1. Korea Advanced Institute of Science and Technology

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    1. Mentioned In 37 Articles

    2. In vivo deep tissue imaging using wavefront shaping optical coherence tomography

      In vivo deep tissue imaging using wavefront shaping optical coherence tomography
      Multiple light scattering in tissue limits the penetration of optical coherence tomography (OCT) imaging. Here, we present in vivo OCT imaging of a live mouse using wavefront shaping (WS) to enhance the penetration depth. A digital micromirror device was used in a spectral-domain OCT system for complex WS of an incident beam which resulted in the optimal delivery of light energy into deep tissue. Ex vivo imaging of chicken breasts ...
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    3. Apparatus and method for generating tomography image

      Apparatus and method for generating tomography image
      A method of generating a tomography image includes performing a depth scan on one spot on a surface of a subject using modulated light received from a spatial light modulator, obtaining depth scan data for each of a plurality of patterns of the spatial light modulator by repeating the depth scan on the spot for each of the plurality of patterns, forming a matrix R representing a vector space based ...
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    4. Intracoronary dual-modal optical coherence tomography-near-infrared fluorescence structural–molecular imaging with a clinical dose of indocyanine green for the assessment of high-risk plaques and stent-associated inflammation in a beating coronary artery

      Intracoronary dual-modal optical coherence tomography-near-infrared fluorescence structural–molecular imaging with a clinical dose of indocyanine green for the assessment of high-risk plaques and stent-associated inflammation in a beating coronary artery
      Aims Inflammation plays essential role in development of plaque disruption and coronary stent-associated complications. This study aimed to examine whether intracoronary dual-modal optical coherence tomography (OCT)-near-infrared fluorescence (NIRF) structuralmolecular imaging with indocyanine green (ICG) can estimate inflammation in swine coronary artery. Methods and results After administration of clinically approved NIRF-enhancing ICG (2.0 mg/kg) or saline, rapid coronary imaging (20 mm/s pullback speed) using a fully integrated ...
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    5. In vivo deep tissue imaging using wavefront shaping optical coherence tomography

      In vivo deep tissue imaging using wavefront shaping optical coherence tomography
      Multiple light scattering in tissue limits the penetration of optical coherence tomography (OCT) imaging. Here, we present in-vivo OCT imaging of a live mouse using wavefront shaping to enhance the penetration depth. A digital micro-mirror device (DMD) was used in a spectral-domain OCT system for complex wavefront shaping of an incident beam which resulted in the optimal delivery of light energy into deep tissue. Ex-vivo imaging of chicken breasts and ...
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    6. Tomographic image generation apparatus having modulation and correction device and method of operating the same

      Tomographic image generation apparatus having modulation and correction device and method of operating the same
      A tomographic image generation apparatus includes a light source unit configured to emit light to be used for scanning an object; an optical control unit configured to control a direction of propagation of light; an optical coupler configured to divide and combine incident light; a plurality of optical systems optically connected to the optical coupler; and a modulation and correction device configured to modulate and correct the light to be ...
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    7. Smart Sensors for Health and Environment Monitoring (Book)

      Smart Sensors for Health and Environment Monitoring (Book)
      This book covers two most important applications of smart sensors, namely bio-health sensing and environmental monitoring. The approach taken is holistic and covers the complete scope of the subject matter from the principles of the sensing mechanism, through device physics, circuit and system implementation techniques, and energy issues to wireless connectivity solutions. It is written at a level suitable mainly for post-graduate level researchers interested in practical applications. The chapters ...
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    8. Broadband supercontinuum generation using a hollow optical fiber filled with copper-ion-modified DNA

      Broadband supercontinuum generation using a hollow optical fiber filled with copper-ion-modified DNA
      We experimentally demonstrated supercontinuum generation through a hollow core photonic bandgap fiber (HC-PBGF) filled with DNA nanocrystals modified by copper ions in a solution. Both double-crossover nano DNA structure and copper-ion-modified structure provided a sufficiently high optical nonlinearity within a short length of hollow optical fiber. Adding a higher concentration of copper ion into the DNA nanocrystals, the bandwidth of supercontinuum output was monotonically increased. Finally, we achieved the bandwidth ...
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    9. All-fiber wavelength swept ring laser based on Fabry-Perot filter for optical frequency domain imaging

      All-fiber wavelength swept ring laser based on  Fabry-Perot filter for optical frequency domain  imaging
      ...spital and Harvard Medical School, Boston, Massachusetts 02114, USA ^2Department of Mechanical Engineering, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, South Korea ^3Harvard-MIT Division of Health Sciences and...
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    10. Feature Of The Week 8/31/14: Fully Integrated High-speed Intravascular OCT/NIRF Structural/Molecular Imaging In Vivo using a Clinically-available NIRF Emitting Indocyanine Green to Detect Inflamed Lipid-rich Atheromata in Coronary-sized Vessels

      Feature Of The Week 8/31/14: Fully Integrated High-speed Intravascular OCT/NIRF Structural/Molecular Imaging In Vivo using a Clinically-available NIRF Emitting Indocyanine Green to Detect Inflamed Lipid-rich Atheromata in Coronary-sized Vessels
      In current study, we fully integrated near-infrared fluorescence (NIRF) molecular imaging into intravascular OCT structural imaging. The OCT/NIRF single catheter imaging clearly demonstrated the microstructure of atheromata and simultaneously identified ICG-enhancing macrophage abundant lipid-rich areas of the plaques. Ex vivo NIRF imaging evidently validated in vivo OCT-NIRF imaging. NIRF signals on ex vivo fluorescence reflectance imaging colocalized well with in vivo NIRF imaging. In vitro ICG cell uptake, correlative ...
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    11. Parallel guidance endoscopic optical coherence tomography system for internal diagnosis through active cannulas

      Parallel guidance endoscopic optical coherence tomography system for internal diagnosis through active cannulas
      A parallel guidance endoscopic optical coherence tomography (OCT) system is proposed for minimally invasive internal inspection of inner organs or complex structures for diagnosis. The system is maneuvered to access the target using an active cannulas steerable structures. The integration of a specially designed linkage device with the developed system allows the OCT endoscope to scan with enhanced signal-collective performance, while maintaining its tip at a constant distance from the ...
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    12. Fully Integrated High-Speed Intravascular OCT/NIRF Structural/Molecular Imaging In Vivo Using a Clinically Available Near-Infrared Fluorescence–Emitting Indocyanine Green to Detect Inflamed Lipid-Rich Atheromata in Coronary-Sized Vessels

      Fully Integrated High-Speed Intravascular OCT/NIRF Structural/Molecular Imaging In Vivo Using a Clinically Available Near-Infrared Fluorescence–Emitting Indocyanine Green to Detect Inflamed Lipid-Rich Atheromata in Coronary-Sized Vessels
      ...Engineering, KAIST, 335 Gwahangno, Yuseong-gu, Daejeon 305–701, Republic of Korea. E-mail: woh1{at}kaist.ac.kr 1. ↵* Dr S. Lee, M.W. Lee, and H.S. Cho contributed equally to this work. 2. ↵† Drs Kim, Yoo, an...
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  2. About Korea Advanced Institute of Science and Technology

    Korea Advanced Institute of Science and Technology

    Korea Advanced Institute of Science and Technology (KAIST) was established in 1971 as the nation’s first graduate school specializing in science and engineering education and research. The school’s founding was a catalyst for Korea’s rapid rise from a producer of light industry goods to a world leader in high-technology industries.