1. Kings College London

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    1. Mentioned In 30 Articles

    2. Cocoa flavanol consumption improves lower extremity endothelial function in healthy individuals and people with type 2 diabetes

      Cocoa flavanol consumption improves lower extremity endothelial function in healthy individuals and people with type 2 diabetes
      Background : diabetes and age are major risk factors for the development of lower extremity peripheral artery disease (PAD). Cocoa flavanol (CF) consumption is associated with lower risk for PAD and improves brachial artery (BA) endothelial function. Objectives : to assess if femoral artery (FA) endothelial function and dermal microcirculation are impaired in individuals with type 2 diabetes mellitus (T2DM) and evaluate the acute effect of CF consumption on FA endothelial function ...
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    3. Surgical biomicroscopy-guided intra-operative optical coherence tomography (iOCT) image super-resolution

      Surgical biomicroscopy-guided intra-operative optical coherence tomography (iOCT) image super-resolution
      Purpose: Intra-retinal delivery of novel sight-restoring therapies will require the precision of robotic systems accompanied by excellent visualisation of retinal layers. Intra-operative Optical Coherence Tomography (iOCT) provides cross-sectional retinal images in real time but at the cost of image quality that is insufficient for intra-retinal therapy delivery.This paper proposes a super-resolution methodology that improves iOCT image quality leveraging spatiotemporal consistency of incoming iOCT video streams. Methods: To overcome the ...
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    4. Associations Between Retinal Nerve Fiber Layer and Ganglion Cell Layer in Middle Age and Cognition From Childhood to Adulthood

      Associations Between Retinal Nerve Fiber Layer and Ganglion Cell Layer in Middle Age and Cognition From Childhood to Adulthood
      Importance The retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) have been proposed as potential biomarkers for Alzheimer disease (AD). Although a number of studies have shown that knowing the thickness of RNFL and GCL can help differentiate between patients with AD and healthy controls, it is unclear whether these associations are observable earlier in life. Objective To examine whether RNFL and GCL thickness was associated with global ...
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    5. Macular thickness varies with age-related macular degeneration genetic risk variants in the UK Biobank cohort

      Macular thickness varies with age-related macular degeneration genetic risk variants in the UK Biobank cohort
      To evaluate the influence AMD risk genomic variants have on macular thickness in the normal population. UK Biobank participants with no significant ocular history were included using the UK Biobank Resource (project 2112). Spectral-domain optical coherence tomography (SD-OCT) images were taken and segmented to define retinal layers. The influence of AMD risk single-nucleotide polymorphisms (SNP) on retinal layer thickness was analysed. AMD risk associated SNPs were strongly associated with outer-retinal ...
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    6. Long-term in vivo monitoring of gliotic sheathing of ultrathin entropic coated brain microprobes with fiber-based optical coherence tomography

      Long-term in vivo monitoring of gliotic sheathing of ultrathin entropic coated brain microprobes with fiber-based optical coherence tomography
      Microfabricated neuroprosthetic devices have made possible important observations on neuron activity; however, long-term high-fidelity recording performance of these devices has yet to be realized. Tissue-device interactions appear to be a primary source of lost recording performance. The current state of the art for visualizing the tissue response surrounding brain implants in animals is Immunohistochemistry + Confocal Microscopy, which is mainly performed after sacrificing the animal. Monitoring the tissue response as it ...
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    7. Applications and Future Directions for Optical Coherence Tomography in Dermatology

      Applications and Future Directions for Optical Coherence Tomography in Dermatology
      Optical coherence tomography (OCT) is a non‐invasive optical imaging method that can generate high‐resolution en‐face and cross‐sectional images of the skin in vivo to a maximum depth of 2mm. Whilst OCT holds considerable potential for non‐invasive diagnosis and disease monitoring, it is poorly understood by many dermatologists. Here, we aim to equip the practicing dermatologist with an understanding of the principles of skin OCT and ...
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    8. An Update on Imaging in Idiopathic Intracranial Hypertension

      An Update on Imaging in Idiopathic Intracranial Hypertension
      Neuroimaging plays an essential role in the diagnostic workup of idiopathic intracranial hypertension with the aims to exclude secondary causes of elevated intracranial pressure and to identify imaging signs that are commonly observed in this disorder. As a valuable expansion of brain imaging, the imaging of the retina using optical coherence tomography has been of increasing value. In particular, this is the case with the latest devices that allow a ...
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    9. Intravascular Healing Is Not Affected by Approaches in Contemporary CTO PCI: The CONSISTENT CTO Study

      Intravascular Healing Is Not Affected by Approaches in Contemporary CTO PCI: The CONSISTENT CTO Study
      Objectives The aim of this study was to assess angiographic, imaging, and clinical outcomes following chronic total occlusion (CTO) percutaneous coronary intervention (PCI) with dissection and re-entry techniques (DART) and subintimal (SI) stenting compared with intimal techniques. Background Reliable procedural success and safety in CTO PCI require the use of DART to treat the most complex patients. Potential concerns regarding the durability of DART with SI stenting still need to ...
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    10. Deep iterative vessel segmentation in OCT angiography

      Deep iterative vessel segmentation in OCT angiography
      This paper addresses retinal vessel segmentation on optical coherence tomography angiography (OCT-A) images of the human retina. Our approach is motivated by the need for high precision image-guided delivery of regenerative therapies in vitreo-retinal surgery. OCT-A visualizes macular vasculature, the main landmark of the surgically targeted area, at a level of detail and spatial extent unattainable by other imaging modalities. Thus, automatic extraction of detailed vessel maps can ultimately inform ...
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    11. Randomized comparison of optical coherence tomography versus angiography to guide Bioresorbable vascular scaffold implantation: The OPTICO BVS stud

      Randomized comparison of optical coherence tomography versus angiography to guide Bioresorbable vascular scaffold implantation: The OPTICO BVS stud
      Purpose We investigated whether optical coherence tomography (OCT)-guided bioresorbable vascular scaffolds (BVS) implantation can improve in-scaffold minimal lumen area (MLA) at 6-month compared with angiography guidance. Methods The OPTICO BVS was a randomized, international multicenter, assessor blind, superiority trial comparing OCT- versus angiography-guided percutaneous coronary intervention (PCI) (1:1 allocation) in patients with coronary artery disease undergoing Absorb BVS 1.1 implantation. The primary endpoint was in-scaffold MLA at ...
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    12. Disease classification of macular Optical Coherence Tomography scans using deep learning software: validation on independent, multi-centre data

      Disease classification of macular Optical Coherence Tomography scans using deep learning software: validation on independent, multi-centre data
      Purpose: To evaluate Pegasus-OCT, a clinical decision support software for the identification of features of retinal disease from macula OCT scans, across heterogenous populations involving varying patient demographics, device manufacturers, acquisition sites and operators. Methods: 5,588 normal and anomalous macular OCT volumes (162,721 B-scans), acquired at independent centres in five countries, were processed using the software. Results were evaluated against ground truth provided by the dataset owners. Results ...
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    13. Spontaneous Coronary Artery Dissection: Pathophysiological Insights From Optical Coherence Tomography

      Spontaneous Coronary Artery Dissection: Pathophysiological Insights From Optical Coherence Tomography
      Objectives This study used optical coherence tomography to investigate the mechanism of false lumen (FL) formation in spontaneous coronary artery dissection (SCAD) by studying: 1) differences between fenestrated and nonfenestrated SCAD; 2) vasa vasorum density; and 3) light attenuation characteristics of the FL. Background SCAD is an increasingly recognized cause of acute coronary syndromes , characterized by FL formation and compression of the true lumen (TL). The mechanisms underlying FL formation ...
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    14. Feature Of The Week 08/01/2018: OCT Shows Promise in Effecting Outcomes after Coronary Intervention Being Associated with Improved Long-Term Survival

      Feature Of The Week 08/01/2018: OCT Shows Promise in Effecting Outcomes after Coronary Intervention Being Associated with Improved Long-Term Survival
      Objectives This study aimed to determine the effect on long-term survival of using optical coherence tomography (OCT) during percutaneous coronary intervention (PCI). Background Angiographic guidance for PCI has substantial limitations. The superior spatial resolution of OCT could translate into meaningful clinical benefits, although limited data exist to date about their effect on clinical endpoints. Methods This was a cohort study based on the Pan-London (United Kingdom) PCI registry, which includes ...
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    15. Optical Coherence Tomography Characterization of Coronary Lithoplasty for Treatment of Calcified Lesions: First Description

      Optical Coherence Tomography Characterization of Coronary Lithoplasty for Treatment of Calcified Lesions: First Description
      Objectives This study sought to determine the mechanistic effects of a novel balloon-based lithoplasty system on heavily calcified coronary lesions and subsequent stent placement using optical coherence tomography (OCT). Background The Shockwave Coronary Rx Lithoplasty System (Shockwave Medical, Fremont, California) delivers localized, lithotripsy-enhanced disruption of calcium within the target lesion (i.e., lithoplasty) for vessel preparation before stent implantation. Methods We analyzed OCT findings in 31 patients in whom lithoplasty ...
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    16. Quantitative Swept-Source Optical Coherence Tomography of Early Enamel Erosion in vivo

      Quantitative Swept-Source Optical Coherence Tomography of Early Enamel Erosion in vivo
      Swept-source optical coherence tomography (SS-OCT) shows potential for the in vivo quantitative evaluation of micro-structural enamel surface phenomena occurring during early erosive demineralization. This randomized controlled single-blind cross-over clinical study aimed to evaluate the use of SS-OCT for detecting optical changes in the enamel of 30 healthy volunteers subjected to orange juice rinsing (erosive challenge) in comparison to mineral water rinsing (control), according to wiped and non-wiped enamel surface states ...
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  2. About Kings College London

    Kings College London

    King's College London is a British higher education institution and co-founding constituent college of the University of London. Founded by King George IV in 1829, its royal charter is predated only by those of the Universities of Oxford and Cambridge. King's has a strong academic reputation; in 2007 it was ranked 6th in the UK, 6th in Europe and 24th in the world by The Times Higher Education Supplement. King's is a founding member of the Russell Group and the Golden Triangle, constitutes the biggest centre for the education of healthcare professionals in Europe, and houses five Medical Research Council Centres - more than anywhere else in the world. Today, King's is arranged into nine Schools of Study, spread across four Thames-side campuses in Central London and one in Denmark Hill, South London.