1. Juan Luis Gutiérrez-Chico

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    1. Mentioned In 26 Articles

    2. Diagnostic accuracy and reproducibility of optical flow ratio for functional evaluation of coronary stenosis in a prospective series

      Diagnostic accuracy and reproducibility of optical flow ratio for functional evaluation of coronary stenosis in a prospective series
      Background: Evaluating prospectively the feasibility, accuracy and reproducibility of optical flow ratio (OFR), a novel method of computational physiology based on optical coherence tomography (OCT). Methods and results: Sixty consecutive patients (76 vessels) underwent prospectively OCT, angiography-based quantitative flow ratio (QFR) and fractional flow ratio (FFR). OFR was computed offline in a central core-lab by analysts blinded to FFR. OFR was feasible in 98.7% of the lesions and showed ...
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    3. Comparison of Diagnostic Performance of Intracoronary Optical Coherence Tomography-based and Angiography-based Fractional Flow Reserve for Evaluation of Coronary Stenosis

      Comparison of Diagnostic Performance of Intracoronary Optical Coherence Tomography-based and Angiography-based Fractional Flow Reserve for Evaluation of Coronary Stenosis
      Aims: To evaluate the diagnostic performance of OCT-based optical flow ratio (OFR) in unselected patients and compare it with angiography-based quantitative flow ratio (QFR), using wire-based FFR as reference standard. Methods and results: All patients with OCT and FFR assessment prior to revascularization were analyzed. OFR and QFR were computed in blinded fashion and compared with FFR, all applying same cut-off value of 0.80 to define ischemia. Paired comparison ...
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    4. Challenging treatment of in-stent restenosis in a coronary bifurcation by implantation of a bioresorbable scaffold under optical coherence tomography guidance

      Challenging treatment of in-stent restenosis in a coronary bifurcation by implantation of a bioresorbable scaffold under optical coherence tomography guidance
      A 67-year-old male patient with stable angina, hypertension and hypercholesterolemia who underwent bare metal stent (BMS) implantation in the distal right coronary artery (RCA) (Azule 3 9 mm) and everolimus-eluting stent (EES) implantation in the first diagonal branch (D1) (Xience 2.25 18 mm) and in the proximal circumflex branch (LCx) (Xience 3 28 mm). One year subsequent to the precedure the patient was readmitted for relapse of the angina ...
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    5. A formula to calculate the contrast volume required for optimal imaging quality in optical coherence tomography with non-occlusive technique

      A formula to calculate the contrast volume required for optimal imaging quality in optical coherence tomography with non-occlusive technique
      Background: Non-occlusive technique is universally accepted for acquisition of coronary optical coherence tomography (OCT), but the amount of contrast infused is still inconsistently calculated. Proposed herein, is an empirical formula for accurate contrast volume calculation. Methods: In an observational prospective study, contrast volume of consecutive patients undergoing OCT was either calculated with formula, or eyeballed based on manufacturer recommendations. The quality of pullback, defined as % of high quality cross-sections (CS ...
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    6. Rational and Design of the European Randomized Optical Coherence Tomography Optimized Bifurcation Event Reduction Trial (OCTOBER)

      Rational and Design of the European Randomized Optical Coherence Tomography Optimized Bifurcation Event Reduction Trial (OCTOBER)
      Background Percutaneous coronary intervention (PCI) in complex bifurcation lesions is prone to suboptimal implantation results and is associated with increased risk of subsequent clinical events. Angiographic ambiguity is high during bifurcation stenting but it is unknown if procedural guidance by intravascular optical coherence tomography (OCT) improves clinical outcome. Methods and design OCTOBER is a randomized, investigator initiated, multi-center trial aimed to show superiority of OCT guided stent implantation compared to ...
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    7. Implantation of bioresorbable scaffolds under guidance of optical coherence tomography: feasibility and pilot clinical results of a systematic protocol

      Implantation of bioresorbable scaffolds under guidance of optical coherence tomography: feasibility and pilot clinical results of a systematic protocol
      Background: We hypothesise that a comprehensive optical coherence tomography (OCT)-guided implantation protocol for bioresorbable scaffolds (BRS) might improve expansion and apposition, thus translating into better clinical outcomes, particularly reducing thrombotic events. Methods: Patients considered suitable for BRS therapy in de novo coronary lesions underwent OCT. The predominant type of plaque was classified as lipidic, fibrous or calcific, undergoing tailored plaque preparation accordingly. After proper sizing, BRS was deployed and ...
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    8. Endothelial progenitor cells and plaque burden in stented coronary artery segments: an optical coherence tomography study six months after elective PCI

      Endothelial progenitor cells and plaque burden in stented coronary artery segments: an optical coherence tomography study six months after elective PCI
      Background Endothelial progenitor cells (EPC) are involved in neovascularization and endothelial integrity. They might be protective in atherosclerosis. Optical coherence tomography (OCT) is a precise intracoronary imaging modality that allows assessment of subintimal plaque development. We evaluated the influence of EPC on coronary plaque burden in stable disease and implemented a novel computational plaque analysis algorithm using OCT. Methods Forty-three patients (69.8% males, 69.6 7.7 years) were ...
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    9. Implantation of magnesium-bioresorbable scaffolds in a bifurcation under optical coherence tomography guidance

      Implantation of magnesium-bioresorbable scaffolds in a bifurcation under optical coherence tomography guidance
      A 68-years-old female with positive test of ischaemia in the anterior wall presented a severe coronary bifurcation lesion in the anterior descending (LAD) and first diagonal (D1) arteries, Medina 010 ( Panel A ; Supplementary material online, Video 1 ). OCT showed lipid-rich plaques in both vessels, extending proximally and distally to the take-off of the D1 (optical Medina 110). Balloons and scaffolds were sized
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    10. Time course of vascular response after an a priori strategy of bare metal stent implantation post-dilated with a paclitaxel-coated balloon: Implementation of a three dimensional analysis algorithm with optical coherence tomography

      Time course of vascular response after an a priori strategy of bare metal stent implantation post-dilated with a paclitaxel-coated balloon: Implementation of a three dimensional analysis algorithm with optical coherence tomography
      Background: An a priori combined therapy of a bare metal stent (BMS) post-dilated with a paclitaxel-coated balloon (PCB) was investigated with optical coherence tomography (OCT) at 2- and 6 months regarding vessel response. Previous studies have shown inconsistent results and the time course of vessel healing after such an interventional strategy is unknown. Methods: Thirty-three de novo lesions in 32 patients were electively treated. Six-month OCT analysis was available in ...
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    11. Impact of Side Branch Modeling on Computation of Endothelial Shear Stress in Coronary Artery Disease Coronary Tree Reconstruction by Fusion of 3D Angiography and OCT

      Impact of Side Branch Modeling on Computation of Endothelial Shear Stress in Coronary Artery Disease Coronary Tree Reconstruction by Fusion of 3D Angiography and OCT
      Background Computational fluid dynamics allow virtual evaluation of coronary physiology and shear stress (SS). Most studies hitherto assumed the vessel as a single conduit without accounting for the flow through side branches. Objectives This study sought to develop a new approach to reconstruct coronary geometry that also computes outgoing flow through side branches in hemodynamic and biomechanical calculations, using fusion of optical coherence tomography (OCT) and 3-dimensional (3D) angiography. Methods ...
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    12. Incomplete Stent Apposition Causes High Shear Flow Disturbances and Delay in Neointimal Coverage as a Function of Strut to Wall Detachment Distance: Implications for the Management of Incomplete Stent Apposition

      Incomplete Stent Apposition Causes High Shear Flow Disturbances and Delay in Neointimal Coverage as a Function of Strut to Wall Detachment Distance: Implications for the Management of Incomplete Stent Apposition
      ...nt Distance Implications for the Management of Incomplete Stent Apposition 1. Nicolas Foin, MSc, PhD*, 2. Juan Luis Gutiérrez-Chico, MD, PhD*, 3. Shimpei Nakatani, MD*, 4. Ryo Torii, MSc, PhD*, 5. Christos V. Bourant...
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    13. In vivo evaluation of neointimal healing after stenting with optical coherence tomography (Thesis)

      In vivo evaluation of neointimal healing after stenting with optical coherence tomography (Thesis)
      Ischemic heart disease is still today the first cause of mortality in the world, especially in the developed countries. The vast majority of cases are due to atherosclerosis, a complex systemic degenerative process resulting in cholesterol accumulation in the extra-cellular space of the arterial intima, with inflammation, foam-cells formation, and necrosis. The clinical manifestations of coronary atherosclerosis comprise from stable angina, due to flow-limiting stenosis of the artery, to acute ...
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    14. Tissue coverage and neointimal hyperplasia in overlap versus nonoverlap segments of drug-eluting stents 9 to 13 months after implantation: In vivo assessment with optical coherence tomography

      Tissue coverage and neointimal hyperplasia in overlap versus nonoverlap segments of drug-eluting stents 9 to 13 months after implantation: In vivo assessment with optical coherence tomography
      Background: Histologic experimental studies have reported incomplete neointimal healing in overlapping with respect to nonoverlapping segments in drug-eluting stents (DESs), but these observations have not been confirmed in human coronary arteries hitherto. On the contrary, angiographic and optical coherence tomography studies suggest that DES overlap elicits rather an exaggerated than an incomplete neointimal reaction.Methods: Optical coherence tomography studies from 2 randomized trials including sirolimus-eluting, biolimus-eluting, everolimus-eluting, and zotarolimus-eluting stents ...
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    15. Plaque sealing and passivation with a mechanical self-expanding low outward force nitinol VShield device for the treatment of intravascular ultrasound and optical coherence tomography-derived thin cap fibroatheromas (TCFAS) in native coronary arteries

      Plaque sealing and passivation with a mechanical self-expanding low outward force nitinol VShield device for the treatment of intravascular ultrasound and optical coherence tomography-derived thin cap fibroatheromas (TCFAS) in native coronary arteries
      Aims: The aim of the pilot SECRITT trial was to evaluate the safety and feasibility of sealing the high risk IVUS and optical coherence tomography-derived thin cap fibroatheroma (TCFA), with a dedicated nitinol self-expanding vShield device. Methods and results: After screening with angiography, fractional flow reserve (FFR), intravascular ultrasound virtual histology (IVUS-VH) and optical coherence tomography (OCT), 23 patients met enrolment criteria (presence of non-obstructive VH-derived TCFA lesion with thin ...
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  2. About Juan Luis Gutiérrez-Chico

    Juan Luis Gutiérrez-Chico

    Juan Luis Gutiérrez-Chico is an interventional cardiologist with the Erasmus Medical Center, Thoraxcentrum, Interventional Cardiology Department in Rotterdam, The Netherlands.