1. Kings College London

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    1. Mentioned In 20 Articles

    2. Disease classification of macular Optical Coherence Tomography scans using deep learning software: validation on independent, multi-centre data

      Disease classification of macular Optical Coherence Tomography scans using deep learning software: validation on independent, multi-centre data
      Purpose: To evaluate Pegasus-OCT, a clinical decision support software for the identification of features of retinal disease from macula OCT scans, across heterogenous populations involving varying patient demographics, device manufacturers, acquisition sites and operators. Methods: 5,588 normal and anomalous macular OCT volumes (162,721 B-scans), acquired at independent centres in five countries, were processed using the software. Results were evaluated against ground truth provided by the dataset owners. Results ...
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    3. Spontaneous Coronary Artery Dissection: Pathophysiological Insights From Optical Coherence Tomography

      Spontaneous Coronary Artery Dissection: Pathophysiological Insights From Optical Coherence Tomography
      Objectives This study used optical coherence tomography to investigate the mechanism of false lumen (FL) formation in spontaneous coronary artery dissection (SCAD) by studying: 1) differences between fenestrated and nonfenestrated SCAD; 2) vasa vasorum density; and 3) light attenuation characteristics of the FL. Background SCAD is an increasingly recognized cause of acute coronary syndromes , characterized by FL formation and compression of the true lumen (TL). The mechanisms underlying FL formation ...
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    4. Feature Of The Week 08/01/2018: OCT Shows Promise in Effecting Outcomes after Coronary Intervention Being Associated with Improved Long-Term Survival

      Feature Of The Week 08/01/2018: OCT Shows Promise in Effecting Outcomes after Coronary Intervention Being Associated with Improved Long-Term Survival
      Objectives This study aimed to determine the effect on long-term survival of using optical coherence tomography (OCT) during percutaneous coronary intervention (PCI). Background Angiographic guidance for PCI has substantial limitations. The superior spatial resolution of OCT could translate into meaningful clinical benefits, although limited data exist to date about their effect on clinical endpoints. Methods This was a cohort study based on the Pan-London (United Kingdom) PCI registry, which includes ...
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    5. Optical Coherence Tomography Characterization of Coronary Lithoplasty for Treatment of Calcified Lesions: First Description

      Optical Coherence Tomography Characterization of Coronary Lithoplasty for Treatment of Calcified Lesions: First Description
      Objectives This study sought to determine the mechanistic effects of a novel balloon-based lithoplasty system on heavily calcified coronary lesions and subsequent stent placement using optical coherence tomography (OCT). Background The Shockwave Coronary Rx Lithoplasty System (Shockwave Medical, Fremont, California) delivers localized, lithotripsy-enhanced disruption of calcium within the target lesion (i.e., lithoplasty) for vessel preparation before stent implantation. Methods We analyzed OCT findings in 31 patients in whom lithoplasty ...
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    6. Quantitative Swept-Source Optical Coherence Tomography of Early Enamel Erosion in vivo

      Quantitative Swept-Source Optical Coherence Tomography of Early Enamel Erosion in vivo
      Swept-source optical coherence tomography (SS-OCT) shows potential for the in vivo quantitative evaluation of micro-structural enamel surface phenomena occurring during early erosive demineralization. This randomized controlled single-blind cross-over clinical study aimed to evaluate the use of SS-OCT for detecting optical changes in the enamel of 30 healthy volunteers subjected to orange juice rinsing (erosive challenge) in comparison to mineral water rinsing (control), according to wiped and non-wiped enamel surface states ...
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    7. The REMEDEE-OCT Study : An Evaluation of the Bioengineered COMBO Dual-Therapy CD34 Antibody–Covered Sirolimus-Eluting Coronary Stent Compared With a Cobalt-Chromium Everolimus-Eluting Stent in Patients With Acute Coronary Syndromes: Insights From Optical

      The REMEDEE-OCT Study : An Evaluation of the Bioengineered COMBO Dual-Therapy CD34 Antibody–Covered Sirolimus-Eluting Coronary Stent Compared With a Cobalt-Chromium Everolimus-Eluting Stent in Patients With Acute Coronary Syndromes: Insights From Optical
      Objectives The aim of the present study was to evaluate vascular healing of the bioengineered COMBO Dual Therapy Stent compared with a cobalt-chromium (CoCr) everolimus-eluting stent (EES) as assessed by optical coherence tomography in patients with acute coronary syndromes. Background CD34+ cells promote endothelial repair after vascular injury. The bioengineered COMBO Dual Therapy Stent combines CD34+ cellcapturing technology with abluminal sirolimus release, but more data from clinical studies evaluating the ...
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    8. Optical coherence tomography use in the diagnosis of enamel defects

      Optical coherence tomography use in the diagnosis of enamel defects
      Molar incisor hypomineralization (MIH) affects the permanent incisors and molars, whose undermineralized matrix is evidenced by lesions ranging from white to yellow/brown opacities to crumbling enamel lesions incapable of withstanding normal occlusal forces and function. Diagnosing the condition involves clinical and radiographic examination of these teeth, with known limitations in determining the depth extent of the enamel defects in particular. Optical coherence tomography (OCT) is an emerging hard and ...
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    9. Age, Gender and Ethnic Variations in Inner and Outer Retinal and Choroidal Thickness on Spectral Domain Optical Coherence Tomography

      Age, Gender and Ethnic Variations in Inner and Outer Retinal and Choroidal Thickness on Spectral Domain Optical Coherence Tomography
      Purpose To evaluate age, gender and ethnic variations in inner and outer retinal and choroidal thickness and foveal pit, using spectral-domain optical coherence tomography (SD-OCT). Design Single-center observational cross-sectional study. Methods Ninety randomly selected, healthy individuals of White, Black and South Asian origin underwent SD-OCT (Spectralis HRA+OCT, Heidelberg engineering, Germany) raster and enhanced-depth imaging scan. Manual measurements of inner and outer retinal thickness and choroidal thickness up to 3mm ...
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    10. Surface pre-conditioning with bioactive glass air-abrasion can enhance enamel white spot lesion remineralization

      Surface pre-conditioning with bioactive glass air-abrasion can enhance enamel white spot lesion remineralization
      Objective To evaluate the effect of pre-conditioning enamel white spot lesion (WSL) surfaces using bioactive glass (BAG) air-abrasion prior to remineralization therapy. Methods Ninety human enamel samples with artificial WSLs were assigned to three WSL surface pre-conditioning groups ( n = 30): (a) air-abrasion with BAG-polyacrylic acid (PAA-BAG) powder, (b) acid-etching using 37% phosphoric acid gel (positive control) and (c) unconditioned (negative control). Each group was further divided into three subgroups according ...
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    11. Automated registration of optical coherence tomography and dermoscopy in the assessment of sub-clinical spread in basal cell carcinoma

      Automated registration of optical coherence tomography and dermoscopy in the assessment of sub-clinical spread in basal cell carcinoma
      Optical coherence tomography (OCT) has been shown to be of clinical value in imaging basal cell carcinoma (BCC). A novel dual OCT-video imaging system, providing automated registration of OCT and dermoscopy, has been developed to assess the potential of OCT in measuring the degree of sub-clinical spread of BCC. Seventeen patients selected for Mohs micrographic surgery (MMS) for BCC were recruited to the study. The extent of BCC infiltration beyond ...
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    12. Motion tracking to enable pre-surgical margin mapping in basal cell carcinoma using optical imaging modalities: initial feasibility study using optical coherence tomography

      Motion tracking to enable pre-surgical margin mapping in basal cell carcinoma using optical imaging modalities: initial feasibility study using optical coherence tomography
      A system has been developed to assess the feasibility of using motion tracking to enable pre-surgical margin mapping of basal cell carcinoma (BCC) in the clinic using optical coherence tomography (OCT). This system consists of a commercial OCT imaging system (the VivoSight 1500, MDL Ltd., Orpington, UK), which has been adapted to incorporate a webcam and a single-sensor electromagnetic positional tracking module (the Flock of Birds, Ascension Technology Corp, Vermont ...
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    13. Correlation of Fundus Fluorescein Angiography and Spectral-Domain Optical Coherence Tomography in Identification of Membrane Subtypes in Neovascular Age-Related Macular Degeneration

      Correlation of Fundus Fluorescein Angiography and Spectral-Domain Optical Coherence Tomography in Identification of Membrane Subtypes in Neovascular Age-Related Macular Degeneration
      Aims: To assess the sensitivity and specificity of spectral-domain optical coherence tomography (SDOCT) for the determination of choroidal neovascularization (CNV) subtypes in neovascular age-related macular degeneration (AMD) compared to fundus fluorescein angiography (FFA) and also the agreement between the two procedures. Design: This was a retrospective, observational study. Methods: We evaluated and compared the CNV subtypes on FFA and OCT in 100 eyes initiated on ranibizumab for neovascular AMD. Results ...
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    14. A comparison of CBCT and periapical radiography for the detection of vertical root fractures in non-endodontically treated teeth

      A comparison of CBCT and periapical radiography for the detection of vertical root fractures in non-endodontically treated teeth
      Aims To compare in an ex vivo model, the diagnostic accuracy of periapical radiography and cone beam computed tomography (CBCT) in the detection of artificially induced incomplete and complete vertical root fractures (VRFs), and to determine whether the width of the VRFs had an impact on the diagnostic accuracy of the imaging systems. Methodology Incomplete VRFs were induced in 30 non-endodontically treated human mandibular premolar and molar teeth. VRF widths ...
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    15. Macular spectral domain optical coherence tomography findings in Tanzanian endemic optic neuropathy

      Macular spectral domain optical coherence tomography findings in Tanzanian endemic optic neuropathy
      Bilateral optic neuropathy in Dar es Salaam is now considered endemic and is estimated to affect 0.32.4% of young adults. The condition is characterized by a subacute bilateral loss of central vision of unknown aetiology. Findings of spectral domain optical coherence tomography have not previously been reported for these patients. All patients diagnosed with endemic optic neuropathy over a 2-year period at the Muhimbili National Hospital underwent spectral ...
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    16. Macular Epiretinal Brachytherapy in Treated Age-Related Macular Degeneration (MERITAGE Study) 12 Month Optical Coherence Tomography and Fluorescein Angiography

      Macular Epiretinal Brachytherapy in Treated Age-Related Macular Degeneration (MERITAGE Study) 12 Month Optical Coherence Tomography and Fluorescein Angiography
      ...rresponding Author Information Correspondence Timothy L. Jackson, PhD, FRCOphth, Department of Ophthalmology, King's College Hospital, London SE5 9RS, United Kingdom email address Received 6 May 2012; received in revised...
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  2. About Kings College London

    Kings College London

    King's College London is a British higher education institution and co-founding constituent college of the University of London. Founded by King George IV in 1829, its royal charter is predated only by those of the Universities of Oxford and Cambridge. King's has a strong academic reputation; in 2007 it was ranked 6th in the UK, 6th in Europe and 24th in the world by The Times Higher Education Supplement. King's is a founding member of the Russell Group and the Golden Triangle, constitutes the biggest centre for the education of healthcare professionals in Europe, and houses five Medical Research Council Centres - more than anywhere else in the world. Today, King's is arranged into nine Schools of Study, spread across four Thames-side campuses in Central London and one in Denmark Hill, South London.