1. Jun Zhang

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    1. Mentioned In 40 Articles

    2. Dynamic-range compression and contrast enhancement in swept-source optical coherence tomography systems with a frequency gain compensation amplifier

      Dynamic-range compression and contrast enhancement in swept-source optical coherence tomography systems with a frequency gain compensation amplifier
      Significance: Optical coherence tomography (OCT) has been widely used in clinical studies. However, the image quality of OCT decreases with increasing imaging depth since the light is rapidly attenuated in biological tissues. Aim: We present a compensation approach to preserve weak high-frequency signals from deep structures and compress the dynamic range of the detected signal for superior analog-to-digital conversion and image display capability. Approach: A homemade frequency gain compensation amplifier ...
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    3. Integrated Multifunctional Laryngoscope for Medical Diagnosis and Treatment

      Integrated Multifunctional Laryngoscope for Medical Diagnosis and Treatment
      Laryngeal lesions can cause great inconvenience to patients. Early diagnosis and corresponding treatments are critical to the survival of patients. However, the diagnosis and precise removal of tumors remain a challenge under the use of a white light laryngoscope. In this work, an integrated, multifunctional laryngoscope was designed and tested for the imaging evaluation and precision laser surgery for laryngeal tissue. This integrated diagnostic and therapeutic endoscopic system included two ...
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    4. Identification of oral cancer in OCT images based on an optical attenuation model

      Identification of oral cancer in OCT images based on an optical attenuation model
      Surgery is still the first choice to treat oral cancer, where it is important to detect surgical margins in order to reduce cancer recurrence and maintain oral-maxillofacial function simultaneously. As a non-invasive and in situ imaging technique, optical coherence tomography (OCT) can obtain images close to the resolution of histopathology, which makes it have great potential in intraoperative diagnosis. However, it is not enough to find surgical margins accurately just ...
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    5. Rapid, High-Resolution, Label-Free, and 3-Dimensional Imaging to Differentiate Colorectal Adenomas and Non-Neoplastic Polyps With Micro-Optical Coherence Tomography

      Rapid, High-Resolution, Label-Free, and 3-Dimensional Imaging to Differentiate Colorectal Adenomas and Non-Neoplastic Polyps With Micro-Optical Coherence Tomography
      INTRODUCTION: Resectanddiscard paradigmisoneofthemainstrategiestodealwithcolorectaldiminutivepolyps after optical diagnosis. However, there are risks that unrecognized potentially malignant lesions are discarded without accurate diagnosis. The purpose of this study is to validate the potential of micro- optical coherence tomography ( m OCT) to improve the diagnostic accuracy of colorectal lesions and help endoscopists make better clinical decision without additional pathology costs. METHODS: RESULTS: DISCUSSION: Fresh tissue samples were obtained from patients with colorectal polyps or ...
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    6. Correction of saturation effects in endoscopic swept-source optical coherence tomography based on dual-channel detection

      Correction of saturation effects in endoscopic swept-source optical coherence tomography based on dual-channel detection
      Saturation artifacts that are commonly observed in endoscopic swept-source optical coherence tomography (SSOCT) images cause image degradation and loss of image information. We present work on the correction of saturation effects in endoscopic SSOCT imaging. This method utilizes a broadband power divider with excellent pick-off flatness to divide the detected interference signal into the two channels of an analog-to-digital converter. Based on the precise calibration of the splitting ratio between ...
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    7. Dynamically focused optical coherence tomography for endoscopic applications

      Dynamically focused optical coherence tomography for endoscopic applications
      We report a demonstration of a small liquid-filled polymer lens that may be used to dynamically provide scanning depth focus for endoscopic optical coherence tomography (OCT) applications. The focal depth of the lens is controlled by changing the hydraulic pressure within the lens, enabling dynamic focal depth control without the need for articulated parts. The 1 mm diameter lens is shown to have resolving power of 5 m, and can ...
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    8. Contrast improvement for swept source optical coherence tomography image of sub-surface tissue

      Contrast improvement for swept source optical coherence tomography image of sub-surface tissue
      Swept source optical coherence tomography (SSOCT) is an attractive biological imaging technology due to its advantages of simple setup and high imaging speed. As the light intensity attenuated rapidly in high scattering biological tissues, the contrast of OCT image will drop with depth. In this paper a new method was introduced to compensate the attenuation of imaging contrast in SSOCT. The interference signal was divided into two channels of analog ...
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    9. Suppression of saturation artifacts in swept source optical coherence tomography using dual channel detection

      Suppression of saturation artifacts in swept source optical coherence tomography using dual channel detection
      A technique to suppress saturation artifacts in swept source optical coherence tomography (SSOCT) system was presented. The detected signal was split into two channels of a high speed data acquisition card with two levels by a power divider. The signal in one channel with higher level was used to reconstruct OCT images and the signal in the other channel with lower level was used to compensate the saturated signal in ...
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    10. Trimodality imaging system and intravascular endoscopic probe: combined optical coherence tomography, fluorescence imaging and ultrasound imaging

      Trimodality imaging system and intravascular endoscopic probe: combined optical coherence tomography, fluorescence imaging and ultrasound imaging
      ...ical Society of America Shanshan Liang, Teng Ma, Joseph Jing, Xiang Li, Jiawen Li, K. Kirk Shung, Qifa Zhou, Jun Zhang, and Zhongping Chen, "Trimodality imaging system and intravascular endoscopic probe: combined optica...
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    11. Integrated IVUS-OCT for Real-Time Imaging of Coronary Atherosclerosis

      Integrated IVUS-OCT for Real-Time Imaging of Coronary Atherosclerosis
      Accurate assessment of atherosclerotic plaque characteristics and the subsequent tailoring of optimal therapy holds great promise for preventing acute coronary syndromes (ACS) and life-threatening sequelae 1 . Combined use of optical coherence tomography (OCT) and intravascular ultrasound (IVUS) was proposed as a potential method for accurate assessment of plaque characteristics and vulnerability ( 2 , ). However, significant challenges remain in trying to adapt an integrated OCT-IVUS system for clinical applications. We report here ...
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    12. Feature Of The Week 11/24/13 : Miniature OCT/IVUS probe for automatically co-registered three-dimensional intracoronary imaging with real-time display

      Feature Of The Week 11/24/13 : Miniature OCT/IVUS probe for automatically co-registered three-dimensional intracoronary imaging with real-time display
      Combined use of intravascular ultrasound (IVUS) and optical coherence tomography (OCT) holds the potential of combining the strengths of both imaging modalities and improving the diagnostic accuracy of atherosclerotic plaque vulnerability. In this manuscript, we reported a co-registered intracoronary OCT-IVUS system and catheter with real-time imaging and polar-coordinate displaying capability, well-suited for clinical utilization in guiding interventional cardiologists. With an eventual goal of clinical use in humans, this novel catheter ...
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    13. Miniature optical coherence tomography-ultrasound probe for automatically coregistered three-dimensional intracoronary imaging with real-time display

      Miniature optical coherence tomography-ultrasound probe for automatically coregistered three-dimensional intracoronary imaging with real-time display
      ...s probe and our upgraded system. Histology validation is also presented. Jiawen Li ; Teng Ma ; Joseph Jing ; Jun Zhang ; Pranav M. Patel, et al. "Miniature optical coherence tomography-ultrasound probe for automaticall...
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    14. Imaging and quantifying Brownian motion of micro- and nanoparticles using phase-resolved Doppler variance optical coherence tomography

      Imaging and quantifying Brownian motion of micro- and nanoparticles using phase-resolved Doppler variance optical coherence tomography
      Different types and sizes of micro- and nanoparticles have been synthesized and developed for numerous applications. It is crucial to characterize the particle sizes. Traditional dynamic light scattering, a predominant method used to characterize particle size, is unable to provide depth resolved information or imaging functions. Doppler variance optical coherence tomography (OCT) measures the spectral bandwidth of the Doppler frequency shift due to the Brownian motion of the particles utilizing ...
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    15. 1-15 of 40 1 2 3 »
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  2. About Jun Zhang

    Jun Zhang

    Jun Zhang received the Ph.D. degree in optics from Shanghai Jiaotong University, China, in 2001. He is currently an Assistant Project Scientist in the Beckman Laser Institute at the University of California, Irvine.  His research experience and interests are in the areas of development of optical coherence tomography (OCT), fiber-optic endoscopy and translation of these techniques to address clinical problems. Dr. Zhang has published more than 50 peer reviewed technical papers and multiple patents. He is currently Principal Investigator for two studies: an NIH grant designed to evaluate obstructive sleep apnea with long range 3D endoscopic FDOCT; a California Tobacco-Related Disease Research Program (TRDRP) supported grant to combine high speed 3-D imaging techniques with the surgical laser into a system for detection and treatment of smoke induced cancer.