1. Kirill V. Larin

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    1. Mentioned In 75 Articles

    2. A focused air-pulse system for optical-coherence-tomography-based measurements of tissue elasticity

      A focused air-pulse system for optical-coherence-tomography-based measurements of tissue elasticity

      Accurate non-invasive assessment of tissue elasticity in vivo is required for early diagnostics of many tissue abnormalities. We have developed a focused air-pulse system that produces a low-pressure and short-duration air stream, which can be used to excite transient surface waves (SWs) in soft tissues. System characteristics were studied using a high-resolution analog pressure transducer to describe the excitation pressure. Results indicate that the excitation pressure provided by the air-pulse system can be easily controlled by the air source pressure, the angle of delivery, and the distance between the tissue surface and the port of the air-pulse system. Furthermore, we ...

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    3. Feature Of The Week 5/19/13: Using Optical Coherence Tomography For Anti-Spoof Fingerprint Detection

      Feature Of The Week 5/19/13: Using Optical Coherence Tomography For Anti-Spoof Fingerprint Detection

      Fingerprint biometrics, including automated fingerprint identification systems (AFIS), currently occupy two-thirds of the biometric market and are expected to remain the dominant player in this area. The technology can be integrated into small, compact devices and the instruments are relatively fast. However, the overall success of using fingerprints for identification and verification purposes greatly depends upon the quality of the fingerprints initially enrolled. For example, fingerprints captured from older people are significantly lower quality than those from younger people due primarily to ridge-wearing and difficulty of interacting effectively with conventional fingerprint scanners. The ramification is that the problem of obtaining ...

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    4. Feasibility of correlation mapping optical coherence tomography (cmOCT) for anti-spoof sub-surface fingerprinting

      Feasibility of correlation mapping optical coherence tomography (cmOCT) for anti-spoof sub-surface fingerprinting

      We propose the use of correlation mapping optical coherence tomography (cmOCT) to deliver additional biometrics associated with the finger that could complement existing fingerprint technology for law enforcement applications. The current study extends the existing fingerprint paradigm by measuring additional biometrics associated with sub-surface finger tissue such as sub-surface fingerprints, sweat glands, and the pattern of the capillary bed to yield a user-friendly cost effective and anti-spoof multi-mode biometric solution associated with the finger. To our knowledge no other method has been able to capture sub-surface fingerprint, papillary pattern and horizontal vessel pattern in a single scan or to show ...

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    5. Measuring tissue elasticity for tumor detection

      Measuring tissue elasticity for tumor detection

      Optical coherence tomography combined with a focused air-puff system non-invasively assesses the mechanical properties of soft tissues and can be used to differentiate tumors during surgical treatment. Surgical resection is currently the most effective treatment for patients with soft-tissue tumors, which develop within connective tissues such as muscle and fat. To minimize the removal region and reduce the chance of recurrence, it is important to delineate the boundaries of the tumor prior to resection. As tumorigenesis involves a change in tissue stiffness, probing the mechanical properties (e.g. elasticity) of soft tissues could complement structural imaging (x-ray and magnetic resonance ...

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    6. Comparative assessments of the effects of alcohol exposure on fetal brain development using optical coherence tomography and ultrasound imaging

      Comparative assessments of the effects of alcohol exposure on fetal brain development using optical coherence tomography and ultrasound imaging

      The developing fetal brain is vulnerable to a variety of environmental agents including maternal ethanol consumption. Preclinical studies on the development and amelioration of fetal teratology would be significantly facilitated by the application of high resolution imaging technologies like optical coherence tomography (OCT) and high-frequency ultrasound (US). This study investigates the ability of these imaging technologies to measure the effects of maternal ethanol exposure on brain development, ex vivo , in fetal mice. Pregnant mice at gestational day 12.5 were administered ethanol ( 3     g / Kg b.wt.) or water by intragastric gavage, twice daily for three consecutive days. On gestational ...

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    7. 4D Reconstruction of the Beating Embryonic Heart From Two Orthogonal Sets of Parallel Optical Coherence Tomography Slice-Sequences

      4D Reconstruction of the Beating Embryonic Heart From Two Orthogonal Sets of Parallel Optical Coherence Tomography Slice-Sequences

      Current methods to build dynamic optical coherence tomography (OCT) volumes of the beating embryonic heart involve synchronization of 2D+time slice-sequences acquired over separate heartbeats. Temporal registration of these sequences is performed either through gating or post-processing. While synchronization algorithms that exclusively rely on image-intrinsic signals allow forgoing external gating hardware, they are prone to error accumulation, require operator-supervised correction, or lead to non-isotropic resolution. Here, we propose an imagebased, retrospective reconstruction technique that uses two sets of parallel 2D+T slice-sequences, acquired perpendicularly to each other, to yield accurate and automatic reconstructions with isotropic resolution. The method utilizes the ...

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    8. Noncontact measurement of elasticity for the detection of soft-tissue tumors using phase-sensitive optical coherence tomography combined with a focused air-puff system

      Noncontact measurement of elasticity for the detection of soft-tissue tumors using phase-sensitive optical coherence tomography combined with a focused air-puff system
      ...redes M. Menodiado, Davis R. Ingram, Michael D. Twa, Alexander J. Lazar, Dina C. Lev, Raphael E. Pollock, and Kirill V. Larin, "Noncontact measurement of elasticity for the detection of soft-tissue tumors using phase-sen...
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    9. In vivo estimation of elastic wave parameters using phase-stabilized swept source optical coherence elastography

      In vivo estimation of elastic wave parameters using phase-stabilized swept source optical coherence elastography
      We report a highly sensitive method based on phase-stabilized swept source optical coherence elastography (PhS-SSOCE) to measure elastic wave propagation in soft tissues in vivo. The waves were introduced using a mechanical stimulus and were assessed using the phase response of the swept source optical coherence tomography signal. The technique was utilized to measure age-related changes in elastic flexural wave velocity and attenuation in mice cornea in vivo. Results demonstrate that the wave velocity increases with animal age, supporting previous observations that stiffness of mice cornea gradually increases with age. Our studies suggest that the PhS-SSOCE technique could potentially be ...
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    10. 1-15 of 75 1 2 3 4 5 »
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  2. About Kirill V. Larin

    Kirill V. Larin

    Kirill V. Larin is Assistant Professor of Biomedical Engineering at the University of Houston, Houston, TX. His research interests focuses on development and application of OCT for noninvasive and nondestructive imaging and diagnostics of tissues and cells. Larin has authored more than 40 peer-reviewed journal publications and chapters in two textbooks on Biomedical Optics. He is recipient of Boris Yeltsin Presidential Award, Wallace Coulter Young Investigator Translation Award, Office of Naval Research Young Investigator Award, and Outstanding Young Investigator Award from the Houston Society for Engineers in Medicine and Biology.

  3. Quotes

    1. We are using OCT to image mouse and rat embryos, looking at video taken about seven days after conception, out of a 20-day typical mammalian pregnancy...this way, we are able to capture video of the embryonic heart before it begins beating, and a day later we can see the heart beginning to form in the shape of a tube and see whether or not the chambers are contracting. Then, we begin to see blood distribution and the heart rate.
      In The Embryonic Heart: Imaging Life as it Happens - University of Houston Professor Captures Video of Heart Before it Begins to Beat (Video Snippet)
    2. Our primary objective is to develop noninvasive, early detection methods to diagnose various diseases.
      In U. Houston professor expands Optics research