1. Kate Grieve

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    1. Mentioned In 25 Articles

    2. Real-time, non-contact, cellular imaging and angiography of human cornea and limbus with common-path Full-field/SD OCT

      Real-time, non-contact, cellular imaging and angiography of human cornea and limbus with common-path Full-field/SD OCT
      In todays clinics, a cellular-resolution view of the cornea can be achieved only with an in vivo confocal microscope (IVCM) in contact with the eye. Here, we present a common-path Full-field/Spectral-domain OCT microscope (FF/SD OCT), which, for the first time, enables cell-detail imaging of the entire ocular surface (central and peripheral cornea, limbus, sclera, tear film) without contact and in real time. The device, that has been successfully ...
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    3. Curved-Full-Field OCT for high-resolution imaging of living human retina over a large field-of-view

      Curved-Full-Field OCT for high-resolution imaging of living human retina over a large field-of-view
      Allying high-resolution with a large field-of-view (FOV) is of great importance in the fields of biology and medicine [1, 2, 3], but particularly challenging when imaging non-flat living samples such as the human retina. Indeed, high-resolution is normally achieved with adaptive optics (AO) and scanning methods, which considerably reduce the useful FOV and increase the system complexity. An alternative technique is time-domain Full-Field Optical Coherence Tomography (FF-OCT) [4, 5], which ...
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    4. ATTENUATION OUTER RETINAL BANDS ON OPTICAL COHERENCE TOMOGRAPHY FOLLOWING MACULAR EDEMA: A Possible Manifestation of Photoreceptor Misalignmen

      ATTENUATION OUTER RETINAL BANDS ON OPTICAL COHERENCE TOMOGRAPHY FOLLOWING MACULAR EDEMA: A Possible Manifestation of Photoreceptor Misalignmen
      Purpose: Macular edema is a common retinal disease which may leave important anatomical and functional sequelaes. Directional fundus imaging consists of comparing on- and off-axis images to reveal angle-dependent reflectance properties of fundus structures, which may be related to misaligned photoreceptors . Here, we analyzed directional optical coherence tomography (OCT) and flood-illumination adaptive optics ophthalmoscopy images to detect evidence of misaligned photoreceptors following macular edema . Methods: Transversal, observational study. Nine patients ...
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    5. Dynamic full-field optical coherence tomography: 3D live-imaging of retinal organoids

      Dynamic full-field optical coherence tomography: 3D live-imaging of retinal organoids
      Optical coherence tomography offers astounding opportunities to image the complex structure of living tissue, but lacks functional information. We present dynamic full-field optical coherence tomography to image living human induced pluripotent stem cell-derived retinal organoids non-invasively. Colored images with an endogenous contrast linked to organelle motility are generated, with sub-micrometer spatial resolution and millisecond temporal resolution, opening an avenue to identify specific cell types in living tissue via their function.
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    6. Highlighting Directional Reflectance Properties of Retinal Substructures From D-OCT Images

      Highlighting Directional Reflectance Properties of Retinal Substructures From D-OCT Images
      Optical coherence tomography (OCT), which is routinely used in ophthalmology, enables transverse optical imaging of the retina and, hence, the identification of the different neuronal layers. Directional OCT (D-OCT) extends this technology by acquiring sets of images at different incidence angles of the light beam. In this way, reflectance properties of photoreceptor substructures are highlighted, enabling physicians to study their orientation, which is potentially an interesting biomarker for retinal diseases ...
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    7. Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT

      Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT
      We describe recent technological progress in multimodal en face full-field optical coherence tomography that has allowed detection of slow and fast dynamic processes in the eye. We show that by combining static, dynamic and fluorescence contrasts we can achieve label-free high-resolution imaging of the retina and anterior eye with temporal resolution from milliseconds to several hours, allowing us to probe biological activity at subcellular scales inside 3D bulk tissue. Our ...
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    8. Spectral Domain Optical Coherence Tomography in Limbal Stem Cell Deficiency. A Case Control Study

      Spectral Domain Optical Coherence Tomography in Limbal Stem Cell Deficiency. A Case Control Study
      Purpose To evaluate the efficacy of optical coherence tomography as a non-contact method for imaging the ocular surface in limbal stem cell deficiency (LSCD) and normal eyes. Design Retrospective case-control study. Methods: Setting Institutional. Study population 22 eyes with LSCD (study group, 22 patients) and 10 normal eyes (control group, 10 patients). Observation procedures SD-OCT and confocal microscopy in both the limbal and central corneal zones. Main outcome measures Pachymetry ...
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      Mentions: Kate Grieve
    9. In vivo imaging through the entire thickness of human cornea by full-field optical coherence tomography

      In vivo imaging through the entire thickness of human cornea by full-field optical coherence tomography
      Despite obvious improvements in visualization of the in vivo cornea through the faster imaging speeds and higher axial resolutions, cellular imaging stays unresolvable task for OCT, as en face viewing with a high lateral resolution is required. The latter is possible with FFOCT, a method that relies on a camera, moderate numerical aperture (NA) objectives and an incoherent light source to provide en face images with a micrometer-level resolution. Recently ...
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    10. In vivo high resolution human corneal imaging using full-field optical coherence tomography

      In vivo high resolution human corneal imaging using full-field optical coherence tomography
      We present the first full-field optical coherence tomography (FFOCT) device capable of in vivo imaging of the human cornea. We obtained images of the epithelial structures, Bowmans layer, sub-basal nerve plexus (SNP), anterior and posterior stromal keratocytes, stromal nerves, Descemets membrane and endothelial cells with visible nuclei. Images were acquired with a high lateral resolution of 1.7 m and relatively large field-of-view of 1.26 mm x 1.26 ...
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    11. Cell Motility as Contrast Agent in Retinal Explant Imaging With Full-Field Optical Coherence Tomography

      Cell Motility as Contrast Agent in Retinal Explant Imaging With Full-Field Optical Coherence Tomography
      Purpose : To use cell motility as a contrast agent in retinal explants. Methods : Macaque and mouse retinal explants were imaged with high resolution full field optical coherence tomography (FFOCT) and dynamic FFOCT, coupled with fluorescence imaging. Results : Static and dynamic FFOCT create complementary contrast from different structures within a cell. When imaging in vitro samples, static FFOCT detects steep refractive index gradients to reveal stationary structures including fibers, vessels, collagen ...
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    12. Full-field OCT technique for high speed event-based optical flow and particle tracking

      Full-field OCT technique for high speed event-based optical flow and particle tracking
      This article introduces a method to extract the speed and density of microparticles in real time at several kHz using an asynchronous event-based camera mounted on a full-field optical coherence tomography (FF-OCT) setup. These cameras detect significant amplitude changes, allowing scene-driven acquisitions. They are composed of an array of autonomously operating pixels. Events are triggered when an illuminance change at the pixel level is significant at 1 s time precision ...
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      Mentions: Kate Grieve
    13. En face coherence microscopy [Invited]

      En face coherence microscopy [Invited]
      En face coherence microscopy or flying spot or full field optical coherence tomography or microscopy (FF-OCT/FF-OCM) belongs to the OCT family because the sectioning ability is mostly linked to the source coherence length. In this article we will focus our attention on the advantages and the drawbacks of the following approaches: en face versus B scan tomography in terms of resolution, coherent versus incoherent illumination and influence of aberrations ...
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    14. Imaging Microscopic Features of Keratoconic Corneal Morphology

      Imaging Microscopic Features of Keratoconic Corneal Morphology
      Purpose: To search for gold-standard histology indicators using alternative imaging modalities in keratoconic corneas. Methods: Prospective observational casecontrol study. Fourteen keratoconic corneas and 20 normal corneas (10 in vivo healthy subjects and 10 ex vivo donor corneas) were examined. Images of corneas were taken by spectral domain optical coherence tomography (SD-OCT) and in vivo confocal microscopy (IVCM) before keratoplasty. The same removed corneal buttons were imaged after keratoplasty with full-field ...
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  2. About Kate Grieve

    Kate Grieve

    Kate Grieve is based at Institut Langevin (ESPCI, Paris) and works closely with LLTech, the start-up company offering commercial full-field OCT systems for the pathology lab. She has worked in the field of optical techniques for medical imaging since completing her PhD on the development of full-field OCT in 2005.