1. Justis P. Ehlers

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    1. Mentioned In 60 Articles

    2. Intraoperative Optical Coherence Tomography–Assisted Chorioretinal Biopsy in the DISCOVER Study

      Intraoperative Optical Coherence Tomography–Assisted Chorioretinal Biopsy in the DISCOVER Study
      Infiltrative conditions such as lymphoproliferative disorders, amyloidosis, and autoimmune and infectious disorders can overlap in their ophthalmic clinical presentation. Malignancies and other infiltrative disease processes can masquerade as ocular inflammatory conditions. To obtain a definitive clinical diagnosis, a biopsy of the choroid and/or retina may be warranted. When conducting biopsy of intraocular structures, preoperative understanding of retinal microanatomy frequently informs surgical planning. Although office-based, clinical table-top optical coherence tomography ...
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    3. Cleveland Clinic Receives a NIH Grant for Intraoperative Optical Coherence Tomography for Ophthalmic Surgery

      Cleveland Clinic Receives a NIH Grant for Intraoperative Optical Coherence Tomography for Ophthalmic Surgery
      ...s. This research activity will focus on translating OCT technology into the operating room and will be led by Justis P. Ehlers, MD, of the Cleveland Clinic Cole Eye Institute. Dr. Ehlers is a highly trained retina surgeo...
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    4. Intraoperative optical coherence tomography-compatible surgical instruments for real-time image-guided ophthalmic surgery

      Intraoperative optical coherence tomography-compatible surgical instruments for real-time image-guided ophthalmic surgery
      Intraoperative optical coherence tomography (OCT) is a potentially transformational technology that is now commercially available to ophthalmic surgeons. Currently, the use of the technology is primarily limited to a stop and image approach due to the lack of OCT compatibility with surgical instrumentation. In this report, we describe multiple OCT-compatible surgical instruments that were developed for various surgical needs, based on previous evaluation of potential surgical materials for optical features ...
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    5. Outcomes of Intraoperative OCT–Assisted Epiretinal Membrane Surgery from the PIONEER Study

      Outcomes of Intraoperative OCT–Assisted Epiretinal Membrane Surgery from the PIONEER Study
      Purpose To assess the retinal architecture changes that occur during epiretinal membrane (ERM) surgery, utilizing intraoperative OCT ( i OCT). Design Prospective multisurgeon single-center study. Subjects Subjects from the PIONEER i OCT study who underwent surgical intervention for management of ERM. Methods All subjects underwent vitrectomy with ERM peeling with optional internal limiting membrane (ILM) peeling. Preoperative, intraoperative, and postoperative quantitative and qualitative OCT assessments were performed. Clinical characteristics including visual ...
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    6. Microscope-Integrated OCT Feasibility and Utility With the EnFocus System in the DISCOVER Study

      Microscope-Integrated OCT Feasibility and Utility With the EnFocus System in the DISCOVER Study
      BACKGROUND AND OBJECTIVE: To evaluate the feasibility and utility of a novel microscope-integrated intraoperative optical coherence tomography (OCT) system. PATIENTS AND METHODS: The DISCOVER study is an investigational device study evaluating microscope-integrated intraoperative OCT systems for ophthalmic surgery. This report focuses on subjects imaged with the EnFocus prototype system (Leica Microsystems/Bioptigen, Morrisville, NC). OCT was performed at surgeon-directed milestones. Surgeons completed a questionnaire after each case to evaluate the ...
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    7. Optical Coherence Tomography Features in Diabetic Macular Edema and the Impact on Anti-VEGF Response

      Optical Coherence Tomography Features in Diabetic Macular Edema and the Impact on Anti-VEGF Response
      BACKGROUND AND OBJECTIVE: To assess the relationship between spectral-domain optical coherence tomography (SD-OCT) features and functional outcomes for diabetic macular edema (DME) undergoing treatment with intravitreal bevacizumab (Avastin; Genentech, South San Francisco, CA). PATIENTS AND METHODS: Institutional review board-approved, retrospective, consecutive case series of eyes receiving intravitreal bevacizumab (1.25 mg) for DME. SD-OCT features were evaluated and correlated with functional response to anti-vascular endothelial growth factor (VEGF) therapy. RESULTS ...
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    8. Intraoperative Interface Fluid Dynamics and Clinical Outcomes for Intraoperative OCT-Assisted DSAEK from the Pioneer Study

      Intraoperative Interface Fluid Dynamics and Clinical Outcomes for Intraoperative OCT-Assisted DSAEK from the Pioneer Study
      Purpose To correlate intraoperative interface fluid dynamics during Descemet stripping automated endothelial keratoplasty (DSAEK) surgery using intraoperative optical coherence tomography (iOCT) in the PIONEER (Prospective Intraoperative and Perioperative Ophthalmic ImagiNg with Optical CohEncE TomogRaphy) study with postoperative outcomes. Design Prospective consecutive, interventional, comparative case series Participants One hundred and seventy-eight eyes of 173 patients undergoing DSAEK from the Cole Eye Institute, Cleveland, USA. Methods Eyes that underwent DSAEK between October ...
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    9. Volumetric analysis of pathologies

      Volumetric analysis of pathologies
      Systems and methods are provided for volumetric analysis of pathologies. A segmentation component is configured to determine, for each of a series of images of a region of interest containing a pathological feature, a set of segmentation boundaries within the image representing a cross-section of the pathological feature. A mesh generation component is configured to link the sets of segmentation boundaries from adjacent images in the series of images to ...
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    10. Clinical utility of intraoperative optical coherence tomography

      Clinical utility of intraoperative optical coherence tomography
      Purpose of review: To explore the clinical utility of intraoperative optical coherence tomography (iOCT) for the management of vitreoretinal conditions. Recent findings: The role of iOCT in guiding surgical decision-making and surgical manipulations during vitreoretinal procedures has been evaluated by multiple studies. This imaging modality is emerging as a valuable asset during procedures for vitreoretinal interface disorders, retinal detachments, submacular surgeries and therapeutics, and in pediatric conditions such as retinopathy ...
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    11. Intraoperative optical coherence tomography: past, present, and future

      Intraoperative optical coherence tomography: past, present, and future
      To provide an overview of the current state of intraoperative optical coherence tomography (OCT). Literature review of studies pertaining to intraoperative OCT examining both the technology aspects of the imaging platform and the current evidence for patient care. Over the last several years, there have been significant advances in integrative technology for intraoperative OCT. This has resulted in the development of multiple microscope-integrated systems and a rapidly expanding field of ...
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    12. Membrane Peeling-Induced Retinal Alterations on Intraoperative OCT in Vitreomacular Interface Disorders From the PIONEER Study

      Membrane Peeling-Induced Retinal Alterations on Intraoperative OCT in Vitreomacular Interface Disorders From the PIONEER Study
      Purpose : To assess retinal architectural alterations that occur following membrane peeling procedures and the impact of peel technique on these alterations utilizing intraoperative optical coherence tomography ( i OCT). Methods : This is a subanalysis of the prospective PIONEER i OCT study of eyes undergoing a membrane peeling for a vitreomacular interface (VMI) disorder. Intraoperative scanning was performed with a microscope-mounted OCT system. Macroarchitectural alterations (e.g., full-thickness retinal elevations) and microarchitectural ...
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  2. About Justis P. Ehlers

    Justis P. Ehlers

    Justis P. Ehlers is a staff physician at the Cole Eye Institute, Vitreoretinal Service at Cleveland Clinic.