1. Karol Karnowski

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    1. Mentioned In 34 Articles

    2. Influence of tissue fixation on depth-resolved birefringence of oral cavity tissue samples

      Influence of tissue fixation on depth-resolved birefringence of oral cavity tissue samples
      Significance: To advance our understanding of the contrast observed when imaging with polarization-sensitive optical coherence tomography (PS-OCT) and its correlation with oral cancerous pathologies, a detailed comparison with histology provided via ex vivo fixed tissue is required. The effects of tissue fixation, however, on such polarization-based contrast have not yet been investigated. Aim: A study was performed to assess the impact of tissue fixation on depth-resolved (i.e., local) birefringence ...
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    3. Jones matrix‐based speckle‐decorrelation angiography using polarization‐sensitive optical coherence tomography

      Jones matrix‐based speckle‐decorrelation angiography using polarization‐sensitive optical coherence tomography
      We show that polarization‐sensitive optical coherence tomography angiography (PS‐OCTA) based on full Jones matrix assessment of speckle decorrelation offers improved contrast and depth of vessel imaging over conventional OCTA. We determine how best to combine the individual Jones matrix elements and compare the resulting image quality to that of a conventional OCT scanner by co‐locating and imaging the same skin locations with closely matched scanning setups. Vessel ...
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    4. Vectorial birefringence imaging by optical coherence microscopy for assessing fibrillar microstructures in the cornea and limbus

      Vectorial birefringence imaging by optical coherence microscopy for assessing fibrillar microstructures in the cornea and limbus
      The organization of fibrillar tissue on the micrometer scale carries direct implications for health and disease but remains difficult to assess in vivo . Polarization-sensitive optical coherence tomography measures birefringence, which relates to the microscopic arrangement of fibrillar tissue components. Here, we demonstrate a critical improvement in leveraging this contrast mechanism by employing the improved spatial resolution of focus-extended optical coherence microscopy (1.4 m axially in air and 1.6 ...
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    5. Depth-resolved birefringence imaging of collagen fiber organization in the human oral mucosa in vivo

      Depth-resolved birefringence imaging of collagen fiber organization in the human oral mucosa in vivo
      Stromal collagen organization has been identified as a potential prognostic indicator in a variety of cancers and other diseases accompanied by fibrosis. Changes in the connective tissue are increasingly considered for grading dysplasia and progress of oral squamous cell carcinoma, investigated mainly ex vivo by histopathology. In this study, polarization-sensitive optical coherence tomography (PS-OCT) with local phase retardation imaging is used for the first time to visualize depth-resolved (i.e ...
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    6. Robust reconstruction of local optic axis orientation with fiber-based polarization-sensitive optical coherence tomography

      Robust reconstruction of local optic axis orientation with fiber-based polarization-sensitive optical coherence tomography
      It is challenging to recover local optic axis orientation from samples probed with fiber-based polarization-sensitive optical coherence tomography (PS-OCT). In addition to the effect of preceding tissue layers, the transmission through fiber and system elements, and imperfect system alignment, need to be compensated. Here, we present a method to retrieve the required correction factors from measurements with depth-multiplexed PS-OCT, which accurately measures the full Jones matrix. The correction considers both ...
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    7. Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air‐puff optical coherence tomography and corneal hysteresis

      Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air‐puff optical coherence tomography and corneal hysteresis
      Application of the air‐puff swept source OCT (SS‐OCT) instrument to determine the influence of viscoelasticity on the relation between overall the air‐puff force and corneal apex displacement of porcine corneas ex vivo is demonstrated. Simultaneous recording of time‐evolution of the tissue displacement and air pulse stimulus allows obtaining valuable information related in part to the mechanical properties of the cornea. A novel approach based on quantitative ...
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    8. Label‐free volumetric imaging of conjunctival collecting lymphatics ex vivo by optical coherence tomography lymphangiography

      Label‐free volumetric imaging of conjunctival collecting lymphatics ex vivo by optical coherence tomography lymphangiography
      We employ optical coherence tomography (OCT) and optical coherence microscopy (OCM) to study conjunctival lymphatics in porcine eyes ex vivo . This study is a precursor to the development of in vivo imaging of the collecting lymphatics for potentially guiding and monitoring glaucoma filtration surgery. OCT scans at 1300 nm and higher‐resolution OCM scans at 785 nm reveal the lymphatic vessels via their optical transparency. Equivalent signal characteristics are also ...
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    9. A study of the effects of supine position and fluid intake on normal airway geometry using anatomical optical coherence tomography

      A study of the effects of supine position and fluid intake on normal airway geometry using anatomical optical coherence tomography
      Airway inhalation injuries are present in up to a third of all major burns patients and are the leading cause of mortality among this population. Understanding the mechanism of injury could minimise oedema (swelling) and airway damage. In this study, we present an anatomical OCT (aOCT) imaging system, based on a 1300-nm wavelength, high-speed, long-range MEMS-VCSEL swept laser source, for real-time volumetric imaging and assessment of inhalation injuries in airways ...
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    10. Swept source optical coherence tomography and tunable lens technology for comprehensive imaging and biometry of the whole eye

      Swept source optical coherence tomography and tunable lens technology for comprehensive imaging and biometry of the whole eye
      Standard optical systems in ophthalmology are strictly dedicated either to retinal or to anterior segment imaging due to the refractive properties of the eye. We demonstrate a swept source optical coherence tomography platform with an electrically tunable lens (ETL) for versatile 3D in vivo imaging of both the eyes anterior segment and the retina. The optimized optical setup with adaptive operational states of the ETL permits focusing on the retina ...
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    11. New instrument lets doctors view the entire eye with unprecedented level of detail

      New instrument lets doctors view the entire eye with unprecedented level of detail
      Researchers have developed the first instrument that can provide a detailed image of the entire eye. By incorporating a lens that changes optical parameters in response to an electric current, the innovative technology can produce higher quality images than currently available and could make eye examinations faster and more comfortable for patients by avoiding the need to undergo imaging with multiple instruments to look at different areas of the eye ...
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    12. Research Associate / Research Fellow Microscope-in-a-Needle at the University of Western Australia

      Research Associate / Research Fellow Microscope-in-a-Needle at the University of Western Australia
      Job no: 499437 Work type: full-time Location: Crawley Categories: Health and Medical Sciences, Engineering and Mathematical Sciences 1 year appointment Salary range: Level A $67,352 - $91,397 p.a. or Level B $96,210 - $114,250 p.a. (dependent on qualifications and experience) Research Development In Biomedical Photonics/Optical Microscopy (Australia) The University of Western Australia (UWA) is ranked amongst the top Australian universities and a member of the ...
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    13. Feature Of The Week 10/08/2017: Optical Coherence Microscopy as a Novel, Non-Invasive Method for the 4D Live Imaging of Early Mammalian Embryos

      Feature Of The Week 10/08/2017: Optical Coherence Microscopy as a Novel, Non-Invasive Method for the 4D Live Imaging of Early Mammalian Embryos
      ...apter in imaging-based preimplantation embryo diagnostics. For more information see recent Article . Courtesy Karol Karnowski from Nicolaus Copernicus University . Imaging of living cells based on traditional fluorescenc...
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    14. 1-15 of 34 1 2 3 »
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  2. About Karol Karnowski

    Karol Karnowski

    Karol Karnowski (b. 1979) received his MSc in physics from Nicholas Copernicus University (NCU), Torun, Poland. Presently he is a PhD student in Medical Physics Group managed by Dr Maciej Wojtkowski. His research interest includes ultra-high speed Swept Source OCT systems.