Nerve Fiber Layer Defects in Glaucoma Using Enhanced Spectral-Domain Optical Coherence Tomography

      Objective:To compare retinal nerve fiber layer (RNFL) defects on fundus photographs with circumpapillary RNFL (cpRNFL) thinning or disruption on images obtained by speckle-noise–reduced spectral-domain optical coherence tomography (enhanced SD OCT), single-scan SD OCT, and single-scan time-domain OCT (TD OCT).Design:Retrospective, comparative case series.Participants:Forty-four eyes of 44 patients with open-angle glaucoma with localized, wedge-shaped RNFL defects on red-free photographs and 35 normal eyes of 35 volunteers.Methods:Cross-sectional images of the cpRNFL and cpRNFL thinning, compared with the confidence interval limit of the normative database where the RNFL defect was photographically identified, were compared between the ...

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    6. Spectral-domain optical coherence tomography for three-dimensional visualization of the detached membrane in Valsalva retinopathy

      Spectral-domain optical coherence tomography for three-dimensional visualization of the detached membrane in Valsalva retinopathy
      Valsalva retinopathy occurs in patients with a history of increased intrathoracic pressure, and is characterized by hemorrhagic detachment of the internal limiting membrane (ILM), preretinal hemorrhage, or vitreous hemorrhage.1 Several reports have described the time-domain optical coherence tomography (TD-OCT) features of premacular hemorrhage and the preretinal membrane in patients with Valsalva retinopathy.2,3 However, the information is of limited use because of the relatively slow scan speed and low axial resolution of TD-OCT. Spectral-domain optical coherence tomography (SD-OCT) achieves higher imaging speeds as well as a higher signal-to-noise ratio than TD-OCT, and can produce three-dimensional (3D) data. To ...
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    7. Inner retinal changes in acute-phase Vogt-Koyanagi-Harada disease measured by enhanced spectral domain optical coherence tomography

      Inner retinal changes in acute-phase Vogt-Koyanagi-Harada disease measured by enhanced spectral domain optical coherence tomography
      Purpose To assess the changes of inner retinal thickness in patients with Vogt-Koyanagi-Harada disease (VKH) using enhanced spectral domain optical coherence tomography (SD-OCT). Methods We retrospectively reviewed enhanced SD-OCT images of 12 eyes of seven consecutive patients with VKH in both acute and convalescent phases. Inner retinal thickness, measured from the inner limiting membrane to the inner plexiform layer (ILM-IPL), and nerve fiber layer (NFL) thickness at 1.5 and 2.0 mm along the outer border of the IPL from the central fovea at nasal, temporal, superior, and inferior points were measured. Twelve eyes of 12 patients with central ...
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    8. Canon donation supports establishment of Kyoto University advanced medical device development and clinical research center

      Canon donation supports establishment of Kyoto University advanced medical device development and clinical research center
      ...the establishment of the Center. Academic partnership with Kyoto University: CK Project In 2006, Canon and Kyoto University launched the Innovative Techno-hub for Integrated Medical Bio-imaging project, also known as ...
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    9. High-Resolution Imaging of the Photoreceptor Layer in Epiretinal Membrane Using Adaptive Optics Scanning Laser Ophthalmoscopy

      High-Resolution Imaging of the Photoreceptor Layer in Epiretinal Membrane Using Adaptive Optics Scanning Laser Ophthalmoscopy
      Objective: To compare, in eyes with an idiopathic epiretinal membrane (ERM), photoreceptor cell structural abnormalities identified on high-resolution images obtained by adaptive optics scanning laser ophthalmoscopy (AO-SLO) with the severity of metamorphopsia and anatomic findings on spectral-domain optical coherence tomography (SD-OCT). Design: Observational case series. Participants: Twenty-five eyes of 24 patients with idiopathic ERM and 20 normal eyes of 20 volunteer subjects. Methods: All participants underwent a full ophthalmologic examination, SD-OCT, and imaging with an original prototype AO-SLO system that incorporated liquid crystal-on-silicon technology. In eyes with ERM, M-CHARTS results were used to quantify metamorphopsia. Main Outcome Measures: Cone mosaic ...
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  2. About Kyoto University Graduate School of Medicine

    Kyoto University Graduate School of Medicine

    Kyoto University is a major national university in Kyoto, Japan. It is the second oldest university in Japan, and formerly one of the Imperial Universities of Japan. The university has a total of about 22,000 students enrolled in its undergraduate and graduate programs.  Kyoto University has historically advocated a "spirit of freedom" in its academic activities. Kyoto University Graduate School of Medicine is a medical school associated with Kyoto University.