1. Korea University

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    1. Mentioned In 85 Articles

    2. Macrophage targeted theranostic strategy for accurate detection and rapid stabilization of the inflamed high-risk plaque

      Macrophage targeted theranostic strategy for accurate detection and rapid stabilization of the inflamed high-risk plaque
      Rationale: Inflammation plays a pivotal role in the pathogenesis of the acute coronary syndrome. Detecting plaques with high inflammatory activity and specifically treating those lesions can be crucial to prevent life-threatening cardiovascular events. Methods: Here, we developed a macrophage mannose receptor (MMR)-targeted theranostic nanodrug (mannose-polyethylene glycol-glycol chitosan-deoxycholic acid-cyanine 7-lobeglitazone; MMR-Lobe-Cy) designed to identify inflammatory activity as well as to deliver peroxisome proliferator-activated gamma (PPAR) agonist, lobeglitazone, specifically to high-risk ...
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      Mentions: Korea University
    3. Imaging catheter system

      Imaging catheter system
      Disclosed is an imaging catheter system that utilizes optical coherence tomography and autofluorescence lifetime imaging microscopy. The disclosed imaging catheter system may include: an autofluorescence light source; an OCT device; a catheter device configured to receive rays inputted from the autofluorescence light source and an OCT light source of the OCT device and scan a specimen; an optical detector unit configured to detect autofluorescence generated from the specimen; and a ...
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    4. Relationship between retinal capillary vessel density of OCT angiography and intraocular pressure in pig

      Relationship between retinal capillary vessel density of OCT angiography and intraocular pressure in pig
      The purpose of this study was to evaluate density change in the retinal capillary plexus during intra ocular pressure (IOP) elevation in vitrectomized pigs' eyes using optical coherence tomography angiography (OCTA). Eight eyes of eight micro pigs received vitrectomy and the IOP was controlled from 15 mmHg (baseline) to 105 mmHg in 15 mmHg increments using a vented-gas forced-infusion system, and then decreased back to normal IOP (recovery state). The ...
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      Mentions: Korea University
    5. First-In-Human Intracoronary OCT-FLIm In Patients Undergoing PCI

      First-In-Human Intracoronary OCT-FLIm In Patients Undergoing PCI
      Patients will undergo intracoronary imaging using combined optical coherence tomography- fluorescence lifetime imaging (OCT-FLIm) during percutaneous coronary intervention, and the obtained imaging data will be used to assess the efficacy of this dual-modal catheter imaging strategy in characterizing high-risk plaque.
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      Mentions: Korea University
    6. Single-shot multi-depth full-field optical coherence tomography using spatial frequency division multiplexing

      Single-shot multi-depth full-field optical coherence tomography using spatial frequency division multiplexing
      Fast 3D volumetric imaging has been essential for biology, medicine and industrial inspections, and various optical coherence tomography (OCT) methods have been developed to meet such needs. Point-scanning based approaches, such as swept-source OCT and spectral domain OCT, can obtain a depth information at once, but they require lateral scan for full 3D imaging. On the contrary, full-field OCT needs the scanning of imaging depth while it records a full ...
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    7. Optical coherence tomography-based machine learning for predicting fractional flow reserve in intermediate coronary stenosis: a feasibility study

      Optical coherence tomography-based machine learning for predicting fractional flow reserve in intermediate coronary stenosis: a feasibility study
      Machine learning approaches using intravascular optical coherence tomography (OCT) to predict fractional flow reserve (FFR) have not been investigated. Both OCT and FFR data were obtained for left anterior descending artery lesions in 125 patients. Training and testing groups were partitioned in the ratio of 5:1. The OCT-based machine learning-FFR was derived for the testing group and compared with wire-based FFR in terms of ischemia diagnosis (FFR 0.8 ...
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    8. Identification of plaque ruptures using a novel discriminative model comprising biomarkers in patients with acute coronary syndrome

      Identification of plaque ruptures using a novel discriminative model comprising biomarkers in patients with acute coronary syndrome
      Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1), neutrophil gelatinase-associated lipocalin (NGAL), and matrix metalloproteinase-9 (MMP-9) are inflammatory biomarkers involved in plaque destabilization resulting in acute coronary syndrome (ACS). This study aimed to investigate the diagnostic value of a combination of biomarkers to discriminate plaque ruptures in the setting of ACS. Eighty-five ACS patients with optical coherence tomography (OCT) images of the culprit plaque were included and categorized into two groups ...
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      Mentions: Korea University
    9. Optical coherence tomographic features of macular telangiectasia type 2: Korean Macular Telangiectasia Type 2 Study—Report No. 1

      Optical coherence tomographic features of macular telangiectasia type 2: Korean Macular Telangiectasia Type 2 Study—Report No. 1
      We analysed the imaging findings of macular telangiectasia (MacTel) type 2 in Korea using spectral domain optical coherence tomography (SD-OCT) and investigated their relationship with visual acuity and clinical stages. A retrospective multicentre cross-sectional study was conducted in six tertiary hospitals in Korea and included 129 patients. We analysed all the SD-OCT images encompassing the macular area. Hyporeflective cavities (77.7%) were the most frequently detected abnormalities in SD-OCT. Disruption ...
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    10. Comparison of optical coherence tomography–guided versus intravascular ultrasound–guided percutaneous coronary intervention: Rationale and design of a randomized, controlled OCTIVUS trial

      Comparison of optical coherence tomography–guided versus intravascular ultrasound–guided percutaneous coronary intervention: Rationale and design of a randomized, controlled OCTIVUS trial
      Background The clinical value of intracoronary imaging for percutaneous coronary intervention (PCI) guidance is well acknowledged. Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) are the most commonly used intravascular imaging to guide and optimize PCI in day-to-day practice. However, the comparative effectiveness of IVUS-guided versus OCT-guided PCI with respect to clinical end points remains unknown. Methods and design The OCTIVUS study is a prospective, multicenter, open-label, parallel-arm, randomized trial ...
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    11. Flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure

      Flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure
      Micro-optical coherence tomography (OCT) is a novel imaging approach enabling visualization of the microstructures of biological tissues at a cellular or sub-cellular level. However, it has been challenging to develop a miniaturized flexible endoscopic OCT probe allowing helical luminal scanning. In this study, we built a flexible endoscopic OCT probe with an outer diameter of 1.2mm, which acquires three-dimensional images of the arterial microstructures via helical scanning with an ...
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    12. Cross‐scanning optical coherence tomography angiography for eye motion correction

      Cross‐scanning optical coherence tomography angiography for eye motion correction
      We propose a cross‐scanning optical coherence tomography (CS‐OCT) system to correct eye motion artifacts in OCT angiography images. This system employs a dual illumination configuration with two orthogonally polarized beams, each of which simultaneously perform raster scanning in perpendicular direction with each other over the same area. In the reference arm, a polarization delay unit is used to acquire the two orthogonally polarized interferograms with a single photodetector ...
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      Mentions: Korea University
    13. Clinical Implications of Suspended Scattering Particles in Motion Observed by Optical Coherence Tomography Angiography

      Clinical Implications of Suspended Scattering Particles in Motion Observed by Optical Coherence Tomography Angiography
      The objective of this study was to investigate the relationship between suspended scattering particles in motion (SSPiM) in optical coherence tomography angiography (OCTA) and treatment response in diabetic macular edema (DME). We retrospectively reviewed the medical records of patients diagnosed with DME who had undergone intravitreal injection. The optical density ratio (ODR) of the intraretinal cyst and the numbers of hyperreflective foci from OCT images and SSPiM from OCTA images ...
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    14. Characteristics of diffuse retinal nerve fiber layer defects in red-free photographs as observed in optical coherence tomography en face images

      Characteristics of diffuse retinal nerve fiber layer defects in red-free photographs as observed in optical coherence tomography en face images
      Backgroud To determine whether diffuse retinal nerve fiber layer (RNFL) defects, identified on red-free fundus photographs, could be identified on optical coherence tomography (OCT) en face structural images and to evaluate which factors are related to the different recognition patterns on en face images. Methods This retrospective, cross-sectional study included open-angle glaucoma eyes with diffuse RNFL defects in the inferior hemifield, identified in red-free photographs. The corresponding OCT en face ...
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      Mentions: Korea University
    15. Visualising ganglion cell layer based on image entropy optimisation for adaptive contrast enhancement

      Visualising ganglion cell layer based on image entropy optimisation for adaptive contrast enhancement
      Optical coherence tomography cannot easily be used for visual identification of the ganglion cell layer (GCL) for diagnosing retinal diseases owing to the extremely low image contrast between adjacent layers. To solve this problem, the authors used a limit-clipping optimisation method along with the image entropy to enhance the image contrast of targeted layers. As a result, the GCL was successfully extracted using an intelligent tracking system without impacting the ...
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    16. Localized Retinal Nerve Fiber Layer Defect Location Among Red-free Fundus Photographs, En Face Structural Images, and Cirrus HD-OCT Maps

      Localized Retinal Nerve Fiber Layer Defect Location Among Red-free Fundus Photographs, En Face Structural Images, and Cirrus HD-OCT Maps
      Precis: Although the localized retinal nerve fiber layer (RNFL) defects in the en face structural images showed excellent topographic correlation with those in red-free photographs, the RNFL defect was frequently misidentified by the optical coherence tomography (OCT) deviation map. Purpose: The purpose of this study was to compare the location of localized RNFL defects using red-free fundus photographs, OCT en face structural images, and OCT RNFL deviation and thickness maps ...
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      Mentions: Korea University
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  2. About Korea University

    Korea University

    Korea University is a private research university located primarily in Seoul, South Korea, and a member of the SKY (universities). It was founded by Lee Yong-ik in the present-day town of Anam in 1905. The university is the oldest institution of higher education in South Korea. Korea University is a comprehensive research institution consisting of 81 academic departments in 15 colleges and 75 research institutes.  Korea University College of Medicine.