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2. Cocoa flavanol consumption improves lower extremity endothelial function in healthy individuals and people with type 2 diabetes
  
  Explore RSC Publishing Home Sep 20 2022 Ophthalmology
  
  Background : diabetes and age are major risk factors for the development of lower extremity peripheral artery disease (PAD). Cocoa flavanol (CF) consumption is associated with lower risk for PAD and improves brachial artery (BA) endothelial function. Objectives : to assess if femoral artery (FA) endothelial function and dermal microcirculation are impaired in individuals with type 2 diabetes mellitus (T2DM) and evaluate the acute effect of CF consumption on FA endothelial function ...
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  Mentions: University College London University of Western Australia Kings College London
3. Surgical biomicroscopy-guided intra-operative optical coherence tomography (iOCT) image super-resolution
  
  Explore Home - Springer Apr 4 2022 Ophthalmology
  
  Purpose: Intra-retinal delivery of novel sight-restoring therapies will require the precision of robotic systems accompanied by excellent visualisation of retinal layers. Intra-operative Optical Coherence Tomography (iOCT) provides cross-sectional retinal images in real time but at the cost of image quality that is insufficient for intra-retinal therapy delivery.This paper proposes a super-resolution methodology that improves iOCT image quality leveraging spatiotemporal consistency of incoming iOCT video streams. Methods: To overcome the ...
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  Mentions: University College London Kings College London
4. Associations Between Retinal Nerve Fiber Layer and Ganglion Cell Layer in Middle Age and Cognition From Childhood to Adulthood
  
  Explore The JAMA Network Feb 11 2022 Neurology , Ophthalmology
  
  Importance The retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) have been proposed as potential biomarkers for Alzheimer disease (AD). Although a number of studies have shown that knowing the thickness of RNFL and GCL can help differentiate between patients with AD and healthy controls, it is unclear whether these associations are observable earlier in life. Objective To examine whether RNFL and GCL thickness was associated with global ...
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  Mentions: Singapore Eye Research Institute University of Otago Kings College London
5. Macular thickness varies with age-related macular degeneration genetic risk variants in the UK Biobank cohort
  
  Explore Nature Publishing Group Dec 10 2021 Ophthalmology
  
  To evaluate the influence AMD risk genomic variants have on macular thickness in the normal population. UK Biobank participants with no significant ocular history were included using the UK Biobank Resource (project 2112). Spectral-domain optical coherence tomography (SD-OCT) images were taken and segmented to define retinal layers. The influence of AMD risk single-nucleotide polymorphisms (SNP) on retinal layer thickness was analysed. AMD risk associated SNPs were strongly associated with outer-retinal ...
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  Mentions: University College London University of Southampton Kings College London
6. Long-term in vivo monitoring of gliotic sheathing of ultrathin entropic coated brain microprobes with fiber-based optical coherence tomography
  
  Explore IOPscience Mar 4 2021 Neurology , Probes
  
  Microfabricated neuroprosthetic devices have made possible important observations on neuron activity; however, long-term high-fidelity recording performance of these devices has yet to be realized. Tissue-device interactions appear to be a primary source of lost recording performance. The current state of the art for visualizing the tissue response surrounding brain implants in animals is Immunohistochemistry + Confocal Microscopy, which is mainly performed after sacrificing the animal. Monitoring the tissue response as it ...
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  Mentions: University of Washington University of Freiburg Kings College London
7. Applications and Future Directions for Optical Coherence Tomography in Dermatology
  
  Explore Wiley Online Library Sep 26 2020 Dermatology
  
  Optical coherence tomography (OCT) is a non‐invasive optical imaging method that can generate high‐resolution en‐face and cross‐sectional images of the skin in vivo to a maximum depth of 2mm. Whilst OCT holds considerable potential for non‐invasive diagnosis and disease monitoring, it is poorly understood by many dermatologists. Here, we aim to equip the practicing dermatologist with an understanding of the principles of skin OCT and ...
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  Mentions: Kings College London
8. An Update on Imaging in Idiopathic Intracranial Hypertension
  
  Explore Frontiers Jun 27 2020 Neurology , Ophthalmology
  
  Neuroimaging plays an essential role in the diagnostic workup of idiopathic intracranial hypertension with the aims to exclude secondary causes of elevated intracranial pressure and to identify imaging signs that are commonly observed in this disorder. As a valuable expansion of brain imaging, the imaging of the retina using optical coherence tomography has been of increasing value. In particular, this is the case with the latest devices that allow a ...
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  Mentions: Kings College London
9. Intravascular Healing Is Not Affected by Approaches in Contemporary CTO PCI: The CONSISTENT CTO Study
  
  Explore ScienceDirect Jun 20 2020 Cardiology
  
  Objectives The aim of this study was to assess angiographic, imaging, and clinical outcomes following chronic total occlusion (CTO) percutaneous coronary intervention (PCI) with dissection and re-entry techniques (DART) and subintimal (SI) stenting compared with intimal techniques. Background Reliable procedural success and safety in CTO PCI require the use of DART to treat the most complex patients. Potential concerns regarding the durability of DART with SI stenting still need to ...
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  Mentions: Kings College London
10. Deep iterative vessel segmentation in OCT angiography
  
  Explore OSA | OSA Publishing Jun 6 2020 Ophthalmology
  
  This paper addresses retinal vessel segmentation on optical coherence tomography angiography (OCT-A) images of the human retina. Our approach is motivated by the need for high precision image-guided delivery of regenerative therapies in vitreo-retinal surgery. OCT-A visualizes macular vasculature, the main landmark of the surgically targeted area, at a level of detail and spatial extent unattainable by other imaging modalities. Thus, automatic extraction of detailed vessel maps can ultimately inform ...
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  Mentions: University College London Kings College London
11. Randomized comparison of optical coherence tomography versus angiography to guide Bioresorbable vascular scaffold implantation: The OPTICO BVS stud
  
  Explore ScienceDirect Mar 24 2020 Cardiology
  
  Purpose We investigated whether optical coherence tomography (OCT)-guided bioresorbable vascular scaffolds (BVS) implantation can improve in-scaffold minimal lumen area (MLA) at 6-month compared with angiography guidance. Methods The OPTICO BVS was a randomized, international multicenter, assessor blind, superiority trial comparing OCT- versus angiography-guided percutaneous coronary intervention (PCI) (1:1 allocation) in patients with coronary artery disease undergoing Absorb BVS 1.1 implantation. The primary endpoint was in-scaffold MLA at ...
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  Mentions: University of Bern Kings College London
12. Disease classification of macular Optical Coherence Tomography scans using deep learning software: validation on independent, multi-centre data
  
  Explore arxiv.org Jul 16 2019
  
  Purpose: To evaluate Pegasus-OCT, a clinical decision support software for the identification of features of retinal disease from macula OCT scans, across heterogenous populations involving varying patient demographics, device manufacturers, acquisition sites and operators. Methods: 5,588 normal and anomalous macular OCT volumes (162,721 B-scans), acquired at independent centres in five countries, were processed using the software. Results were evaluated against ground truth provided by the dataset owners. Results ...
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  Mentions: Cardiff University Kings College London
13. Spontaneous Coronary Artery Dissection: Pathophysiological Insights From Optical Coherence Tomography
  
  Explore ScienceDirect Mar 19 2019 Cardiology
  
  Objectives This study used optical coherence tomography to investigate the mechanism of false lumen (FL) formation in spontaneous coronary artery dissection (SCAD) by studying: 1) differences between fenestrated and nonfenestrated SCAD; 2) vasa vasorum density; and 3) light attenuation characteristics of the FL. Background SCAD is an increasingly recognized cause of acute coronary syndromes , characterized by FL formation and compression of the true lumen (TL). The mechanisms underlying FL formation ...
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  Mentions: Royal Brompton Hospital San Carlos University Hospital Kings College London
14. Feature Of The Week 08/01/2018: OCT Shows Promise in Effecting Outcomes after Coronary Intervention Being Associated with Improved Long-Term Survival
  
  Explore Optical Coherence Tomography News Aug 1 2018 Cardiology
  
  Objectives This study aimed to determine the effect on long-term survival of using optical coherence tomography (OCT) during percutaneous coronary intervention (PCI). Background Angiographic guidance for PCI has substantial limitations. The superior spatial resolution of OCT could translate into meaningful clinical benefits, although limited data exist to date about their effect on clinical endpoints. Methods This was a cohort study based on the Pan-London (United Kingdom) PCI registry, which includes ...
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  Mentions: Imperial College London Kings College London
15. Optical Coherence Tomography Characterization of Coronary Lithoplasty for Treatment of Calcified Lesions: First Description
  
  Explore ScienceDirect Aug 8 2017 Cardiology
  
  Objectives This study sought to determine the mechanistic effects of a novel balloon-based lithoplasty system on heavily calcified coronary lesions and subsequent stent placement using optical coherence tomography (OCT). Background The Shockwave Coronary Rx Lithoplasty System (Shockwave Medical, Fremont, California) delivers localized, lithotripsy-enhanced disruption of calcium within the target lesion (i.e., lithoplasty) for vessel preparation before stent implantation. Methods We analyzed OCT findings in 31 patients in whom lithoplasty ...
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  Mentions: Cardiovascular Research Foundation Stanford University Royal Brompton Hospital
16. Quantitative Swept-Source Optical Coherence Tomography of Early Enamel Erosion in vivo
  
  Explore Karger Publishers Jun 22 2017 Dentistry
  
  Swept-source optical coherence tomography (SS-OCT) shows potential for the in vivo quantitative evaluation of micro-structural enamel surface phenomena occurring during early erosive demineralization. This randomized controlled single-blind cross-over clinical study aimed to evaluate the use of SS-OCT for detecting optical changes in the enamel of 30 healthy volunteers subjected to orange juice rinsing (erosive challenge) in comparison to mineral water rinsing (control), according to wiped and non-wiped enamel surface states ...
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  Mentions: University of Manchester Kings College London
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