1. Korea Advanced Institute of Science and Technology

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    1. Mentioned In 68 Articles

    2. In Vivo Cellular-Level 3D Imaging of Peripheral Nerves Using a Dual-Focusing Technique for Intra-Neural Interface Implantation

      In Vivo Cellular-Level 3D Imaging of Peripheral Nerves Using a Dual-Focusing Technique for Intra-Neural Interface Implantation
      In vivo volumetric imaging of the microstructural changes of peripheral nerves with an inserted electrode could be key for solving the chronic implantation failure of an intra-neural interface necessary to provide amputated patients with natural motion and sensation. Thus far, no imaging devices can provide a cellular-level three-dimensional (3D) structural images of a peripheral nerve in vivo. In this study, an optical coherence tomography-based peripheral nerve imaging platform that employs ...
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    3. Optical Coherence Tomography of Plaque Erosion: JACC Focus Seminar Part 2/3

      Optical Coherence Tomography of Plaque Erosion: JACC Focus Seminar Part 2/3
      Plaque erosion, a distinct histopathological and clinical entity, accounts for over 30% of acute coronary syndromes (ACS). Optical coherence tomography allows in vivo diagnosis of plaque erosion. Local flow perturbation with activation of Toll-like receptor 2 and CD8 + T cells and subsequent desquamation of endothelium and neutrophil extracellular trap formation contribute to mechanisms of plaque erosion. Compared with ACS patients with plaque rupture, those with plaque erosion are younger, have ...
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    4. Imaging catheter system

      Imaging catheter system
      Disclosed is an imaging catheter system that utilizes optical coherence tomography and autofluorescence lifetime imaging microscopy. The disclosed imaging catheter system may include: an autofluorescence light source; an OCT device; a catheter device configured to receive rays inputted from the autofluorescence light source and an OCT light source of the OCT device and scan a specimen; an optical detector unit configured to detect autofluorescence generated from the specimen; and a ...
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    5. Robust and easy-to-operate stretched-pulse mode-locked wavelength-swept laser with an all-polarization-maintaining fiber cavity for 10 MHz A-line rate optical coherence tomography

      Robust and easy-to-operate stretched-pulse mode-locked wavelength-swept laser with an all-polarization-maintaining fiber cavity for 10 MHz A-line rate optical coherence tomography
      We demonstrate robust and easy-to-operate stretched-pulse mode-locked laser (SPML) architectures using all-polarization-maintaining fiber laser cavities. Because of the polarization-maintaining construction, the laser performance is unaffected by mechanical perturbation on the cavity fibers. The lasers automatically initiate linear-in-wavenumber sweeps across 100 nm centered at 1290 nm with a 10 MHz repetition rate. OCT imaging with a sensitivity of 98 dB and a single-sided 6 dB coherence length of 2.5 mm ...
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    6. Visualization of three-dimensional microcirculation of rodents’ retina and choroid for studies of critical illness using optical coherence tomography angiography

      Visualization of three-dimensional microcirculation of rodents’ retina and choroid for studies of critical illness using optical coherence tomography angiography
      We developed a method to measure the relative blood flow speed using optical coherence tomography angiography (OCTA) in retina and choroid, and investigated the feasibility of this method for assessing microcirculatory function in rat models of sepsis and hemorrhagic shock. Two sepsis models, 6-h severe sepsis without treatment and 30-h moderate sepsis maintaining mean arterial pressure, and volume controlled hemorrhagic shock and fluid resuscitation model were used to see the ...
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    7. Quantification of retinal microvascular parameters by severity of diabetic retinopathy using wide-field swept-source optical coherence tomography angiography

      Quantification of retinal microvascular parameters by severity of diabetic retinopathy using wide-field swept-source optical coherence tomography angiography
      Purpose: To investigate the diagnostic utility of microvascular parameters for grading the severity of diabetic retinopathy (DR) with a range of views using wide-field swept-source optical coherence tomography angiography (SS-OCTA). Methods: This retrospective study grouped 235 eyes with diabetes into the five grades: diabetes without retinopathy (no-DR), mild non-proliferative DR (NPDR), moderate NPDR, severe NPDR, and proliferative DR (PDR). Foveal avascular zone (FAZ) metrics, vessel density (VD), and the capillary ...
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    8. Visualization of two-dimensional transverse blood flow direction using optical coherence tomography angiography

      Visualization of two-dimensional transverse blood flow direction using optical coherence tomography angiography
      Significance: Evaluation of vessel patency and blood flow direction is important in various medical situations, including diagnosis and monitoring of ischemic diseases, and image-guided vascular surgeries. While optical coherence tomography angiography (OCTA) is the most widely used functional extension of optical coherence tomography that visualizes three-dimensional vasculature, inability to provide information of blood flow direction is one of its limitations. Aim: We demonstrate two-dimensional (2D) transverse blood flow direction imaging ...
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    9. Visualization of two-dimensional transverse blood flow direction using optical coherence tomography angiography

      Visualization of two-dimensional transverse blood flow direction using optical coherence tomography angiography
      Significance: Evaluation of vessel patency and blood flow direction is important in various medical situations, including diagnosis and monitoring of ischemic diseases, and image-guided vascular surgeries. While optical coherence tomography angiography (OCTA) is the most widely used functional extension of optical coherence tomography that visualizes three-dimensional vasculature, inability to provide information of blood flow direction is one of its limitations. Aim: We demonstrate two-dimensional (2D) transverse blood flow direction imaging ...
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    10. High-speed optical coherence tomography angiography for the measurement of stimulus-induced retrograde vasodilation of cerebral pial arteries in awake mice

      High-speed optical coherence tomography angiography for the measurement of stimulus-induced retrograde vasodilation of cerebral pial arteries in awake mice
      Significance: Having a clear understanding of functional hyperemia is crucial for functional brain imaging and neurological disease research. Vasodilation induced by sensory stimulus propagates from the arterioles to the upstream pial arteries in a retrograde fashion. As retrograde vasodilation occurs briefly in the early stage of functional hyperemia, an imaging technique with a high temporal resolution is required for its measurement. Aim: We aimed to present an imaging method to ...
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    11. Astigmatism-corrected endoscopic imaging probe for optical coherence tomography using soft lithography

      Astigmatism-corrected endoscopic imaging probe for optical coherence tomography using soft lithography
      In endoscopic optical coherence tomography, a transparent protective sheath is used to protect the optics and tissue. However, the sheath causes astigmatism, which degrades transverse resolution and signal-to-noise ratio due to the cylindrical lens effect. Generally used methods for correcting this astigmatism are complex, difficult to control precisely, high-cost, and increase the dimensions of the imaging probe. To overcome these problems, we have developed an astigmatism-corrected imaging probe with an ...
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    12. In vivo imaging of the hyaloid vascular regression and retinal and choroidal vascular development in rat eyes using optical coherence tomography angiography

      In vivo imaging of the hyaloid vascular regression and retinal and choroidal vascular development in rat eyes using optical coherence tomography angiography
      This study investigates the hyaloid vascular regression and its relationship to the retinal and choroidal vascular developments using optical coherence tomography angiography (OCTA). Normal and oxygen-induced retinopathy (OIR) rat eyes at postnatal day 15, 18, 21, and 24 were longitudinally imaged using OCTA. At each day, two consecutive imaging for visualizing the hyaloid vasculature and the retinal and choroidal vasculatures were conducted. The hyaloid vessel volume and the retinal and ...
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    13. Apparatus for angiographic optical coherence tomography in retina or choroid, and method for diagnosing diseases by using same

      Apparatus for angiographic optical coherence tomography in retina or choroid, and method for diagnosing diseases by using same
      The present disclosure relates to an apparatus for angiographic optical coherence tomography in the retina or the choroid, and a method for diagnosing diseases by using the same and, more specifically, to: an apparatus for angiographic optical coherence tomography in the retina and the choroid, capable of diagnosing, at an early stage, shock states or diseases such as those of sepsis by quickly and objectively recognizing the low perfusion of ...
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    14. 9.4 MHz A-line rate optical coherence tomography at 1300 nm using a wavelength-swept laser based on stretched-pulse active mode-locking

      9.4 MHz A-line rate optical coherence tomography at 1300 nm using a wavelength-swept laser based on stretched-pulse active mode-locking
      In optical coherence tomography (OCT), high-speed systems based at 1300nm are among the most broadly used. Here, we present 9.4 MHz A-line rate OCT system at 1300nm. A wavelength-swept laser based on stretched-pulse active mode locking (SPML) provides a continuous and linear-in-wavenumber sweep from 1240nm to 1340nm, and the OCT system using this light source provides a sensitivity of 98dB and a single-sided 6-dB roll-off depth of 2.5mm ...
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    15. Flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure

      Flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure
      Micro-optical coherence tomography (OCT) is a novel imaging approach enabling visualization of the microstructures of biological tissues at a cellular or sub-cellular level. However, it has been challenging to develop a miniaturized flexible endoscopic OCT probe allowing helical luminal scanning. In this study, we built a flexible endoscopic OCT probe with an outer diameter of 1.2mm, which acquires three-dimensional images of the arterial microstructures via helical scanning with an ...
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    16. Retinal Blood Vessel Caliber Estimation for Optical Coherence Tomography Angiography Images Based on 3D Superellipsoid Modeling

      Retinal Blood Vessel Caliber Estimation for Optical Coherence Tomography Angiography Images Based on 3D Superellipsoid Modeling
      Changes of retinal blood vessel calibers may reflect various retinal diseases and even several non-retinal diseases. We propose a new method to estimate retinal vessel calibers from 3D optical coherence tomography angiography (OCTA) images based on 3D modeling using superellipsoids. Taking advantage of 3D visualization of the retinal tissue microstructures in vivo provided by OCTA, our method can detect retinal blood vessels precisely, estimate their calibers reliably, and show the ...
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  2. About Korea Advanced Institute of Science and Technology

    Korea Advanced Institute of Science and Technology

    Korea Advanced Institute of Science and Technology (KAIST) was established in 1971 as the nation’s first graduate school specializing in science and engineering education and research. The school’s founding was a catalyst for Korea’s rapid rise from a producer of light industry goods to a world leader in high-technology industries.