Recently, Optical Coherence Tomography (OCT) has become one of the preferred clinical techniques for intracoronary diagnostic imaging. Thanks to its high resolution imaging capability, the OCT technique allows to identify microscopic features associated with various types of coronary plaque and to track of stent position, malaposition and neo-intimal tissue growth after stent implantation. Accurate visualization of stent struts can help to examine the status of implanted stents potentially leading to proper treatment of the coronary artery disease. However, unfortunately, current stent identification involves time-consuming segmentation algorithms sometimes requiring labor-intensive manual analysis process. To resolve the problem, we propose a high-speed ...

We present polarization-sensitive full-field optical coherence tomography (PS-FF-OCT), which is based on a bi-stable polarization switch (BSPS) device. The proposed PS-FF-OCT is a Linnik type interferometer, and allows getting both the birefringence-induced phase retardation and the intensity images of specimens with high resolutions using a pair of micro objectives and a BSPS device. Two orthogonal polarization states are formed with a regular time interval by the BSPS device that changes the polarization direction of light in a short time by switching its optic axes. Therefore, both the horizontally polarized light signal and the vertically polarized light signal from the sample ...

We report on an approach to exploit multiple light scattering by shaping the incident wavefront in optical coherence tomography (OCT). Most of the reflected signal from biological tissue consists of multiply scattered light, which is regarded as noise in OCT. A digital mirror device (DMD) is utilized to shape the incident wavefront such that the maximal energy is focused at a specific depth in a highly scattering sample using a coherence-gated reflectance signal as feedback. The proof-of-concept experiment demonstrates that this approach enhances depth-selective focusing in the presence of optical inhomogeneity, and thus extends the penetration depth in spectral domain-OCT ...