1. Kirill V. Larin

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    1. Mentioned In 196 Articles

    2. In Vivo Human Corneal Shear-wave Optical Coherence Elastography

      Explore LWW Online Ophthalmology
      In Vivo Human Corneal Shear-wave Optical Coherence Elastography
      SIGNIFICANCE A novel imaging technology, dynamic optical coherence elastography (OCE), was adapted for clinical noninvasive measurements of corneal biomechanics. PURPOSE Determining corneal biomechanical properties is a long-standing challenge. Elasticity imaging methods have recently been developed and applied for clinical evaluation of soft tissues in cancer detection, atherosclerotic plaque evaluation, surgical guidance, and more. Here, we describe the use of dynamic OCE to characterize mechanical wave propagation in the human cornea ...
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      Mentions: Kirill V. Larin University of Alabama University of Houston

    3. Confocal air-coupled ultrasonic optical coherence elastography probe for quantitative biomechanics

      Explore OSA | OSA Publishing Ophthalmology
      Confocal air-coupled ultrasonic optical coherence elastography probe for quantitative biomechanics
      We present an air-coupled ultrasonic radiation force probe co-focused with a phase-sensitive optical coherence tomography (OCT) system for quantitative wave-based elastography. A custom-made 1 MHz spherically focused piezoelectric transducer with a concentric 10 mm wide circular opening allowed for confocal micro-excitation of waves and phase-sensitive OCT imaging.
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      Mentions: Kirill V. Larin University of Houston Michael D. Twa

    5. Dynamic Optical Coherence Elastography of the Anterior Eye: Understanding the Biomechanics of the Limbus

      Explore IOVS Journal Ophthalmology
      Dynamic Optical Coherence Elastography of the Anterior Eye: Understanding the Biomechanics of the Limbus
      Purpose : Currently, the biomechanical properties of the corneo-scleral limbus when the eye-globe deforms are largely unknown. The purpose of this study is to evaluate changes in elasticity of the cornea, sclera, and limbus when subjected to different intraocular pressures (IOP) using wave-based optical coherence elastography (OCE). Special attention was given to the elasticity changes of the limbal region with respect to the elasticity variations in the neighboring corneal and scleral ...
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      Mentions: Kirill V. Larin University of Houston Michael D. Twa

    9. Optical coherence tomography angiography to evaluate murine fetal brain vasculature changes caused by prenatal exposure to nicotine

      Explore OSA | OSA Publishing
      Optical coherence tomography angiography to evaluate murine fetal brain vasculature changes caused by prenatal exposure to nicotine
      Maternal smoking causes several defects ranging from intrauterine growth restriction to sudden infant death syndrome and spontaneous abortion. While several studies have documented the effects of prenatal nicotine exposure in development and behavior, acute vasculature changes in the fetal brain due to prenatal nicotine exposure have not been evaluated yet. This study uses correlation mapping optical coherence angiography to evaluate changes in fetal brain vasculature flow caused by maternal exposure ...
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      Mentions: Baylor College of Medicine Kirill V. Larin University of Houston

    11. Heartbeat OCE: corneal biomechanical response to simulated heartbeat pulsation measured by optical coherence elastography

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      Heartbeat OCE: corneal biomechanical response to simulated heartbeat pulsation measured by optical coherence elastography
      Significance: It is generally agreed that the corneal mechanical properties are strongly linked to many eye diseases and could be used to assess disease progression and response to therapies. Elastography is the most notable method of assessing corneal mechanical properties, but it generally requires some type of external excitation to induce a measurable displacement in the tissue. Aim: We present Heartbeat Optical Coherence Elastography (Hb-OCE), a truly passive method that ...
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      Mentions: Kirill V. Larin University of Houston Manmohan Singh

    14. Clinical Corneal Optical Coherence Elastography Measurement Precision: Effect of Heartbeat and Respiration

      Explore TVST Journal Ophthalmology
      Clinical Corneal Optical Coherence Elastography Measurement Precision: Effect of Heartbeat and Respiration
      Purpose : Normal physiological movements (e.g., respiration and heartbeat) induce eye motions during clinical measurements of human corneal biomechanical properties using optical coherence elastography (OCE). We quantified the effects of respiratory and cardiac-induced eye motions on clinical corneal OCE measurement precision and repeatability. Methods : Corneal OCE was performed using low-force, micro-air-pulse tissue stimulation and high-resolution phase-sensitive optical coherence tomography (OCT) imaging. Axial surface displacements of the corneal apex were measured ...
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      Mentions: Kirill V. Larin University of Alabama University of Houston

    15. Multimodal quantitative optical elastography of the crystalline lens with optical coherence elastography and Brillouin microscopy

      Explore OSA | OSA Publishing Ophthalmology
      Multimodal quantitative optical elastography of the crystalline lens with optical coherence elastography and Brillouin microscopy
      Assessing the biomechanical properties of the crystalline lens can provide crucial information for diagnosing disease and guiding precision therapeutic interventions. Existing noninvasive methods have been limited to global measurements. Here, we demonstrate the quantitative assessment of the elasticity of crystalline lens with a multimodal optical elastography technique, which combines dynamic wave-based optical coherence elastography (OCE) and Brillouin microscopy to overcome the drawbacks of individual modalities. OCE can provide direct measurements ...
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      Mentions: University of Maryland Baylor College of Medicine Kirill V. Larin

    16. Laser-induced elastic wave classification: thermoelastic versus ablative regimes for all-optical elastography applications

      Explore SPIE Digital Library
      Laser-induced elastic wave classification: thermoelastic versus ablative regimes for all-optical elastography applications
      Significance : Shear wave optical coherence elastography is an emerging technique for characterizing tissue biomechanics that relies on the generation of elastic waves to obtain the mechanical contrast. Various techniques, such as contact, acoustic, and pneumatic methods, have been used to induce elastic waves. However, the lack of higher-frequency components within the elastic wave restricts their use in thin samples. The methods also require moving parts and/or tubing, which therefore ...
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      Mentions: Kirill V. Larin University of Houston
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  4. About Kirill V. Larin

    Kirill V. Larin

    Kirill V. Larin is Assistant Professor of Biomedical Engineering at the University of Houston, Houston, TX. His research interests focuses on development and application of OCT for noninvasive and nondestructive imaging and diagnostics of tissues and cells. Larin has authored more than 40 peer-reviewed journal publications and chapters in two textbooks on Biomedical Optics. He is recipient of Boris Yeltsin Presidential Award, Wallace Coulter Young Investigator Translation Award, Office of Naval Research Young Investigator Award, and Outstanding Young Investigator Award from the Houston Society for Engineers in Medicine and Biology.

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  6. Quotes

    1. We will develop a novel method for the imaging and assessment of corneal elastic properties that could potentially be used for routine clinical diagnostics of different corneal diseases and treatment.
      In New technology could improve LASIK surgery, eye disease detection
    2. When the heart develops, it becomes stiffer as required for ability to contract and pump blood...So the question is - does it become stiff because it's contracting, or is it stiff to begin with because it is genetically predefined?
      In Understanding congenital heart defects to prevent them
    3. When the heart develops, it becomes stiffer as required for ability to contract and pump blood...So the question is - does it become stiff because it’s contracting, or is it stiff to begin with because it is genetically predefined?
      In Understanding Congenital Heart Defects To Prevent Them
    4. We will create this hybrid microscope putting these two powerful technologies together. OCT will image the development of the neural tube while at the same time, Brillouin spectroscopy will probe its mechanical properties. We will be imaging and sensing at the same time...If we find out what causes the tube to close, what is exactly happening, we can develop new drug treatments for at-risk embryos...It's still one of the great mysteries of life, no one on earth knows how this happens and that is really exciting to us, because we will be the ones to find out.
      In Watching an embryo's neural tube close
    5. Today about one million people suffer heart attacks every year, and there is currently no cure for the resulting cardiac tissue scarring...We are working to develop ways to regenerate heart tissue and our research works to measure the mechanical properties to determine if the heart is healing in response to therapies.
      In Biomechanical mapping method aids development of therapies for damaged heart tissue
    6. Experiments have shown that tissue from newborn mammalian hearts can completely regenerate, but with age this regeneration capability diminishes...Martin's group is working on ways to manipulate these molecular pathways in a way that stimulates the adult heart tissue to repair itself.
      In Biomechanical mapping method aids development of therapies for damaged heart tissue
    7. We are using OCT to image mouse and rat embryos, looking at video taken about seven days after conception, out of a 20-day typical mammalian pregnancy...this way, we are able to capture video of the embryonic heart before it begins beating, and a day later we can see the heart beginning to form in the shape of a tube and see whether or not the chambers are contracting. Then, we begin to see blood distribution and the heart rate.
      In The Embryonic Heart: Imaging Life as it Happens - University of Houston Professor Captures Video of Heart Before it Begins to Beat (Video Snippet)
    8. Our primary objective is to develop noninvasive, early detection methods to diagnose various diseases.
      In U. Houston professor expands Optics research