1. Korea University

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    1. Mentioned In 93 Articles

    2. Comparison of choroidal hyperreflective spots on optical coherence tomography images between both eyes of normal subjects

      Comparison of choroidal hyperreflective spots on optical coherence tomography images between both eyes of normal subjects
      Background: Advancement of optical coherence tomography (OCT) technology allows for better in vivo visualization of the choroidal architecture, which comprises vessels and stroma. However, most OCT studies using image binarization methods have focused only on choroidal vessels represented by dark pixels. This study aimed to compare the distribution of choroidal hyperreflective spots on swept-source OCT (SS-OCT) images between both eyes of normal subjects. Methods: In this observational comparative study, we ...
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      Mentions: Korea University
    3. Comprehensive Assessment of High-Risk Plaques by Dual-Modal Imaging Catheter in Coronary Artery

      Comprehensive Assessment of High-Risk Plaques by Dual-Modal Imaging Catheter in Coronary Artery
      Coronary plaque destabilization involves alterations in microstructure and biochemical composition; however, no imaging approach allows such comprehensive characterization. Herein, the authors demonstrated a simultaneous microstructural and biochemical assessment of high-risk plaques in the coronary arteries in a beating heart using a fully integrated optical coherence tomography and fluorescence lifetime imaging (FLIm). It was found that plaque components such as lipids, macrophages, lipids+macrophages, and fibrotic tissues had unique fluorescence lifetime ...
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    4. Predictive role of optical coherence tomography angiography for exudation recurrence in patients with type 1 neovascular age-related macular degeneration treated with pro-re-nata protocol

      Predictive role of optical coherence tomography angiography for exudation recurrence in patients with type 1 neovascular age-related macular degeneration treated with pro-re-nata protocol
      Objectives We sought to identify the consecutive changes and predictive features for exudation recurrence in macular neovascularization (MNV) using optical coherence tomography angiography (OCTA) in type 1 neovascular age-related macular degeneration (NVAMD). Methods A total of 291 OCTA images in consecutive visit of 45 patients newly diagnosed with type 1 NMV and treated with three loading intravitreal antivascular endothelial growth factor injections (IVIs) and a pro-re-nata (PRN) therapy regimen were ...
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      Mentions: Korea University
    5. Analysis of Microvasculature in Nonhuman Primate Macula With Acute Elevated Intraocular Pressure Using Optical Coherence Tomography Angiography

      Analysis of Microvasculature in Nonhuman Primate Macula With Acute Elevated Intraocular Pressure Using Optical Coherence Tomography Angiography
      Purpose: To investigate responses of macular capillary vessel area density (VAD) of superficial and deep retinal vascular plexuses to elevations in intraocular pressure (IOP) in cynomolgus macaque monkeys using optical coherence tomography angiography (OCTA). Methods: In five general anesthetized male cynomolgus monkeys, the IOP was increased incrementally by 10 mmHg from baseline (10 mmHg) to 70 mmHg and then decreased back to 10 mmHg (recovery state). Structural OCT (30 30 ...
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      Mentions: Korea University
    6. Normative Data of Ocular Biometry, Optical Coherence Tomography, and Electrophysiology Conducted for Cynomolgus Macaque Monkeys

      Normative Data of Ocular Biometry, Optical Coherence Tomography, and Electrophysiology Conducted for Cynomolgus Macaque Monkeys
      Purpose: To present normative data of optical coherence tomography (OCT) parameters, electrophysiological tests, and optical biometry conducted for cynomolgus monkeys. Methods: Multimodal examinations were performed for 11 adult cynomolgus monkeys (Macaca fascicularis, weighing 2.6-7.5 kg, aged 45-99 months). A-scan biometry was performed to measure ocular biometry. OCT images were obtained at 30 and 55. After the pupils were fully dilated, electroretinogram (ERG) and visual evoked potentials (VEP) were ...
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      Mentions: Korea University
    7. MORPHOLOGICAL AND ANATOMICAL FEATURES OF TYPE 1 MACULAR NEOVASCULARIZATION TRUNKS IN AGE-RELATED MACULAR DEGENERATION USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      MORPHOLOGICAL AND ANATOMICAL FEATURES OF TYPE 1 MACULAR NEOVASCULARIZATION TRUNKS IN AGE-RELATED MACULAR DEGENERATION USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
      Purpose: To evaluate the morphological features of macular neovascularization (MNV) trunks at different layers using optical coherence tomography angiography (OCTA). Methods: Type 1 MNV trunks in age-related macular degeneration were retrospectively evaluated at the sub-retinal pigment epithelium (subRPE) and sub-Bruchs membrane (subBM) layers. The detectability and location of the trunks were compared. MNV trunks at the subBM layer on OCTA b-scans were evaluated using a flow overlay. The correlations of ...
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      Mentions: Korea University
    8. Single-shot multiple-depth macroscopic imaging by spatial frequency multiplexing

      Single-shot multiple-depth macroscopic imaging by spatial frequency multiplexing
      We present a low-coherence interferometric imaging system designed for 3-dimensional (3-D) imaging of a macroscopic object through a narrow passage. Our system is equipped with a probe-type port composed of a bundle fiber for imaging and a separate multimode optical fiber for illumination. To eliminate the need for mechanical depth scanning, we employ a spatial frequency multiplexing method by installing a 2-D diffraction grating and an echelon in the reference ...
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    9. Macrophage targeted theranostic strategy for accurate detection and rapid stabilization of the inflamed high-risk plaque

      Macrophage targeted theranostic strategy for accurate detection and rapid stabilization of the inflamed high-risk plaque
      Rationale: Inflammation plays a pivotal role in the pathogenesis of the acute coronary syndrome. Detecting plaques with high inflammatory activity and specifically treating those lesions can be crucial to prevent life-threatening cardiovascular events. Methods: Here, we developed a macrophage mannose receptor (MMR)-targeted theranostic nanodrug (mannose-polyethylene glycol-glycol chitosan-deoxycholic acid-cyanine 7-lobeglitazone; MMR-Lobe-Cy) designed to identify inflammatory activity as well as to deliver peroxisome proliferator-activated gamma (PPAR) agonist, lobeglitazone, specifically to high-risk ...
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      Mentions: Korea University
    10. Imaging catheter system

      Imaging catheter system
      Disclosed is an imaging catheter system that utilizes optical coherence tomography and autofluorescence lifetime imaging microscopy. The disclosed imaging catheter system may include: an autofluorescence light source; an OCT device; a catheter device configured to receive rays inputted from the autofluorescence light source and an OCT light source of the OCT device and scan a specimen; an optical detector unit configured to detect autofluorescence generated from the specimen; and a ...
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    11. Relationship between retinal capillary vessel density of OCT angiography and intraocular pressure in pig

      Relationship between retinal capillary vessel density of OCT angiography and intraocular pressure in pig
      The purpose of this study was to evaluate density change in the retinal capillary plexus during intra ocular pressure (IOP) elevation in vitrectomized pigs' eyes using optical coherence tomography angiography (OCTA). Eight eyes of eight micro pigs received vitrectomy and the IOP was controlled from 15 mmHg (baseline) to 105 mmHg in 15 mmHg increments using a vented-gas forced-infusion system, and then decreased back to normal IOP (recovery state). The ...
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      Mentions: Korea University
    12. First-In-Human Intracoronary OCT-FLIm In Patients Undergoing PCI

      First-In-Human Intracoronary OCT-FLIm In Patients Undergoing PCI
      Patients will undergo intracoronary imaging using combined optical coherence tomography- fluorescence lifetime imaging (OCT-FLIm) during percutaneous coronary intervention, and the obtained imaging data will be used to assess the efficacy of this dual-modal catheter imaging strategy in characterizing high-risk plaque.
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      Mentions: Korea University
    13. Single-shot multi-depth full-field optical coherence tomography using spatial frequency division multiplexing

      Single-shot multi-depth full-field optical coherence tomography using spatial frequency division multiplexing
      Fast 3D volumetric imaging has been essential for biology, medicine and industrial inspections, and various optical coherence tomography (OCT) methods have been developed to meet such needs. Point-scanning based approaches, such as swept-source OCT and spectral domain OCT, can obtain a depth information at once, but they require lateral scan for full 3D imaging. On the contrary, full-field OCT needs the scanning of imaging depth while it records a full ...
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    14. Optical coherence tomography-based machine learning for predicting fractional flow reserve in intermediate coronary stenosis: a feasibility study

      Optical coherence tomography-based machine learning for predicting fractional flow reserve in intermediate coronary stenosis: a feasibility study
      Machine learning approaches using intravascular optical coherence tomography (OCT) to predict fractional flow reserve (FFR) have not been investigated. Both OCT and FFR data were obtained for left anterior descending artery lesions in 125 patients. Training and testing groups were partitioned in the ratio of 5:1. The OCT-based machine learning-FFR was derived for the testing group and compared with wire-based FFR in terms of ischemia diagnosis (FFR 0.8 ...
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    15. Identification of plaque ruptures using a novel discriminative model comprising biomarkers in patients with acute coronary syndrome

      Identification of plaque ruptures using a novel discriminative model comprising biomarkers in patients with acute coronary syndrome
      Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1), neutrophil gelatinase-associated lipocalin (NGAL), and matrix metalloproteinase-9 (MMP-9) are inflammatory biomarkers involved in plaque destabilization resulting in acute coronary syndrome (ACS). This study aimed to investigate the diagnostic value of a combination of biomarkers to discriminate plaque ruptures in the setting of ACS. Eighty-five ACS patients with optical coherence tomography (OCT) images of the culprit plaque were included and categorized into two groups ...
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      Mentions: Korea University
    16. Optical coherence tomographic features of macular telangiectasia type 2: Korean Macular Telangiectasia Type 2 Study—Report No. 1

      Optical coherence tomographic features of macular telangiectasia type 2: Korean Macular Telangiectasia Type 2 Study—Report No. 1
      We analysed the imaging findings of macular telangiectasia (MacTel) type 2 in Korea using spectral domain optical coherence tomography (SD-OCT) and investigated their relationship with visual acuity and clinical stages. A retrospective multicentre cross-sectional study was conducted in six tertiary hospitals in Korea and included 129 patients. We analysed all the SD-OCT images encompassing the macular area. Hyporeflective cavities (77.7%) were the most frequently detected abnormalities in SD-OCT. Disruption ...
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  2. About Korea University

    Korea University

    Korea University is a private research university located primarily in Seoul, South Korea, and a member of the SKY (universities). It was founded by Lee Yong-ik in the present-day town of Anam in 1905. The university is the oldest institution of higher education in South Korea. Korea University is a comprehensive research institution consisting of 81 academic departments in 15 colleges and 75 research institutes.  Korea University College of Medicine.