1. K. Divakar Rao

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    1. Mentioned In 19 Articles

    2. Feasibility of speckle variance OCT for imaging cutaneous microvasculature regeneration during healing of wounds in diabetic mice

      Feasibility of speckle variance OCT for imaging cutaneous microvasculature regeneration during healing of wounds in diabetic mice
      We report on a study to assess the feasibility of a swept source-based speckle variance optical coherence tomography setup for monitoring cutaneous microvasculature. Punch wounds created in the ear pinnae of diabetic mice were monitored at different times post wounding to assess the structural and vascular changes. It was observed that the epithelium thickness increases post wounding and continues to be thick even after healing. Also, the wound size assessed ...
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    3. Noncontact three-dimensional quantitative profiling of fast aspheric lenses by optical coherence tomography

      Noncontact three-dimensional quantitative profiling of fast aspheric lenses by optical coherence tomography
      The use of optical coherence tomography (OCT) for noncontact three-dimensional aspheric lens profiling and retrieval of aspheric surface parameters is demonstrated. Two commercially available aspheric lenses with different focal length-to-diameter ratio have been imaged using OCT, and the measured optical path length distribution has been least square fitted with the aspheric lens surface retrieving the radius of curvature, aspheric constant, and conic constants. The refractive index of these lenses has ...
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      Mentions: K. Divakar Rao
    4. A dual-modal optical system combining depth-sensitive laser induced fluorescence (LIF) spectroscopy and optical coherence tomography (OCT) for analyzing layered biological tissue

      A dual-modal optical system combining depth-sensitive laser induced fluorescence (LIF) spectroscopy and optical coherence tomography (OCT) for analyzing layered biological tissue
      Background:There is a significant current interest in combining multiple modalities in a single optical system for a more complete characterization of tissue for improved diagnosis. Objective:We report development of a dual-modal optical system combing the depth-sensitive laser induced fluorescence (LIF) spectroscopy and optical coherence tomography (OCT) for analysis of layered biological tissues. Methods:A time-domain, real-time OCT system, assembled in-house, was used as the platform for developing the ...
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    5. Perspectives of optical coherence tomography imaging and Raman spectroscopy in cancer diagnosis

      Perspectives of optical coherence tomography imaging and Raman spectroscopy in cancer diagnosis
      Biomedical optical imaging and optical spectroscopy are rapidly emerging as strong contenders for non-invasive optical biopsy. In biomedical imaging, Optical Coherence Tomography (OCT) is an established imaging modality for non-contact depth-resolved three-dimensional imaging with micrometer scale resolution. OCT provides label-free micro-structural morphological information of the tissue. Raman spectroscopy is a complementary tool for obtaining molecular-specific information for diagnosis. This article provides a brief overview of the underlying principles of OCT ...
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      Mentions: K. Divakar Rao
    6. Optical coherence tomography for shape and radius of curvature measurements of deeply curved machined metallic surfaces: a comparison with two-beam laser interferometry

      Optical coherence tomography for shape and radius of curvature measurements of deeply curved machined metallic surfaces: a comparison with two-beam laser interferometry
      An application of optical coherence tomography (OCT) for measuring shape and the radius of curvature of deeply curved metallic surfaces in precision mechanical components is demonstrated. Measurements carried out by OCT technique on concave and convex hemispherical metallic surfaces generated by diamond turning process is presented. The technique is compared with a two-beam laser interferometric method for determinations of shape errors and radius of curvature. It is shown that OCT ...
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      Mentions: K. Divakar Rao
    7. Effect of Intraocular Pressure and Anisotropy on the Optical Properties of the Cornea: A Study Using Polarization Sensitive Optical Coherence Tomography

      Effect of Intraocular Pressure and Anisotropy on the Optical Properties of the Cornea: A Study Using Polarization Sensitive Optical Coherence Tomography
      Purpose: We hypothesize that because of the anisotropic properties of the cornea, there should be a nonuniform change in birefringence with an increase in intraocular pressure (IOP). In this in vitro study, anisotropic properties, stress distribution within the cornea, and the effect of IOP on changes in stress level were investigated. Design: Button inflation tests for deformation with polarization sensitive optical coherence tomography were used to demonstrate optical and material ...
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    8. Depth-sensitive Raman spectroscopy combined with optical coherence tomography for layered tissue analysis

      Depth-sensitive Raman spectroscopy combined with optical coherence tomography for layered tissue analysis
      Complete characterization of a layered tissue requires probing both the biochemical and the morphological information from its different layers at various depths. We report the development of a combined Raman spectroscopy (RS) and optical coherence tomography (OCT) system that is capable of measuring depth-sensitive Raman signal from the tissue layers imaged by the OCT. The sample arm of a real-time time-domain OCT system was modified to allow for co-alignment of ...
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    9. Single mode fiber based polarization sensitive optical coherence tomography using a swept laser source

      Single mode fiber based polarization sensitive optical coherence tomography using a swept laser source
      We report the development of a near real time single mode fiber-optic based polarization sensitive optical coherence tomography (PSOCT) setup utilizing a swept source. The setup has a polarization modulator (PM) and polarizer in a sample arm to serve as a polarization state generator and analyzer. Since only intensity information is used to retrieve the polarization parameters of the sample, the problem of phase jitters present in the swept source ...
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    10. Noninvasive imaging of ethanol-induced developmental defects in zebrafish embryos using optical coherence tomography

      Noninvasive imaging of ethanol-induced developmental defects in zebrafish embryos using optical coherence tomography
      In this article, we report the use of optical coherence tomography for noninvasive cross-sectional real-time imaging of ethanol-induced developmental defects in zebrafish embryos larvae. For ethanol concentration of over 300 mM, developmental defects of eye (shrinkage and retinal abnormalities), malformation of the notochord and ataxia arising due to the toxic effects of ethanol were observed in OCT images from 3 days post fertilization onwards. The results suggest that OCT could ...
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    11. Feature Of The Week 4/11/10: Noninvasive Assessment of Healing of Bacteria Infected and Uninfected Wounds using Optical Coherence Tomography

      Feature Of The Week 4/11/10: Noninvasive Assessment of Healing of Bacteria Infected and Uninfected Wounds using Optical Coherence Tomography
      Feature Of The Week 4/11/10: Microbial infection is one of the major factors for the impairment of wound healing as the microbial toxins have a detrimental effect on collagen in the wounded tissue. Infected wounds can cause increased trauma, could severely compromise the overall health of an individual as well as increase the cost of treatment. To facilitate a faster healing of wounds it will be desirable if ...
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    12. Non-invasive assessment of healing of bacteria infected and uninfected wounds using optical coherence tomography

      Non-invasive assessment of healing of bacteria infected and uninfected wounds using optical coherence tomography
      Bacterial infection is one of the main predisposing factors for the delay in wound healing. To facilitate a timely decision for correct therapy, it is important to accurately monitor the morphological changes in the infected wounds using noninvasive tools. In the present study, we have explored the use of optical coherence tomography (OCT) for monitoring the healing of superficial wounds infected with Staphylococcus aureus in mice under in vitro and ...
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    13. Real-time in vivo imaging of adult Zebrafish brain using optical coherence tomography

      Real-time in vivo imaging of adult Zebrafish brain using optical coherence tomography
      We report noninvasive imaging of the brain of adult Zebrafish (Danio rerio) using real time optical coherence tomography (OCT) capable of acquiring cross sectional 2D OCT images @ 8 frames/sec. Anatomic features such as telencephalon, tectum opticum, eminentia Granularis and cerebellum were clearly resolved in the OCT images. A 3D model of Zebrafish brain was reconstructed, for the first time to our knowledge, using these 2D OCT images.
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  2. About K. Divakar Rao

    K. Divakar Rao is a researcher at the Laser Biomedical Applications and Instrumentation Division at the Raja Ramanna Centre for Advanced Technology in Indore, India.