1. Julia Welzel

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    1. Mentioned In 32 Articles

    2. Michelson Diagnostics: Imaging Reveals Changes in Blood Vessel Growth in Deadly Melanoma Skin Cance

      Michelson Diagnostics: Imaging Reveals Changes in Blood Vessel Growth in Deadly Melanoma Skin Cance
      ...dentify advanced metastatic melanomas so that patients can be fast-tracked to the right treatment. Professor Julia Welzel (General Hospital Augsburg, Germany ) said: "Our goal with this work is to help develop a faster,...
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    3. Optical coherence tomography provides an optical biopsy of burn wounds in children—a pilot study

      Optical coherence tomography provides an optical biopsy of burn wounds in children—a pilot study
      Thermic injuries are among the most severe injuries in childhood. Burn depth is the most relevant prognostic factor, and still its assessment is both difficult and controversial. This diagnostic uncertainty results in repeated wound assessments over a 10-day period and carries a relevant risk for over- and undertreatment. Precise wound assessment would thus be a significant step toward improved care. Optical coherence tomography (OCT) is a noninvasive laser-based technique with ...
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    4. The vascular morphology of melanoma is related to Breslow index: an in vivo study with dynamic optical coherence tomography

      The vascular morphology of melanoma is related to Breslow index: an in vivo study with dynamic optical coherence tomography
      Background Malignant melanoma is an aggressive skin cancer, which can lead to metastasis development. Vascularization enhancement is fundamental for tumor growth, worsening the prognosis. Dynamic Optical Coherence Tomography (D‐OCT) enables the in vivo evaluation of vascular patterns in skin lesions. Objective In vivo evaluation of the melanoma vessel morphology by means of D‐OCT and correlation with Breslow index. Methods Retrospective analysis of histologically proven melanomas, evaluated by D ...
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    5. Optical coherence tomography of basal cell carcinoma: influence of location, subtype, observer variability and image quality on diagnostic performance

      Optical coherence tomography of basal cell carcinoma: influence of location, subtype, observer variability and image quality on diagnostic performance
      Background We previously described the principal results from an observational, prospective, multi-centre, clinical trial of the diagnostic value of optical coherence tomography (OCT) for basal cell carcinoma (BCC) in a clinical setting. In this trial, much additional useful information was gathered that warranted further analysis, presented here. Objectives To investigate the influence of candidate diagnostic criteria, OCT image quality, lesion location, and observer confidence and inter-observer variability on the diagnostic ...
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    6. Optical coherence tomography for margin definition of basal cell carcinoma before micrographic surgery—recommendations regarding the marking and scanning technique

      Optical coherence tomography for margin definition of basal cell carcinoma before micrographic surgery—recommendations regarding the marking and scanning technique
      Background/purpose Mohs Micrographic Surgery (MMS) is the preferred therapeutic treatment for high-risk basal cell carcinoma (BCC). Optical Coherence Tomography (OCT) is a non-invasive imaging technique that enables the diagnosis of BCC. We thought to determine the margins of BCCs with OCT, prior to MMS, to reduce the number of surgical steps. Methods Different permanent markers were tested on the skin regarding line width, resistance against disinfection and brightness in ...
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    7. Dynamic optical coherence tomography of skin blood vessels – proposed terminology and practical guidelines

      Dynamic optical coherence tomography of skin blood vessels – proposed terminology and practical guidelines
      Background Dynamic optical coherence tomography (D-OCT) has recently been introduced in dermatology. In contrast to Standard OCT imaging, which exclusively relies on the morphological analysis of the tissue, D-OCT allows the in-vivo visualisation of blood flow. Preliminary D-OCT data showed differences in the vascularisation of nevus to melanoma transition, suggesting that this technology may help to differentiate between benign and malignant lesions. Objective Several factors may influence the quality of ...
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    8. Validation of Dynamic optical coherence tomography for non-invasive, in vivo microcirculation imaging of the skin

      Validation of Dynamic optical coherence tomography for non-invasive, in vivo microcirculation imaging of the skin
      Objectives Dynamic optical coherence tomography (D-OCT) is anangiographic variation of OCT that non-invasively provides images of the in vivo microvasculature of the skin by combining conventional OCT images with flow data. The objective of this study was to investigate and report on the D-OCT technique for imaging of the vascular networks in skin as well as to validate the method by comparing the results against already accepted blood flow measuring ...
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    9. Dynamic Optical Coherence Tomography in Dermatology

      Dynamic Optical Coherence Tomography in Dermatology
      Optical coherence tomography (OCT) represents a non-invasive imaging technology, which may be applied to the diagnosis of non-melanoma skin cancer and which has recently been shown to improve the diagnostic accuracy of basal cell carcinoma. Technical developments of OCT continue to expand the applicability of OCT for different neoplastic and inflammatory skin diseases. Of these, dynamic OCT (D-OCT) based on speckle variance OCT is of special interest as it allows ...
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    10. Study shows VivoSight OCT is able to differentiate between actinic keratosis (AK) and basal cell carcinoma (BCC) by quantification of signal intensity and layer thickness

      Study shows VivoSight OCT is able to differentiate between actinic keratosis (AK) and basal cell carcinoma (BCC) by quantification of signal intensity and layer thickness
      ...therapy, where the diagnosis, grading, subtype and/or lesion thickness is unclear” explained author Professor Julia Welzel, Klinikum Augsburg, Germany. “This data published shows that VivoSight OCT is not only able to di...
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    11. In vivo, micro-morphological vascular changes induced by topical brimonidine studied by Dynamic optical coherence tomography

      In vivo, micro-morphological vascular changes induced by topical brimonidine studied by Dynamic optical coherence tomography
      Background Brimonidine is a selective 2 adrenergic receptor agonist with potent vasoconstrictive activity topically used for treatment of facial flushing and erythema caused by rosacea. Direct evidence for the in vivo morphology changes in skin vessels induced by topical application of brimonidine is limited. Dynamic optical coherence tomography is a novel technology that combines conventional OCT with information on flow and thereby provides supplementary information about the microvasculature. Dynamic OCT ...
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    12. Optical coherence tomography of actinic keratoses and basal cell carcinomas – differentiation by quantification of signal intensity and layer thickness

      Optical coherence tomography of actinic keratoses and basal cell carcinomas – differentiation by quantification of signal intensity and layer thickness
      Background Previous studies have shown that actinic keratoses (AKs) and basal cell carcinomas (BCCs) can be diagnosed by optical coherence tomography (OCT) based on morphological characteristics. There is a lack of systematic studies that give standardized information on signal intensity and layer thickness of AKs and BCCs. Objective The aim of this study was to find out if AKs and BCCs can be objectively diagnosed through standardized measurement of signal ...
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    13. Comparison of different optical coherence tomography devices for diagnosis of non-melanoma skin cancer

      Comparison of different optical coherence tomography devices for diagnosis of non-melanoma skin cancer
      Purpose To compare the diagnostic imaging ability of three different optical coherence tomography (OCT) devices in non-melanoma skin cancer (NMSC). Methods Thirty actinic keratoses (AKs) and 27 basal cell carcinomas (BCCs) of 29 patients were examined with three different OCT devices, VivoSight , Callisto and Skintell . Results Complete data sets were available for 16 BCCs and 10 AKs of 18 patients. All OCT devices were able to discriminate BCCs and AKs ...
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    14. The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of nonpigmented basal cell carcinoma: an observational study - Ulrich - 2015 - British Journal of Dermatology - Wiley Online Library

      The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of nonpigmented basal cell carcinoma: an observational study - Ulrich - 2015 - British Journal of Dermatology - Wiley Online Library
      Background The diagnostic criteria for basal cell carcinoma (BCC) using optical coherence tomography (OCT) have been described previously, but the clinical value of these findings remains unknown. Objectives To investigate the diagnostic value of OCT for BCC in a typical clinical setting. The primary efficacy end point was a diagnosis of BCC for each lesion. Secondary end points were the diagnosis of other possible conditions. Methods This was an observational ...
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    15. The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of non-pigmented basal cell carcinoma - an observational study

      The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of non-pigmented basal cell carcinoma - an observational study
      Background The diagnostic criteria for basal cell carcinoma (BCC) using optical coherence tomography (OCT) have been described previously, but the clinical value of these findings has been unknown. Objective The aim of this study was to investigate the diagnostic value of OCT for BCC in a typical clinical setting. The primary efficacy endpoint was a diagnosis of BCC for each lesion. Secondary endpoints were the diagnosis of other possible conditions ...
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  2. About Julia Welzel

    Julia Welzel

    Julia Welzel, Professor, Chief physician, Clinic for Dermatology and Allergology, Klinikum Augsburg, Germany. Prof Welzel is a renowned expert in non-invasive imaging of the skin and has published many paper on the use of OCT in dermatology. She is undertaking research using VivoSight to monitor, amongst other things, topical therapies for actinic keratosis and basal cell carcinoma.

  3. Quotes

    1. Our goal with this work is to help develop a faster, more efficient and less invasive diagnostic and treatment pathway for melanoma. Patients with advanced disease should get aggressive treatment as quickly as possible; also those with early-stage melanomas should not have to undergo expensive invasive Sentinel Lymph Node Biopsy operations if their melanoma is reliably confirmed as very low-risk. We believe Dynamic OCT imaging could help with these goals and the results of this study are very encouraging. The next stage of our work is to analyse the link between vessel shapes and the actual degree of metastasis of the melanomas in a larger cohort, and not just the Breslow depth.
      In Michelson Diagnostics: Imaging Reveals Changes in Blood Vessel Growth in Deadly Melanoma Skin Cance
    2. In the majority of cases it is clinically and dermoscopically possible to differentiate between AK and BCC, but there are difficult situations, especially in early cases or during topical therapy, where the diagnosis, grading, subtype and/or lesion thickness is unclear...This data published shows that VivoSight OCT is not only able to differentiate between the two diseases by means of epidermal thickness and signal intensity measurements but also able to be used as a non-invasive technique to determine and monitor the treatment. This technology significantly improves the diagnostic methods currently used resulting in better outcomes for patients.
      In Study shows VivoSight OCT is able to differentiate between actinic keratosis (AK) and basal cell carcinoma (BCC) by quantification of signal intensity and layer thickness
    3. The availability of this scan could revolutionise melanoma treatment; by reducing the number of patients with early stage melanomas who unnecessarily undergo expensive invasive procedures performed under general anaesthesia, and also helping to definitively detect metastatic melanomas requiring urgent treatment much more quickly, potentially saving lives.
      In Michelson Diagnostics targets malignant melanoma using OCT imaging with €2.3M EU funding