1. Korea Advanced Institute of Science and Technology

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    1. Mentioned In 60 Articles

    2. High-speed optical coherence tomography angiography for the measurement of stimulus-induced retrograde vasodilation of cerebral pial arteries in awake mice

      High-speed optical coherence tomography angiography for the measurement of stimulus-induced retrograde vasodilation of cerebral pial arteries in awake mice
      Significance: Having a clear understanding of functional hyperemia is crucial for functional brain imaging and neurological disease research. Vasodilation induced by sensory stimulus propagates from the arterioles to the upstream pial arteries in a retrograde fashion. As retrograde vasodilation occurs briefly in the early stage of functional hyperemia, an imaging technique with a high temporal resolution is required for its measurement. Aim: We aimed to present an imaging method to ...
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    3. Astigmatism-corrected endoscopic imaging probe for optical coherence tomography using soft lithography

      Astigmatism-corrected endoscopic imaging probe for optical coherence tomography using soft lithography
      In endoscopic optical coherence tomography, a transparent protective sheath is used to protect the optics and tissue. However, the sheath causes astigmatism, which degrades transverse resolution and signal-to-noise ratio due to the cylindrical lens effect. Generally used methods for correcting this astigmatism are complex, difficult to control precisely, high-cost, and increase the dimensions of the imaging probe. To overcome these problems, we have developed an astigmatism-corrected imaging probe with an ...
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    4. In vivo imaging of the hyaloid vascular regression and retinal and choroidal vascular development in rat eyes using optical coherence tomography angiography

      In vivo imaging of the hyaloid vascular regression and retinal and choroidal vascular development in rat eyes using optical coherence tomography angiography
      This study investigates the hyaloid vascular regression and its relationship to the retinal and choroidal vascular developments using optical coherence tomography angiography (OCTA). Normal and oxygen-induced retinopathy (OIR) rat eyes at postnatal day 15, 18, 21, and 24 were longitudinally imaged using OCTA. At each day, two consecutive imaging for visualizing the hyaloid vasculature and the retinal and choroidal vasculatures were conducted. The hyaloid vessel volume and the retinal and ...
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    5. Apparatus for angiographic optical coherence tomography in retina or choroid, and method for diagnosing diseases by using same

      Apparatus for angiographic optical coherence tomography in retina or choroid, and method for diagnosing diseases by using same
      The present disclosure relates to an apparatus for angiographic optical coherence tomography in the retina or the choroid, and a method for diagnosing diseases by using the same and, more specifically, to: an apparatus for angiographic optical coherence tomography in the retina and the choroid, capable of diagnosing, at an early stage, shock states or diseases such as those of sepsis by quickly and objectively recognizing the low perfusion of ...
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    6. 9.4 MHz A-line rate optical coherence tomography at 1300 nm using a wavelength-swept laser based on stretched-pulse active mode-locking

      9.4 MHz A-line rate optical coherence tomography at 1300 nm using a wavelength-swept laser based on stretched-pulse active mode-locking
      In optical coherence tomography (OCT), high-speed systems based at 1300nm are among the most broadly used. Here, we present 9.4 MHz A-line rate OCT system at 1300nm. A wavelength-swept laser based on stretched-pulse active mode locking (SPML) provides a continuous and linear-in-wavenumber sweep from 1240nm to 1340nm, and the OCT system using this light source provides a sensitivity of 98dB and a single-sided 6-dB roll-off depth of 2.5mm ...
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    7. Flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure

      Flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure
      Micro-optical coherence tomography (OCT) is a novel imaging approach enabling visualization of the microstructures of biological tissues at a cellular or sub-cellular level. However, it has been challenging to develop a miniaturized flexible endoscopic OCT probe allowing helical luminal scanning. In this study, we built a flexible endoscopic OCT probe with an outer diameter of 1.2mm, which acquires three-dimensional images of the arterial microstructures via helical scanning with an ...
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    8. Retinal Blood Vessel Caliber Estimation for Optical Coherence Tomography Angiography Images Based on 3D Superellipsoid Modeling

      Retinal Blood Vessel Caliber Estimation for Optical Coherence Tomography Angiography Images Based on 3D Superellipsoid Modeling
      Changes of retinal blood vessel calibers may reflect various retinal diseases and even several non-retinal diseases. We propose a new method to estimate retinal vessel calibers from 3D optical coherence tomography angiography (OCTA) images based on 3D modeling using superellipsoids. Taking advantage of 3D visualization of the retinal tissue microstructures in vivo provided by OCTA, our method can detect retinal blood vessels precisely, estimate their calibers reliably, and show the ...
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    9. Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration

      Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration
      Choriocapillary loss is a major cause of neovascular age-related macular degeneration (NV-AMD). Although vascular endothelial growth factor (VEGF) blockade for NV-AMD has shown beneficial outcomes, unmet medical needs for patients refractory or tachyphylactic to anti-VEGF therapy exist. In addition, the treatment could exacerbate choriocapillary rarefaction, necessitating advanced treatment for fundamental recovery from NV-AMD. In this study, Tie2 activation by angiopoietin-2binding and Tie2-activating antibody (ABTAA) presents a therapeutic strategy for NV-AMD ...
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    10. Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging

      Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging
      Comprehensive imaging of both the structural and biochemical characteristics of atherosclerotic plaque is essential for the diagnosis and study of coronary artery disease because both a plaques morphology and its biochemical composition affect the level of risk it poses. Optical coherence tomography (OCT) and fluorescence lifetime imaging (FLIm) are promising optical imaging methods for characterizing coronary artery plaques morphologically and biochemically, respectively. In this study, we present a hybrid intravascular ...
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    11. Finite-difference time-domain analysis of increased penetration depth in optical coherence tomography by wavefront shaping

      Finite-difference time-domain analysis of increased penetration depth in optical coherence tomography by wavefront shaping
      Multiple scattering in turbid media inhibits optimal light focusing and thus limits the penetration depth in optical coherence tomography (OCT). However, the effects of multiple scattering in a turbid medium can be systematically controlled by shaping the incident wavefront. The authors utilize the reciprocity of Maxwells equations and finite-difference time-domain numerical analysis to investigate the ultimate performance bounds of wavefront shaping-OCT under ideal and realistic configurations and compare them with ...
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    12. Wide dynamic range high-speed three-dimensional quantitative OCT angiography with a hybrid-beam scan

      Wide dynamic range high-speed three-dimensional quantitative OCT angiography with a hybrid-beam scan
      We demonstrate a novel hybrid-beam scanning-based quantitative optical coherence tomography angiography (OCTA) that provides high-speed wide dynamic range blood flow speed imaging. The hybrid-beam scanning scheme enables multiple OCTA image acquisitions with a wide range of multiple time intervals simultaneously providing wide dynamic range blood flow speed imaging independent of the blood vessel orientation, which was quantified over a speed range of 0.6 104 mm / s 0.6104mm/s ...
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    13. Multispectral analog-mean-delay fluorescence lifetime imaging combined with optical coherence tomography

      Multispectral analog-mean-delay fluorescence lifetime imaging combined with optical coherence tomography
      The pathophysiological progression of chronic diseases, including atherosclerosis and cancer, is closely related to compositional changes in biological tissues containing endogenous fluorophores such as collagen, elastin, and NADH, which exhibit strong autofluorescence under ultraviolet excitation. Fluorescence lifetime imaging (FLIm) provides robust detection of the compositional changes by measuring fluorescence lifetime, which is an inherent property of a fluorophore. In this paper, we present a dual-modality system combining a multispectral analog-mean-delay ...
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    14. Feature Of The Week 04.05.2018: Fiber-Coupled Multimodal Imaging for Non-Destructive Assessment of Vascular Biomaterials

      Feature Of The Week 04.05.2018: Fiber-Coupled Multimodal Imaging for Non-Destructive Assessment of Vascular Biomaterials
      We present a novel fiber-based imaging platform that allows simultaneous fluorescence lifetime imaging (FLIm) and optical coherence tomography (OCT) using a double-clad fiber. This platform acquires co-registered images showing structural and compositional contrast in unlabeled biological samples by scanning the fiber tip across the sample surface. In this Letter, we report a characterization of each modality and show examples of co-registered FLIm and OCT images acquired from a lemon segment ...
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    15. Comparison of Accuracy of One Use Methods for Calculating Fractional Flow Reserve by Intravascular Optical Coherence Tomography to That Determined by the Pressure-Wire Method

      Comparison of Accuracy of One Use Methods for Calculating Fractional Flow Reserve by Intravascular Optical Coherence Tomography to That Determined by the Pressure-Wire Method
      While identification of hemodynamic significance of coronary lesions becomes important for revascularization strategy, the potential role of three-dimensional high-resolution intracoronary Optical coherence tomography (OCT) for predicting functional significance of coronary lesions remains unclear. We assessed the diagnostic performance of two computational approaches for deriving fractional flow reserve (FFR) from intravascular OCT images. We developed two methods to derive FFR from volumetric OCT images by applying analytical fluid dynamics (FFR-OCTAFD) and ...
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  2. About Korea Advanced Institute of Science and Technology

    Korea Advanced Institute of Science and Technology

    Korea Advanced Institute of Science and Technology (KAIST) was established in 1971 as the nation’s first graduate school specializing in science and engineering education and research. The school’s founding was a catalyst for Korea’s rapid rise from a producer of light industry goods to a world leader in high-technology industries.